High Cholesterol Completed Phase 3 Trials for Simvastatin (DB00641)

Also known as: High Blood Cholesterol Level / Hypercholesterolemia / Hypercholesteremia / Hypercholesterolaemia / Congenital xanthoma / Hypercholesteraemia / Elevated cholesterol

IndicationStatusPhase
DBCOND0037835 (High Cholesterol)Completed3
clinicaltrials.gov IdentifierTitlePurposeDrugs
NCT03885921Safety and Tolerability Study of Ezetimibe (SCH 058235/MK-0653) Plus Atorvastatin or Simvastatin in Homozygous Familial Hypercholesterolemia (P01417/MK-0653-019)Treatment
NCT00202878IMPROVE-IT: Examining Outcomes in Subjects With Acute Coronary Syndrome: Vytorin (Ezetimibe/Simvastatin) vs Simvastatin (P04103)Treatment
NCT02715726Evaluation of Alirocumab Versus Ezetimibe on Top of Statin in Asia in High Cardiovascular Risk Patients With HypercholesterolemiaTreatment
NCT00423488Ezetimibe and Simvastatin in Primary Hypercholesterolemia, Diabetes Mellitus Type 2, and Coronary Heart Disease (COMPLETED)Treatment
NCT00344175Follow-on Protocol of Pitavastatin Versus Simvastatin in Patients With Hypercholesterolemia or Dyslipidemia and Coronary Heart Disease Risk FactorsTreatment
NCT00385931Efficacy and Safety of Valsartan and the Combination of Valsartan and SimvastatinTreatment
NCT00409773Ezetimibe/Simvastatin in Patients With Metabolic Syndrome (0653A-107)(COMPLETED)Treatment
NCT00309738Study to Compare the Efficacy and Safety of Pitavastatin and SimvastatinTreatment
NCT00286481Efficacy of Lapaquistat Acetate Alone or Combined With Simvastatin in Subjects With HypercholesterolemiaTreatment
NCT00309777Study to Compare the Efficacy and Safety of Pitavastatin and SimvastatinTreatment
NCT00082251Safety & Efficacy of a Combination Niacin ER/Simvastatin in Patients With Dyslipidemia: A Dose-Ranging Study - SEACOASTTreatment
NCT00080275Evaluation of the Safety & Efficacy of a Combination of Niacin ER & Simvastatin in Patients With Dyslipidemia (OCEANS)Treatment
NCT00171093A 10-12 Week Study to Evaluate the Safety and Efficacy of 320 mg Valsartan and 80 mg Simvastatin in Combination and as Monotherapies in Treating Hypertension and HypercholesterolemiaTreatment
NCT00650819Comparison of Ezetimibe Plus Simvastatin Versus Ezetimibe or Simvastatin Alone in Subjects With Primary Hypercholesterolemia (Study P03757)(COMPLETED)Treatment
NCT00552097Effect of Ezetimibe Plus Simvastatin Versus Simvastatin Alone on Atherosclerosis in the Carotid Artery (ENHANCE)(P02578)Prevention
NCT00132717A 12 Week Study of MK0653A in Patients Who Have Been Hospitalized for a Possible Heart Problem (0653A-808)Treatment
NCT00092157Effectiveness of Two Approved Drugs in Lowering High Cholesterol (0733-224)Treatment
NCT00256178Efficacy of Lapaquistat Acetate and Simvastatin in Subjects With Primary Dyslipidemia.Treatment
NCT00254475A Study to Evaluate the Efficacy of Valsartan/Simvastatin Combinations in Patients With Both Essential Hypertension and HypercholesterolemiaTreatment
NCT00267254A Clinical Trial Comparing Torcetrapib/Atorvastatin To Simvastatin In Subjects With High Cholesterol.Treatment
NCT00271817To Evaluate Ezetimibe/Simvastatin and Niacin (Extended Release Tablet) in Patients With Type IIa or Type IIb Hyperlipidemia (0653A-091)(COMPLETED)Treatment
NCT00129402Effects of Ezetimibe With Simvastatin in the Therapy of Adolescents With HeFH (Study P02579)Treatment
NCT01420549Efficacy and Safety of FDC in High Risk Patients With Primary Hypercholesterolemia or Mixed DyslipidemiaTreatment
NCT00782184Ezetimibe/Simvastatin (10 mg/40 mg) vs. the Doubling of Atorvastatin in High Risk Participants (MK-0653A-134 AM1)(COMPLETED)Treatment
NCT00654537STELLAR-Rosuvastatin vs. Atorvastatin, Pravastatin, Simvastatin Across Dose RangesTreatment
NCT00654407Mercury II - Compare the Efficacy and Safety of Lipid Lowering Agents Atorvastatin and Simvastatin With Rosuvastatin in High Risk Subjects With Type IIa and IIb HypercholesterolemiaTreatment
NCT00654173Comparing the Efficacy and Safety of Rosuvastatin With Atorvastatin and Simvastatin (SOLAR)Treatment
NCT00653523Coadministration of Ezetimibe and Simvastatin in Patients With Primary Hypercholesterolemia (P05457)Treatment
NCT00479713A Study to Assess the Cholesterol Lowering Effect of an Ezetimibe/Simvastatin Combination Tablet Compared to Another Cholesterol Lowering Drug in Patients With High Cholesterol and With High Cardiovascular Risk (0653A-809)(COMPLETED)Treatment
NCT00496730A Multicenter, Randomized, Open Label Study to Evaluate the Lipid Lowering Efficacy and Safety of Vytorin® 10/20 vs. Atorvastatin 10mg in Hypercholesterolemia Patients With Metabolic Syndrome in Korea (0653A-129)(COMPLETED)Treatment
NCT0052582412-week Open-label, Phase IIIb Comparing Efficacy and Safety of Rosuvastatin (CRESTOR™) in Combination With EzetimibeTreatment