Multiple Myeloma (MM)

Also known as: MULTIPLE MYELOMA (MM) / Multiple myeloma / Myeloma, Multiple / Multiple Myelomas / Multiple Myeloma(MM) / Plasma cell myelomas / Myelomatosis multiple / Peripheral plasma cell myeloma / Myelomatosis / Multiple myeloma myelomatosis / Plasma cell myeloma / Myeloma / Multiple myeloma with failed remission

DrugDrug NameDrug Description
DB00188BortezomibBortezomib (originally PS-341 and marketed as Velcade by Millennium Pharmaceuticals) is the first therapeutic proteasome inhibitor to be tested in humans. The boron atom within bortezomib catalytically binds the active site of the 26S proteasome with high affinity and specificity, thereby resulting in cell cycle arrest and apoptosis. In normal cells, the proteasome is involved in degradation of ubiquitylated proteins that have been tagged for destruction because they are damaged or unneeded by the cell. However, in cancerous cells, proteasome activity degrades pro-apoptotic proteins such as p53 that would normally result in programmed cell death of the dysfunctional cells. Proteasome inhibitors such as bortezomib interrupt this process, resulting in destruction of cancerous cells. Bortezomib is approved in the U.S. for treating relapsed multiple myeloma and mantle cell lymphoma. In multiple myeloma, complete clinical responses have been obtained in patients with otherwise refractory or rapidly advancing disease.
DB00515CisplatinCisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also includes carboplatin and oxaliplatin.
DB00531CyclophosphamidePrecursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer. [PubChem]
DB09331DaratumumabDaratumumab is an anti-cancer drug indicated for multiple myeloma in patients who have received at least 3 prior treatments. It was granted accelerated approval by the FDA in November 2016. Marketed under the brand name Darzalex by Janssen Biotech, daratumumab is the first monoclonal antibody injection approved for this indication and provides another options for patients with multiple myeloma resistant to other therapies. Daratumumab induces apoptosis of cancer cells by targeting the CD38 epitope, which is highly expressed on haematological malignancies.
DB00997DoxorubicinDoxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius. Doxorubicin binds to nucleic acids, presumably by specific intercalation of the planar anthracycline nucleus with the DNA double helix.
DB00773EtoposideA semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle. [PubChem]
DB09570IxazomibIxazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy. It was found to have similar efficacy to bortezomib (the first PI approved for multiple myeloma therapy) in the control of myeloma growth and prevention of bone loss. Ixazomib citrate is marketed by Takeda Pharmaceuticals under the brand name Ninlaro, which is a prodrug that becomes quickly converted to its active metabolite, ixazomib, after administration.
DB00480LenalidomideLenalidomide (initially known as CC-5013 and marketed as Revlimid® by Celgene) is a derivative of thalidomide introduced in 2004. It was initially intended as a treatment for multiple myeloma, for which thalidomide is an accepted therapeutic modality, but has also shown efficacy in the hematological disorders known as the myelodysplastic syndromes. [Wikipedia] FDA approved on December 27, 2005.
DB01042MelphalanAn alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - melphalan, the racemic mixture - merphalan, and the dextro isomer - medphalan; toxic to bone marrow, but little vesicant action; potential carcinogen. [PubChem]
DB00282PamidronatePamidronic acid (INN) or pamidronate disodium (USAN), marketed as pamidronate disodium pentahydrate under the brand name Aredia, is a bisphosphonate. [Wikipedia]
DB01041ThalidomideA piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppresive and anti-angiogenic activity. It inhibits release of tumor necrosis factor-alpha from monocytes, and modulates other cytokine action. [PubChem]
DB00541VincristineVincristine is an antitumor vinca alkaloid isolated from Vinca Rosea. It is marketed under several brand names, many of which have different formulations such as Marqibo (liposomal injection) and Vincasar. Vincristine is indicated for the treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, and acute panmyelosis. vincristine sulfate is often chosen as part of polychemotherapy because of lack of significant bone–marrow suppression (at recommended doses) and of unique clinical toxicity (neuropathy).
DB00399Zoledronic acidZoledronate (zoledronic acid, marketed by Novartis under the trade names Zometa and Reclast) is a bisphosphonate. Zometa is used to prevent skeletal fractures in patients with cancers such as multiple myeloma and prostate cancer. It can also be used to treat hypercalcemia of malignancy and can be helpful for treating pain from bone metastases. An annual dose of Zoledronate may also prevent recurring fractures in patients with a previous hip fracture. Zoledronate is a single 5 mg infusion for the treatment of Paget's disease of bone. In 2007, the FDA also approved Reclast for the treatment of postmenopausal osteoporosis.
