Acute Coronary Syndromes (ACS)

Also known as: Coronary Acute Syndrome / Acute Coronary Syndrome (ACS) / Acute Coronary Syndrome / Acute Coronary Syndromes

DrugDrug NameDrug Description
DB00945Acetylsalicylic acidThe prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Acetylsalicylic acid also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
DB00006BivalirudinBivalirudin is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin. Once bound to the active site, thrombin cannot activate fibrinogen into fibrin, the crucial step in the formation of thrombus. It is administered intravenously. Because it can cause blood stagnation, it is important to monitor changes in hematocrit, activated partial thromboplastin time, international normalized ratio and blood pressure.
DB00758ClopidogrelClopidogrel, an antiplatelet agent structurally and pharmacologically similar to ticlopidine, is used to inhibit blood clots in a variety of conditions such as peripheral vascular disease, coronary artery disease, and cerebrovascular disease. Clopidogrel is sold under the name Plavix by Sanofi and Bristol-Myers Squibb. The drug is an irreversible inhibitor of the P2Y12 adenosine diphosphate receptor found on the membranes of platelet cells. Clopidogrel use is associated with several serious adverse drug reactions such as severe neutropenia, various forms of hemorrhage, and cardiovascular edema.
DB01225EnoxaparinEnoxaparin is a low molecular weight heparin. Enoxaparin is used to prevent and treat deep vein thrombosis or pulmonary embolism, and is given as a subcutaneous injection. Enoxaparin binds to and accelerates the activity of antithrombin III. By activating antithrombin III, enoxaparin preferentially potentiates the inhibition of coagulation factors Xa and IIa. Factor Xa catalyzes the conversion of prothrombin to thrombin, so enoxaparin's inhibition of this process results in decreased thrombin and ultimately the prevention of fibrin clot formation. Low molecular weight heparins are less effective at inactivating factor IIa due to their shorter length compared to unfractionated heparin.
DB00063EptifibatideSynthetic cyclic hexapeptide that binds to platelet receptor glycoprotein and inhibits platelet aggregation.
DB08816TicagrelorTicagrelor (trade name Brilinta in the US, Brilique and Possia in the EU) is a platelet aggregation inhibitor produced by AstraZeneca. Unlike clopidogrel, ticagrelor is not a prodrug and does not require metabolic activation. The drug was approved for use in the European Union by the European Commission on December 3, 2010. The drug was approved by the US Food and Drug Administration on July 20, 2011.
DrugDrug NameTargetType
DB00945Acetylsalicylic acidProstaglandin G/H synthase 1target
DB00945Acetylsalicylic acidProstaglandin G/H synthase 2target
DB00945Acetylsalicylic acidSerum albumincarrier
DB00945Acetylsalicylic acidAldo-keto reductase family 1 member C1target
DB00945Acetylsalicylic acidSolute carrier family 22 member 6transporter
DB00945Acetylsalicylic acidMultidrug resistance protein 1transporter
DB00945Acetylsalicylic acidSolute carrier family 22 member 7transporter
DB00945Acetylsalicylic acidCytochrome P450 2C19enzyme
