Treatment Resistant Depression (TRD)

Also known as: Treatment Resistant Depression

DrugDrug NameDrug Description
DB11823EsketamineMajor depressive disorder (MDD) is a significant cause of disability worldwide and the most common illness preceding suicide [L5596], [A175462]. On March 5, 2019, the nasal spray drug, _esketamine_, also known as _Spravato_ (by Janssen Pharmaceuticals), was approved by the FDA for treatment-resistant major depression. Esketamine is the s-enantiomer of [Ketamine]. Ketamine is a mixture of two enantiomers (mirror image molecules). This is the first time that the FDA has approved esketamine for any use. The FDA approved ketamine (Ketalar) in 1970 [L5593]. Esketamine may prove to be a promising treatment for patients diagnosed with major depressive disorder who have not experienced an improvement in symptoms despite treatment with various medications and therapies. The intranasal route of administration for this drug allows for easy administration and a fast onset of action, which sets it apart from many other antidepressant agents that may take several weeks to take effect.
DrugDrug NamePhaseStatusCount
DB01221Ketamine0Enrolling by Invitation1
DB00083Botulinum toxin type A1Not Yet Recruiting1
DB12675PF-049952741Recruiting1
DB09153Sodium chloride1Not Yet Recruiting1
DB00945Acetylsalicylic acid2Recruiting1
DB05205CX1572Completed1
DB01221Ketamine2Active Not Recruiting1
DB01221Ketamine2Completed2
DB01221Ketamine2Enrolling by Invitation1
DB01221Ketamine2Withdrawn1
DB01356Lithium cation2Withdrawn1
DB00683Midazolam2Completed2
DB06690Nitrous oxide2Recruiting1
DB11664Psilocybine2Not Yet Recruiting1
DB00936Salicylic acid2Recruiting1
DB01221Ketamine2 / 3Recruiting1
DB00683Midazolam2 / 3Recruiting1
DB00818Propofol2 / 3Recruiting2
DB00472Fluoxetine3Completed1
DB00472Fluoxetine3Terminated1
DB01221Ketamine3Recruiting1
DB01356Lithium cation3Completed1
DB01017Minocycline3Not Yet Recruiting1
DB00334Olanzapine3Completed1
DB00334Olanzapine3Terminated1
DB01224Quetiapine3Completed1
DB00641Simvastatin3Not Yet Recruiting1
DB00285Venlafaxine3Completed1
DB01238Aripiprazole4Recruiting1
DB01156Bupropion4Recruiting1
DB00260Cycloserine4Not Yet Recruiting1
DB01221Ketamine4Completed1
DB01221Ketamine4Not Yet Recruiting1
DB01221Ketamine4Recruiting1
DB01221Ketamine4Withdrawn1
DB01356Lithium cation4Recruiting1
DB00540Nortriptyline4Recruiting1
DB00818Propofol4Completed1
DB00734Risperidone4Withdrawn1
DB00321AmitriptylineNot AvailableUnknown Status1
DB01156BupropionNot AvailableUnknown Status1
DB00215CitalopramNot AvailableUnknown Status1
DB01242ClomipramineNot AvailableUnknown Status1
DB00476DuloxetineNot AvailableUnknown Status1
DB01175EscitalopramNot AvailableUnknown Status1
DB00472FluoxetineNot AvailableUnknown Status1
DB00176FluvoxamineNot AvailableUnknown Status1
DB00458ImipramineNot AvailableUnknown Status1
DB01221KetamineNot AvailableRecruiting1
DB01356Lithium cationNot AvailableUnknown Status1
DB00683MidazolamNot AvailableRecruiting1
DB00370MirtazapineNot AvailableUnknown Status1
DB00540NortriptylineNot AvailableUnknown Status1
DB00715ParoxetineNot AvailableUnknown Status1
DB00734RisperidoneNot AvailableUnknown Status1
DB01104SertralineNot AvailableUnknown Status1
DB00391SulpirideNot AvailableUnknown Status1
DB00752TranylcypromineNot AvailableUnknown Status1
DB00656TrazodoneNot AvailableUnknown Status1
DB00285VenlafaxineNot AvailableUnknown Status1