DrugDrug NameTargetType
DB00188BortezomibCytochrome P450 3A4enzyme
DB00188BortezomibCytochrome P450 2C19enzyme
DB00188BortezomibCytochrome P450 1A2enzyme
DB00188BortezomibCytochrome P450 2D6enzyme
DB00188BortezomibCytochrome P450 2C9enzyme
DB00188BortezomibProteasome subunit beta type-5target
DB00188BortezomibProteasome subunit beta type-1target
DB00515CisplatinDNAtarget
DB00515CisplatinCanalicular multispecific organic anion transporter 2transporter
DB00515CisplatinMultidrug resistance-associated protein 5transporter
DB00515CisplatinCanalicular multispecific organic anion transporter 1transporter
DB00515CisplatinSolute carrier family 22 member 2transporter
DB00515CisplatinHigh affinity copper uptake protein 1transporter
DB00515CisplatinProbable low affinity copper uptake protein 2transporter
DB00515CisplatinMultidrug resistance-associated protein 6transporter
DB00515CisplatinMultidrug resistance protein 1transporter
DB00515CisplatinCopper-transporting ATPase 2transporter
DB00515CisplatinCopper-transporting ATPase 1transporter
DB00515CisplatinProstaglandin G/H synthase 2enzyme
DB00515CisplatinMyeloperoxidaseenzyme
DB00515CisplatinXanthine dehydrogenase/oxidaseenzyme
DB00515CisplatinArylamine N-acetyltransferaseenzyme
DB00515CisplatinCytochrome P450 2C9enzyme
DB00515CisplatinCytochrome P450 2B6enzyme
DB00515CisplatinCholinesteraseenzyme
DB00515CisplatinCytochrome P450 4A11enzyme
DB00515CisplatinATP-binding cassette sub-family G member 2transporter
DB00515CisplatinGlutathione S-transferase theta-1enzyme
DB00515CisplatinMetallothionein-1Aenzyme
DB00515CisplatinMetallothionein-2enzyme
DB00515CisplatinSuperoxide dismutase [Cu-Zn]enzyme
DB00515CisplatinGlutathione S-transferase Penzyme
DB00515CisplatinNAD(P)H dehydrogenase [quinone] 1enzyme
DB00515CisplatinGlutathione S-transferase Mu 1enzyme
DB00515CisplatinDNA-3-methyladenine glycosylasetarget
DB00515CisplatinAlpha-2-macroglobulintarget
DB00515CisplatinSerum albumincarrier
DB00515CisplatinSerotransferrintarget
DB00515CisplatinCopper transport protein ATOX1target
DB00531CyclophosphamideDNAtarget
DB00531CyclophosphamideCytochrome P450 2B6enzyme
DB00531CyclophosphamideCytochrome P450 2C9enzyme
DB00531CyclophosphamideCytochrome P450 3A4enzyme
DB00531CyclophosphamideCytochrome P450 2C19enzyme
DB00531CyclophosphamideCytochrome P450 2A6enzyme
DB00531CyclophosphamideCytochrome P450 2C18enzyme
DB00531CyclophosphamideCytochrome P450 2C8enzyme
DB00531CyclophosphamideCytochrome P450 2D6enzyme
DB00531CyclophosphamideCytochrome P450 3A7enzyme
DB00531CyclophosphamideCytochrome P450 3A5enzyme
DB00531CyclophosphamideNuclear receptor subfamily 1 group I member 2target
DB09331DaratumumabADP-ribosyl cyclase 1target
DB00997DoxorubicinDNA topoisomerase 2-alphatarget
DB00997DoxorubicinDNAtarget
DB00997DoxorubicinCytochrome P450 3A4enzyme
DB00997DoxorubicinCytochrome P450 2D6enzyme
DB00997DoxorubicinCytochrome P450 2B6enzyme
DB00997DoxorubicinMultidrug resistance protein 1transporter
DB00997DoxorubicinCanalicular multispecific organic anion transporter 2transporter
DB00997DoxorubicinMultidrug resistance-associated protein 6transporter
DB00997DoxorubicinMultidrug resistance-associated protein 1transporter
DB00997DoxorubicinMultidrug resistance-associated protein 7transporter
DB00997DoxorubicinATP-binding cassette sub-family G member 2transporter
DB00997DoxorubicinBile salt export pumptransporter
DB00997DoxorubicinSolute carrier family 22 member 16transporter
DB00997DoxorubicinATP-binding cassette sub-family B member 8, mitochondrialtransporter
DB00997DoxorubicinCytochrome P450 1B1enzyme
DB00997DoxorubicinCarbonyl reductase [NADPH] 1enzyme
DB00997DoxorubicinCarbonyl reductase [NADPH] 3enzyme
DB00997DoxorubicinAlcohol dehydrogenase [NADP(+)]enzyme
DB00997DoxorubicinAldo-keto reductase family 1 member C3enzyme
DB00997DoxorubicinNAD(P)H dehydrogenase [quinone] 1enzyme
DB00997DoxorubicinXanthine dehydrogenase/oxidaseenzyme
DB00997DoxorubicinNitric oxide synthase, endothelialenzyme
DB00997DoxorubicinNitric oxide synthase, inducibleenzyme
DB00997DoxorubicinNitric oxide synthase, brainenzyme
DB00997DoxorubicinNADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrialenzyme
DB00997DoxorubicinNADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrialenzyme
DB00997DoxorubicinNADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrialenzyme
DB00997DoxorubicinNADPH--cytochrome P450 reductaseenzyme
DB00997DoxorubicinRalA-binding protein 1transporter
DB00997DoxorubicinCanalicular multispecific organic anion transporter 1transporter
DB00997DoxorubicinSerum albumincarrier
DB00997DoxorubicinNucleolar and coiled-body phosphoprotein 1target
