Fevers

Also known as: Fever / Hyperthermia / Body temperature increased / Fever NOS / Feverish / High temperature / Pyrexial / Pyrexia NOS / Temperature elevation / Pyrexia

DrugDrug NameDrug Description
DB00316AcetaminophenAcetaminophen (paracetamol), also commonly known as _Tylenol_, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO) [A176318]. It is also used for its antipyretic effects, helping to reduce fever [F4124]. This drug was initially approved by the U.S. FDA in 1951 [FDA label] and is available in a variety of forms including syrup form, regular tablets, effervescent tablets, injection, suppository, and other forms [L5756, L5774, F4124], [FDA label]. Acetaminophen is often found combined with other drugs in more than 600 over the counter (OTC) allergy medications, cold medications, sleep medications, pain relievers, and other products [L5783]. Confusion about dosing of this drug may be caused by the availability of different formulas, strengths, and dosage instructions for children of different ages [L5783]. Due to the possibility of fatal overdose and liver failure associated with the incorrect use of acetaminophen, it is important to follow current and available national and manufacturer dosing guidelines while this drug is taken or prescribed [L5786, L5789], [FDA label].
DB00945Acetylsalicylic acidAlso known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial infarction (MI) [FDA label]. Interestingly, the results of various studies have demonstrated that long-term use of acetylsalicylic acid may decrease the risk of various cancers, including colorectal, esophageal, breast, lung, prostate, liver and skin cancer [A177325]. Aspirin is classified as a _non-selective cyclooxygenase (COX) inhibitor_ [A32682, A177268] and is available in many doses and forms, including chewable tablets, suppositories, extended release formulations, and others [L5968]. Acetylsalicylic acid is a very common cause of accidental poisoning in young children. It should be kept out of reach from young children, toddlers, and infants [FDA label].
DB14006Choline salicylateCholine salicylate is an anti-inflammatory pain reliever agent that is related to aspirin. It is used to decrease swelling and to treat mild-moderate pain. It is used to treat arthritis in both children and adults. This medicine can also be used for fever [L2129]. Choline Salicylate is the choline salt of salicylic acid, used as an analgesic, antipyretic and antirheumatic. It relieves mild to moderate pain and reduce fever and inflammation or swelling. Choline salicylate is effective in the treatment of gout, rheumatic fever, rheumatoid arthritis and muscle injuries [L2136]. This drug is also a main ingredient in teething gels to relieve pains associated with tooth growth in the infant population [L2134]. The UK government has regulated its use, due to toxicity in those under 16 years of age. Topical oral salicylate gels are no longer indicated for people younger than 16 years for pain associated with infant teething, orthodontic devices, cold sores, or mouth ulcers [L2134].
DB11278DL-MethylephedrineMethylephedrine is a sympathomimetic amine that appears in various over-the-counter cough and cold medications throughout the world [L2838], [L2839], [L2840]. The abuse of methylephedrine-containing medications has been reported in Japan. Methylephedrine is not legally available in the United States, but has been identified in cases of drug abuse [L2836].
DB01050IbuprofenIbuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics.[A39074] The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin.[A39075] Ibuprofen was finally patented in 1961 and this drug was first launched against rheumatoid arthritis in the UK in 1969 and USA in 1974. It was the first available over-the-counter NSAID.[A39076] On the available products, ibuprofen is administered as a racemic mixture. Once administered, the R-enantiomer undergoes extensive interconversion to the S-enantiomer _in vivo_ by the activity of the alpha-methylacyl-CoA racemase. In particular, it is generally proposed that the S-enantiomer is capable of eliciting stronger pharmacological activity than the R-enantiomer.[A39194]
DB00939Meclofenamic acidA non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis.
