Diffuse Lewy Body Disease

Also known as: Lewy Body Disease / Dementia, Lewy Body / Lewy Body Dementia / Lewy Body's Dementia / Dementia With Lewy Bodies / Dementia with Parkinsonism

DrugDrug NameDrug Description
DB00843DonepezilAn acetylcholinesterase inhibitor used to treat the behavioral and cognitive effects of Alzheimer's Disease and other types of dementia.
DB00674GalantamineA benzazepine derivative used to treat mild to moderate dementia associated with Alzheimer's Disease.
DB00989RivastigmineA cholinesterase inhibitor used to treat mild to moderate dementia in Alzheimer's and Parkinson's.
DrugDrug NameTargetType
DB00843DonepezilAcetylcholinesterasetarget
DB00843Donepezil5-hydroxytryptamine receptor 2Atarget
DB00843DonepezilCytochrome P450 3A4enzyme
DB00843DonepezilCytochrome P450 2D6enzyme
DB00843DonepezilCytochrome P450 2C9enzyme
DB00843DonepezilCholinesterasetarget
DB00843DonepezilNitric oxide synthase, braintarget
DB00843DonepezilTumor necrosis factor-inducible gene 6 proteintarget
DB00843DonepezilInterleukin-1 betatarget
DB00843DonepezilNuclear factor NF-kappa-Btarget
DB00843DonepezilATP-binding cassette sub-family G member 2transporter
DB00843DonepezilP-glycoprotein 1transporter
DB00843DonepezilNMDA receptortarget
DB00674GalantamineAcetylcholinesterasetarget
DB00674GalantamineCytochrome P450 3A4enzyme
DB00674GalantamineCytochrome P450 2D6enzyme
DB00674GalantamineAcetylcholine receptor subunit alphatarget
DB00674GalantamineAcetylcholine receptor subunit betatarget
DB00674GalantamineAcetylcholine receptor subunit deltatarget
DB00674GalantamineAcetylcholine receptor subunit gammatarget
DB00674GalantamineAcetylcholine receptor subunit epsilontarget
DB00674GalantamineNeuronal acetylcholine receptor subunit alpha-2target
DB00674GalantamineNeuronal acetylcholine receptor subunit alpha-3target
DB00674GalantamineNeuronal acetylcholine receptor subunit alpha-4target
DB00674GalantamineNeuronal acetylcholine receptor subunit alpha-5target
DB00674GalantamineNeuronal acetylcholine receptor subunit alpha-6target
DB00674GalantamineNeuronal acetylcholine receptor subunit alpha-7target
DB00674GalantamineNeuronal acetylcholine receptor subunit alpha-9target
DB00674GalantamineNeuronal acetylcholine receptor subunit alpha-10target
DB00674GalantamineNeuronal acetylcholine receptor subunit beta-2target
DB00674GalantamineNeuronal acetylcholine receptor subunit beta-3target
DB00674GalantamineNeuronal acetylcholine receptor subunit beta-4target
DB00674GalantamineCholinesterasetarget
DB00989RivastigmineAcetylcholinesterasetarget
DB00989RivastigmineCholinesterasetarget
DrugDrug NamePhaseStatusCount
DB04868Nilotinib1Completed1
DB14945Florbenazine F-181 / 2Completed1
DB09149Florbetapir (18F)1 / 2Completed1
DB06616Bosutinib2Recruiting1
DB12680Intepirdine2Completed2
DB01043Memantine2Completed1
DB12555Nelotanserin2Completed2
DB12555Nelotanserin2Terminated1
DB04868Nilotinib2Recruiting1
DB12680Intepirdine2 / 3Terminated1
DB00674Galantamine3Completed1
DB08824Ioflupane I-1233Completed1
DB06413Armodafinil4Completed1
DB00843Donepezil4Completed1
DB00843Donepezil4Not Yet Recruiting1
DB15033Flortaucipir4Enrolling by Invitation1
DB01043Memantine4Completed1
DB01043Memantine4Not Yet Recruiting1
DB15161Pittsburgh Compound B4Enrolling by Invitation2
DB00843DonepezilNot AvailableCompleted1
DB00674GalantamineNot AvailableCompleted1
DB00980RamelteonNot AvailableWithdrawn1
DB00989RivastigmineNot AvailableCompleted1