Metastatic Hormone Refractory Prostate Cancer

Also known as: Metastatic hormone refractory Prostate cancer / Metastatic Prostate cancer / Prostate cancer metastatic / Metastatic Prostate Carcinoma / Carcinoma of the prostate metastatic / Prostatic cancer metastatic

DrugDrug NameDrug Description
DB04839Cyproterone acetateAn anti-androgen that, in the form of its acetate (cyproterone acetate), also has progestational properties. It is used in the treatment of hypersexuality in males, as a palliative in prostatic carcinoma, and, in combination with estrogen, for the therapy of severe acne and hirsutism in females.
DB01248DocetaxelDocetaxel is a clinically well established anti-mitotic chemotherapy medication used mainly for the treatment of breast, ovarian, and non-small cell lung cancer. Docetaxel reversibly binds to tubulin with high affinity in a 1:1 stoichiometric ratio
DB01196EstramustineA nitrogen mustard linked to estradiol, usually as phosphate; used to treat prostatic neoplasms; also has radiation protective properties.
DB00665NilutamideNilutamide is an antineoplastic hormonal agent primarily used in the treatment of prostate cancer. Nilutamide is a pure, nonsteroidal anti-androgen with affinity for androgen receptors (but not for progestogen, estrogen, or glucocorticoid receptors). Consequently, Nilutamide blocks the action of androgens of adrenal and testicular origin that stimulate the growth of normal and malignant prostatic tissue. Prostate cancer is mostly androgen-dependent and can be treated with surgical or chemical castration. To date, antiandrogen monotherapy has not consistently been shown to be equivalent to castration.
DrugDrug NameTargetType
DB04839Cyproterone acetateAndrogen receptortarget
DB04839Cyproterone acetateCytochrome P450 19A1enzyme
DB04839Cyproterone acetateProstate-specific antigentarget
DB04839Cyproterone acetateCytochrome P450 3A4enzyme
DB01248DocetaxelApoptosis regulator Bcl-2target
DB01248DocetaxelTubulin beta-1 chaintarget
DB01248DocetaxelCytochrome P450 3A4enzyme
DB01248DocetaxelCytochrome P450 3A5enzyme
DB01248DocetaxelCytochrome P450 3A7enzyme
DB01248DocetaxelMultidrug resistance protein 1transporter
DB01248DocetaxelMultidrug resistance-associated protein 7transporter
DB01248DocetaxelCytochrome P450 1B1enzyme
DB01248DocetaxelMicrotubule-associated protein 2target
DB01248DocetaxelMicrotubule-associated protein 4target
DB01248DocetaxelMicrotubule-associated protein tautarget
DB01248DocetaxelSolute carrier organic anion transporter family member 1B3transporter
DB01248DocetaxelSolute carrier family 22 member 7transporter
DB01248DocetaxelATP-binding cassette sub-family G member 2transporter
DB01248DocetaxelCanalicular multispecific organic anion transporter 1transporter
DB01248DocetaxelMultidrug resistance-associated protein 1transporter
DB01248DocetaxelNuclear receptor subfamily 1 group I member 2target
DB01196EstramustineEstrogen receptor betatarget
DB01196EstramustineEstrogen receptor alphatarget
DB01196EstramustineMicrotubule-associated protein 2target
