Respiratory Depression

Also known as: Lung function decreased / Lung function decreased (NOS) / Function pulmonary decreased / Respiration depressed / Depression respiratory / Decreased respiration

DrugDrug NameDrug Description
DB00201CaffeineA stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. It is also used in to prevent and treat pulmonary complications of premature birth.
DB01010EdrophoniumA cholinesterase inhibitor used to diagnose and evaluate myasthenia gravis.
DB01183NaloxoneAn opioid receptor antagonist used to rapidly reverse an opioid overdose. Also included in some drug formulations as an abuse deterrent to prevent injection.
DrugDrug NameTargetType
DB00201CaffeineAdenosine receptor A1target
DB00201CaffeinecAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
DB00201CaffeineAdenosine receptor A2atarget
DB00201CaffeineCytochrome P450 1A2enzyme
DB00201CaffeineRyanodine receptor 1target
DB00201CaffeineCytochrome P450 3A4enzyme
DB00201CaffeineCytochrome P450 2E1enzyme
DB00201CaffeineCytochrome P450 2C8enzyme
DB00201CaffeineCytochrome P450 2C9enzyme
DB00201CaffeineCytochrome P450 1A1enzyme
DB00201CaffeineCytochrome P450 1B1enzyme
DB00201CaffeineCytochrome P450 2D6enzyme
DB00201CaffeineCyclic nucleotide phosphodiesterasetarget
DB00201CaffeineDNA-dependent protein kinase catalytic subunittarget
DB00201CaffeinePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformtarget
DB00201CaffeinePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformtarget
DB00201CaffeinePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformtarget
DB00201CaffeineInositol 1,4,5-trisphosphate receptortarget
DB00201CaffeineSerine-protein kinase ATMtarget
DB00201CaffeineATP-binding cassette sub-family G member 2transporter
DB00201CaffeineAdenosine receptor A2btarget
DB00201CaffeineAdenosine receptor A3target
DB00201CaffeinePhosphodiesterase enzymestarget
DB01010EdrophoniumAcetylcholinesterasetarget
DB01010EdrophoniumCholinesterasetarget
DB01183NaloxoneMu-type opioid receptortarget
DB01183NaloxoneEstrogen receptor alphatarget
DB01183NaloxoneCyclic AMP-responsive element-binding protein 1target
DB01183NaloxoneDelta-type opioid receptortarget
DB01183NaloxoneSolute carrier organic anion transporter family member 1A2transporter
DB01183NaloxoneP-glycoprotein 1transporter
DB01183NaloxoneKappa-type opioid receptortarget
DB01183NaloxoneCytochrome P450 3A4enzyme
DB01183NaloxoneSerum albumincarrier
DB01183NaloxoneToll-like receptor 4target
DB01183NaloxoneLiver carboxylesterase 1target
DB01183NaloxoneUDP-glucuronosyltransferase 1-1enzyme
DrugDrug NamePhaseStatusCount
DB00921Buprenorphine1Recruiting1
DB09157Carbon dioxide1Recruiting1
DB00497Oxycodone1Recruiting1
DB09140Oxygen1Recruiting1
DB00899Remifentanil1Recruiting1
DB00633Dexmedetomidine1 / 2Completed1
DB00295Morphine2Active Not Recruiting1
DB00295Morphine2 / 3Not Yet Recruiting1
DB00316Acetaminophen3Recruiting1
DB01234Dexamethasone3Recruiting1
DB00633Dexmedetomidine3Recruiting1
DB00813Fentanyl3Completed1
DB00813Fentanyl3Recruiting1
DB00996Gabapentin3Recruiting1
DB01221Ketamine3Recruiting1
DB00281Lidocaine3Recruiting1
DB00904Ondansetron3Recruiting1
DB01236Sevoflurane3Recruiting1
DB01183Naloxone4Completed1
DB00296Ropivacaine4Completed1
DB00813FentanylNot AvailableNot Yet Recruiting2
DB00327HydromorphoneNot AvailableTerminated1
DB01221KetamineNot AvailableRecruiting1
DB00295MorphineNot AvailableNot Yet Recruiting1
DB00295MorphineNot AvailableTerminated1