Treatment Naive

Also known as: Treatment naïve / Treatment-Naïve / Therapy naive / Treatment-naive / Drug-naïve patients / Treatment naive (finding)

DrugDrug NameDrug Description
DB11595AtezolizumabA monoclonal antibody used to treat advanced or metastatic urothelial carcinoma with disease progression during or up to 12 months after platinum-containing chemotherapy.
DB11945AvelumabAn anti-PD-L1 monoclonal antibody used to treat metastatic merkel cell carcinoma, metastatic urothelial carcinoma, or renal cell carcinoma.
DB06626AxitinibAn oral VEGFR and kinase inhibitor used for the treatment of advanced renal cell carcinoma after failure of one prior systemic therapy.
DB08875CabozantinibA tyrosine kinase inhibitor used to treat advanced renal cell carcinoma, hepatocellular carcinoma, and medullary thyroid cancer.
DB08930DolutegravirAn antiviral agent used for the treatment of HIV-1 infections in combination with other antiretroviral agents.
DB06210EltrombopagA thrombopoietin receptor agonist used to treat thrombocytopenia or aplastic anemia associated with various etiologies.
DB09101ElvitegravirAn antiretroviral agent used in combination with other antiretrovirals for the treatment of HIV-1 infection in antiretroviral treatment-experienced adults.
DB00530ErlotinibAn EGFR tyrosine kinase inhibitor used to treat certain small cell lung cancers or advanced metastatic pancreatic cancers.
DB00317GefitinibA tyrosine kinase inhibitor used as first-line therapy to treat non-small cell lung carcinoma (NSCLC) that meets certain genetic mutation criteria.
DB09053IbrutinibAn antineoplastic agent used to treat chronic lymphocytic leukemia, mantle cell lymphoma, and Waldenstrom's Macroglobulinemia.
DB06186IpilimumabA human cytotoxic T-lymphocyte antigen 4 (CTLA-4) blocking antibody used to treat metastatic or unresectable melanoma.
DB01029IrbesartanAn angiotensin receptor blocker used to treat hypertension, delay progression of diabetic nephropathy, and treat congestive heart failure.
DB00709LamivudineA reverse transcriptase inhibitor used to treat HIV and hepatitis B infections.
DB06650OfatumumabAn anti-CD20 antibody used for the treatment of chronic lymphocytic leukemia (CLL) in selected patients with certain treatment histories and responsiveness to anticancer medications.
DB00059PegaspargaseA modified form of L-asparagine amidohydrolase used to treat acute lymphoblastic leukemia, which is dependent on an external source of asparagine.
DB08864RilpivirineA non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with other antiretrovirals to specifically treat human immunodeficiency virus type 1 (HIV-1).
DB05521TelaprevirAn NS3/4A viral protease inhibitor used in combination with other antivirals for the curative treatment of chronic Hepatitis C Virus infections.
DB09299Tenofovir alafenamideA nucleoside analog reverse transcriptase inhibitor used for the treatment of chronic hepatitis B virus infection in adults with compensated liver disease.
DB08911TrametinibA kinase inhibitor used alone or in combination with dabrafenib to treat patients with cancers with specific BRAF mutations, such as melanoma and non-small cell lung cancer.
DrugDrug NameTargetType
DB11595AtezolizumabProgrammed cell death 1 ligand 1target
DB11595AtezolizumabProgrammed cell death protein 1target
DB11945AvelumabProgrammed cell death 1 ligand 1target
DB06626AxitinibVascular endothelial growth factor receptor 1target
DB06626AxitinibVascular endothelial growth factor receptor 2target
DB06626AxitinibVascular endothelial growth factor receptor 3target
DB06626AxitinibCytochrome P450 3A4enzyme
DB06626AxitinibCytochrome P450 3A5enzyme
DB06626AxitinibCytochrome P450 1A2enzyme
DB06626AxitinibCytochrome P450 2C19enzyme
DB06626AxitinibUDP-glucuronosyltransferase 1-1enzyme
DB06626AxitinibP-glycoprotein 1transporter
DB06626AxitinibSolute carrier organic anion transporter family member 1B1transporter
DB08875CabozantinibCytochrome P450 3A4enzyme
DB08875CabozantinibCytochrome P450 2C9enzyme
