Metastatic Non-Small Cell Lung Cancer

Also known as: Metastatic untreated non small cell lung cancer / Non-Small Cell Lung Cancer Metastatic / Metastatic Non-small Cell Lung Cancer (NSCLC) / Metastatic Non-Small-Cell Lung Cancer / Lung cancer non-small cell stage IV / Non-small cell lung cancer stage IV

DrugDrug NameDrug Description
DB08916AfatinibAn antineoplastic agent used for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) with non-resistant EGFR mutations or resistance to platinum-based chemotherapy.
DB11595AtezolizumabA monoclonal antibody used to treat advanced or metastatic urothelial carcinoma with disease progression during or up to 12 months after platinum-containing chemotherapy.
DB12267BrigatinibAn anaplastic lymphoma kinase inhibitor used to treat anaplastic lymphoma kinase positive metastatic non small cell lung cancer.
DB08865CrizotinibA receptor tyrosine kinase inhibitor used to treat metastatic non-small cell lung cancer (NSCLC) where the tumors have been confirmed to be anaplastic lymphoma kinase (ALK), or ROS1-positive.
DB11963DacomitinibA medication used to treat non small cell lung cancer with EGFR exon 19 deletion of exon 21 L858R substitution.
DB01248DocetaxelA taxoid antineoplastic agent used in the treatment of various cancers, such as locally advanced or metastatic breast cancer, metastatic prostate cancer, gastric adenocarcinoma, and head and neck cancer.
DB00530ErlotinibAn EGFR tyrosine kinase inhibitor used to treat certain small cell lung cancers or advanced metastatic pancreatic cancers.
DB00317GefitinibA tyrosine kinase inhibitor used as first-line therapy to treat non-small cell lung carcinoma (NSCLC) that meets certain genetic mutation criteria.
DB09559NecitumumabA monoclonal antibody used to treat metastatic squamous non-small cell lung cancer.
DB09330OsimertinibA tyrosine kinase inhibitor used in the treatment of certain types of non-small cell lung carcinoma.
DB01229PaclitaxelA taxoid chemotherapeutic agent used as first-line and subsequent therapy for the treatment of advanced carcinoma of the ovary, and other various cancers including breast and lung cancer.
DrugDrug NameTargetType
DB08916AfatinibEpidermal growth factor receptortarget
DB08916AfatinibReceptor tyrosine-protein kinase erbB-2target
DB08916AfatinibReceptor tyrosine-protein kinase erbB-4target
DB08916AfatinibP-glycoprotein 1transporter
DB08916AfatinibATP-binding cassette sub-family G member 2transporter
DB11595AtezolizumabProgrammed cell death 1 ligand 1target
DB12267BrigatinibALK tyrosine kinase receptortarget
DB12267BrigatinibEpidermal growth factor receptortarget
DB12267BrigatinibTyrosine-protein kinase ABL1target
DB12267BrigatinibInsulin-like growth factor 1 receptortarget
DB12267BrigatinibReceptor-type tyrosine-protein kinase FLT3target
DB12267BrigatinibCytochrome P450 2C8enzyme
DB12267BrigatinibCytochrome P450 3A4enzyme
DB12267BrigatinibInsulin receptortarget
DB12267BrigatinibHepatocyte growth factor receptortarget
DB12267BrigatinibReceptor tyrosine-protein kinase erbB-4target
DB12267BrigatinibReceptor tyrosine-protein kinase erbB-2target
DB12267BrigatinibATP-binding cassette sub-family B member 5transporter
