Primary Central Nervous System Lymphoma (PCNSL)

Also known as: Primary Central Nervous System Lymphoma / Primary CNS Lymphoma (PCNSL) / PCNSL (Primary CNS Lymphoma) / Primary CNS Lymphoma / Lymphoma / Central nervous system lymphoma

DrugDrug NameDrug Description
DB00515CisplatinCisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also includes carboplatin and oxaliplatin.
DB01168ProcarbazineAn antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
DB00853TemozolomideTemozolomide (Temodar and Temodal) is an oral alkylating agent used for the treatment of refractory anaplastic astrocytoma -- a type of cancerous brain tumor. Temozolomide is not active until it is converted at physiologic pH to the active form, 5-(3-methyltriazen-1-yl)imidazole-4-carboxamide (MTIC).
DrugDrug NameTargetType
DB00515CisplatinDNAtarget
DB00515CisplatinCanalicular multispecific organic anion transporter 2transporter
DB00515CisplatinMultidrug resistance-associated protein 5transporter
DB00515CisplatinCanalicular multispecific organic anion transporter 1transporter
DB00515CisplatinSolute carrier family 22 member 2transporter
DB00515CisplatinHigh affinity copper uptake protein 1transporter
DB00515CisplatinProbable low affinity copper uptake protein 2transporter
DB00515CisplatinMultidrug resistance-associated protein 6transporter
DB00515CisplatinMultidrug resistance protein 1transporter
DB00515CisplatinCopper-transporting ATPase 2transporter
DB00515CisplatinCopper-transporting ATPase 1transporter
DB00515CisplatinProstaglandin G/H synthase 2enzyme
DB00515CisplatinMyeloperoxidaseenzyme
DB00515CisplatinXanthine dehydrogenase/oxidaseenzyme
DB00515CisplatinArylamine N-acetyltransferaseenzyme
DB00515CisplatinCytochrome P450 2C9enzyme
DB00515CisplatinCytochrome P450 2B6enzyme
DB00515CisplatinCholinesteraseenzyme
DB00515CisplatinCytochrome P450 4A11enzyme
DB00515CisplatinATP-binding cassette sub-family G member 2transporter
DB00515CisplatinGlutathione S-transferase theta-1enzyme
DB00515CisplatinMetallothionein-1Aenzyme
DB00515CisplatinMetallothionein-2enzyme
DB00515CisplatinSuperoxide dismutase [Cu-Zn]enzyme
DB00515CisplatinGlutathione S-transferase Penzyme
DB00515CisplatinNAD(P)H dehydrogenase [quinone] 1enzyme
DB00515CisplatinGlutathione S-transferase Mu 1enzyme
DB00515CisplatinDNA-3-methyladenine glycosylasetarget
DB00515CisplatinAlpha-2-macroglobulintarget
DB00515CisplatinSerum albumincarrier
DB00515CisplatinSerotransferrintarget
DB00515CisplatinCopper transport protein ATOX1target
DB01168ProcarbazineDNAtarget
DB01168ProcarbazineXanthine dehydrogenase/oxidaseenzyme
DB01168ProcarbazineMonoamine oxidasetarget
DB00853TemozolomideDNAtarget
DrugDrug NamePhaseStatusCount
DB14857Avadomide1Active Not Recruiting1
DB09053Ibrutinib1Recruiting1
DB00480Lenalidomide1Recruiting1
DB00073Rituximab1Recruiting1
DB11850Ublituximab1 / 2Active Not Recruiting1
DB11702Antineoplaston A102Withdrawn1
DB14846Bimiralisib2Completed1
DB14846Bimiralisib2Withdrawn1
DB11666Buparlisib2Completed1
DB00987Cytarabine2Recruiting1
DB11714Durvalumab2Withdrawn1
DB00125L-Arginine2Recruiting1
DB00480Lenalidomide2Not Yet Recruiting1
DB00480Lenalidomide2Withdrawn1
DB00134Methionine2Recruiting1
DB00563Methotrexate2Not Yet Recruiting1
DB00563Methotrexate2Recruiting3
DB00563Methotrexate2Unknown Status1
DB00959Methylprednisolone2Unknown Status1
DB09037Pembrolizumab2Recruiting1
DB00642Pemetrexed2Withdrawn1
DB01168Procarbazine2Not Yet Recruiting1
DB00073Rituximab2Not Yet Recruiting1
DB00073Rituximab2Recruiting2
DB00853Temozolomide2Not Yet Recruiting1
DB00853Temozolomide2Recruiting2
DB00853Temozolomide2Unknown Status1
DB08828Vismodegib2Terminated1
DB00563Methotrexate3Recruiting1
DB00073Rituximab3Recruiting1
DB00853Temozolomide3Recruiting1
DB00091CiclosporinNot AvailableCompleted1
DB01073FludarabineNot AvailableCompleted1
DB00688Mycophenolate mofetilNot AvailableCompleted1