Pseudobulbar Affect (PBA)

Also known as: Pseudobulbar affect / Pseudobulbar affect (finding) / Affect lability / Labile affect (finding) / Labile affect

Drug	Drug Name	Drug Description
DB00514	Dextromethorphan	An NMDA receptor antagonist used to treat cases of dry cough.
DB00908	Quinidine	A medication used to restore normal sinus rhythm, treat atrial fibrillation and flutter, and treat ventricular arrhythmias.

Drug	Drug Name	Target	Type
DB00514	Dextromethorphan	Sigma non-opioid intracellular receptor 1	target
DB00514	Dextromethorphan	Neuronal acetylcholine receptor subunit alpha-2	target
DB00514	Dextromethorphan	Sodium-dependent serotonin transporter	target
DB00514	Dextromethorphan	Glutamate receptor ionotropic, NMDA 3A	target
DB00514	Dextromethorphan	Cytochrome P450 2D6	enzyme
DB00514	Dextromethorphan	Cytochrome P450 3A4	enzyme
DB00514	Dextromethorphan	Cytochrome P450 3A7	enzyme
DB00514	Dextromethorphan	Cytochrome P450 2C9	enzyme
DB00514	Dextromethorphan	Cytochrome P450 2B6	enzyme
DB00514	Dextromethorphan	Cytochrome P450 2C19	enzyme
DB00514	Dextromethorphan	Membrane-associated progesterone receptor component 1	target
DB00514	Dextromethorphan	Neuronal acetylcholine receptor subunit alpha-3	target
DB00514	Dextromethorphan	Neuronal acetylcholine receptor subunit alpha-4	target
DB00514	Dextromethorphan	Neuronal acetylcholine receptor subunit beta-4	target
DB00514	Dextromethorphan	Neuronal acetylcholine receptor subunit beta-2	target
DB00514	Dextromethorphan	Neuronal acetylcholine receptor subunit alpha-7	target
DB00514	Dextromethorphan	Mu-type opioid receptor	target
DB00514	Dextromethorphan	Delta-type opioid receptor	target
DB00514	Dextromethorphan	Kappa-type opioid receptor	target
DB00514	Dextromethorphan	NADPH oxidase	target
DB00514	Dextromethorphan	Sodium-dependent noradrenaline transporter	target
DB00514	Dextromethorphan	UDP-glucuronosyltransferase 2B4	enzyme
DB00514	Dextromethorphan	UDP-glucuronosyltransferase 2B7	enzyme
DB00514	Dextromethorphan	UDP-glucuronosyltransferase 2B15	enzyme
DB00514	Dextromethorphan	UDP-glucuronosyltransferase 2B17	enzyme
DB00908	Quinidine	Sodium channel protein type 5 subunit alpha	target
DB00908	Quinidine	Alpha-1-acid glycoprotein 1	carrier
DB00908	Quinidine	Potassium voltage-gated channel subfamily H member 2	target
DB00908	Quinidine	Potassium channel subfamily K member 1	target
DB00908	Quinidine	Potassium channel subfamily K member 6	target
DB00908	Quinidine	Cytochrome P450 1A2	enzyme
DB00908	Quinidine	Cytochrome P450 2E1	enzyme
DB00908	Quinidine	Cytochrome P450 1A1	enzyme
DB00908	Quinidine	Cytochrome P450 2D6	enzyme
DB00908	Quinidine	Cytochrome P450 3A4	enzyme
DB00908	Quinidine	Cytochrome P450 3A7	enzyme
DB00908	Quinidine	Solute carrier family 22 member 2	transporter
DB00908	Quinidine	Solute carrier family 22 member 1	transporter
DB00908	Quinidine	Solute carrier family 22 member 5	transporter
DB00908	Quinidine	P-glycoprotein 1	transporter
DB00908	Quinidine	Solute carrier organic anion transporter family member 1A2	transporter
DB00908	Quinidine	Solute carrier family 22 member 8	transporter
DB00908	Quinidine	Canalicular multispecific organic anion transporter 1	transporter
DB00908	Quinidine	Solute carrier family 22 member 4	transporter
DB00908	Quinidine	Solute carrier organic anion transporter family member 1B1	transporter
DB00908	Quinidine	Cytochrome P450 2B6	enzyme
DB00908	Quinidine	Cytochrome P450 2C9	enzyme
DB00908	Quinidine	Alpha-1A adrenergic receptor	target
DB00908	Quinidine	Alpha-1B adrenergic receptor	target
DB00908	Quinidine	Alpha-1D adrenergic receptor	target
DB00908	Quinidine	Bile salt export pump	transporter
DB00908	Quinidine	Cytochrome P450 2C8	enzyme
DB00908	Quinidine	Serum albumin	carrier

Drug	Drug Name	Phase	Status	Count
DB00514	Dextromethorphan	3	Completed	1
DB00908	Quinidine	3	Completed	1
DB00514	Dextromethorphan	4	Completed	1
DB00514	Dextromethorphan	4	Terminated	1
DB00908	Quinidine	4	Completed	1
DB00908	Quinidine	4	Terminated	1