DB01196EstramustineMicrotubule-associated protein 1Atarget
DB01196EstramustineMultidrug resistance protein 1transporter
DB01196EstramustineCytochrome P450 3A4enzyme
DB00665NilutamideAndrogen receptortarget
DB00665NilutamideCytochrome P450 2C19enzyme
DB00665NilutamideNADPH--cytochrome P450 reductaseenzyme
DB00665NilutamideCytochrome P450 2C8enzyme
DrugDrug NamePhaseStatusCount
DB15029AZD-81861Recruiting1
DB05812Abiraterone1Recruiting1
DB11901Apalutamide1Recruiting1
DB11595Atezolizumab1Recruiting1
DB00493Cefotaxime1Completed1
DB00493Cefotaxime1Recruiting1
DB00531Cyclophosphamide1Completed1
DB00531Cyclophosphamide1Recruiting1
DB14805DCFPyL F-181Active Not Recruiting2
DB01248Docetaxel1Completed1
DB01248Docetaxel1Recruiting2
DB05094Enzalutamide1Completed1
DB08899Enzalutamide1Completed1
DB05094Enzalutamide1Recruiting1
DB08899Enzalutamide1Recruiting1
DB08899Enzalutamide1Terminated1
DB01073Fludarabine1Recruiting1
DB09150Fludeoxyglucose F-181Recruiting1
DB09502Fludeoxyglucose F-181Recruiting1
DB09398Fluoride ion F-181Active Not Recruiting1
DB09398Fluoride ion F-181Recruiting1
DB13034Foxy-51Completed1
DB15306MEDI-64691Completed1
DB06803Niclosamide1Completed1
DB06803Niclosamide1Recruiting1
DB11793Niraparib1Terminated1
DB09037Pembrolizumab1Not Yet Recruiting1
DB00635Prednisone1Recruiting1
DB15185Rasdegafusp alfa1Completed1
DB06688Sipuleucel-T1Recruiting1
DB00877Sirolimus1Completed1
DB00399Zoledronic acid1Completed1
DB05812Abiraterone1 / 2Recruiting1
DB11595Atezolizumab1 / 2Recruiting1
DB11945Avelumab1 / 2Recruiting1
DB06772Cabazitaxel1 / 2Active Not Recruiting1
DB06772Cabazitaxel1 / 2Recruiting1
DB00958Carboplatin1 / 2Active Not Recruiting1
DB00958Carboplatin1 / 2Recruiting1
DB01254Dasatinib1 / 2Completed1
DB01248Docetaxel1 / 2Completed1
DB01248Docetaxel1 / 2Recruiting1
DB08899Enzalutamide1 / 2Not Yet Recruiting1
DB05094Enzalutamide1 / 2Recruiting2
DB08899Enzalutamide1 / 2Recruiting3
DB11717Epacadostat1 / 2Recruiting1
DB00328Indometacin1 / 2Recruiting1
DB11743Ipatasertib1 / 2Recruiting1
DB12637Onapristone1 / 2Recruiting1
DB09037Pembrolizumab1 / 2Recruiting1
DB00635Prednisone1 / 2Recruiting1
DB11730Ribociclib1 / 2Recruiting1
DB00877Sirolimus1 / 2Recruiting1
DB15113Utomilumab1 / 2Recruiting1
DB11581Venetoclax1 / 2Not Yet Recruiting1
DB05812Abiraterone2Active Not Recruiting1
DB05812Abiraterone2Completed3
DB05812Abiraterone2Enrolling by Invitation1
DB05812Abiraterone2Not Yet Recruiting3
DB05812Abiraterone2Recruiting3
DB12775Abituzumab2Completed1
DB11901Apalutamide2Not Yet Recruiting1
DB11901Apalutamide2Recruiting1
DB11794Berzosertib2Recruiting1
DB00112Bevacizumab2Completed1
DB06772Cabazitaxel2Completed2
DB06772Cabazitaxel2Recruiting2
DB05153Cabozantinib2Terminated1
DB08875Cabozantinib2Terminated1
DB00958Carboplatin2Recruiting3
DB04849Cediranib2Active Not Recruiting1
DB00482Celecoxib2Completed1
DB14707Cemiplimab2Recruiting1
DB14805DCFPyL F-182Recruiting2
DB06699Degarelix2Recruiting1
DB01248Docetaxel2Completed6
DB01248Docetaxel2Recruiting4
DB01248Docetaxel2Terminated1
DB13925Dotatate gallium Ga-682Recruiting1
