Pulmonary Arterial Hypertension (PAH)

Also known as: Hypertension, Pulmonary Artery / Pulmonary arterial hypertension

DrugDrug NameDrug Description
DB01240EpoprostenolA prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension.
DB08931RiociguatRiociguat is a soluble guanylate cyclase (sGC) agonist approved in the USA, Europe and several other regions for patients with group I PAH (pulmonary arterial hypertension) in WHO FC II or III; and for the treatment of patients with inoperable CTEPH (chronic thromboembolic pulmonary hypertension), or persistent/recurrent PH (pulmonary hypertension) after pulmonary endarterectomy in WHO FC II or III. Riociguat is marketed under the brand AdempasĀ® by Bayer HealthCare Pharmaceuticals. Treatment with riociguat costs USD $7,500 for 30 days of treatment.
DB00820TadalafilTadalafil is an orally adminstered drug used to treat male erectile dysfunction (impotence). It is marketed worldwide under the brand name Cialis. It is a phosphodiesterase 5 (PDE5) inhibitor. Tadalafil's distinguishing pharmacologic feature is its longer half-life (17.5 hours) compared with Viagra and Levitra (4-5 hours). This longer half-life results in a longer duration of action and is, in part, responsible for the Cialis nickname of the "weekend pill." This longer half-life also is the basis of current investigation for tadalafil's use in pulmonary arterial hypertension as a once-daily therapy. [Wikipedia]
DrugDrug NamePhaseStatusCount
DB00559Bosentan0Completed1
DB09074Olaparib0Not Yet Recruiting1
DB00503Ritonavir0Unknown Status1
DB01232Saquinavir0Unknown Status1
DB06268Sitaxentan0Completed1
DB00026Anakinra1Recruiting1
DB12054BQ-1231Recruiting1
DB00559Bosentan1Completed1
DB00736Esomeprazole1Completed1
DB00950Fexofenadine1Recruiting1
DB00281Lidocaine1Not Yet Recruiting1
DB05063Mitoquinone1Recruiting1
DB00692Phentolamine1Recruiting1
DB00863Ranitidine1Recruiting1
DB00243Ranolazine1Completed1
DB00206Reserpine1Not Yet Recruiting1
DB01045Rifampicin1Withdrawn1
DB00503Ritonavir1Withdrawn1
DB00360Sapropterin1Completed1
DB00360Sapropterin1Recruiting1
DB00203Sildenafil1Terminated1
DB06268Sitaxentan1Terminated1
DB06268Sitaxentan1Withdrawn2
DB00398Sorafenib1Completed1
DB00820Tadalafil1Terminated1
DB00374Treprostinil1Completed2
DB00126Vitamin C1Recruiting1
DB01136Carvedilol1 / 2Completed1
DB01136Carvedilol1 / 2Withdrawn1
DB00421Spironolactone1 / 2Recruiting1
DB00820Tadalafil1 / 2Recruiting1
DB01217Anastrozole2Completed1
DB01217Anastrozole2Recruiting1
DB00559Bosentan2Active Not Recruiting1
DB06774Capsaicin2Completed1
DB01136Carvedilol2Recruiting1
DB12766Cicletanine2Terminated1
DB00472Fluoxetine2Completed1
DB00947Fulvestrant2Recruiting1
DB00743Gadobenic acid2Terminated1
DB01088Iloprost2Completed1
DB01088Iloprost2Withdrawn1
DB00331Metformin2Withdrawn1
DB04868Nilotinib2Terminated1
DB00435Nitric Oxide2Completed3
DB12529Nitrite2Terminated1
DB12462Ralinepag2Completed1
DB12462Ralinepag2Recruiting1
DB09112Sodium Nitrite2Recruiting1
DB09112Sodium Nitrite2Terminated1
DB06273Tocilizumab2Recruiting1