DB00788NaproxenNaproxen is classified as a nonsteroidal anti-inflammatory dug (NSAID) and was initially approved for prescription use in 1976 and then for over-the-counter (OTC) use in 1994.[A178975]
DrugDrug NameTargetType
DB00316AcetaminophenProstaglandin G/H synthase 1target
DB00316AcetaminophenProstaglandin G/H synthase 2target
DB00316AcetaminophenCytochrome P450 1A2enzyme
DB00316AcetaminophenCytochrome P450 2E1enzyme
DB00316AcetaminophenMultidrug resistance protein 1transporter
DB00316AcetaminophenCytochrome P450 2D6enzyme
DB00316AcetaminophenCytochrome P450 2A6enzyme
DB00316AcetaminophenCytochrome P450 3A4enzyme
DB00316AcetaminophenUDP-glucuronosyltransferase 1-1enzyme
DB00316AcetaminophenUDP-glucuronosyltransferase 1-6enzyme
DB00316AcetaminophenUDP-glucuronosyltransferase 1-9enzyme
DB00316AcetaminophenUDP-glucuronosyltransferase 2B15enzyme
DB00316AcetaminophenSulfotransferase 1A1enzyme
DB00316AcetaminophenSulfotransferase 1A3/1A4enzyme
DB00316AcetaminophenArylamine N-acetyltransferase 2enzyme
DB00316AcetaminophenProstaglandin G/H synthase 3target
DB00316AcetaminophenFatty-acid amide hydrolase 1target
DB00316AcetaminophenTransient receptor potential cation channel subfamily V member 1target
DB00316AcetaminophenGlutathione S-transferase Ptarget
DB00945Acetylsalicylic acidProstaglandin G/H synthase 1target
DB00945Acetylsalicylic acidProstaglandin G/H synthase 2target
DB00945Acetylsalicylic acidAldo-keto reductase family 1 member C1target
DB00945Acetylsalicylic acidSolute carrier family 22 member 6transporter
DB00945Acetylsalicylic acidMultidrug resistance protein 1transporter
DB00945Acetylsalicylic acidCytochrome P450 2C19enzyme
DB00945Acetylsalicylic acidCytochrome P450 2C9enzyme
DB00945Acetylsalicylic acid5'-AMP-activated protein kinasetarget
DB00945Acetylsalicylic acidEndothelin-1 receptortarget
DB00945Acetylsalicylic acidNuclear factor kappa b beta subunittarget
DB00945Acetylsalicylic acidCellular tumor antigen p53target
DB00945Acetylsalicylic acid78 kDa glucose-regulated proteintarget
DB00945Acetylsalicylic acidRibosomal protein S6 kinase alpha-3target
DB00945Acetylsalicylic acidNF-kappa-B inhibitor alphatarget
DB00945Acetylsalicylic acidTumor necrosis factor-inducible gene 6 proteintarget
DB00945Acetylsalicylic acidCaspase-1target
DB00945Acetylsalicylic acidCaspase-3target
DB00945Acetylsalicylic acidInhibitor of nuclear factor kappa-B kinase subunit betatarget
DB00945Acetylsalicylic acidExtracellular signal-regulated kinase (ERK)target
DB00945Acetylsalicylic acidG1/S-specific cyclin-D1target
DB00945Acetylsalicylic acidMyc proto-oncogene proteintarget
DB00945Acetylsalicylic acidProliferating cell nuclear antigentarget
DB00945Acetylsalicylic acidCyclin Atarget
DB00945Acetylsalicylic acidUDP-glucuronosyltransferase 1-6enzyme
DB00945Acetylsalicylic acidArylamine N-acetyltransferase 2enzyme
DB00945Acetylsalicylic acidSolute carrier family 22 member 8transporter
DB14006Choline salicylateCholine-phosphate cytidylyltransferase Btarget
DB14006Choline salicylateAcetylcholinesterasetarget
DB14006Choline salicylateCholine-phosphate cytidylyltransferase Atarget
DB14006Choline salicylatePhospholipase D2target
DB14006Choline salicylateCholinesterasetarget
DB14006Choline salicylatePhospholipase D1target
DB14006Choline salicylatePhosphoethanolamine/phosphocholine phosphatasetarget
DB14006Choline salicylateSolute carrier family 22 member 2transporter
