Chronic Myeloid Leukemia (CML)

Also known as: Leukemia, Chronic Myeloid / Chronic Myeloid Leukaemia / Chronic myeloid leukemia / Myeloid leukemia, chronic / Leukemia, Myelogenous, Chronic, BCR-ABL Positive / CML / Chronic myelogenous leukaemia / Chronic myelocytic leukaemia / Leukemia myelocytic chronic / Chronic myelogenous leukemia / Leukaemia myelocytic chronic / Chronic granulocytic leukemia / Leukaemias chronic myeloid / Chronic myelocytic leukemia / Chronic granulocytic leukaemia / Myeloid leukaemia, chronic

DrugDrug NameDrug Description
DB00531CyclophosphamidePrecursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer. [PubChem]
DB01254DasatinibDasatinib is an oral dual BCR/ABL and Src family tyrosine kinase inhibitor approved for use in patients with chronic myelogenous leukemia (CML). The main targets of Dasatinib, are BCRABL, SRC, Ephrins and GFR.
DB00619ImatinibImatinib is a small molecule kinase inhibitor used to treat certain types of cancer. It is currently marketed by Novartis as Gleevec (USA) or Glivec (Europe/Australia) as its mesylate salt, imatinib mesilate (INN). It is occasionally referred to as CGP57148B or STI571 (especially in older publications). It is used in treating chronic myelogenous leukemia (CML), gastrointestinal stromal tumors (GISTs) and a number of other malignancies. It is the first member of a new class of agents that act by inhibiting particular tyrosine kinase enzymes, instead of non-specifically inhibiting rapidly dividing cells.
DrugDrug NameTargetType
DB00531CyclophosphamideCytochrome P450 2B6enzyme
DB00531CyclophosphamideCytochrome P450 2C9enzyme
DB00531CyclophosphamideCytochrome P450 3A4enzyme
DB00531CyclophosphamideCytochrome P450 2C19enzyme
DB00531CyclophosphamideCytochrome P450 2A6enzyme
DB00531CyclophosphamideCytochrome P450 2C18enzyme
DB00531CyclophosphamideCytochrome P450 2C8enzyme
DB00531CyclophosphamideCytochrome P450 2D6enzyme
DB00531CyclophosphamideCytochrome P450 3A7enzyme
DB00531CyclophosphamideCytochrome P450 3A5enzyme
DB00531CyclophosphamideDNAtarget
DB00531CyclophosphamideNuclear receptor subfamily 1 group I member 2target
DB00531CyclophosphamideMultidrug resistance protein 1transporter
DB01254DasatinibTyrosine-protein kinase ABL1target
DB01254DasatinibAbelson tyrosine-protein kinase 2target
DB01254DasatinibProto-oncogene tyrosine-protein kinase Srctarget
DB01254DasatinibTyrosine-protein kinase Fyntarget
DB01254DasatinibTyrosine-protein kinase Lcktarget
DB01254DasatinibTyrosine-protein kinase Yestarget
DB01254DasatinibMast/stem cell growth factor receptor Kittarget
DB01254DasatinibPlatelet-derived growth factor receptor betatarget
DB01254DasatinibEphrin type-A receptor 2target
DB01254DasatinibSignal transducer and activator of transcription 5Btarget
DB01254DasatinibCytochrome P450 3A4enzyme
DB01254DasatinibMultidrug resistance protein 1transporter
DB01254DasatinibATP-binding cassette sub-family G member 2transporter
DB01254DasatinibCytochrome P450 1A1enzyme
DB01254DasatinibCytochrome P450 1A2enzyme
DB01254DasatinibCytochrome P450 1B1enzyme
DB01254DasatinibCytochrome P450 3A5enzyme
DB01254DasatinibDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB01254DasatinibTyrosine-protein kinase BTKtarget
DB01254DasatinibNuclear receptor subfamily 4 group A member 3target
DB01254DasatinibBreakpoint cluster region proteintarget
DB01254DasatinibTyrosine-protein kinase CSKtarget
DB01254DasatinibEphrin type-A receptor 5target
DB01254DasatinibEphrin type-B receptor 4target
DB01254DasatinibTyrosine-protein kinase Fgrtarget
DB01254DasatinibTyrosine-protein kinase FRKtarget