DB12267BrigatinibATP-binding cassette sub-family G member 2transporter
DB12267BrigatinibSolute carrier family 22 member 1transporter
DB12267BrigatinibMultidrug and toxin extrusion protein 1transporter
DB12267BrigatinibMultidrug and toxin extrusion protein 2transporter
DB12267BrigatinibCytochrome P450 3A Subfamilyenzyme
DB08865CrizotinibCytochrome P450 3A4enzyme
DB08865CrizotinibCytochrome P450 3A5enzyme
DB08865CrizotinibP-glycoprotein 1transporter
DB08865CrizotinibALK tyrosine kinase receptortarget
DB08865CrizotinibHepatocyte growth factor receptortarget
DB08865CrizotinibCytochrome P450 2B6enzyme
DB08865CrizotinibCytochrome P450 3A Subfamilyenzyme
DB11963DacomitinibCytochrome P450 2D6enzyme
DB11963DacomitinibSerum albumincarrier
DB11963DacomitinibCytochrome P450 3A4enzyme
DB11963DacomitinibCytochrome P450 2C9enzyme
DB11963DacomitinibUDP-glucuronosyltransferase 1-1enzyme
DB11963DacomitinibP-glycoprotein 1transporter
DB11963DacomitinibATP-binding cassette sub-family G member 2transporter
DB11963DacomitinibSolute carrier family 22 member 1transporter
DB11963DacomitinibEpidermal growth factor receptortarget
DB01248DocetaxelApoptosis regulator Bcl-2target
DB01248DocetaxelTubulin beta-1 chaintarget
DB01248DocetaxelCytochrome P450 3A4enzyme
DB01248DocetaxelCytochrome P450 3A5enzyme
DB01248DocetaxelCytochrome P450 3A7enzyme
DB01248DocetaxelP-glycoprotein 1transporter
DB01248DocetaxelMultidrug resistance-associated protein 7transporter
DB01248DocetaxelCytochrome P450 1B1enzyme
DB01248DocetaxelMicrotubule-associated protein 2target
DB01248DocetaxelMicrotubule-associated protein 4target
DB01248DocetaxelMicrotubule-associated protein tautarget
DB01248DocetaxelSolute carrier organic anion transporter family member 1B3transporter
DB01248DocetaxelSolute carrier family 22 member 7transporter
DB01248DocetaxelATP-binding cassette sub-family G member 2transporter
DB01248DocetaxelCanalicular multispecific organic anion transporter 1transporter
DB01248DocetaxelMultidrug resistance-associated protein 1transporter
DB01248DocetaxelNuclear receptor subfamily 1 group I member 2target
DB00530ErlotinibEpidermal growth factor receptortarget
DB00530ErlotinibCytochrome P450 3A4enzyme
DB00530ErlotinibATP-binding cassette sub-family G member 2transporter
DB00530ErlotinibP-glycoprotein 1transporter
DB00530ErlotinibNuclear receptor subfamily 1 group I member 2target
DB00530ErlotinibCytochrome P450 3A5enzyme
DB00530ErlotinibCytochrome P450 1A1enzyme
DB00530ErlotinibCytochrome P450 1A2enzyme
DB00530ErlotinibCytochrome P450 1B1enzyme
DB00530ErlotinibCytochrome P450 2D6enzyme
DB00530ErlotinibCytochrome P450 2C8enzyme
DB00530ErlotinibUDP-glucuronosyltransferase 1-1enzyme
DB00530ErlotinibSerum albumincarrier
DB00530ErlotinibAlpha-1-acid glycoprotein 1carrier
DB00530ErlotinibSolute carrier organic anion transporter family member 2B1transporter
DB00317GefitinibEpidermal growth factor receptortarget
DB00317GefitinibCytochrome P450 3A4enzyme
DB00317GefitinibCytochrome P450 2D6enzyme
DB00317GefitinibP-glycoprotein 1transporter
DB00317GefitinibATP-binding cassette sub-family G member 2transporter