DB14006Choline salicylateSolute carrier family 22 member 1transporter
DB14006Choline salicylateSolute carrier family 22 member 3transporter
DB14006Choline salicylateSolute carrier family 22 member 5transporter
DB14006Choline salicylateSolute carrier family 22 member 4transporter
DB14006Choline salicylateCholine/ethanolaminephosphotransferase 1enzyme
DB14006Choline salicylateCholine transporter-like protein 1transporter
DB14006Choline salicylateCholine transporter-like protein 4transporter
DB14006Choline salicylateCholine transporter-like protein 2transporter
DB14006Choline salicylateCholine transporter-like protein 3transporter
DB14006Choline salicylateCholine/ethanolamine kinaseenzyme
DB14006Choline salicylateCholine O-acetyltransferaseenzyme
DB14006Choline salicylateCholine kinase alphaenzyme
DB14006Choline salicylateCholine dehydrogenase, mitochondrialenzyme
DB14006Choline salicylateHigh affinity choline transporter 1transporter
DB14006Choline salicylateNeuronal acetylcholine receptor subunit alpha-7target
DB11278DL-MethylephedrineBeta-1 adrenergic receptortarget
DB11278DL-MethylephedrineAlpha-2A adrenergic receptortarget
DB11278DL-MethylephedrineAlpha adrenergic receptortarget
DB11278DL-MethylephedrineBeta adrenergic receptortarget
DB01050IbuprofenProstaglandin G/H synthase 1target
DB01050IbuprofenProstaglandin G/H synthase 2target
DB01050IbuprofenCytochrome P450 2C9enzyme
DB01050IbuprofenSerum albumincarrier
DB01050IbuprofenMultidrug resistance-associated protein 4transporter
DB01050IbuprofenMultidrug resistance-associated protein 1transporter
DB01050IbuprofenSolute carrier organic anion transporter family member 1A2transporter
DB01050IbuprofenSolute carrier family 22 member 6transporter
DB01050IbuprofenSolute carrier family 22 member 8transporter
DB01050IbuprofenSolute carrier family 22 member 11transporter
DB01050IbuprofenSolute carrier organic anion transporter family member 2B1transporter
DB01050IbuprofenMultidrug resistance protein 1transporter
DB01050IbuprofenUDP-glucuronosyltransferase 1-3enzyme
DB01050IbuprofenUDP-glucuronosyltransferase 1-9enzyme
DB01050IbuprofenUDP-glucuronosyltransferase 2B4enzyme
DB01050IbuprofenUDP-glucuronosyltransferase 2B7enzyme
DB01050IbuprofenCytochrome P450 2C8enzyme
DB01050IbuprofenCytochrome P450 2C19enzyme
DB01050IbuprofenApoptosis regulator Bcl-2target
DB01050IbuprofenThrombomodulintarget
DB01050IbuprofenFatty acid-binding protein, intestinaltarget
DB01050IbuprofenPeroxisome proliferator-activated receptor gammatarget
DB01050IbuprofenCystic fibrosis transmembrane conductance regulatortarget
DB01050IbuprofenPeroxisome proliferator-activated receptor alphatarget
DB01050IbuprofenPlatelet glycoprotein Ib alpha chaintarget
DB01050IbuprofenProtein S100-A7target
DB01050IbuprofenAlpha-methylacyl-CoA racemaseenzyme
DB00939Meclofenamic acidProstaglandin G/H synthase 1target
DB00939Meclofenamic acidProstaglandin G/H synthase 2target
DB00939Meclofenamic acidArachidonate 5-lipoxygenasetarget
DB00939Meclofenamic acidSolute carrier family 22 member 6transporter
DB00939Meclofenamic acidSolute carrier organic anion transporter family member 1C1transporter
DB00939Meclofenamic acidPotassium voltage-gated channel subfamily KQT member 2target
DB00939Meclofenamic acidPotassium voltage-gated channel subfamily KQT member 3target
DB00939Meclofenamic acidThyroxine-binding globulincarrier
DB00788NaproxenProstaglandin G/H synthase 1target
