Restless Legs Syndrome (RLS)

Also known as: Restless Legs Syndrome / Restless Legs / Restless Leg Syndrome (RLS) / Restless Leg Syndrome / Restless Leg Disorder / Legs restless / Syndrome restless legs

DrugDrug NameDrug Description
DB00915AmantadineA medication used to treat dyskinesia in Parkinson's patients receiving levodopa, as well as extrapyramidal side effects of medications.
DB00564CarbamazepineAn anticonvulsant used to treat various types of seizures and pain resulting from trigeminal neuralgia.
DB01068ClonazepamA long-acting benzodiazepine with intermediate onset commonly used to treat panic disorders, severe anxiety, and seizures.
DB08872Gabapentin enacarbilA gabapentin prodrug used to treat Restless Legs Syndrome (RLS) and postherpetic neuralgia (PHN).
DB01592IronAn essential element commonly used for the treatment of patients with documented iron deficiency.
DB01235LevodopaA dopamine precursor used in the management of Parkinson's disease, often in combination with carbidopa, as well as other conditions associated with parkinsonism.
DrugDrug NameTargetType
DB00915AmantadineDopamine D2 receptortarget
DB00915AmantadineMatrix protein 2target
DB00915AmantadineAromatic-L-amino-acid decarboxylaseenzyme
DB00915AmantadineAmine oxidase [flavin-containing] Benzyme
DB00915AmantadineSolute carrier family 22 member 2transporter
DB00915AmantadineSolute carrier family 22 member 1transporter
DB00915AmantadineGlutamate receptor ionotropic, NMDA 3Atarget
DB00915AmantadineNeuronal acetylcholine receptor subunit alpha-7target
DB00915AmantadineNeuronal acetylcholine receptor subunit alpha-4target
DB00915AmantadineNeuronal acetylcholine receptor subunit alpha-3target
DB00564CarbamazepineVoltage-gated sodium channel alpha subunittarget
DB00564CarbamazepineCytochrome P450 2C8enzyme
DB00564CarbamazepineCytochrome P450 2B6enzyme
DB00564CarbamazepineCytochrome P450 3A4enzyme
DB00564CarbamazepineCytochrome P450 1A2enzyme
DB00564CarbamazepineCytochrome P450 2C19enzyme
DB00564CarbamazepineCytochrome P450 2C9enzyme
DB00564CarbamazepineP-glycoprotein 1transporter
DB00564CarbamazepineCytochrome P450 3A5enzyme
DB00564CarbamazepineUDP-glucuronosyltransferase 2B7enzyme
DB00564CarbamazepineRalA-binding protein 1transporter
DB00564CarbamazepineCanalicular multispecific organic anion transporter 1transporter
DB00564CarbamazepineNeuronal acetylcholine receptor subunit alpha-4target
DB00564CarbamazepineNuclear receptor subfamily 1 group I member 2target
DB00564CarbamazepineUDP-glucuronosyltransferase 1-1enzyme
DB00564CarbamazepineUDP-glucuronosyltransferase 1-6enzyme
DB00564CarbamazepineUDP-glucuronosyltransferase 1-7enzyme
DB01068ClonazepamTranslocator proteintarget
DB01068ClonazepamCytochrome P450 3A4enzyme
DB01068ClonazepamSerum albumincarrier
DB01068ClonazepamCytochrome P450 2E1enzyme
DB01068ClonazepamArylamine N-acetyltransferase 2enzyme
DB01068ClonazepamGABA-A receptor (anion channel)target
DB01068ClonazepamNuclear receptor subfamily 1 group I member 2target
DB08872Gabapentin enacarbilVoltage-dependent calcium channel subunit alpha-2/delta-1target
DB08872Gabapentin enacarbilVoltage-dependent calcium channel subunit alpha-2/delta-2target
DB08872Gabapentin enacarbilSodium-coupled monocarboxylate transporter 1transporter
DB08872Gabapentin enacarbilSodium-dependent multivitamin transportertransporter
DB01592IronTransferrin receptor protein 1target
DB01592IronEgl nine homolog 1target
DB01592IronHistone deacetylase 8target
DB01592IronAlpha-hemoglobin-stabilizing proteintarget
DB01592IronHemoglobin subunit alphatarget
DB01592IronFrataxin, mitochondrialtarget
