Chronic Asthma

Also known as: Asthma Chronic / Asthma, unspecified / Asthma bronchial / Asthma unspecified / Asthmatic bronchitis NOS / Asthma NOS / Asthma / Asthmatic / Br. asthma / Bronchitic asthma

DrugDrug NameDrug Description
DB00744ZileutonLeukotrienes are substances that induce numerous biological effects including augmentation of neutrophil and eosinophil migration, neutrophil and monocyte aggregation, leukocyte adhesion, increased capillary permeability, and smooth muscle contraction. These effects contribute to inflammation, edema, mucus secretion, and bronchoconstriction in the airways of asthmatic patients. Zileuton relieves such symptoms through its selective inhibition of 5-lipoxygenase, the enzyme that catalyzes the formation of leukotrienes from arachidonic acid. Specifically, it inhibits leukotriene LTB4, LTC4, LTD4, and LTE4 formation. Both the R(+) and S(-) enantiomers are pharmacologically active as 5-lipoxygenase inhibitors in in vitro systems. The immediate release tablet of Zileuton has been withdrawn from the US market.
DrugDrug NamePhaseStatusCount
DB00471Montelukast1Completed1
DB01001Salbutamol1Completed1
DB00207Azithromycin2Recruiting1
DB01222Budesonide2Completed1
DB00983Formoterol2Completed1
DB01222Budesonide3Not Yet Recruiting1
DB09273Doxofylline3Not Yet Recruiting1
DB06209Prasugrel4Completed1