Prosthetic Joint Infection

Also known as: Prosthetic joint infection

DrugDrug NameDrug Description
DB01212CeftriaxoneA broad-spectrum cephalosporin antibiotic with a very long half-life and high penetrability to meninges, eyes and inner ears. [PubChem]
DB01137LevofloxacinA synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
DB01045RifampicinA semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)
DrugDrug NameTargetType
DB01212CeftriaxoneSerum albumincarrier
DB01212CeftriaxoneSolute carrier family 15 member 1transporter
DB01212CeftriaxoneSolute carrier family 15 member 2transporter
DB01212CeftriaxoneSolute carrier family 22 member 6transporter
DB01212CeftriaxoneSolute carrier family 22 member 8transporter
DB01212CeftriaxoneSolute carrier family 22 member 11transporter
DB01212CeftriaxonePenicillin-binding protein 2Btarget
DB01212CeftriaxoneGlutamine synthetaseenzyme
DB01212CeftriaxoneSolute carrier family 22 member 11target
DB01212CeftriaxoneSolute carrier family 22 member 6target
DB01212CeftriaxoneSolute carrier family 22 member 8target
DB01212CeftriaxoneSolute carrier family 15 member 1target
DB01137LevofloxacinDNA gyrase subunit Atarget
DB01137LevofloxacinDNA topoisomerase 4 subunit Atarget
DB01137LevofloxacinDNA topoisomerase 2-alphatarget
DB01137LevofloxacinCytochrome P450 1A2enzyme
DB01137LevofloxacinSolute carrier family 22 member 2transporter
DB01137LevofloxacinMultidrug resistance protein 1transporter
DB01137LevofloxacinSolute carrier family 22 member 4transporter
DB01137LevofloxacinSolute carrier family 22 member 6transporter
DB01137LevofloxacinCytochrome P450 3A4enzyme
DB01045RifampicinDNA-directed RNA polymerase subunit betatarget
DB01045RifampicinNuclear receptor subfamily 1 group I member 2target
DB01045RifampicinCytochrome P450 3A4enzyme
DB01045RifampicinCytochrome P450 1A2enzyme
DB01045RifampicinCytochrome P450 2C8enzyme
DB01045RifampicinUDP-glucuronosyltransferase 1-1enzyme
DB01045RifampicinCytochrome P450 2C9enzyme
DB01045RifampicinCytochrome P450 2B6enzyme
DB01045RifampicinCytochrome P450 2C19enzyme
DB01045RifampicinCanalicular multispecific organic anion transporter 2transporter
DB01045RifampicinMultidrug resistance-associated protein 5transporter
DB01045RifampicinMultidrug resistance protein 1transporter
DB01045RifampicinCanalicular multispecific organic anion transporter 1transporter
DB01045RifampicinSolute carrier organic anion transporter family member 2B1transporter
DB01045RifampicinBile salt export pumptransporter
DB01045RifampicinMultidrug resistance-associated protein 1transporter
DB01045RifampicinSolute carrier organic anion transporter family member 1A2transporter
DB01045RifampicinSolute carrier organic anion transporter family member 1B3transporter
DB01045RifampicinSolute carrier family 22 member 7transporter
DB01045RifampicinSolute carrier organic anion transporter family member 1B1transporter
DB01045RifampicinDNA-directed RNA polymerase subunit beta'target
DB01045RifampicinCytochrome P450 2A6enzyme
DB01045RifampicinCytochrome P450 2E1enzyme
DB01045RifampicinCytochrome P450 3A43enzyme
DB01045RifampicinCytochrome P450 3A5enzyme
DB01045RifampicinCytochrome P450 3A7enzyme
DB01045RifampicinCytochrome P450 4A11enzyme
DB01045RifampicinSolute carrier organic anion transporter family member 1B1target
DB01045RifampicinSolute carrier organic anion transporter family member 1A2target
DB01045RifampicinSolute carrier organic anion transporter family member 1B3target
DB01045RifampicinLanosterol 14-alpha demethylasetarget
DB01045RifampicinSerum albumintarget
DB01045RifampicinSolute carrier organic anion transporter family member 2B1target
DrugDrug NamePhaseStatusCount
DB01327Cefazolin4Recruiting1
DB06219Dalbavancin4Recruiting1
DB00080Daptomycin4Recruiting1
DB00828Fosfomycin4Recruiting1
DB00607Nafcillin4Recruiting1
DB00512Vancomycin4Recruiting1
DB01327CefazolinNot AvailableCompleted1
DB00537CiprofloxacinNot AvailableNot Yet Recruiting1
DB01190ClindamycinNot AvailableNot Yet Recruiting1
DB00254DoxycyclineNot AvailableNot Yet Recruiting1
DB02703Fusidic AcidNot AvailableNot Yet Recruiting1
DB01137LevofloxacinNot AvailableNot Yet Recruiting1
DB01017MinocyclineNot AvailableNot Yet Recruiting1
DB01165OfloxacinNot AvailableNot Yet Recruiting1
DB01045RifampicinNot AvailableNot Yet Recruiting1
DB09042Tedizolid PhosphateNot AvailableNot Yet Recruiting1
DB06149TeicoplaninNot AvailableNot Yet Recruiting1
DB00512VancomycinNot AvailableCompleted1