Human Immunodeficiency Virus - Type 1

Also known as: Human Immunodeficiency Virus 1 / Human Immunodeficiency Virus-Type 1 / Human Immunodeficiency Virus-1 (HIV-1) / Human Immunodeficiency Virus Type 1 (HIV-1) / Human Immunodeficiency Virus-1 / Immunodeficiency Virus Type 1, Human / Human Immunodeficiency Virus Type 1 / HIV-1 / HIV-I / Human T-cell leukemia virus III / Human T-cell leukaemia virus III / Human immunodeficiency virus type I (organism) / Human immunodeficiency virus [HIV] disease / HIV disease / HIV infection NOS / Human immunodeficiency virus syndrome / HIV Infections / HIV infection / Human immunodeficiency virus infection (disorder)

Drug	Drug Name	Drug Description
DB11751	Cabotegravir	An HIV-1 integrase inhibitor used for treatment and pre-exposure prophylaxis of HIV-1 infection.
DB12301	Doravirine	A non-nucleoside reverse transcriptase inhibitor used in combination with other antiretrovirals to treat HIV-1 infections.
DB00109	Enfuvirtide	An HIV-1 gp41 fusion inhibitor used in patients experiencing HIV-1 replication who are already being treated with other anti-retrovirals.
DB08864	Rilpivirine	A non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with other antiretrovirals to specifically treat human immunodeficiency virus type 1 (HIV-1).

Drug	Drug Name	Target	Type
DB11751	Cabotegravir	Solute carrier family 22 member 6	transporter
DB11751	Cabotegravir	Solute carrier family 22 member 8	transporter
DB11751	Cabotegravir	UDP-glucuronosyltransferase 1-1	enzyme
DB11751	Cabotegravir	UDP-glucuronosyltransferase 1-9	enzyme
DB11751	Cabotegravir	P-glycoprotein 1	transporter
DB11751	Cabotegravir	ATP-binding cassette sub-family G member 2	transporter
DB11751	Cabotegravir	Serum albumin	carrier
DB11751	Cabotegravir	Integrase	target
DB12301	Doravirine	Cytochrome P450 3A4	enzyme
DB12301	Doravirine	Cytochrome P450 3A5	enzyme
DB12301	Doravirine	Reverse transcriptase/RNaseH	target
DB00109	Enfuvirtide	Envelope glycoprotein	target
DB00109	Enfuvirtide	Cytochrome P450 2C19	enzyme
DB00109	Enfuvirtide	Cytochrome P450 2E1	enzyme
DB08864	Rilpivirine	Cytochrome P450 3A4	enzyme
DB08864	Rilpivirine	Reverse transcriptase/RNaseH	target
DB08864	Rilpivirine	Nuclear receptor subfamily 1 group I member 2	target
DB08864	Rilpivirine	Cytochrome P450 2C19	enzyme
DB08864	Rilpivirine	Cytochrome P450 2B6	enzyme
DB08864	Rilpivirine	P-glycoprotein 1	transporter
DB08864	Rilpivirine	ATP-binding cassette sub-family G member 2	transporter
DB08864	Rilpivirine	Solute carrier organic anion transporter family member 1B1	transporter
DB08864	Rilpivirine	Solute carrier organic anion transporter family member 1B3	transporter
DB08864	Rilpivirine	Serum albumin	carrier
DB08864	Rilpivirine	Cytochrome P450 2D6	enzyme
DB08864	Rilpivirine	Cytochrome P450 2C9	enzyme
DB08864	Rilpivirine	Cytochrome P450 2C8	enzyme
DB08864	Rilpivirine	Cytochrome P450 2E1	enzyme