DB08875CabozantinibHepatocyte growth factor receptortarget
DB08875CabozantinibVascular endothelial growth factor receptor 2target
DB08875CabozantinibProto-oncogene tyrosine-protein kinase receptor Rettarget
DB08875CabozantinibCytochrome P450 2C8enzyme
DB08930DolutegravirUDP-glucuronosyltransferase 1-1enzyme
DB08930DolutegravirCytochrome P450 3A Subfamilyenzyme
DB08930DolutegravirIntegrasetarget
DB08930DolutegravirSolute carrier family 22 member 2transporter
DB08930DolutegravirUDP-glucuronosyltransferase 1-3enzyme
DB08930DolutegravirUDP-glucuronosyltransferase 1-9enzyme
DB08930DolutegravirATP-binding cassette sub-family G member 2transporter
DB08930DolutegravirSolute carrier family 22 member 6transporter
DB08930DolutegravirSolute carrier family 22 member 8transporter
DB08930DolutegravirP-glycoprotein 1transporter
DB08930DolutegravirMultidrug and toxin extrusion protein 1transporter
DB08930DolutegravirSerum albumincarrier
DB08930Dolutegraviralpha1-acid glycoproteincarrier
DB06210EltrombopagThrombopoietin receptortarget
DB06210EltrombopagCytochrome P450 2C8enzyme
DB06210EltrombopagCytochrome P450 1A2enzyme
DB06210EltrombopagUDP-glucuronosyltransferase 1-1enzyme
DB06210EltrombopagUDP-glucuronosyltransferase 1-3enzyme
DB06210EltrombopagSolute carrier organic anion transporter family member 1B1transporter
DB06210EltrombopagATP-binding cassette sub-family G member 2transporter
DB06210EltrombopagUDP-glucuronosyltransferase 1-9enzyme
DB09101ElvitegravirIntegrasetarget
DB09101ElvitegravirCytochrome P450 3A4enzyme
DB09101ElvitegravirUDP-glucuronosyltransferase 1-1enzyme
DB00530ErlotinibEpidermal growth factor receptortarget
DB00530ErlotinibCytochrome P450 3A4enzyme
DB00530ErlotinibATP-binding cassette sub-family G member 2transporter
DB00530ErlotinibP-glycoprotein 1transporter
DB00530ErlotinibNuclear receptor subfamily 1 group I member 2target
DB00530ErlotinibCytochrome P450 3A5enzyme
DB00530ErlotinibCytochrome P450 1A1enzyme
DB00530ErlotinibCytochrome P450 1A2enzyme
DB00530ErlotinibCytochrome P450 1B1enzyme
DB00530ErlotinibCytochrome P450 2D6enzyme
DB00530ErlotinibCytochrome P450 2C8enzyme
DB00530ErlotinibUDP-glucuronosyltransferase 1-1enzyme
DB00530ErlotinibSerum albumincarrier
DB00530ErlotinibAlpha-1-acid glycoprotein 1carrier
DB00530ErlotinibSolute carrier organic anion transporter family member 2B1transporter
DB00530ErlotinibEpidermal growth factor receptorenzyme
DB00317GefitinibEpidermal growth factor receptortarget
DB00317GefitinibCytochrome P450 3A4enzyme
DB00317GefitinibCytochrome P450 2D6enzyme
DB00317GefitinibP-glycoprotein 1transporter
DB00317GefitinibATP-binding cassette sub-family G member 2transporter
DB00317GefitinibCytochrome P450 3A5enzyme
DB00317GefitinibCytochrome P450 1A1enzyme
DB00317GefitinibCytochrome P450 2C9enzyme
DB00317GefitinibCytochrome P450 2C19enzyme
DB00317GefitinibSerum albumincarrier
DB00317GefitinibAlpha-1-acid glycoprotein 1carrier
DB09053IbrutinibTyrosine-protein kinase BTKtarget
DB09053IbrutinibCytochrome P450 3A4enzyme
DB09053IbrutinibCytochrome P450 3A5enzyme
DB09053IbrutinibSerum albumincarrier
DB09053Ibrutinibalpha1-acid glycoproteincarrier
DB09053IbrutinibCytochrome P450 2D6enzyme
DB06186IpilimumabCytotoxic T-lymphocyte protein 4target
DB01029IrbesartanType-1 angiotensin II receptortarget
DB01029IrbesartanTranscription factor AP-1target
DB01029IrbesartanCytochrome P450 2C9enzyme
DB01029IrbesartanCytochrome P450 2C8enzyme
DB01029IrbesartanUDP-glucuronosyltransferase 1-3enzyme
DB01029IrbesartanProstaglandin G/H synthase 1enzyme
DB01029IrbesartanCytochrome P450 3A4enzyme
DB01029IrbesartanSerum albumincarrier
DB01029Irbesartanalpha1-acid glycoproteincarrier
DB00709LamivudineDNAtarget
DB00709LamivudineProtein Ptarget
DB00709LamivudineMultidrug resistance-associated protein 1transporter
DB00709LamivudineSolute carrier family 22 member 6transporter
DB00709LamivudineATP-binding cassette sub-family G member 2transporter
DB00709LamivudineReverse transcriptase/RNaseHtarget
DB00709LamivudineSolute carrier family 22 member 1transporter
