Pulmonary Arterial Hypertension (PAH)

Also known as: Hypertension, Pulmonary Artery / Pulmonary arterial hypertension

DrugDrug NameDrug Description
DB01240EpoprostenolA prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension.
DB08931RiociguatRiociguat is a soluble guanylate cyclase (sGC) agonist approved in the USA, Europe and several other regions for patients with group I PAH (pulmonary arterial hypertension) in WHO FC II or III; and for the treatment of patients with inoperable CTEPH (chronic thromboembolic pulmonary hypertension), or persistent/recurrent PH (pulmonary hypertension) after pulmonary endarterectomy in WHO FC II or III. Riociguat is marketed under the brand AdempasĀ® by Bayer HealthCare Pharmaceuticals. Treatment with riociguat costs USD $7,500 for 30 days of treatment.
DB00820TadalafilTadalafil is an orally administered drug used to treat male erectile dysfunction (impotence). It is marketed worldwide under the brand name Cialis. It is a phosphodiesterase 5 (PDE5) inhibitor. Tadalafil's distinguishing pharmacologic feature is its longer half-life (17.5 hours) compared with Viagra and Levitra (4-5 hours). This longer half-life results in a longer duration of action and is, in part, responsible for the Cialis nickname of the "weekend pill." This longer half-life also is the basis of current investigation for tadalafil's use in pulmonary arterial hypertension as a once-daily therapy.
DrugDrug NamePhaseStatusCount
DB12000Apabetalone0Not Yet Recruiting1
DB00559Bosentan0Completed1
DB09074Olaparib0Recruiting1
DB00503Ritonavir0Unknown Status1
DB01232Saquinavir0Unknown Status1
DB06268Sitaxentan0Completed1
DB00026Anakinra1Completed1
DB00126Ascorbic acid1Recruiting1
DB12054BQ-1231Recruiting1
DB00559Bosentan1Completed1
DB05161Elafin1Recruiting1
DB00736Esomeprazole1Completed1
DB00950Fexofenadine1Recruiting1
DB00281Lidocaine1Not Yet Recruiting1
DB05063Mitoquinone1Recruiting1
DB00218Moxifloxacin1Active Not Recruiting1
DB09074Olaparib1Not Yet Recruiting1
DB00692Phentolamine1Recruiting1
DB00863Ranitidine1Recruiting1
DB00243Ranolazine1Completed1
DB00206Reserpine1Not Yet Recruiting1
DB01045Rifampicin1Withdrawn1
DB00503Ritonavir1Withdrawn1
DB00360Sapropterin1Completed1
DB00360Sapropterin1Recruiting1
DB00203Sildenafil1Terminated1
DB06268Sitaxentan1Terminated1
DB06268Sitaxentan1Withdrawn2
DB00398Sorafenib1Completed1
DB00820Tadalafil1Terminated1
DB00374Treprostinil1Completed2
DB12389Zamicastat1Active Not Recruiting1
DB12389Zamicastat1Recruiting1
DB01136Carvedilol1 / 2Completed1
DB01136Carvedilol1 / 2Withdrawn1
DB00820Tadalafil1 / 2Active Not Recruiting1
DB01217Anastrozole2Completed1
DB01217Anastrozole2Recruiting1
DB05983Bardoxolone methyl2Completed1
DB00559Bosentan2Active Not Recruiting1
DB06774Capsaicin2Completed1
DB01136Carvedilol2Recruiting1
DB12766Cicletanine2Terminated1
DB00927Famotidine2Not Yet Recruiting1
DB00472Fluoxetine2Active Not Recruiting1
DB00472Fluoxetine2Completed1
DB00947Fulvestrant2Completed1
DB00743Gadobenic acid2Terminated1
DB00741Hydrocortisone2Active Not Recruiting1
DB01088Iloprost2Completed1
DB01088Iloprost2Withdrawn1
DB00331Metformin2Recruiting1
DB00331Metformin2Withdrawn1
DB00295Morphine2Enrolling by Invitation1
DB04868Nilotinib2Terminated1
DB00435Nitric Oxide2Completed3
DB12529Nitrite2Terminated1
DB09112Nitrous acid2Completed1
DB09112Nitrous acid2Terminated1
DB01708Prasterone2Recruiting1
DB12462Ralinepag2Active Not Recruiting1
DB12462Ralinepag2Completed1
DB11362Selexipag2Recruiting1
DB00641Simvastatin2Enrolling by Invitation1
DB09153Sodium chloride2Recruiting1
DB12118Sotatercept2Recruiting2
DB00421Spironolactone2Recruiting1
DB00675Tamoxifen2Recruiting1
DB06558Tezosentan2Terminated2
DB06273Tocilizumab2Completed1
DB00374Treprostinil2Completed1
DB00374Treprostinil2Not Yet Recruiting1
DB09069Trimetazidine2Recruiting1
DB03424Ubenimex2Completed1
DB03424Ubenimex2Terminated1
DB06267Udenafil2Completed1
DB00559Bosentan2 / 3Completed1
DB00619Imatinib2 / 3Completed1
DB00203Sildenafil2 / 3Unknown Status1
DB06267Udenafil2 / 3Completed1
DB06403Ambrisentan3Completed4
DB00559Bosentan3Completed4
