Opioid Induced Constipation (OIC)

Also known as: Opioid-Induced Constipation / Opioid induced constipation / Opioid-induced Constipation (OIC) / Constipation, unspecified / Constipation (& symptom) / Constipation

DrugDrug NameDrug Description
DB01046LubiprostoneA prostaglandin derivative used to treat constipation caused by irritable bowel syndrome and opioid-use.
DB06800MethylnaltrexoneA μ-opioid antagonist used for the treatment of opioid-induced constipation in palliative patients that are inadequately responding to laxative therapy.
DB11691NaldemedineAn opioid antagonist used to to treat opioid-induced constipation.
DB09049NaloxegolA peripherally-selective opioid antagonist used to treat opioid-induced constipation (OIC) in adult patients with chronic non-cancer pain.
DB06480PrucaloprideA P2Y12 platelet receptor antagonist used during percutaneous coronary intervention to reduce the risk for periprocedural myocardial infarction (MI), repeat coronary revascularization, and stent thrombosis (ST).
DrugDrug NamePhaseStatusCount
DB09049Naloxegol1Completed1
DB12013Axelopran1 / 2Completed1
DB12013Axelopran2Completed3
DB12464Bevenopran2Completed1
DB08890Linaclotide2Completed1
DB06800Methylnaltrexone2Completed1
DB15241Methylsamidorphan2Completed2
DB11691Naldemedine2Completed1
DB09049Naloxegol2Completed1
DB01183Naloxone2Completed1
DB06800Methylnaltrexone2 / 3Recruiting1
DB12464Bevenopran3Terminated4
DB06800Methylnaltrexone3Completed1
DB06800Methylnaltrexone3Unknown Status1
DB11691Naldemedine3Completed3
DB09049Naloxegol3Completed4
DB09049Naloxegol3Terminated1
DB01183Naloxone3Recruiting1
DB06480Prucalopride3Terminated1
DB01079Tegaserod3Terminated2
DB06800Methylnaltrexone4Completed2
DB06800Methylnaltrexone4Withdrawn1
DB09049Naloxegol4Completed1
DB01183Naloxone4Unknown Status1
DB00497Oxycodone4Unknown Status1
DB09287Polyethylene glycol4Completed1
DB01046LubiprostoneNot AvailableRecruiting1
DB06800MethylnaltrexoneNot AvailableCompleted1
DB11691NaldemedineNot AvailableRecruiting1
DB09049NaloxegolNot AvailableRecruiting5