Treatment Resistant Depression (TRD)

Also known as: Major depressive disorder, recurrent episode / Treatment-Resistant Depression / Treatment Resistant Depression / Major depressive disorder, recurrent, unspecified / Recurrent major depressive episodes (disorder) / Major depressive disorder, recurrent / Recurrent major depression (disorder) / Treatment resistant depression (disorder) / Depressive Disorder, Treatment-Resistant / Major depressive disorder, single episode, unspecified / Major depressive disorder / Major depressive illness / Major depressive disorder (disorder) / Major depression / Major depressive disorder NOS / Depressive Disorder, Major / Depressive state / Depression NOS / Depressed state / Depression / Depression mental

DrugDrug NameDrug Description
DB11823EsketamineA NMDA receptor antagonist used for treatment-resistant depression.
DB00472FluoxetineA selective serotonin reuptake inhibitor used to treat major depressive disorder, bulimia, OCD, premenstrual dysphoric disorder, panic disorder, and bipolar I.
DB00334OlanzapineAn antipsychotic drug used in the management of schizophrenia, bipolar 1 disorder, and agitation associated with these disorders.
DrugDrug NameTargetType
DB11823EsketamineNMDA receptortarget
DB11823EsketamineCytochrome P450 2B6enzyme
DB11823EsketamineCytochrome P450 3A4enzyme
DB11823EsketamineCytochrome P450 2C19enzyme
DB11823EsketamineCytochrome P450 2C9enzyme
DB11823EsketamineGlutamate receptor ionotropic, NMDA 2Btarget
DB11823EsketamineElongation factor 2target
DB11823EsketamineBrain-derived neurotrophic factortarget
DB11823EsketamineBDNF/NT-3 growth factors receptortarget
DB00472FluoxetineSodium-dependent serotonin transportertarget
DB00472FluoxetineCytochrome P450 2C9enzyme
DB00472FluoxetineCytochrome P450 2D6enzyme
DB00472FluoxetineCYP2B proteinenzyme
DB00472FluoxetineCytochrome P450 1A2enzyme
DB00472FluoxetineCytochrome P450 3A4enzyme
DB00472FluoxetineCytochrome P450 2C19enzyme
DB00472FluoxetineP-glycoprotein 1transporter
DB00472FluoxetineCytochrome P450 2B6enzyme
DB00472FluoxetineCytochrome P450 3A5enzyme
DB00472FluoxetineSerum albumincarrier
DB00472FluoxetineAlpha-1-acid glycoprotein 1carrier
DB00472FluoxetinePotassium voltage-gated channel subfamily H member 2target
DB00472Fluoxetine5-hydroxytryptamine receptor 2Ctarget
DB00472FluoxetineCyclin-dependent kinases regulatory subunit 1target
DB00472FluoxetineNeuronal acetylcholine receptor subunit alpha-2target
DB00472FluoxetineNeuronal acetylcholine receptor subunit alpha-3target
DB00472FluoxetineNeuronal acetylcholine receptor subunit beta-4target
DB00334OlanzapineDopamine D1 receptortarget
DB00334OlanzapineMuscarinic acetylcholine receptor M1target
DB00334OlanzapineMuscarinic acetylcholine receptor M3target
DB00334Olanzapine5-hydroxytryptamine receptor 2Atarget
DB00334OlanzapineDopamine D4 receptortarget
DB00334OlanzapineHistamine H1 receptortarget
DB00334OlanzapineMuscarinic acetylcholine receptor M4target
DB00334OlanzapineMuscarinic acetylcholine receptor M2target
DB00334OlanzapineDopamine D2 receptortarget
DB00334Olanzapine5-hydroxytryptamine receptor 2Ctarget
DB00334OlanzapineDopamine D3 receptortarget
DB00334OlanzapineAlpha-1B adrenergic receptortarget
DB00334OlanzapineCytochrome P450 1A2enzyme
DB00334Olanzapine5-hydroxytryptamine receptor 3Atarget
DB00334Olanzapine5-hydroxytryptamine receptor 6target
DB00334OlanzapineAlpha-1A adrenergic receptortarget
DB00334OlanzapineDopamine D5 receptortarget
DB00334OlanzapineSerum albumincarrier
DB00334OlanzapineAlpha-1-acid glycoprotein 1carrier
DB00334OlanzapineDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB00334OlanzapineCytochrome P450 2D6enzyme
DB00334OlanzapineP-glycoprotein 1transporter
DB00334OlanzapineCytochrome P450 2C19enzyme
DB00334OlanzapineD(1) dopamine receptortarget
DB00334OlanzapineBeta adrenergic receptortarget
DB00334Olanzapine5-hydroxytryptamine receptor 1target
DB00334OlanzapineGABA(A) Receptor Benzodiazepine Binding Sitetarget
DB00334OlanzapineCytochrome P450 2C9enzyme
DB00334OlanzapineUDP-glucuronosyltransferase 1-4enzyme
DB00334OlanzapineCytochrome P450 3A4enzyme
DB00334OlanzapineCytochrome P450 3A Subfamilyenzyme
DrugDrug NamePhaseStatusCount
DB01221Ketamine0Enrolling by Invitation1
DB01221Ketamine0Unknown Status1
DB00083Botulinum toxin type A1Withdrawn1