DB00773EtoposideDNA topoisomerase 2-alphatarget
DB00773EtoposideCytochrome P450 3A4enzyme
DB00773EtoposideCanalicular multispecific organic anion transporter 2transporter
DB00773EtoposideMultidrug resistance-associated protein 6transporter
DB00773EtoposideMultidrug resistance protein 1transporter
DB00773EtoposideMultidrug resistance-associated protein 1transporter
DB00773EtoposideMultidrug resistance-associated protein 7transporter
DB00773EtoposideCanalicular multispecific organic anion transporter 1transporter
DB00773EtoposideATP-binding cassette sub-family G member 2transporter
DB00773EtoposideCytochrome P450 1A2enzyme
DB00773EtoposideCytochrome P450 2C8enzyme
DB00773EtoposideCytochrome P450 2E1enzyme
DB00773EtoposideCytochrome P450 3A5enzyme
DB00773EtoposideUDP-glucuronosyltransferase 1-1enzyme
DB00773EtoposideDNA topoisomerase 2-betatarget
DB00773EtoposideGlutathione S-transferase theta-1enzyme
DB00773EtoposideGlutathione S-transferase Penzyme
DB00773EtoposideProstaglandin G/H synthase 2enzyme
DB00773EtoposideProstaglandin G/H synthase 1enzyme
DB09570IxazomibCytochrome P450 3A4enzyme
DB09570IxazomibCytochrome P450 1A2enzyme
DB09570IxazomibCytochrome P450 2B6enzyme
DB09570IxazomibCytochrome P450 2C8enzyme
DB09570IxazomibCytochrome P450 2D6enzyme
DB09570IxazomibCytochrome P450 2C19enzyme
DB09570IxazomibCytochrome P450 2C9enzyme
DB00480LenalidomideProstaglandin G/H synthase 2target
DB00480LenalidomideTumor necrosis factor ligand superfamily member 11target
DB00480LenalidomideCadherin-5target
DB00480LenalidomideProtein cereblontarget
DB00480LenalidomideMultidrug resistance protein 1transporter
DB01042MelphalanDNAtarget
DB01042MelphalanSolute carrier family 22 member 3transporter
DB01042MelphalanLarge neutral amino acids transporter small subunit 1transporter
DB00282PamidronateFarnesyl pyrophosphate synthasetarget
DB00282PamidronateHydroxylapatitetarget
DB01041ThalidomideTumor necrosis factortarget
DB01041ThalidomideNuclear factor NF-kappa-B p105 subunittarget
DB01041ThalidomideProstaglandin G/H synthase 2target
DB01041ThalidomideCytochrome P450 2C19enzyme
DB01041ThalidomideCytochrome P450 1A2enzyme
DB01041ThalidomideCytochrome P450 1A1enzyme
DB01041ThalidomideCytochrome P450 2E1enzyme
DB01041ThalidomideCytochrome P450 2C9enzyme
DB01041ThalidomideProstaglandin G/H synthase 1enzyme
DB01041ThalidomideProstaglandin G/H synthase 2enzyme
DB01041ThalidomideCytochrome P450 3A5enzyme
DB01041ThalidomideFibroblast growth factor receptor 2target
DB01041ThalidomideDNAtarget
DB01041ThalidomideProtein cereblontarget
DB01041ThalidomideNuclear factor kappa-light-chain-enhancer of activated B cellstarget
DB01041Thalidomidealpha1-acid glycoproteintarget
DB00541VincristineTubulin beta chaintarget
DB00541VincristineCytochrome P450 3A4enzyme
DB00541VincristineCytochrome P450 3A5enzyme
DB00541VincristineCytochrome P450 3A7enzyme
DB00541VincristineMultidrug resistance protein 1transporter
DB00541VincristineCanalicular multispecific organic anion transporter 2transporter
DB00541VincristineSolute carrier family 22 member 3transporter
DB00541VincristineMultidrug resistance-associated protein 1transporter
DB00541VincristineMultidrug resistance-associated protein 7transporter
DB00541VincristineCanalicular multispecific organic anion transporter 1transporter
DB00541VincristineBile salt export pumptransporter
DB00541VincristineATP-binding cassette sub-family G member 2transporter
DB00541VincristineTubulin alpha-4A chaintarget
DB00541VincristineRalA-binding protein 1transporter
DB00541VincristineSolute carrier organic anion transporter family member 1B1transporter
DB00541VincristineSolute carrier organic anion transporter family member 1B3transporter
DB00399Zoledronic acidFarnesyl pyrophosphate synthasetarget
DB00399Zoledronic acidGeranylgeranyl pyrophosphate synthasetarget
DB00399Zoledronic acidHydroxylapatitetarget
DB00399Zoledronic acidMultidrug resistance-associated protein 1transporter
DrugDrug NamePhaseStatusCount
DB09052Blinatumomab0Recruiting1
DB00188Bortezomib0Active Not Recruiting1
DB00188Bortezomib0Terminated1
DB08889Carfilzomib0Terminated1
DB00493Cefotaxime0Withdrawn1
DB00531Cyclophosphamide0Terminated1
DB00531Cyclophosphamide0Withdrawn1
DB01234Dexamethasone0Active Not Recruiting1
DB01234Dexamethasone0Terminated1
DB06210Eltrombopag0Active Not Recruiting1
DB00099Filgrastim0Terminated1
DB00099Filgrastim0Withdrawn1
DB01073Fludarabine0Withdrawn1
DB09134Ioversol0Completed1
DB00480Lenalidomide0Terminated1
DB01042Melphalan0Active Not Recruiting1
DB01042Melphalan0Withdrawn1
DB00688Mycophenolate mofetil0Withdrawn1
DB01024Mycophenolic acid0Withdrawn1