Drug	Drug Name	Phase	Status	Count
DB01072	Atazanavir	1	Completed	2
DB16668	Budigalimab	1	Completed	1
DB09065	Cobicistat	1	Completed	1
DB01264	Darunavir	1	Completed	1
DB12301	Doravirine	1	Completed	1
DB15653	Islatravir	1	Completed	1
DB00238	Nevirapine	1	Completed	1
DB05083	Rilpivirine	1	Completed	1
DB08864	Rilpivirine	1	Completed	2
DB05083	Rilpivirine	1	Terminated	1
DB08864	Rilpivirine	1	Terminated	1
DB00503	Ritonavir	1	Completed	1
DB00582	Voriconazole	1	Completed	1
DB08639	Dapivirine	1 / 2	Completed	1
DB01048	Abacavir	2	Completed	1
DB01072	Atazanavir	2	Completed	1
DB01264	Darunavir	2	Completed	4
DB12301	Doravirine	2	Completed	1
DB00625	Efavirenz	2	Completed	3
DB00625	Efavirenz	2	Terminated	1
DB09101	Elvitegravir	2	Completed	1
DB00879	Emtricitabine	2	Completed	5
DB00109	Enfuvirtide	2	Completed	1
DB06414	Etravirine	2	Completed	3
DB06414	Etravirine	2	Terminated	2
DB00709	Lamivudine	2	Active Not Recruiting	1
DB00709	Lamivudine	2	Completed	3
DB11649	Lersivirine	2	Completed	2
DB11649	Lersivirine	2	Terminated	2
DB01601	Lopinavir	2	Completed	1
DB04835	Maraviroc	2	Completed	2
DB11066	Pancrelipase protease	2	Completed	1
DB06817	Raltegravir	2	Completed	1
DB05083	Rilpivirine	2	Active Not Recruiting	1
DB08864	Rilpivirine	2	Active Not Recruiting	1
DB05083	Rilpivirine	2	Completed	1
DB08864	Rilpivirine	2	Completed	2
DB00503	Ritonavir	2	Completed	5
DB15623	TMC-310911	2	Completed	1
DB14126	Tenofovir	2	Completed	1
DB00300	Tenofovir disoproxil	2	Completed	5
DB00495	Zidovudine	2	Completed	2
DB01048	Abacavir	3	Completed	1
DB11751	Cabotegravir	3	Completed	2
DB09065	Cobicistat	3	Completed	2
DB01264	Darunavir	3	Completed	3
DB01264	Darunavir	3	Terminated	1
DB12301	Doravirine	3	Completed	1
DB00625	Efavirenz	3	Completed	3
DB09101	Elvitegravir	3	Completed	1
DB00879	Emtricitabine	3	Active Not Recruiting	1
DB00879	Emtricitabine	3	Completed	3
DB00879	Emtricitabine	3	Terminated	1
DB06414	Etravirine	3	Active Not Recruiting	1
DB06414	Etravirine	3	Completed	2
DB01319	Fosamprenavir	3	Terminated	1
DB15653	Islatravir	3	Active Not Recruiting	1
DB00709	Lamivudine	3	Completed	3
DB01601	Lopinavir	3	Terminated	1
DB04835	Maraviroc	3	Completed	1
DB04835	Maraviroc	3	Terminated	1
DB04835	Maraviroc	3	Withdrawn	1
DB11066	Pancrelipase protease	3	Completed	1
DB05083	Rilpivirine	3	Completed	2
DB08864	Rilpivirine	3	Completed	4
DB00503	Ritonavir	3	Completed	2
DB00503	Ritonavir	3	Terminated	2
DB09299	Tenofovir alafenamide	3	Completed	2
DB00300	Tenofovir disoproxil	3	Active Not Recruiting	1
DB00300	Tenofovir disoproxil	3	Completed	1
DB00300	Tenofovir disoproxil	3	Terminated	1
DB00495	Zidovudine	3	Completed	1
DB01048	Abacavir	4	Completed	1
DB01072	Atazanavir	4	Completed	2
DB01264	Darunavir	4	Completed	3
DB08930	Dolutegravir	4	Completed	1
DB00625	Efavirenz	4	Completed	2
DB00879	Emtricitabine	4	Completed	4
DB01319	Fosamprenavir	4	Completed	1
DB00709	Lamivudine	4	Completed	2
DB01601	Lopinavir	4	Completed	4
DB00238	Nevirapine	4	Completed	1
DB11066	Pancrelipase protease	4	Completed	1
DB08864	Rilpivirine	4	Completed	1
DB00503	Ritonavir	4	Completed	5
DB14126	Tenofovir	4	Completed	1
DB00300	Tenofovir disoproxil	4	Completed	3
DB00495	Zidovudine	4	Completed	1
DB01264	Darunavir	Not Available	Withdrawn	1
DB00109	Enfuvirtide	Not Available	Completed	1
DB04835	Maraviroc	Not Available	Completed	1