DB00709LamivudineSolute carrier family 22 member 2transporter
DB00709LamivudineSolute carrier family 22 member 3transporter
DB00709LamivudineDeoxycytidine kinaseenzyme
DB00709LamivudineUMP-CMP kinaseenzyme
DB00709LamivudinePhosphoglycerate kinase 1enzyme
DB00709LamivudineNucleoside diphosphate kinase Aenzyme
DB00709LamivudineNucleoside diphosphate kinase Benzyme
DB00709LamivudineCholine-phosphate cytidylyltransferase Aenzyme
DB00709LamivudineEthanolamine-phosphate cytidylyltransferaseenzyme
DB00709LamivudineP-glycoprotein 1transporter
DB00709LamivudineMultidrug resistance-associated protein 4transporter
DB00709LamivudineCanalicular multispecific organic anion transporter 2transporter
DB00709LamivudineCanalicular multispecific organic anion transporter 1transporter
DB00709Lamivudine5'(3')-deoxyribonucleotidase, cytosolic typeenzyme
DB00709LamivudineSerum albumincarrier
DB06650OfatumumabB-lymphocyte antigen CD20target
DB00059PegaspargaseL-asparaginetarget
DB00059PegaspargaseThyroxine-binding globulincarrier
DB08864RilpivirineCytochrome P450 3A4enzyme
DB08864RilpivirineReverse transcriptase/RNaseHtarget
DB08864RilpivirineNuclear receptor subfamily 1 group I member 2target
DB08864RilpivirineCytochrome P450 2C19enzyme
DB08864RilpivirineCytochrome P450 2B6enzyme
DB08864RilpivirineP-glycoprotein 1transporter
DB08864RilpivirineATP-binding cassette sub-family G member 2transporter
DB08864RilpivirineSolute carrier organic anion transporter family member 1B1transporter
DB08864RilpivirineSolute carrier organic anion transporter family member 1B3transporter
DB08864RilpivirineSerum albumincarrier
DB08864RilpivirineCytochrome P450 2D6enzyme
DB08864RilpivirineCytochrome P450 2C9enzyme
DB08864RilpivirineCytochrome P450 2C8enzyme
DB08864RilpivirineCytochrome P450 2E1enzyme
DB05521TelaprevirCytochrome P450 3A4enzyme
DB05521TelaprevirNS3/4A proteintarget
DB05521TelaprevirP-glycoprotein 1transporter
DB05521TelaprevirSerum albumincarrier
DB05521TelaprevirAlpha-1-acid glycoprotein 1carrier
DB05521TelaprevirSolute carrier organic anion transporter family member 1B1target
DB05521TelaprevirSolute carrier organic anion transporter family member 2B1target
DB09299Tenofovir alafenamideReverse transcriptase/RNaseHtarget
DB09299Tenofovir alafenamideP-glycoprotein 1transporter
DB09299Tenofovir alafenamideMultidrug resistance-associated protein 4transporter
DB09299Tenofovir alafenamideSolute carrier family 22 member 6transporter
DB09299Tenofovir alafenamideSolute carrier family 22 member 8transporter
DB09299Tenofovir alafenamideLysosomal protective proteinenzyme
DB09299Tenofovir alafenamideLiver carboxylesterase 1enzyme
DB09299Tenofovir alafenamideATP-binding cassette sub-family G member 2transporter
DB09299Tenofovir alafenamideSolute carrier organic anion transporter family member 1B1transporter
DB09299Tenofovir alafenamideSolute carrier organic anion transporter family member 1B3transporter
DB09299Tenofovir alafenamideReverse transcriptasetarget
DB09299Tenofovir alafenamideDNA polymerasetarget
DB09299Tenofovir alafenamideSerum albumincarrier
DB09299Tenofovir alafenamideCytochrome P450 3A4enzyme
DB09299Tenofovir alafenamideAdenylate kinase isoenzyme 1enzyme
DB09299Tenofovir alafenamideAdenylate kinase 2, mitochondrialenzyme
DB09299Tenofovir alafenamideNucleoside diphosphate kinase Aenzyme
DB09299Tenofovir alafenamideNucleoside diphosphate kinase Benzyme
DB08911TrametinibCytochrome P450 2C8enzyme
DB08911TrametinibCytochrome P450 3A4enzyme
DB08911TrametinibDual specificity mitogen-activated protein kinase kinase 1target
DB08911TrametinibDual specificity mitogen-activated protein kinase kinase 2target
DrugDrug NamePhaseStatusCount
DB00531Cyclophosphamide1Terminated1
DB01204Mitoxantrone1Terminated1
DB00635Prednisone1Terminated1
DB00541Vincristine1Terminated1
DB12785Furaprevir2Completed1
DB00811Ribavirin2Completed1
DB12785Furaprevir3Completed1
DB00008Peginterferon alfa-2a3Completed1
DB00811Ribavirin3Completed2
DB05521Telaprevir3Completed1