DB00945Acetylsalicylic acidCytochrome P450 2C8enzyme
DB00945Acetylsalicylic acidCytochrome P450 2C9enzyme
DB00945Acetylsalicylic acid5'-AMP-activated protein kinasetarget
DB00945Acetylsalicylic acidEndothelin-1 receptortarget
DB00945Acetylsalicylic acidInhibitor of nuclear factor kappa-B kinase subunit betatarget
DB00945Acetylsalicylic acidCellular tumor antigen p53target
DB00945Acetylsalicylic acid78 kDa glucose-regulated proteintarget
DB00945Acetylsalicylic acidRibosomal protein S6 kinase alpha-3target
DB00945Acetylsalicylic acidNF-kappa-B inhibitor alphatarget
DB00945Acetylsalicylic acidNuclear factor NF-kappa-Btarget
DB00006BivalirudinProthrombintarget
DB00006BivalirudinMyeloperoxidaseenzyme
DB00758ClopidogrelP2Y purinoceptor 12target
DB00758ClopidogrelCytochrome P450 3A4enzyme
DB00758ClopidogrelCytochrome P450 2B6enzyme
DB00758ClopidogrelCytochrome P450 3A5enzyme
DB00758ClopidogrelCytochrome P450 2C19enzyme
DB00758ClopidogrelCytochrome P450 2C9enzyme
DB00758ClopidogrelCytochrome P450 1A2enzyme
DB00758ClopidogrelCytochrome P450 2C8enzyme
DB00758ClopidogrelLiver carboxylesterase 1enzyme
DB00758ClopidogrelMultidrug resistance protein 1transporter
DB00758ClopidogrelSolute carrier family 22 member 1transporter
DB00758ClopidogrelSolute carrier family 22 member 2transporter
DB01225EnoxaparinAntithrombin-IIItarget
DB01225EnoxaparinCoagulation factor Xtarget
DB01225EnoxaparinMyeloperoxidaseenzyme
DB00063EptifibatideIntegrin beta-3target
DB08816TicagrelorCytochrome P450 3A4enzyme
DB08816TicagrelorP2Y purinoceptor 12target
DB08816TicagrelorMultidrug resistance protein 1transporter
DB08816TicagrelorCytochrome P450 2D6enzyme
DB08816TicagrelorCytochrome P450 2C9enzyme
DrugDrug NamePhaseStatusCount
DB05227APD7911Terminated2
DB00945Acetylsalicylic acid1Completed3
DB00945Acetylsalicylic acid1Terminated2
DB06605Apixaban1Completed1
DB01076Atorvastatin1Completed2
DB00758Clopidogrel1Completed2
DB00758Clopidogrel1Terminated3
DB01225Enoxaparin1Completed1
DB12270Losmapimod1Completed1
DB00218Moxifloxacin1Completed1
DB09140Oxygen1Completed1
DB00213Pantoprazole1Completed1
DB06209Prasugrel1Terminated1
DB01098Rosuvastatin1Completed2
DB10803Salmonella typhi ty2 vi polysaccharide antigen1Completed1
DB01104Sertraline1Terminated1
DB00641Simvastatin1Terminated1
DB08816Ticagrelor1Completed3
DB05692Vorapaxar1Completed1
DB12000Apabetalone1 / 2Completed1
DB00215Citalopram1 / 2Withdrawn1
DB01590Everolimus1 / 2Recruiting1
DB09499Thiosulfuric acid1 / 2Completed1
DB0581099mTc-glucarate2Completed1
DB05631ALT-20742Completed1
DB00945Acetylsalicylic acid2Completed2
DB09302Alirocumab2Not Yet Recruiting1
DB06605Apixaban2Completed1
DB06605Apixaban2Terminated1
DB12046Atopaxar2Completed2
DB01076Atorvastatin2Completed1
DB12758Atreleuton2Completed1
DB06441Cangrelor2Completed1
DB00758Clopidogrel2Completed7
DB00758Clopidogrel2Recruiting1
DB12289Darexaban2Completed1
DB00633Dexmedetomidine2Unknown Status1
DB00063Eptifibatide2Completed1
DB00063Eptifibatide2Recruiting2
DB09303Evolocumab2Recruiting1
DB01109Heparin2Completed1
DB05683Iodofiltic acid I-1232Completed1
DB11984Letaxaban2Completed1
DB00722Lisinopril2Recruiting1
DB12270Losmapimod2Completed1
DB00264Metoprolol2Recruiting1