DB01592IronFerritin heavy chaintarget
DB01592IronFlap endonuclease 1target
DB01592IronEndonuclease 8-like 1target
DB01592IronEndonuclease 8-like 2target
DB01592IronDNA polymerase betatarget
DB01592IronCeruloplasmintarget
DB01592IronSerotransferrintarget
DB01235LevodopaDopamine D1 receptortarget
DB01235LevodopaDopamine D2 receptortarget
DB01235LevodopaAromatic-L-amino-acid decarboxylaseenzyme
DB01235LevodopaSolute carrier family 15 member 1transporter
DB01235LevodopaMonocarboxylate transporter 10transporter
DB01235LevodopaDopamine D3 receptortarget
DB01235LevodopaDopamine D4 receptortarget
DB01235LevodopaDopamine D5 receptortarget
DB01235LevodopaLarge neutral amino acids transporter small subunit 1transporter
DB01235LevodopaLarge neutral amino acids transporter small subunit 2transporter
DB01235LevodopaSerum albumincarrier
DrugDrug NamePhaseStatusCount
DB01075Diphenhydramine1Completed1
DB04922Gabapentin enacarbil1Completed2
DB08872Gabapentin enacarbil1Completed1
DB00295Morphine1Completed1
DB00218Moxifloxacin1Completed1
DB00268Ropinirole1Completed3
DB00083Botulinum toxin type A1 / 2Completed1
DB12273Ecopipam1 / 2Active Not Recruiting1
DB06620Aplindore2Completed1
DB00083Botulinum toxin type A2Completed1
DB15198Dextromethadone2Not Yet Recruiting1
DB01075Diphenhydramine2Completed1
DB08917Ferric carboxymaltose2Completed2
DB08917Ferric carboxymaltose2Recruiting1
DB13257Ferrous sulfate anhydrous2Recruiting1
DB06215Ferumoxytol2Recruiting1
DB00996Gabapentin2Recruiting1
DB04922Gabapentin enacarbil2Completed3
DB08872Gabapentin enacarbil2Completed1
DB01592Iron2Completed2
DB01592Iron2Recruiting1
DB12208Iron isomaltoside 10002Withdrawn1
DB09146Iron sucrose2Completed1
DB11757Istradefylline2Completed1
DB01202Levetiracetam2Completed1
DB00413Pramipexole2Completed3
DB00230Pregabalin2Completed1
DB00268Ropinirole2Completed1
DB00268Ropinirole2Recruiting1
DB00268Ropinirole2Terminated1
DB05271Rotigotine2Completed4
DB09153Sodium chloride2Withdrawn1
DB00126Ascorbic acid2 / 3Completed1
DB01156Bupropion2 / 3Completed1
DB01367Rasagiline2 / 3Terminated1
DB11094Vitamin D2 / 3Not Yet Recruiting1
DB00163Vitamin E2 / 3Completed1
DB12783Benserazide3Completed1
DB00248Cabergoline3Completed2
DB08917Ferric carboxymaltose3Active Not Recruiting1
DB00996Gabapentin3Completed1
DB00996Gabapentin3Not Yet Recruiting1
DB04922Gabapentin enacarbil3Completed5
DB08872Gabapentin enacarbil3Completed5
DB01235Levodopa3Completed2
DB00589Lisuride3Completed1
DB00413Pramipexole3Completed6
DB00230Pregabalin3Completed1
DB00230Pregabalin3Withdrawn1
DB00268Ropinirole3Completed8
DB00268Ropinirole3Not Yet Recruiting1
DB05271Rotigotine3Completed6
DB05271Rotigotine3Not Yet Recruiting1
DB05271Rotigotine3Recruiting1
DB00921Buprenorphine4Withdrawn1
DB00988Dopamine4Completed1
DB00988Dopamine4Recruiting1
DB08917Ferric carboxymaltose4Completed1
DB00996Gabapentin4Terminated1
DB04922Gabapentin enacarbil4Completed1
DB08872Gabapentin enacarbil4Completed3
DB08872Gabapentin enacarbil4Not Yet Recruiting1
DB08872Gabapentin enacarbil4Terminated1
DB00413Pramipexole4Completed6
DB00413Pramipexole4Recruiting1
DB00230Pregabalin4Withdrawn1
DB00268Ropinirole4Completed2
DB05271Rotigotine4Completed3
DB00273Topiramate4Completed1
DB11094Vitamin D4Suspended1
DB00297BupivacaineNot AvailableUnknown Status1
DB00898EthanolNot AvailableUnknown Status1
DB00996GabapentinNot AvailableCompleted1
DB08872Gabapentin enacarbilNot AvailableCompleted2
DB01235LevodopaNot AvailableUnknown Status1
DB00281LidocaineNot AvailableUnknown Status1
DB00959MethylprednisoloneNot AvailableUnknown Status1
DB00413PramipexoleNot AvailableCompleted3
DB00268RopiniroleNot AvailableCompleted3