DB08910Pomalidomide0Terminated1
DB10293Streptococcus pneumoniae type 1 capsular polysaccharide diphtheria crm197 protein conjugate antigen0Recruiting1
DB00864Tacrolimus0Withdrawn1
DB01041Thalidomide0Terminated1
DB06273Tocilizumab0Withdrawn1
DB04974AP19031Not Yet Recruiting1
DB12565Abexinostat1Completed2
DB11703Acalabrutinib1Active Not Recruiting1
DB00316Acetaminophen1Active Not Recruiting1
DB11648Afuresertib1Completed1
DB05220Alisertib1Completed1
DB00437Allopurinol1Completed1
DB09312Antilymphocyte immunoglobulin (horse)1Recruiting1
DB00098Antithymocyte immunoglobulin (rabbit)1Recruiting2
DB00673Aprepitant1Completed1
DB00928Azacitidine1Active Not Recruiting1
DB00928Azacitidine1Completed2
DB00928Azacitidine1Terminated1
DB06769Bendamustine1Active Not Recruiting2
DB06769Bendamustine1Recruiting1
DB06769Bendamustine1Withdrawn1
DB00307Bexarotene1Terminated1
DB00188Bortezomib1Active Not Recruiting3
DB00188Bortezomib1Completed21
DB00188Bortezomib1Recruiting1
DB00188Bortezomib1Terminated4
DB00188Bortezomib1Unknown Status1
DB00188Bortezomib1Withdrawn2
DB01008Busulfan1Active Not Recruiting1
DB01008Busulfan1Recruiting4
DB11891CUDC-9071Active Not Recruiting1
DB08875Cabozantinib1Completed1
DB09061Cannabidiol1Completed1
DB08889Carfilzomib1Active Not Recruiting4
DB08889Carfilzomib1Completed4
DB08889Carfilzomib1Recruiting1
DB00262Carmustine1Completed1
DB01413Cefepime1Completed1
DB04815Clioquinol1Terminated1
DB09110Coenzyme M1Recruiting1
DB00531Cyclophosphamide1Completed6
DB00531Cyclophosphamide1Recruiting6
DB00091Cyclosporine1Completed2
DB08912Dabrafenib1Recruiting1
DB05539Dacetuzumab1Completed3
DB12589Dacetuzumab1Completed2
DB09331Daratumumab1Active Not Recruiting4
DB09331Daratumumab1Completed2
DB09331Daratumumab1Recruiting4
DB06179Darinaparsin1Completed1
DB01254Dasatinib1Completed1
DB01254Dasatinib1Terminated1
DB00004Denileukin diftitox1Terminated1
DB01234Dexamethasone1Active Not Recruiting15
DB01234Dexamethasone1Completed20
DB01234Dexamethasone1Recruiting7
DB01234Dexamethasone1Terminated6
DB01234Dexamethasone1Withdrawn2
DB12021Dinaciclib1Completed2
DB12021Dinaciclib1Recruiting1
DB01075Diphenhydramine1Active Not Recruiting1
DB05928Dovitinib1Withdrawn1
DB11714Durvalumab1Active Not Recruiting2
DB11894Efatutazone1Terminated1
DB06317Elotuzumab1Completed5
DB06317Elotuzumab1Terminated2
DB00530Erlotinib1Completed1
DB00773Etoposide1Active Not Recruiting1
DB00773Etoposide1Completed1
DB01590Everolimus1Active Not Recruiting1
DB01590Everolimus1Completed1
DB11685Figitumumab1Completed1
DB00099Filgrastim1Completed1
DB00099Filgrastim1Recruiting1
DB01073Fludarabine1Active Not Recruiting1
DB01073Fludarabine1Completed3
DB01073Fludarabine1Recruiting8
DB00623Fluphenazine1Unknown Status1
DB06717Fosaprepitant1Completed1
DB12047Ganetespib1Completed1
DB00441Gemcitabine1Completed1
DB05036Grn163l1Completed2
DB06049IPH 21011Completed1
DB09054Idelalisib1Completed1
DB06186Ipilimumab1Withdrawn1
DB09570Ixazomib1Active Not Recruiting1
DB09570Ixazomib1Completed3
DB09570Ixazomib1Recruiting1
DB00125L-Arginine1Active Not Recruiting1
DB12085LCL-1611Recruiting1
DB00480Lenalidomide1Active Not Recruiting9
DB00480Lenalidomide1Completed13
DB00480Lenalidomide1Recruiting3
DB00480Lenalidomide1Terminated2
DB00480Lenalidomide1Withdrawn1
DB11754Lirilumab1Completed1
DB12089Lorvotuzumab mertansine1Completed2
DB05608MKC-11Completed1
DB11762Marizomib1Completed2
DB01042Melphalan1Active Not Recruiting4
DB01042Melphalan1Completed4
DB01042Melphalan1Not Yet Recruiting1
DB01042Melphalan1Recruiting3
DB00563Methotrexate1Recruiting2
DB12521Methyl pyrrolidone1Recruiting1
DB00959Methylprednisolone1Recruiting1
DB00683Midazolam1Active Not Recruiting1
DB12943Milatuzumab1Active Not Recruiting1
DB00471Montelukast1Active Not Recruiting1
DB00688Mycophenolate mofetil1Completed1
DB09079Nintedanib1Completed1
DB09035Nivolumab1Not Yet Recruiting1
DB09035Nivolumab1Terminated1
DB09035Nivolumab1Withdrawn1
DB00904Ondansetron1Completed1
DB11991Oprozomib1Active Not Recruiting1
DB09073Palbociclib1Terminated1
DB00039Palifermin1Completed1
DB06603Panobinostat1Active Not Recruiting1
DB06603Panobinostat1Completed2
DB06603Panobinostat1Terminated1
DB00019Pegfilgrastim1Active Not Recruiting1
DB09037Pembrolizumab1Active Not Recruiting2
DB09037Pembrolizumab1Recruiting1
DB06641Perifosine1Completed1
DB11759Pevonedistat1Completed1
DB06809Plerixafor1Terminated1
DB04977Plitidepsin1Completed1
DB08910Pomalidomide1Active Not Recruiting7
DB08910Pomalidomide1Completed3
DB08910Pomalidomide1Recruiting3
DB08910Pomalidomide1Terminated2
DB06813Pralatrexate1Completed1
DB00860Prednisolone1Completed1
DB00635Prednisone1Active Not Recruiting1
DB05626Retaspimycin1Completed1