DB09140Oxygen2Recruiting1
DB11839PZ-1282Suspended1
DB06293Pegnivacogin2Completed1
DB00761Potassium chloride2Recruiting1
DB11090Potassium nitrate2Recruiting1
DB06209Prasugrel2Completed3
DB00243Ranolazine2Terminated1
DB06228Rivaroxaban2Completed2
DB08816Ticagrelor2Completed4
DB08816Ticagrelor2Recruiting1
DB00775Tirofiban2Recruiting1
DB12310Trehalose2Not Yet Recruiting1
DB11909Varespladib2Completed1
DB05737Varespladib methyl2Completed1
DB12164Varespladib methyl2Completed1
DB00758Clopidogrel2 / 3Completed1
DB00758Clopidogrel2 / 3Recruiting1
DB01394Colchicine2 / 3Completed1
DB01065Melatonin2 / 3Completed1
DB06209Prasugrel2 / 3Completed1
DB08816Ticagrelor2 / 3Completed1
DB08816Ticagrelor2 / 3Recruiting1
DB00945Acetylsalicylic acid3Completed1
DB00945Acetylsalicylic acid3Terminated2
DB09302Alirocumab3Completed1
DB06203Alogliptin3Completed1
DB06605Apixaban3Terminated1
DB01076Atorvastatin3Completed3
DB01076Atorvastatin3Terminated1
DB00006Bivalirudin3Completed1
DB01156Bupropion3Completed1
DB06441Cangrelor3Terminated2
DB00758Clopidogrel3Completed12
DB00758Clopidogrel3Not Yet Recruiting1
DB00758Clopidogrel3Recruiting3
DB00758Clopidogrel3Terminated3
DB12181Dalcetrapib3Active Not Recruiting1
DB06311Darapladib3Completed1
DB00063Eptifibatide3Completed2
DB09303Evolocumab3Active Not Recruiting1
DB01109Heparin3Completed2
DB09265Lixisenatide3Completed1
DB12270Losmapimod3Completed1
DB06635Otamixaban3Completed1
DB09140Oxygen3Completed2
DB06209Prasugrel3Completed11
DB06209Prasugrel3Recruiting2
DB06228Rivaroxaban3Completed1
DB06228Rivaroxaban3Recruiting1
DB01098Rosuvastatin3Completed2
DB08816Ticagrelor3Active Not Recruiting1
DB04902Ticagrelor3Completed2
DB08816Ticagrelor3Completed4
DB08816Ticagrelor3Not Yet Recruiting1
DB08816Ticagrelor3Recruiting3
DB08816Ticagrelor3Terminated1
DB00775Tirofiban3Withdrawn1
DB01273Varenicline3Completed1
DB05737Varespladib methyl3Terminated1
DB00163Vitamin E3Recruiting1
DB00284Acarbose4Active Not Recruiting1
DB00316Acetaminophen4Completed1
DB00945Acetylsalicylic acid4Completed8
DB00945Acetylsalicylic acid4Recruiting2
DB00945Acetylsalicylic acid4Terminated1
DB00945Acetylsalicylic acid4Unknown Status1
DB09302Alirocumab4Completed1
DB11598Antithrombin III human4Unknown Status1
DB06605Apixaban4Completed1
DB01076Atorvastatin4Active Not Recruiting1
DB01076Atorvastatin4Completed4
DB01076Atorvastatin4Recruiting1
DB01076Atorvastatin4Unknown Status1
DB01393Bezafibrate4Completed1
DB00006Bivalirudin4Completed1
DB00006Bivalirudin4Not Yet Recruiting1
DB00006Bivalirudin4Recruiting1
DB06441Cangrelor4Completed1
DB06441Cangrelor4Not Yet Recruiting1
DB01136Carvedilol4Recruiting1
DB11121Chloroxylenol4Unknown Status1
DB01166Cilostazol4Completed2
DB00215Citalopram4Terminated1
DB00758Clopidogrel4Completed14
DB00758Clopidogrel4Enrolling by Invitation1
DB00758Clopidogrel4Not Yet Recruiting1
DB00758Clopidogrel4Recruiting4
DB00758Clopidogrel4Terminated2
DB00758Clopidogrel4Unknown Status3
DB00758Clopidogrel4Withdrawn1
DB01394Colchicine4Recruiting1
DB01394Colchicine4Unknown Status1
DB06695Dabigatran etexilate4Terminated1
DB00841Dobutamine4Recruiting1
DB01225Enoxaparin4Completed3
DB01225Enoxaparin4Recruiting1
DB00153Ergocalciferol4Unknown Status1
DB00187Esmolol4Unknown Status1