DB00514Dextromethorphan1Completed1
DB01221Ketamine1Recruiting1
DB12675PF-049952741Completed1
DB09153Sodium chloride1Withdrawn1
DB140105-methoxy-N,N-dimethyltryptamine1 / 2Completed1
DB01488Dimethyltryptamine1 / 2Completed1
DB00818Propofol1 / 2Recruiting1
DB140105-methoxy-N,N-dimethyltryptamine2Recruiting1
DB00945Acetylsalicylic acid2Terminated1
DB12341Aticaprant2Terminated1
DB01156Bupropion2Completed1
DB01156Bupropion2Enrolling by Invitation1
DB05205CX1572Completed1
DB01254Dasatinib2Recruiting1
DB00514Dextromethorphan2Completed1
DB00753Isoflurane2Unknown Status1
DB01221Ketamine2Completed5
DB01221Ketamine2Recruiting1
DB01221Ketamine2Terminated1
DB01221Ketamine2Unknown Status1
DB01221Ketamine2Withdrawn1
DB14878Liafensine2Recruiting1
DB14509Lithium carbonate2Withdrawn1
DB00683Midazolam2Completed2
DB00683Midazolam2Recruiting1
DB02701Nicotinamide2Active Not Recruiting1
DB06690Nitrous oxide2Completed1
DB06690Nitrous oxide2Not Yet Recruiting1
DB06690Nitrous oxide2Recruiting1
DB11133Omega-3 fatty acids2Not Yet Recruiting1
DB11664Psilocybin2Active Not Recruiting3
DB11664Psilocybin2Completed3
DB11664Psilocybin2Not Yet Recruiting2
DB11664Psilocybin2Recruiting4
DB04216Quercetin2Recruiting1
DB00734Risperidone2Recruiting1
DB00936Salicylic acid2Terminated1
DB01104Sertraline2Unknown Status1
DB16304TAK-6532Withdrawn1
DB01221Ketamine2 / 3Completed2
DB00683Midazolam2 / 3Completed1
DB00818Propofol2 / 3Active Not Recruiting1
DB00818Propofol2 / 3Withdrawn1
DB01156Bupropion3Completed1
DB00514Dextromethorphan3Completed1
DB00476Duloxetine3Completed3
DB01175Escitalopram3Completed3
DB11823Esketamine3Completed3
DB11823Esketamine3Not Yet Recruiting1
DB11823Esketamine3Withdrawn1
DB00472Fluoxetine3Completed1
DB00472Fluoxetine3Terminated1
DB01221Ketamine3Not Yet Recruiting1
DB01221Ketamine3Recruiting1
DB01221Ketamine3Unknown Status1
DB14509Lithium carbonate3Completed1
DB00683Midazolam3Recruiting1
DB01017Minocycline3Recruiting1
DB00334Olanzapine3Completed1
DB00334Olanzapine3Terminated1
DB11664Psilocybin3Recruiting2
DB01224Quetiapine3Completed1
DB01104Sertraline3Completed3
DB00641Simvastatin3Completed1
DB00285Venlafaxine3Completed4
DB00945Acetylsalicylic acid4Recruiting1
DB00915Amantadine4Recruiting1
DB01238Aripiprazole4Active Not Recruiting1
DB01238Aripiprazole4Completed1
DB00297Bupivacaine4Completed1
DB01156Bupropion4Active Not Recruiting1
DB01156Bupropion4Completed1
DB09061Cannabidiol4Withdrawn1
DB00260Cycloserine4Unknown Status1
DB11823Esketamine4Not Yet Recruiting1
DB01221Ketamine4Completed2
DB01221Ketamine4Not Yet Recruiting1
DB01221Ketamine4Recruiting3
DB01221Ketamine4Unknown Status1
DB01221Ketamine4Withdrawn1
DB14509Lithium carbonate4Active Not Recruiting1
DB14509Lithium carbonate4Completed1
DB00683Midazolam4Active Not Recruiting1
DB00683Midazolam4Recruiting1
DB06690Nitrous oxide4Active Not Recruiting1
DB00540Nortriptyline4Active Not Recruiting1
DB00540Nortriptyline4Completed1
DB00413Pramipexole4Recruiting1
DB00818Propofol4Completed1
DB01224Quetiapine4Recruiting1
DB00734Risperidone4Withdrawn1
DB09289Tianeptine4Recruiting1
DB00321AmitriptylineNot AvailableUnknown Status1
DB01156BupropionNot AvailableUnknown Status1
DB00215CitalopramNot AvailableUnknown Status1
DB01242ClomipramineNot AvailableUnknown Status1
DB00476DuloxetineNot AvailableUnknown Status1
DB01175EscitalopramNot AvailableCompleted1
DB01175EscitalopramNot AvailableUnknown Status1
DB11823EsketamineNot AvailableRecruiting1
DB00472FluoxetineNot AvailableUnknown Status1
DB00176FluvoxamineNot AvailableUnknown Status1
DB00458ImipramineNot AvailableUnknown Status1
DB01221KetamineNot AvailableCompleted3
DB01221KetamineNot AvailableRecruiting4
DB14509Lithium carbonateNot AvailableUnknown Status1
DB00683MidazolamNot AvailableCompleted1
DB00370MirtazapineNot AvailableUnknown Status1
DB06690Nitrous oxideNot AvailableCompleted1
DB00540NortriptylineNot AvailableUnknown Status1
DB09140OxygenNot AvailableCompleted1
DB00715ParoxetineNot AvailableUnknown Status1
DB00734RisperidoneNot AvailableUnknown Status1
DB08839SerotoninNot AvailableCompleted1
DB01104SertralineNot AvailableUnknown Status1
DB00391SulpirideNot AvailableUnknown Status1
DB00752TranylcypromineNot AvailableUnknown Status1
DB00656TrazodoneNot AvailableUnknown Status1
DB00285VenlafaxineNot AvailableUnknown Status1