DB00559Bosentan3Unknown Status1
DB01240Epoprostenol3Completed2
DB01088Iloprost3Completed2
DB01088Iloprost3Terminated1
DB01088Iloprost3Unknown Status1
DB00619Imatinib3Completed2
DB00619Imatinib3Terminated2
DB04335Inosine3Active Not Recruiting2
DB04335Inosine3Withdrawn1
DB00125L-Arginine3Completed1
DB08932Macitentan3Active Not Recruiting1
DB08932Macitentan3Completed4
DB08932Macitentan3Enrolling by Invitation1
DB08932Macitentan3Recruiting2
DB08932Macitentan3Terminated3
DB12462Ralinepag3Enrolling by Invitation1
DB12462Ralinepag3Recruiting1
DB00243Ranolazine3Completed1
DB11362Selexipag3Active Not Recruiting1
DB11362Selexipag3Completed3
DB11362Selexipag3Recruiting1
DB00203Sildenafil3Completed1
DB00203Sildenafil3Terminated3
DB06268Sitaxentan3Terminated4
DB00820Tadalafil3Recruiting1
DB00374Treprostinil3Withdrawn1
DB06403Ambrisentan4Completed2
DB06403Ambrisentan4Terminated2
DB06403Ambrisentan4Unknown Status1
DB00559Bosentan4Active Not Recruiting1
DB00559Bosentan4Completed4
DB00559Bosentan4Withdrawn1
DB00668Epinephrine4Terminated1
DB01240Epoprostenol4Completed2
DB01088Iloprost4Completed1
DB00281Lidocaine4Terminated1
DB08932Macitentan4Active Not Recruiting2
DB08932Macitentan4Terminated1
DB08931Riociguat4Recruiting1
DB11362Selexipag4Recruiting1
DB00203Sildenafil4Active Not Recruiting1
DB00203Sildenafil4Completed5
DB00203Sildenafil4No Longer Available1
DB00203Sildenafil4Recruiting3
DB00203Sildenafil4Terminated1
DB00203Sildenafil4Unknown Status1
DB00203Sildenafil4Withdrawn1
DB00421Spironolactone4Recruiting1
DB00820Tadalafil4Active Not Recruiting1
DB00820Tadalafil4Completed1
DB00820Tadalafil4Recruiting1
DB00820Tadalafil4Terminated2
DB00820Tadalafil4Unknown Status2
DB00374Treprostinil4Completed5
DB00374Treprostinil4Recruiting1
DB00374Treprostinil4Terminated2
DB00374Treprostinil4Withdrawn2
DB00862Vardenafil4Unknown Status2
DB01418AcenocoumarolNot AvailableRecruiting1
DB00802AlfentanilNot AvailableRecruiting1
DB06403AmbrisentanNot AvailableCompleted1
DB06403AmbrisentanNot AvailableUnknown Status1
DB00479AmikacinNot AvailableRecruiting1
DB00513Aminocaproic AcidNot AvailableRecruiting1
DB00559BosentanNot AvailableCompleted2
DB00559BosentanNot AvailableRecruiting1
DB00559BosentanNot AvailableUnknown Status1
DB01413CefepimeNot AvailableRecruiting1
DB00369CidofovirNot AvailableRecruiting1
DB00537CiprofloxacinNot AvailableRecruiting1
DB00363ClozapineNot AvailableRecruiting1
DB00343DiltiazemNot AvailableWithdrawn1
DB01240EpoprostenolNot AvailableCompleted1
DB13136FluindioneNot AvailableRecruiting1
DB00828FosfomycinNot AvailableRecruiting1
DB00502HaloperidolNot AvailableRecruiting1
DB01088IloprostNot AvailableCompleted5
DB01088IloprostNot AvailableTerminated2
DB00598LabetalolNot AvailableRecruiting1
DB08815LurasidoneNot AvailableRecruiting1
DB08932MacitentanNot AvailableRecruiting1
DB09337Medical airNot AvailableRecruiting1
DB00959MethylprednisoloneNot AvailableRecruiting1
DB01618MolindoneNot AvailableRecruiting1
DB00607NafcillinNot AvailableRecruiting1
DB01115NifedipineNot AvailableRecruiting1
DB00497OxycodoneNot AvailableRecruiting1
DB09140OxygenNot AvailableRecruiting1
DB00312PentobarbitalNot AvailableRecruiting1
DB00728RocuroniumNot AvailableRecruiting1
DB00658SevelamerNot AvailableRecruiting1
DB00203SildenafilNot AvailableCompleted3
DB00203SildenafilNot AvailableNo Longer Available2
DB00203SildenafilNot AvailableRecruiting1
DB06268SitaxentanNot AvailableCompleted1
DB06268SitaxentanNot AvailableTerminated1
DB06268SitaxentanNot AvailableUnknown Status1
DB09153Sodium chlorideNot AvailableUnknown Status1
DB00421SpironolactoneNot AvailableRecruiting1
DB00820TadalafilNot AvailableCompleted2
DB00684TobramycinNot AvailableRecruiting1
DB00302Tranexamic acidNot AvailableRecruiting1
DB00374TreprostinilNot AvailableCompleted2
DB00374TreprostinilNot AvailableNot Yet Recruiting1
DB00374TreprostinilNot AvailableRecruiting1
DB00512VancomycinNot AvailableRecruiting1
DB01339VecuroniumNot AvailableRecruiting1
DB00682WarfarinNot AvailableRecruiting2
DB00246ZiprasidoneNot AvailableRecruiting1
DB00425ZolpidemNot AvailableRecruiting1