DB12376Ricolinostat1Active Not Recruiting1
DB06233Ridaforolimus1Completed2
DB01045Rifampicin1Completed1
DB00073Rituximab1Recruiting1
DB08877Ruxolitinib1Recruiting1
DB05969SNS-0321Completed1
DB00020Sargramostim1Active Not Recruiting1
DB00020Sargramostim1Completed1
DB11135Selenium1Recruiting1
DB11942Selinexor1Recruiting1
DB09036Siltuximab1Completed2
DB09036Siltuximab1Terminated1
DB00877Sirolimus1Completed1
DB00877Sirolimus1Terminated1
DB01390Sodium bicarbonate1Terminated1
DB05995Sotatercept1Recruiting1
DB12118Sotatercept1Recruiting1
DB12756TAK-9011Completed1
DB11657Tabalumab1Completed2
DB00864Tacrolimus1Recruiting1
DB00864Tacrolimus1Terminated1
DB01041Thalidomide1Active Not Recruiting1
DB01041Thalidomide1Completed2
DB01041Thalidomide1Recruiting1
DB04572Thiotepa1Recruiting1
DB04960Tipifarnib1Completed1
DB06273Tocilizumab1Not Yet Recruiting1
DB01030Topotecan1Active Not Recruiting1
DB08911Trametinib1Recruiting1
DB11771Tremelimumab1Terminated1
DB07232Veliparib1Unknown Status1
DB11581Venetoclax1Recruiting2
DB00361Vinorelbine1Completed1
DB02546Vorinostat1Active Not Recruiting2
DB02546Vorinostat1Completed3
DB01593Zinc1Active Not Recruiting1
DB00399Zoledronic acid1Completed1
DB05237rhMBL1Completed1
DB12764ABC-2946401 / 2Recruiting1
DB11703Acalabrutinib1 / 2Recruiting2
DB00945Acetylsalicylic acid1 / 2Completed2
DB00087Alemtuzumab1 / 2Active Not Recruiting1
DB00087Alemtuzumab1 / 2Terminated2
DB06263Amrubicin1 / 2Completed1
DB09312Antilymphocyte immunoglobulin (horse)1 / 2Withdrawn1
DB00098Antithymocyte immunoglobulin (rabbit)1 / 2Withdrawn1
DB01169Arsenic trioxide1 / 2Completed1
DB00126Ascorbic acid1 / 2Completed1
DB11595Atezolizumab1 / 2Recruiting1
DB05513Atiprimod1 / 2Completed1
DB06769Bendamustine1 / 2Active Not Recruiting2
DB06769Bendamustine1 / 2Completed1
DB06769Bendamustine1 / 2Recruiting1
DB06769Bendamustine1 / 2Terminated1
DB06769Bendamustine1 / 2Unknown Status3
DB00188Bortezomib1 / 2Active Not Recruiting3
DB00188Bortezomib1 / 2Completed14
DB00188Bortezomib1 / 2Recruiting4
DB00188Bortezomib1 / 2Terminated5
DB00188Bortezomib1 / 2Unknown Status2
DB00188Bortezomib1 / 2Withdrawn2
DB01008Busulfan1 / 2Completed1
DB01008Busulfan1 / 2Terminated3
DB12101CC-2201 / 2Recruiting1
DB12570CC-2231 / 2Completed1
DB05916CT-0111 / 2Active Not Recruiting1
DB08875Cabozantinib1 / 2Recruiting1
DB08889Carfilzomib1 / 2Active Not Recruiting10
DB08889Carfilzomib1 / 2Completed3
DB08889Carfilzomib1 / 2Recruiting6
DB08889Carfilzomib1 / 2Terminated1
DB08889Carfilzomib1 / 2Withdrawn1
DB00493Cefotaxime1 / 2Completed1
DB00493Cefotaxime1 / 2Terminated1
DB00515Cisplatin1 / 2Recruiting1
DB00631Clofarabine1 / 2Terminated1
DB05239Cobimetinib1 / 2Recruiting1
DB00531Cyclophosphamide1 / 2Active Not Recruiting4
DB00531Cyclophosphamide1 / 2Completed7
DB00531Cyclophosphamide1 / 2Recruiting1
DB00531Cyclophosphamide1 / 2Terminated2
DB00091Cyclosporine1 / 2Active Not Recruiting1
DB09331Daratumumab1 / 2Recruiting3
DB06179Darinaparsin1 / 2Completed1
DB01254Dasatinib1 / 2Recruiting2
DB04932Defibrotide1 / 2Completed1
DB11956Delanzomib1 / 2Terminated2
DB01234Dexamethasone1 / 2Active Not Recruiting26
DB01234Dexamethasone1 / 2Completed10
DB01234Dexamethasone1 / 2Not Yet Recruiting1
DB01234Dexamethasone1 / 2Recruiting14
DB01234Dexamethasone1 / 2Terminated7
DB01234Dexamethasone1 / 2Unknown Status4
DB01234Dexamethasone1 / 2Withdrawn3
DB00514Dextromethorphan1 / 2Completed1
DB00514Dextromethorphan1 / 2Recruiting2
DB01248Docetaxel1 / 2Recruiting1
DB00997Doxorubicin1 / 2Active Not Recruiting2
DB00997Doxorubicin1 / 2Completed3
DB00997Doxorubicin1 / 2Terminated2
DB06317Elotuzumab1 / 2Recruiting1
DB06091Evofosfamide1 / 2Active Not Recruiting1
DB00099Filgrastim1 / 2Not Yet Recruiting1
DB00099Filgrastim1 / 2Terminated2
DB01073Fludarabine1 / 2Completed2
DB01073Fludarabine1 / 2Recruiting1
DB01073Fludarabine1 / 2Terminated2
DB06717Fosaprepitant1 / 2Recruiting1
DB05420Gallium maltolate1 / 2Terminated1
DB00441Gemcitabine1 / 2Recruiting1
DB05653IRX-51831 / 2Completed1
DB09053Ibrutinib1 / 2Active Not Recruiting2
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DB11942Selinexor1 / 2Active Not Recruiting1
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DB00316Acetaminophen2Completed2
DB00945Acetylsalicylic acid2Completed1
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DB00437Allopurinol2Recruiting1
DB00026Anakinra2Recruiting1
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DB00126Ascorbic acid2Not Yet Recruiting1
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DB06626Axitinib2Recruiting2
DB00928Azacitidine2Terminated1
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DB00188Bortezomib2Recruiting17