DB00402Eszopiclone4Completed1
DB01276Exenatide4Completed1
DB00973Ezetimibe4Completed1
DB01039Fenofibrate4Active Not Recruiting1
DB01039Fenofibrate4Completed1
DB01109Heparin4Completed2
DB01611Hydroxychloroquine4Recruiting1
DB00030Insulin Human4Suspended1
DB09083Ivabradine4Unknown Status1
DB00128L-Aspartic Acid4Terminated1
DB06725Lornoxicam4Completed1
DB00264Metoprolol4Completed1
DB00264Metoprolol4Recruiting1
DB00235Milrinone4Recruiting1
DB00471Montelukast4Terminated1
DB00295Morphine4Completed1
DB00622Nicardipine4Unknown Status1
DB00338Omeprazole4Unknown Status1
DB00213Pantoprazole4Unknown Status1
DB00946Phenprocoumon4Completed1
DB00946Phenprocoumon4Terminated1
DB06209Prasugrel4Active Not Recruiting1
DB06209Prasugrel4Completed9
DB06209Prasugrel4Recruiting4
DB06209Prasugrel4Terminated2
DB06209Prasugrel4Unknown Status2
DB00175Pravastatin4Completed1
DB00178Ramipril4Unknown Status1
DB06228Rivaroxaban4Completed1
DB06228Rivaroxaban4Recruiting2
DB01098Rosuvastatin4Completed4
DB01098Rosuvastatin4Recruiting1
DB01098Rosuvastatin4Unknown Status1
DB00641Simvastatin4Active Not Recruiting1
DB01261Sitagliptin4Recruiting1
DB00086Streptokinase4Completed1
DB00966Telmisartan4Unknown Status1
DB00031Tenecteplase4Recruiting1
DB08816Ticagrelor4Active Not Recruiting1
DB08816Ticagrelor4Completed11
DB08816Ticagrelor4Enrolling by Invitation1
DB08816Ticagrelor4Not Yet Recruiting1
DB08816Ticagrelor4Recruiting5
DB08816Ticagrelor4Unknown Status4
DB08816Ticagrelor4Withdrawn1
DB00775Tirofiban4Completed1
DB00775Tirofiban4Recruiting1
DB11094Vitamin D4Unknown Status1
DB00945Acetylsalicylic acidNot AvailableRecruiting1
DB00945Acetylsalicylic acidNot AvailableTerminated1
DB00945Acetylsalicylic acidNot AvailableWithdrawn1
DB00009AlteplaseNot AvailableWithdrawn1
DB01076AtorvastatinNot AvailableUnknown Status2
DB01156BupropionNot AvailableCompleted1
DB00796Candesartan cilexetilNot AvailableTerminated1
DB00758ClopidogrelNot AvailableActive Not Recruiting1
DB00758ClopidogrelNot AvailableCompleted5
DB00758ClopidogrelNot AvailableRecruiting1
DB00758ClopidogrelNot AvailableWithdrawn1
DB06779DalteparinNot AvailableCompleted1
DB01225EnoxaparinNot AvailableWithdrawn1
DB00973EzetimibeNot AvailableUnknown Status1
DB11728FondaparinuxNot AvailableCompleted1
DB00883Isosorbide dinitrateNot AvailableRecruiting1
DB00184NicotineNot AvailableCompleted1
DB00184NicotineNot AvailableRecruiting1
DB06209PrasugrelNot AvailableActive Not Recruiting1
DB06209PrasugrelNot AvailableCompleted1
DB06228RivaroxabanNot AvailableActive Not Recruiting1
DB06228RivaroxabanNot AvailableRecruiting3
DB01098RosuvastatinNot AvailableCompleted1
DB01098RosuvastatinNot AvailableRecruiting1
DB01098RosuvastatinNot AvailableUnknown Status1
DB01104SertralineNot AvailableCompleted1
DB00641SimvastatinNot AvailableUnknown Status1
DB01323St. John's WortNot AvailableWithdrawn1
DB00086StreptokinaseNot AvailableWithdrawn1
DB00966TelmisartanNot AvailableTerminated1
DB08816TicagrelorNot AvailableActive Not Recruiting1
DB08816TicagrelorNot AvailableCompleted7
DB08816TicagrelorNot AvailableRecruiting1
DB00775TirofibanNot AvailableTerminated1
DB01273VareniclineNot AvailableRecruiting1
DB00682WarfarinNot AvailableRecruiting1