Unresectable Hepatocellular Carcinoma

DrugDrug NameDrug Description
DB00398SorafenibSorafenib (rINN), marketed as Nexavar by Bayer, is a drug approved for the treatment of advanced renal cell carcinoma (primary kidney cancer). It has also received "Fast Track" designation by the FDA for the treatment of advanced hepatocellular carcinoma (primary liver cancer), and has since performed well in Phase III trials. Sorafenib is a small molecular inhibitor of Raf kinase, PDGF (platelet-derived growth factor), VEGF receptor 2 & 3 kinases and c Kit the receptor for Stem cell factor. A growing number of drugs target most of these pathways. The originality of Sorafenib lays in its simultaneous targeting of the Raf/Mek/Erk pathway.
DrugDrug NameTargetType
DB00398SorafenibSerine/threonine-protein kinase B-raftarget
DB00398SorafenibReceptor-type tyrosine-protein kinase FLT3target
DB00398SorafenibRAF proto-oncogene serine/threonine-protein kinasetarget
DB00398SorafenibVascular endothelial growth factor receptor 3target
DB00398SorafenibPlatelet-derived growth factor receptor betatarget
DB00398SorafenibMast/stem cell growth factor receptor Kittarget
DB00398SorafenibVascular endothelial growth factor receptor 2target
DB00398SorafenibCytochrome P450 3A4enzyme
DB00398SorafenibUDP-glucuronosyltransferase 1-9enzyme
DB00398SorafenibCytochrome P450 2B6enzyme
DB00398SorafenibCytochrome P450 2C8enzyme
DB00398SorafenibCytochrome P450 3A5enzyme
DB00398SorafenibCytochrome P450 3A7enzyme
DB00398SorafenibCytochrome P450 2C9enzyme
DB00398SorafenibMultidrug resistance-associated protein 4transporter
DB00398SorafenibMultidrug resistance protein 1transporter
DB00398SorafenibCanalicular multispecific organic anion transporter 1transporter
DB00398SorafenibATP-binding cassette sub-family G member 2transporter
DB00398SorafenibCytochrome P450 1A2enzyme
DB00398SorafenibCytochrome P450 2C19enzyme
DB00398SorafenibCytochrome P450 2D6enzyme
DB00398SorafenibUDP-glucuronosyltransferase 1-1enzyme
DB00398SorafenibRalA-binding protein 1transporter
DB00398SorafenibFibroblast growth factor receptor 1target
DB00398SorafenibProto-oncogene tyrosine-protein kinase receptor Rettarget
DB00398SorafenibVascular endothelial growth factor receptor 1target
DB00398SorafenibSolute carrier organic anion transporter family member 1B1transporter
DrugDrug NamePhaseStatusCount
DB09877Corynebacterium diphtheriae0Recruiting1
DB10319Streptococcus pneumoniae type 1 capsular polysaccharide antigen0Recruiting1
DB10332Streptococcus pneumoniae type 14 capsular polysaccharide antigen0Recruiting1
DB10335Streptococcus pneumoniae type 18c capsular polysaccharide antigen0Recruiting1
DB10337Streptococcus pneumoniae type 19a capsular polysaccharide antigen0Recruiting1
DB10336Streptococcus pneumoniae type 19f capsular polysaccharide antigen0Recruiting1
DB10340Streptococcus pneumoniae type 23f capsular polysaccharide antigen0Recruiting1
DB10321Streptococcus pneumoniae type 3 capsular polysaccharide antigen0Recruiting1
DB10322Streptococcus pneumoniae type 4 capsular polysaccharide antigen0Recruiting1
DB10323Streptococcus pneumoniae type 5 capsular polysaccharide antigen0Recruiting1
DB10296Streptococcus pneumoniae type 6a capsular polysaccharide diphtheria crm197 protein conjugate antigen0Recruiting1
DB10324Streptococcus pneumoniae type 6b capsular polysaccharide antigen0Recruiting1
DB10325Streptococcus pneumoniae type 7f capsular polysaccharide antigen0Recruiting1
DB10328Streptococcus pneumoniae type 9v capsular polysaccharide antigen0Recruiting1
DB05136Bavituximab1Withdrawn1
DB00398Sorafenib1Withdrawn1
DB00887Bumetanide1 / 2Recruiting1
DB14986Linrodostat1 / 2Recruiting1
DB09035Nivolumab1 / 2Recruiting1
DB00269Chlorotrianisene2Completed1
DB06592Pegargiminase2Completed1
DB01268Sunitinib2Completed1
DB06026Tivantinib2Completed1
DB12200Tivantinib2Completed1
DB00515Cisplatin3Active Not Recruiting1
DB00997Doxorubicin3Active Not Recruiting2
DB12117Mitometh3Active Not Recruiting1
DB00305Mitomycin3Active Not Recruiting1
DB12257Platinum3Active Not Recruiting1
DB00398Sorafenib3Active Not Recruiting2
DB00269Chlorotrianisene4Completed1