PAH WHO Group I

Also known as: Pulmonary arterial hypertension WHO functional class I / Pulmonary Arterial Hypertension (PAH) (WHO Group 1 PH) / WHO Group 1 Pulmonary arterial hypertension / Pulmonary Arterial Hypertension WHO Group I / Pulmonary Arterial Hypertension / Pulmonary hypertensive arterial disease (disorder)

DrugDrug NameDrug Description
DB06403AmbrisentanA selective type A endothelin receptor antagonist used to treat primary pulmonary arterial hypertension and pulmonary arterial hypertension based on diagnostic classifications.
DB08932MacitentanAn endothelin receptor antagonist used to manage pulmonary arterial hypertension to delay disease progression.
DB11362SelexipagA non prostanoid IP prostacyclin receptor agonist used to treat pulmonary arterial hypertension.
DB12118SotaterceptA recombinant activin receptor fusion protein used to treat pulmonary arterial hypertension.
DrugDrug NameTargetType
DB06403AmbrisentanEndothelin B receptortarget
DB06403AmbrisentanEndothelin-1 receptortarget
DB06403AmbrisentanCytochrome P450 2C19enzyme
DB06403AmbrisentanCytochrome P450 3A4enzyme
DB06403AmbrisentanUDP-glucuronosyltransferase 1-9enzyme
DB06403AmbrisentanUDP-glucuronosyltransferase 1-3enzyme
DB06403AmbrisentanUDP-glucuronosyltransferase 2B7enzyme
DB06403AmbrisentanP-glycoprotein 1transporter
DB06403AmbrisentanSolute carrier organic anion transporter family member 1B1transporter
DB06403AmbrisentanSolute carrier organic anion transporter family member 1B3transporter
DB06403AmbrisentanCytochrome P450 3A5enzyme
DB08932MacitentanCytochrome P450 3A4enzyme
DB08932MacitentanCytochrome P450 2C19enzyme
DB08932MacitentanEndothelin-1 receptortarget
DB08932MacitentanEndothelin B receptortarget
DB08932MacitentanSerum albumincarrier
DB08932MacitentanCytochrome P450 2C9enzyme
DB08932MacitentanCytochrome P450 2C8enzyme
DB08932Macitentanalpha1-acid glycoproteincarrier
DB11362SelexipagProstacyclin receptortarget
DB11362SelexipagLiver carboxylesterase 1enzyme
DB11362SelexipagCytochrome P450 2C8enzyme
DB11362SelexipagCytochrome P450 3A4enzyme
DB11362SelexipagSolute carrier organic anion transporter family member 1B1transporter
DB11362SelexipagSolute carrier organic anion transporter family member 1B3transporter
DB11362SelexipagP-glycoprotein 1transporter
DB12118SotaterceptActivin receptor type-2Atarget
DB12118SotaterceptActivin receptor type-1Btarget
DB12118SotaterceptGrowth/differentiation factor 8target
DB12118SotaterceptGrowth/differentiation factor 11target
DrugDrug NamePhaseStatusCount
DB08932Macitentan3Active Not Recruiting1
DB00820Tadalafil3Active Not Recruiting1
DB06403AmbrisentanNot AvailableWithdrawn1
DB00559BosentanNot AvailableWithdrawn1
DB06268SitaxentanNot AvailableWithdrawn1