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DB00188Bortezomib2Unknown Status7
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DB01008Busulfan2Recruiting4
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DB12476CPG-528522Terminated1
DB05916CT-0112Active Not Recruiting1
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DB08889Carfilzomib2Active Not Recruiting8
DB08889Carfilzomib2Completed5
DB08889Carfilzomib2Not Yet Recruiting2
DB08889Carfilzomib2Recruiting12
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DB00002Cetuximab2Recruiting1
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DB01234Dexamethasone2Not Yet Recruiting7
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DB09560Filgrastim2Recruiting1
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DB00174L-Asparagine2Terminated1
DB00130L-Glutamine2Recruiting1
DB00130L-Glutamine2Terminated1
DB00480Lenalidomide2Active Not Recruiting24
DB00480Lenalidomide2Completed31
DB00480Lenalidomide2Not Yet Recruiting5
DB00480Lenalidomide2Recruiting18
DB00480Lenalidomide2Terminated6
DB00480Lenalidomide2Unknown Status1
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DB00007Leuprolide2Recruiting1
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DB01042Melphalan2Active Not Recruiting10
DB01042Melphalan2Completed26
DB01042Melphalan2Not Yet Recruiting2
DB01042Melphalan2Recruiting12
DB01042Melphalan2Terminated6
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DB00959Methylprednisolone2Completed1
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DB00688Mycophenolate mofetil2Active Not Recruiting3
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DB00688Mycophenolate mofetil2Recruiting6
DB00688Mycophenolate mofetil2Unknown Status1
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DB09035Nivolumab2Not Yet Recruiting1
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DB00282Pamidronate2Completed2
DB06603Panobinostat2Active Not Recruiting1
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DB06603Panobinostat2Recruiting3
DB06603Panobinostat2Terminated2
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DB00059Pegaspargase2Completed1
DB00019Pegfilgrastim2Completed4
DB00019Pegfilgrastim2Terminated1
DB09037Pembrolizumab2Active Not Recruiting2
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DB00552Pentostatin2Completed1
DB00552Pentostatin2Terminated1
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DB06366Pertuzumab2Recruiting1
DB06809Plerixafor2Completed14
DB06809Plerixafor2Recruiting1
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DB06809Plerixafor2Withdrawn1
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DB04977Plitidepsin2Terminated1
DB08910Pomalidomide2Active Not Recruiting8
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DB08910Pomalidomide2Not Yet Recruiting2
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DB00860Prednisolone2Terminated1
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DB00635Prednisone2Recruiting3
DB00571Propranolol2Active Not Recruiting1
DB00165Pyridoxine2Recruiting1
DB10415Rabbit2Active Not Recruiting1
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DB06176Romidepsin2Terminated1
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DB12118Sotatercept2Withdrawn1
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DB12291Tacedinaline2Completed1
DB00864Tacrolimus2Active Not Recruiting3
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DB00864Tacrolimus2Recruiting2
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DB05412Talmapimod2Completed2
DB12568Tecemotide2Completed1
DB06287Temsirolimus2Recruiting2
DB01041Thalidomide2Active Not Recruiting2
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DB01041Thalidomide2Not Yet Recruiting1
DB01041Thalidomide2Recruiting6
DB01041Thalidomide2Terminated3
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DB04572Thiotepa2Recruiting4
DB06822Tinzaparin2Completed1
DB04960Tipifarnib2Completed1
DB00081Tositumomab2Active Not Recruiting1
DB09557Tositumomab2Active Not Recruiting1
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DB00072Trastuzumab2Recruiting1
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DB00440Trimethoprim2Recruiting1
DB06334Tucidinostat2Not Yet Recruiting1
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DB04879Vatalanib2Terminated1
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DB11581Venetoclax2Not Yet Recruiting1
DB11581Venetoclax2Recruiting1
DB00541Vincristine2Completed2
DB00541Vincristine2Terminated1
DB00361Vinorelbine2Not Yet Recruiting1
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DB08828Vismodegib2Recruiting2