DB00788NaproxenProstaglandin G/H synthase 2target
DB00788NaproxenSerum albumincarrier
DB00788NaproxenCytochrome P450 2C9enzyme
DB00788NaproxenCytochrome P450 1A2enzyme
DB00788NaproxenSolute carrier organic anion transporter family member 1A2transporter
DB00788NaproxenSolute carrier family 22 member 6transporter
DB00788NaproxenCytochrome P450 2C8enzyme
DB00788NaproxenUDP-glucuronosyltransferase 1-1enzyme
DB00788NaproxenUDP-glucuronosyltransferase 2B7enzyme
DB00788NaproxenPeptostreptococcal albumin-binding proteintarget
DB00788NaproxenBile salt export pumptransporter
DB00788NaproxenMultidrug resistance protein 1transporter
DrugDrug NamePhaseStatusCount
DB00959Methylprednisolone0Terminated1
DB00316Acetaminophen1Completed2
DB00331Metformin1Active Not Recruiting1
DB00503Ritonavir1Active Not Recruiting1
DB00316Acetaminophen1 / 2Recruiting1
DB01200Bromocriptine1 / 2Recruiting1
DB11121Chloroxylenol1 / 2Recruiting1
DB12121Entospletinib1 / 2Recruiting1
DB08935Obinutuzumab1 / 2Recruiting1
DB00316Acetaminophen2Not Yet Recruiting1
DB00316Acetaminophen2Recruiting2
DB00681Amphotericin B2Completed1
DB00520Caspofungin2Completed1
DB00531Cyclophosphamide2Completed1
DB00080Daptomycin2Completed1
DB01248Docetaxel2Completed1
DB00997Doxorubicin2Completed1
DB00480Lenalidomide2Active Not Recruiting1
DB00480Lenalidomide2Completed1
DB08935Obinutuzumab2Active Not Recruiting1
DB06650Ofatumumab2Completed1
DB00019Pegfilgrastim2Completed1
DB10276Rotavirus Vaccine2Completed1
DB00316Acetaminophen2 / 3Completed1
DB10276Rotavirus Vaccine2 / 3Completed1
DB00316Acetaminophen3Completed8
DB00316Acetaminophen3Suspended1
DB01370Aluminium3Completed1
DB01060Amoxicillin3Terminated1
DB00207Azithromycin3Completed1
DB00112Bevacizumab3Completed1
DB14733Ceftobiprole medocaril3Terminated1
DB00537Ciprofloxacin3Terminated1
DB09213Dexibuprofen3Completed1
DB01050Ibuprofen3Completed5
DB09212Loxoprofen3Completed1
DB04817Metamizole3Suspended1
DB00019Pegfilgrastim3Completed1
DB12150Pelubiprofen3Completed1
DB06614Peramivir3Terminated1
DB10276Rotavirus Vaccine3Completed1
DB10303Rotavirus Vaccine3Completed1
DB00316Acetaminophen4Completed6
DB00316Acetaminophen4Recruiting1
DB00316Acetaminophen4Terminated2
DB00316Acetaminophen4Unknown Status2
DB00945Acetylsalicylic acid4Completed1
DB01060Amoxicillin4Completed2
DB00438Ceftazidime4Not Yet Recruiting1
DB11121Chloroxylenol4Completed1
DB00537Ciprofloxacin4Completed1
DB00766Clavulanic acid4Completed1
DB00586Diclofenac4Terminated1
DB00254Doxycycline4Completed1
DB01050Ibuprofen4Completed4
DB01050Ibuprofen4Recruiting2
DB01050Ibuprofen4Unknown Status3
DB01167Itraconazole4Completed1
DB01137Levofloxacin4Completed1
DB00760Meropenem4Not Yet Recruiting1
DB04817Metamizole4Completed1
DB01165Ofloxacin4Completed1
DB00319Piperacillin4Not Yet Recruiting1
DB09153Sodium chloride4Completed1
DB01606Tazobactam4Not Yet Recruiting1
DB00512Vancomycin4Not Yet Recruiting1
DB09145Water4Completed1
DB09145Water4Enrolling by Invitation1
DB00316AcetaminophenNot AvailableCompleted1
DB00316AcetaminophenNot AvailableTerminated1
DB00316AcetaminophenNot AvailableUnknown Status1
DB00316AcetaminophenNot AvailableWithdrawn1
DB00479AmikacinNot AvailableCompleted1
DB00608ChloroquineNot AvailableTerminated1
DB01147CloxacillinNot AvailableCompleted1
DB00586DiclofenacNot AvailableCompleted1
DB00986GlycopyrroniumNot AvailableCompleted1
DB00741HydrocortisoneNot AvailableCompleted1
DB01050IbuprofenNot AvailableUnknown Status2