DB01254DasatinibHeat shock cognate 71 kDa proteintarget
DB01254DasatinibTyrosine-protein kinase Lyntarget
DB01254DasatinibMitogen-activated protein kinase kinase kinase MLTtarget
DB01254DasatinibMitogen-activated protein kinase 14target
DB01254DasatinibAmidophosphoribosyltransferasetarget
DB00619ImatinibPlatelet-derived growth factor receptor betatarget
DB00619ImatinibTyrosine-protein kinase ABL1target
DB00619ImatinibMast/stem cell growth factor receptor Kittarget
DB00619ImatinibRET proto-oncogenetarget
DB00619ImatinibHigh affinity nerve growth factor receptortarget
DB00619ImatinibMacrophage colony-stimulating factor 1 receptortarget
DB00619ImatinibPlatelet-derived growth factor receptor alphatarget
DB00619ImatinibEpithelial discoidin domain-containing receptor 1target
DB00619ImatinibCytochrome P450 3A4enzyme
DB00619ImatinibBCR/ABL fusion protein isoform X9target
DB00619ImatinibCytochrome P450 1A2enzyme
DB00619ImatinibCytochrome P450 2D6enzyme
DB00619ImatinibCytochrome P450 2C9enzyme
DB00619ImatinibCytochrome P450 2C19enzyme
DB00619ImatinibCytochrome P450 3A5enzyme
DB00619ImatinibCytochrome P450 3A7enzyme
DB00619ImatinibSolute carrier family 22 member 1transporter
DB00619ImatinibMultidrug resistance protein 1transporter
DB00619ImatinibSolute carrier family 22 member 2transporter
DB00619ImatinibATP-binding cassette sub-family G member 2transporter
DB00619ImatinibATP-binding cassette sub-family A member 3transporter
DB00619ImatinibProstaglandin G/H synthase 1enzyme
DB00619ImatinibSerum albumincarrier
DB00619ImatinibAlpha-1-acid glycoprotein 1carrier
DrugDrug NamePhaseStatusCount
DB00619Imatinib0Not Yet Recruiting1
DB04868Nilotinib0Not Yet Recruiting1
DB00316Acetaminophen1Completed1
DB09312Antilymphocyte immunoglobulin (horse)1Recruiting1
DB00098Antithymocyte immunoglobulin (rabbit)1Recruiting1
DB00928Azacitidine1Completed1
DB00928Azacitidine1Not Yet Recruiting1
DB11851Bafetinib1Completed1
DB01008Busulfan1Recruiting1
DB00987Cytarabine1Completed1
DB01254Dasatinib1Active Not Recruiting1
DB01073Fludarabine1Recruiting1
DB00619Imatinib1Completed3
DB00619Imatinib1Terminated1
DB00563Methotrexate1Recruiting1
DB04868Nilotinib1Completed3
DB09035Nivolumab1Active Not Recruiting1
DB06809Plerixafor1Completed1
DB13005Rebastinib1Completed1
DB11689Selumetinib1Not Yet Recruiting1
DB00864Tacrolimus1Recruiting1
DB05184XL2281Terminated1
DB05169AT92831 / 2Terminated1
DB00087Alemtuzumab1 / 2Recruiting1
DB06769Bendamustine1 / 2Terminated1
DB06616Bosutinib1 / 2Completed1
DB01008Busulfan1 / 2Recruiting1
DB00493Cefotaxime1 / 2Recruiting1
DB00531Cyclophosphamide1 / 2Recruiting1
DB00987Cytarabine1 / 2Terminated1
DB00694Daunorubicin1 / 2Terminated1
DB01590Everolimus1 / 2Withdrawn1
DB00099Filgrastim1 / 2Completed1
DB01073Fludarabine1 / 2Recruiting1
DB00619Imatinib1 / 2Terminated1
DB00619Imatinib1 / 2Withdrawn1
DB01042Melphalan1 / 2Recruiting1
DB00959Methylprednisolone1 / 2Recruiting1
DB04868Nilotinib1 / 2Active Not Recruiting1
DB04868Nilotinib1 / 2Not Yet Recruiting1
DB04865Omacetaxine mepesuccinate1 / 2Recruiting1
DB12146Rigosertib1 / 2Completed1
DB08877Ruxolitinib1 / 2Active Not Recruiting1
DB08877Ruxolitinib1 / 2Not Yet Recruiting1
DB00864Tacrolimus1 / 2Recruiting1
DB04572Thiotepa1 / 2Recruiting1
DB00098Antithymocyte immunoglobulin (rabbit)2Recruiting2
DB00098Antithymocyte immunoglobulin (rabbit)2Terminated1
DB09052Blinatumomab2Recruiting1
DB06616Bosutinib2Recruiting1
DB01008Busulfan2Active Not Recruiting1
DB01008Busulfan2Completed1
DB01008Busulfan2Recruiting3
DB00493Cefotaxime2Recruiting1
DB00631Clofarabine2Completed2