DB02546Vorinostat2Withdrawn2
DB09145Water2Completed1
DB05014XL9992Terminated1
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DB00399Zoledronic acid2Completed6
DB00399Zoledronic acid2Terminated1
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DB09110Coenzyme M2 / 3Active Not Recruiting1
DB00531Cyclophosphamide2 / 3Active Not Recruiting1
DB00531Cyclophosphamide2 / 3Not Yet Recruiting1
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DB01234Dexamethasone2 / 3Completed3
DB00773Etoposide2 / 3Not Yet Recruiting1
DB01073Fludarabine2 / 3Recruiting1
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DB00480Lenalidomide2 / 3Active Not Recruiting1
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DB13144Lenograstim2 / 3Completed1
DB01042Melphalan2 / 3Active Not Recruiting1
DB01042Melphalan2 / 3Not Yet Recruiting1
DB06417Somatotropin2 / 3Completed1
DB06398Tanespimycin2 / 3Completed1
DB01041Thalidomide2 / 3Completed2
DB00173Adenine3Completed1
DB00673Aprepitant3Unknown Status1
DB06413Armodafinil3Completed1
DB00188Bortezomib3Active Not Recruiting10
DB00188Bortezomib3Completed29
DB00188Bortezomib3No Longer Available1
DB00188Bortezomib3Recruiting6
DB00188Bortezomib3Terminated4
DB00188Bortezomib3Unknown Status2
DB00188Bortezomib3Withdrawn1
DB01008Busulfan3Completed1
DB08889Carfilzomib3Active Not Recruiting2
DB08889Carfilzomib3Completed3
DB08889Carfilzomib3Recruiting1
DB00262Carmustine3Completed2
DB01136Carvedilol3Completed1
DB11121Chloroxylenol3Recruiting1
DB00537Ciprofloxacin3Completed1
DB00515Cisplatin3Active Not Recruiting1
DB00515Cisplatin3Completed2
DB00515Cisplatin3Recruiting1
DB00515Cisplatin3Terminated1
DB01211Clarithromycin3Recruiting3
DB00531Cyclophosphamide3Active Not Recruiting4
DB00531Cyclophosphamide3Completed7
DB00531Cyclophosphamide3Recruiting4
DB00531Cyclophosphamide3Terminated1
DB00531Cyclophosphamide3Unknown Status1
DB00987Cytarabine3Completed1
DB00987Cytarabine3Terminated1
DB09331Daratumumab3Active Not Recruiting4
DB09331Daratumumab3Recruiting5
DB06643Denosumab3Active Not Recruiting1
DB01234Dexamethasone3Active Not Recruiting19
DB01234Dexamethasone3Completed29
DB01234Dexamethasone3Not Yet Recruiting1
DB01234Dexamethasone3Recruiting15
DB01234Dexamethasone3Terminated5
DB01234Dexamethasone3Unknown Status4
DB01234Dexamethasone3Withdrawn1
DB00514Dextromethorphan3Completed1
DB00514Dextromethorphan3Recruiting2
DB00514Dextromethorphan3Terminated1
DB00997Doxorubicin3Active Not Recruiting1
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DB00997Doxorubicin3Recruiting2
DB00997Doxorubicin3Terminated1
DB06317Elotuzumab3Active Not Recruiting3
DB06317Elotuzumab3Recruiting1
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DB00016Erythropoietin3Completed2
DB00773Etoposide3Active Not Recruiting1
DB00773Etoposide3Completed2
DB00773Etoposide3Recruiting1
DB00773Etoposide3Terminated1
DB00099Filgrastim3Active Not Recruiting1
DB00099Filgrastim3Completed1
DB00099Filgrastim3Terminated1
DB00099Filgrastim3Unknown Status1
DB06717Fosaprepitant3Unknown Status1
DB00710Ibandronate3Terminated1
DB09146Iron saccharate3Completed1
DB09570Ixazomib3Active Not Recruiting2
DB09570Ixazomib3Completed1
DB09570Ixazomib3Recruiting1
DB00480Lenalidomide3Active Not Recruiting14
DB00480Lenalidomide3Completed15
DB00480Lenalidomide3Recruiting5
DB00480Lenalidomide3Withdrawn1
DB01042Melphalan3Active Not Recruiting6
DB01042Melphalan3Completed12
DB01042Melphalan3No Longer Available1
DB01042Melphalan3Recruiting3
DB01042Melphalan3Terminated1
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DB00563Methotrexate3Recruiting1
DB00218Moxifloxacin3Completed1
DB00688Mycophenolate mofetil3Recruiting1
DB05258Natural alpha interferon3Completed1
DB09035Nivolumab3Recruiting1
DB01165Ofloxacin3Completed1
DB00039Palifermin3Completed1
DB00282Pamidronate3Completed1
DB06603Panobinostat3Completed1
DB09037Pembrolizumab3Active Not Recruiting2
DB06641Perifosine3Terminated1
DB06809Plerixafor3Completed1
DB08910Pomalidomide3Active Not Recruiting3
DB08910Pomalidomide3Completed2
DB08910Pomalidomide3Not Yet Recruiting1
DB08910Pomalidomide3Recruiting5
DB00860Prednisolone3Completed2
DB00635Prednisone3Active Not Recruiting4
DB00635Prednisone3Completed6
DB00635Prednisone3No Longer Available1
DB00635Prednisone3Recruiting1
DB00635Prednisone3Unknown Status1
DB00020Sargramostim3Completed1
DB11942Selinexor3Recruiting1
DB09036Siltuximab3Withdrawn1
DB01015Sulfamethoxazole3Completed1
DB00864Tacrolimus3Recruiting1
DB06398Tanespimycin3Completed1
DB01041Thalidomide3Active Not Recruiting1
DB01041Thalidomide3Completed25
DB01041Thalidomide3Recruiting2
DB01041Thalidomide3Terminated3