DB08899Enzalutamide2Active Not Recruiting1
DB08899Enzalutamide2Completed2
DB08899Enzalutamide2Recruiting3
DB01196Estramustine2Completed1
DB00898Ethanol2Completed1
DB00898Ethanol2Not Yet Recruiting2
DB13146Fluciclovine (18F)2Recruiting1
DB09502Fludeoxyglucose F-182Recruiting1
DB09398Fluoride ion F-182Recruiting1
DB12827Indoximod2Active Not Recruiting1
DB06186Ipilimumab2Recruiting1
DB00125L-Arginine2Completed1
DB12167LY-30234142Active Not Recruiting1
DB00480Lenalidomide2Completed1
DB00007Leuprolide2Recruiting1
DB00331Metformin2Completed1
DB00959Methylprednisolone2Completed1
DB01204Mitoxantrone2Terminated1
DB06803Niclosamide2Recruiting1
DB09035Nivolumab2Recruiting1
DB12941ODM-2012Recruiting1
DB09074Olaparib2Active Not Recruiting1
DB09074Olaparib2Recruiting2
DB03010Patupilone2Completed1
DB09037Pembrolizumab2Recruiting1
DB00635Prednisone2Active Not Recruiting1
DB00635Prednisone2Completed4
DB00635Prednisone2Not Yet Recruiting3
DB00635Prednisone2Recruiting3
DB00635Prednisone2Terminated1
DB14646Prednisone acetate2Not Yet Recruiting1
DB14646Prednisone acetate2Recruiting1
DB12813Radium Ra-2232Active Not Recruiting1
DB12332Rucaparib2Recruiting1
DB08877Ruxolitinib2Terminated1
DB06688Sipuleucel-T2Active Not Recruiting1
DB06688Sipuleucel-T2Completed3
DB00398Sorafenib2Terminated1
DB01268Sunitinib2Completed1
DB05861Tasquinimod2Completed1
DB13943Testosterone cypionate2Recruiting1
DB08911Trametinib2Recruiting1
DB05812Abiraterone2 / 3Recruiting1
DB06772Cabazitaxel2 / 3Recruiting1
DB08899Enzalutamide2 / 3Recruiting1
DB05812Abiraterone3Active Not Recruiting1
DB05812Abiraterone3Recruiting2
DB00112Bevacizumab3Active Not Recruiting1
DB06772Cabazitaxel3Completed1
DB06772Cabazitaxel3Recruiting1
DB09277Choline C 113Completed1
DB00515Cisplatin3Active Not Recruiting1
DB14805DCFPyL F-183Recruiting1
DB06643Denosumab3Recruiting1
DB01248Docetaxel3Active Not Recruiting1
DB08899Enzalutamide3Not Yet Recruiting1
DB00898Ethanol3Recruiting1
DB00441Gemcitabine3Active Not Recruiting1
DB11743Ipatasertib3Recruiting1
DB13144Lenograstim3Recruiting1
DB12117Mitometh3Active Not Recruiting1
DB11793Niraparib3Recruiting1
DB12257Platinum3Active Not Recruiting1
DB00635Prednisone3Recruiting2
DB00884Risedronic acid3Terminated1
DB00020Sargramostim3Completed1
DB05812Abiraterone4Active Not Recruiting1
DB05812Abiraterone4Recruiting1
DB01128Bicalutamide4Withdrawn1
DB06772Cabazitaxel4Active Not Recruiting1
DB01234Dexamethasone4Recruiting1
DB08899Enzalutamide4Active Not Recruiting1
DB08899Enzalutamide4Recruiting1
DB00014Goserelin4Withdrawn1
DB00007Leuprolide4Terminated1
DB00860Prednisolone4Completed1
DB00635Prednisone4Active Not Recruiting1
DB00635Prednisone4Completed1
DB00635Prednisone4Recruiting1
DB00958CarboplatinNot AvailableRecruiting1
DB01234DexamethasoneNot AvailableRecruiting1
DB01248DocetaxelNot AvailableRecruiting1
DB05094EnzalutamideNot AvailableRecruiting1
DB08899EnzalutamideNot AvailableRecruiting1
DB00014GoserelinNot AvailableRecruiting1
DB08913Radium Ra 223 DichlorideNot AvailableRecruiting1
DB00399Zoledronic acidNot AvailableCompleted1