Undescended Testis

Also known as: Cryptorchidism / Testicle Undescended / Maldescended testicle / Testicle maldescended / Maldescended testis / Undescended testicle NOS / Undescended testicle / Cryptorchism NOS / Cryptorchism

DrugDrug NameDrug Description
DB09126Chorionic Gonadotropin (Human)Human chorionic gonadotropin (HCG), a polypeptide hormone produced by the human placenta. Endogenously produced HCG interacts with the LHCG receptor of the ovary and promotes the maintenance of the corpus luteum during the beginning of pregnancy. This allows the corpus luteum to continuously secrete the hormone progesterone during the first trimester, which is required for maintenance of the uterus and prevents menstruation. In males, HCG also stimulates the production of gonadal steroid hormones by stimulating the interstitial cells (Leydig cells) of the testis to produce androgens. HCG is composed of an alpha and a beta sub-unit. The alpha sub-unit is essentially identical to the alpha subĀ­ units of the human pituitary gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), as well as to the alpha sub-unit of human thyroid-stimulating hormone (TSH), while the beta subĀ­ units of these hormones differ in amino acid sequence. As a drug product, chorionic gonadotropin is a highly purified pyrogen-free preparation obtained from the urine of pregnant females.
DB13946Testosterone undecanoateTestosterone undecanoate is the ester prodrug of testosterone and has a midchain fatty acid at the 17Beta position. [A176753] It is available as an intramuscular injection and as an oral capsule, and is indicated for treatment of testosterone deficiency. [F4247][FDA Label] It should be noted that testosterone undecanoate is only indicated for treatment of hypogonadal conditions with structural or genetic etiologies and should not be used to manage "age-related hypogonadism". [FDA Label]
DrugDrug NameTargetType
DB09126Chorionic Gonadotropin (Human)Lutropin-choriogonadotropic hormone receptortarget
DB13946Testosterone undecanoateAndrogen receptortarget
DB13946Testosterone undecanoateCytochrome P450 3A4enzyme
DB13946Testosterone undecanoateCytochrome P450 19A1enzyme
DB13946Testosterone undecanoateAmine oxidase [flavin-containing] Aenzyme
DB13946Testosterone undecanoateCholesterol side-chain cleavage enzyme, mitochondrialenzyme
DB13946Testosterone undecanoateSerum albumincarrier
DB13946Testosterone undecanoateSex hormone-binding globulincarrier
DB13946Testosterone undecanoateCytochrome P450 3A5enzyme
DB13946Testosterone undecanoateCytochrome P450 3A7enzyme
DB13946Testosterone undecanoateSolute carrier organic anion transporter family member 1A2transporter
DB13946Testosterone undecanoateSolute carrier family 22 member 8transporter
DB13946Testosterone undecanoateSolute carrier family 22 member 7transporter
DB13946Testosterone undecanoateMultidrug resistance protein 1transporter
DB13946Testosterone undecanoateSodium/bile acid cotransportertransporter
DB13946Testosterone undecanoateSolute carrier family 22 member 4transporter
DB13946Testosterone undecanoateATP-binding cassette sub-family G member 2transporter
DB13946Testosterone undecanoateCytochrome P450 1A1enzyme
DB13946Testosterone undecanoateCytochrome P450 1B1enzyme
DB13946Testosterone undecanoateCytochrome P450 2A13enzyme
DB13946Testosterone undecanoateCytochrome P450 2B6enzyme
DB13946Testosterone undecanoateCytochrome P450 2C19enzyme
DB13946Testosterone undecanoateCytochrome P450 2C8enzyme
DB13946Testosterone undecanoateCytochrome P450 2C9enzyme
DB13946Testosterone undecanoateCytochrome P450 3A43enzyme
DB13946Testosterone undecanoateEstrogen receptor alphatarget
DB13946Testosterone undecanoateMineralocorticoid receptortarget
DB13946Testosterone undecanoate3-oxo-5-alpha-steroid 4-dehydrogenaseenzyme
DB13946Testosterone undecanoateSolute carrier family 22 member 2transporter
DB13946Testosterone undecanoateMultidrug and toxin extrusion protein 1transporter
DB13946Testosterone undecanoateSolute carrier organic anion transporter family member 1B3transporter
DB13946Testosterone undecanoateCytochrome P450 4B1enzyme
DrugDrug NamePhaseStatusCount
DB00633Dexmedetomidine2Completed1
DB01002Levobupivacaine2Completed1
DB01236Sevoflurane2Completed1
DB00818Propofol4Completed1
DB01236Sevoflurane4Completed1
DB00316AcetaminophenNot AvailableRecruiting1
DB01234DexamethasoneNot AvailableRecruiting1
DB00465KetorolacNot AvailableRecruiting1
DB00295MorphineNot AvailableRecruiting1
DB00904OndansetronNot AvailableRecruiting1
DB00818PropofolNot AvailableRecruiting1
DB00899RemifentanilNot AvailableRecruiting1
DB00296RopivacaineNot AvailableRecruiting1
DB01236SevofluraneNot AvailableRecruiting1