DB01041Thalidomide3Unknown Status3
DB00684Tobramycin3Completed1
DB00440Trimethoprim3Completed1
DB11581Venetoclax3Not Yet Recruiting1
DB00541Vincristine3Completed3
DB00541Vincristine3Terminated1
DB02546Vorinostat3Active Not Recruiting1
DB02546Vorinostat3Completed1
DB00399Zoledronic acid3Active Not Recruiting1
DB00399Zoledronic acid3Terminated2
DB06605Apixaban4Enrolling by Invitation1
DB00188Bortezomib4Active Not Recruiting1
DB00188Bortezomib4Completed12
DB00188Bortezomib4Recruiting1
DB00531Cyclophosphamide4Active Not Recruiting1
DB01234Dexamethasone4Active Not Recruiting2
DB01234Dexamethasone4Completed1
DB01234Dexamethasone4Recruiting1
DB00514Dextromethorphan4Completed1
DB00997Doxorubicin4Active Not Recruiting1
DB09570Ixazomib4Recruiting1
DB00480Lenalidomide4Active Not Recruiting1
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DB00480Lenalidomide4Recruiting1
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DB01042Melphalan4Recruiting1
DB00039Palifermin4Completed1
DB00635Prednisone4Completed1
DB00635Prednisone4Recruiting1
DB01041Thalidomide4Active Not Recruiting1
DB01041Thalidomide4Completed1
DB00399Zoledronic acid4Active Not Recruiting1
DB00399Zoledronic acid4Completed3
DB00399Zoledronic acid4Recruiting1
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DB00399Zoledronic acid4Withdrawn1
DB00098Antithymocyte immunoglobulin (rabbit)Not AvailableCompleted1
DB00928AzacitidineNot AvailableCompleted1
DB00074BasiliximabNot AvailableTerminated1
DB01294Bismuth SubsalicylateNot AvailableCompleted1
DB00188BortezomibNot AvailableActive Not Recruiting1
DB00188BortezomibNot AvailableAvailable2
DB00188BortezomibNot AvailableCompleted2
DB00188BortezomibNot AvailableNot Yet Recruiting1
DB00188BortezomibNot AvailableUnknown Status1
DB01008BusulfanNot AvailableActive Not Recruiting1
DB01008BusulfanNot AvailableCompleted1
DB01008BusulfanNot AvailableSuspended1
DB08889CarfilzomibNot AvailableApproved for Marketing1
DB08889CarfilzomibNot AvailableNo Longer Available1
DB00493CefotaximeNot AvailableRecruiting1
DB00515CisplatinNot AvailableCompleted1
DB00720Clodronic AcidNot AvailableCompleted1
DB11672CurcuminNot AvailableCompleted1
DB00531CyclophosphamideNot AvailableCompleted1
DB00531CyclophosphamideNot AvailableRecruiting2
DB00531CyclophosphamideNot AvailableSuspended1
DB00531CyclophosphamideNot AvailableTerminated2
DB00091CyclosporineNot AvailableRecruiting1
DB00091CyclosporineNot AvailableTerminated2
DB09331DaratumumabNot AvailableAvailable1
DB01234DexamethasoneNot AvailableApproved for Marketing1
DB01234DexamethasoneNot AvailableAvailable3
DB01234DexamethasoneNot AvailableCompleted4
DB01234DexamethasoneNot AvailableRecruiting2
DB00997DoxorubicinNot AvailableCompleted2
DB06317ElotuzumabNot AvailableAvailable2
DB06317ElotuzumabNot AvailableNo Longer Available1
DB00016ErythropoietinNot AvailableCompleted2
DB00773EtoposideNot AvailableCompleted1
DB00099FilgrastimNot AvailableCompleted1
DB00196FluconazoleNot AvailableCompleted1
DB01073FludarabineNot AvailableActive Not Recruiting1
DB01073FludarabineNot AvailableCompleted1
DB01073FludarabineNot AvailableRecruiting1
DB01073FludarabineNot AvailableTerminated2
DB01109HeparinNot AvailableCompleted1
DB00480LenalidomideNot AvailableActive Not Recruiting1
DB00480LenalidomideNot AvailableAvailable2
DB00480LenalidomideNot AvailableCompleted3
DB00480LenalidomideNot AvailableRecruiting2
DB00480LenalidomideNot AvailableTerminated1
DB01042MelphalanNot AvailableAvailable1
DB01042MelphalanNot AvailableCompleted2
DB01042MelphalanNot AvailableUnknown Status1
DB00688Mycophenolate mofetilNot AvailableRecruiting1
DB00688Mycophenolate mofetilNot AvailableTerminated2
DB06603PanobinostatNot AvailableAvailable1
DB06603PanobinostatNot AvailableNo Longer Available1
DB06809PlerixaforNot AvailableCompleted1
DB06809PlerixaforNot AvailableNo Longer Available1
DB06809PlerixaforNot AvailableRecruiting1
DB06809PlerixaforNot AvailableUnknown Status2
DB08910PomalidomideNot AvailableApproved for Marketing1
DB08910PomalidomideNot AvailableRecruiting3
DB00020SargramostimNot AvailableActive Not Recruiting1
DB00641SimvastatinNot AvailableTerminated1
DB10286Streptococcus pneumoniae type 4 capsular polysaccharide diphtheria crm197 protein conjugate antigenNot AvailableCompleted1
DB00864TacrolimusNot AvailableRecruiting1
DB12568TecemotideNot AvailableTerminated1
DB01041ThalidomideNot AvailableCompleted2
DB12018UlocuplumabNot AvailableAvailable1
DB11581VenetoclaxNot AvailableAvailable1
DB00541VincristineNot AvailableCompleted1
DB00582VoriconazoleNot AvailableCompleted1
DB00399Zoledronic acidNot AvailableCompleted1
DB00399Zoledronic acidNot AvailableTerminated1