Visceral Leishmaniasis

Also known as: Visceral leishmaniasis / Leishmaniasis, Visceral / Leishmaniasis visceral (kala-azar) / Dumdum fever / Kala-azar / Leishmania donovani infection

DrugDrug NameDrug Description
DB00681Amphotericin BAmphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL in vitro. While Candida albicans is generally quite susceptible to amphotericin B, non-albicans species may be less susceptible. Pseudallescheria boydii and Fusarium sp. are often resistant to amphotericin B. The antibiotic is without effect on bacteria, rickettsiae, and viruses.
DB09031MiltefosineMiltefosine is a broad spectrum antimicrobial, anti-leishmanial, phospholipid drug that was originally developed in the 1980s as an anti-cancer agent. It is currently the only recognized oral agent used to treat visceral, cutaneous, and mucosal forms of leishmaniasis, a neglected tropical disease. It can be administered topically or orally and is only indicated in patients aged 12 years or older. The CDC has also recommended it as a first line treatment for free-living amebae (FLA) infections such as primary amebic meningoencephalitis and granulomatous amebic encephalitis.
DrugDrug NamePhaseStatusCount
DB00681Amphotericin B1Recruiting1
DB09536Titanium dioxide1Recruiting1
DB00681Amphotericin B2Completed1
DB00681Amphotericin B2Terminated1
DB12265Fexinidazole2Terminated1
DB09031Miltefosine2Completed3
DB04909Sitamaquine2Completed1
DB00681Amphotericin B3Completed7
DB09031Miltefosine3Completed3
DB09031Miltefosine3Recruiting1
DB01421Paromomycin3Completed5
DB01421Paromomycin3Recruiting1
DB05630Sodium stibogluconate3Completed1
DB05630Sodium stibogluconate3Recruiting1
DB00681Amphotericin B4Completed1
DB00681Amphotericin B4Not Yet Recruiting1
DB00681Amphotericin B4Terminated1
DB13732Meglumine antimoniate4Completed1
DB01421Paromomycin4Completed1
DB06151AcetylcysteineNot AvailableUnknown Status1
DB00518AlbendazoleNot AvailableCompleted1
DB01592IronNot AvailableCompleted1
DB01421ParomomycinNot AvailableCompleted1
DB00162Vitamin ANot AvailableCompleted1
DB01593ZincNot AvailableCompleted1