DB06189Clofarabine2Completed2
DB09110Coenzyme M2Recruiting2
DB00531Cyclophosphamide2Completed2
DB00531Cyclophosphamide2Recruiting5
DB00987Cytarabine2Completed1
DB01254Dasatinib2Active Not Recruiting1
DB01254Dasatinib2Completed7
DB01254Dasatinib2Recruiting4
DB01254Dasatinib2Terminated1
DB01254Dasatinib2Unknown Status1
DB06210Eltrombopag2Active Not Recruiting1
DB00099Filgrastim2Active Not Recruiting1
DB00099Filgrastim2Recruiting3
DB01073Fludarabine2Active Not Recruiting1
DB01073Fludarabine2Completed2
DB01073Fludarabine2Recruiting5
DB01073Fludarabine2Terminated2
DB01177Idarubicin2Completed1
DB00619Imatinib2Active Not Recruiting1
DB00619Imatinib2Completed7
DB00619Imatinib2Recruiting3
DB00619Imatinib2Unknown Status1
DB01042Melphalan2Completed1
DB01042Melphalan2Recruiting1
DB00563Methotrexate2Active Not Recruiting1
DB00075Muromonab2Completed1
DB00688Mycophenolate mofetil2Completed1
DB00688Mycophenolate mofetil2Recruiting4
DB04868Nilotinib2Active Not Recruiting3
DB04868Nilotinib2Completed1
DB04868Nilotinib2Recruiting3
DB04868Nilotinib2Unknown Status2
DB04865Omacetaxine mepesuccinate2Completed2
DB00038Oprelvekin2Completed1
DB00039Palifermin2Terminated1
DB00039Palifermin2Withdrawn1
DB00022Peginterferon alfa-2b2Unknown Status1
DB00022Peginterferon alfa-2b2Withdrawn1
DB01132Pioglitazone2Not Yet Recruiting1
DB01132Pioglitazone2Recruiting1
DB08901Ponatinib2Active Not Recruiting1
DB08901Ponatinib2Recruiting1
DB10415Rabbit2Recruiting1
DB12323Radotinib2Recruiting1
DB00073Rituximab2Recruiting1
DB00020Sargramostim2Completed1
DB00877Sirolimus2Recruiting2
DB00864Tacrolimus2Active Not Recruiting1
DB00864Tacrolimus2Completed1
DB00864Tacrolimus2Recruiting4
DB04572Thiotepa2Completed1
DB04572Thiotepa2Recruiting2
DB04572Thiotepa2Terminated1
DB11678Treosulfan2Unknown Status1
DB00098Antithymocyte immunoglobulin (rabbit)2 / 3Recruiting1
DB00091Cyclosporine2 / 3Recruiting1
DB01254Dasatinib2 / 3Withdrawn1
DB01073Fludarabine2 / 3Recruiting1
DB00619Imatinib2 / 3Completed1
DB01042Melphalan2 / 3Recruiting1
DB00688Mycophenolate mofetil2 / 3Recruiting1
DB04572Thiotepa2 / 3Recruiting1
DB06616Bosutinib3Completed1
DB00531Cyclophosphamide3Terminated1
DB01254Dasatinib3Recruiting1
DB00619Imatinib3Completed3
DB00619Imatinib3Recruiting2
DB00619Imatinib3Terminated1
DB00619Imatinib3Unknown Status2
DB00563Methotrexate3Terminated1
DB04868Nilotinib3Active Not Recruiting2
DB04868Nilotinib3Approved for Marketing1
DB04868Nilotinib3Completed3
DB04868Nilotinib3No Longer Available1
DB04868Nilotinib3Recruiting3
DB04868Nilotinib3Unknown Status1
DB00008Peginterferon alfa-2a3Recruiting2
DB08901Ponatinib3Terminated1
DB00619Imatinib4Active Not Recruiting1
DB00619Imatinib4Completed2
DB00619Imatinib4Not Yet Recruiting1
DB04868Nilotinib4Completed1
DB04868Nilotinib4Not Yet Recruiting1
DB04868Nilotinib4Recruiting1
DB04868Nilotinib4Withdrawn1
DB06413ArmodafinilNot AvailableTerminated1
DB06616BosutinibNot AvailableCompleted1
DB06616BosutinibNot AvailableRecruiting1
DB00091CyclosporineNot AvailableRecruiting1
DB01254DasatinibNot AvailableAvailable1
DB01254DasatinibNot AvailableCompleted1
DB00619ImatinibNot AvailableAvailable1
DB00619ImatinibNot AvailableCompleted3
DB00619ImatinibNot AvailableRecruiting1
DB00619ImatinibNot AvailableUnknown Status1
DB00563MethotrexateNot AvailableRecruiting1
DB00688Mycophenolate mofetilNot AvailableRecruiting1
DB04868NilotinibNot AvailableCompleted1
DB04868NilotinibNot AvailableUnknown Status1
DB08901PonatinibNot AvailableApproved for Marketing1
DB08901PonatinibNot AvailableNo Longer Available1
DB08901PonatinibNot AvailableRecruiting1