DB00374Treprostinil2Not Yet Recruiting1
DB09069Trimetazidine2Recruiting1
DB03424Ubenimex2Active Not Recruiting2
DB06267Udenafil2Completed1
DB00559Bosentan2 / 3Completed1
DB00619Imatinib2 / 3Completed1
DB00203Sildenafil2 / 3Unknown Status1
DB06267Udenafil2 / 3Completed1
DB06403Ambrisentan3Completed4
DB00559Bosentan3Completed4
DB00559Bosentan3Unknown Status1
DB01240Epoprostenol3Completed2
DB01088Iloprost3Completed2
DB01088Iloprost3Terminated1
DB01088Iloprost3Unknown Status1
DB00619Imatinib3Completed1
DB00619Imatinib3Terminated3
DB04335Inosine3Active Not Recruiting1
DB04335Inosine3Recruiting1
DB00125L-Arginine3Completed1
DB08932Macitentan3Active Not Recruiting4
DB08932Macitentan3Completed2
DB08932Macitentan3Recruiting2
DB08932Macitentan3Terminated2
DB00243Ranolazine3Completed1
DB11362Selexipag3Active Not Recruiting1
DB11362Selexipag3Completed2
DB11362Selexipag3Not Yet Recruiting1
DB11362Selexipag3Recruiting1
DB00203Sildenafil3Completed1
DB00203Sildenafil3Recruiting1
DB00203Sildenafil3Terminated3
DB06268Sitaxentan3Terminated4
DB00820Tadalafil3Recruiting1
DB00374Treprostinil3Not Yet Recruiting1
DB00374Treprostinil3Unknown Status1
DB06403Ambrisentan4Completed2
DB06403Ambrisentan4Recruiting2
DB06403Ambrisentan4Unknown Status1
DB00559Bosentan4Active Not Recruiting1
DB00559Bosentan4Completed4
DB00559Bosentan4Unknown Status1
DB00668Epinephrine4Terminated1
DB01240Epoprostenol4Completed2
DB01088Iloprost4Completed2
DB01088Iloprost4Recruiting1
DB00281Lidocaine4Terminated1
DB08932Macitentan4Active Not Recruiting1
DB08932Macitentan4Recruiting2
DB08931Riociguat4Recruiting1
DB11362Selexipag4Not Yet Recruiting1
DB00203Sildenafil4Active Not Recruiting1
DB00203Sildenafil4Completed4
DB00203Sildenafil4No Longer Available1
DB00203Sildenafil4Not Yet Recruiting1
DB00203Sildenafil4Recruiting2
DB00203Sildenafil4Temporarily Not Available1
DB00203Sildenafil4Terminated1
DB00203Sildenafil4Unknown Status2
DB00820Tadalafil4Active Not Recruiting1
DB00820Tadalafil4Completed1
DB00820Tadalafil4Recruiting2
DB00820Tadalafil4Terminated1
DB00820Tadalafil4Unknown Status2
DB00374Treprostinil4Completed5
DB00374Treprostinil4Terminated2
DB00374Treprostinil4Withdrawn2
DB00862Vardenafil4Unknown Status2
DB01418AcenocoumarolNot AvailableNot Yet Recruiting1
DB06403AmbrisentanNot AvailableCompleted1
DB06403AmbrisentanNot AvailableUnknown Status1
DB00559BosentanNot AvailableCompleted2
DB00559BosentanNot AvailableUnknown Status1
DB00343DiltiazemNot AvailableUnknown Status1
DB01240EpoprostenolNot AvailableCompleted1
DB13136FluindioneNot AvailableNot Yet Recruiting1
DB01088IloprostNot AvailableCompleted2
DB01088IloprostNot AvailableTerminated2
DB08932MacitentanNot AvailableRecruiting1
DB00203SildenafilNot AvailableAvailable1
DB00203SildenafilNot AvailableCompleted3
DB06268SitaxentanNot AvailableCompleted1
DB06268SitaxentanNot AvailableTerminated1
DB06268SitaxentanNot AvailableUnknown Status1
DB00820TadalafilNot AvailableCompleted2
DB00374TreprostinilNot AvailableCompleted2
DB00374TreprostinilNot AvailableRecruiting1
DB00682WarfarinNot AvailableNot Yet Recruiting1