DB00317GefitinibCytochrome P450 3A5enzyme
DB00317GefitinibCytochrome P450 1A1enzyme
DB00317GefitinibCytochrome P450 2C9enzyme
DB00317GefitinibCytochrome P450 2C19enzyme
DB00317GefitinibSerum albumincarrier
DB00317GefitinibAlpha-1-acid glycoprotein 1carrier
DB09559NecitumumabEpidermal growth factor receptortarget
DB09330OsimertinibEpidermal growth factor receptortarget
DB09330OsimertinibP-glycoprotein 1transporter
DB09330OsimertinibATP-binding cassette sub-family G member 2transporter
DB09330OsimertinibCytochrome P450 3A4enzyme
DB09330OsimertinibCytochrome P450 1A2enzyme
DB01229PaclitaxelApoptosis regulator Bcl-2target
DB01229PaclitaxelTubulin beta-1 chaintarget
DB01229PaclitaxelCytochrome P450 2C8enzyme
DB01229PaclitaxelCytochrome P450 3A4enzyme
DB01229PaclitaxelCytochrome P450 3A5enzyme
DB01229PaclitaxelCytochrome P450 3A7enzyme
DB01229PaclitaxelBile salt export pumptransporter
DB01229PaclitaxelP-glycoprotein 1transporter
DB01229PaclitaxelMultidrug resistance-associated protein 1transporter
DB01229PaclitaxelMultidrug resistance-associated protein 7transporter
DB01229PaclitaxelCytochrome P450 19A1enzyme
DB01229PaclitaxelCytochrome P450 1B1enzyme
DB01229PaclitaxelSolute carrier organic anion transporter family member 1B3transporter
DB01229PaclitaxelNuclear receptor subfamily 1 group I member 2target
DB01229PaclitaxelMicrotubule-associated protein 4target
DB01229PaclitaxelMicrotubule-associated protein 2target
DB01229PaclitaxelMicrotubule-associated protein tautarget
DB01229PaclitaxelCanalicular multispecific organic anion transporter 1transporter
DrugDrug NamePhaseStatusCount
DB00041Aldesleukin0Recruiting1
DB11945Avelumab0Recruiting1
DB09035Nivolumab0Recruiting1
DB09037Pembrolizumab0Recruiting1
DB12001Abemaciclib1Recruiting1
DB15327Abivertinib1Active Not Recruiting1
DB00041Aldesleukin1Recruiting1
DB00958Carboplatin1Recruiting1
DB09063Ceritinib1Recruiting1
DB00002Cetuximab1Recruiting1
DB00515Cisplatin1Recruiting1
DB00531Cyclophosphamide1Active Not Recruiting1
DB00531Cyclophosphamide1Recruiting1
DB11963Dacomitinib1Recruiting1
DB14825Danvatirsen1Recruiting1
DB01248Docetaxel1Recruiting1
DB11714Durvalumab1Recruiting1
DB11718Encorafenib1Recruiting1
DB14860Ensartinib1Recruiting1
DB01073Fludarabine1Recruiting1
DB11679Fruquintinib1Recruiting1
DB00441Gemcitabine1Recruiting3
DB05477MUC1 Dendritic Cell Vaccine1Recruiting1
DB00683Midazolam1Recruiting1
DB09035Nivolumab1Recruiting2
DB15088Oleclumab1Recruiting1
DB09330Osimertinib1Recruiting1
DB01229Paclitaxel1Recruiting3
DB09037Pembrolizumab1Active Not Recruiting1
DB09037Pembrolizumab1Recruiting1
DB00642Pemetrexed1Recruiting1
DB05992Plinabulin1Recruiting1
DB00135Tyrosine1Recruiting1
DB13104X-3961Recruiting1
DB05220Alisertib1 / 2Terminated1
DB11945Avelumab1 / 2Recruiting1
DB06626Axitinib1 / 2Recruiting1
DB11714Durvalumab1 / 2Recruiting1
DB00530Erlotinib1 / 2Terminated1
DB09073Palbociclib1 / 2Recruiting1
DB11771Tremelimumab1 / 2Recruiting1
DB15310Vactosertib1 / 2Recruiting1
DB12218AZD-53632Active Not Recruiting1
DB15327Abivertinib2Recruiting1
DB00041Aldesleukin2Recruiting1
DB11363Alectinib2Recruiting1
DB00112Bevacizumab2Completed1
DB00958Carboplatin2Completed1
DB00958Carboplatin2Not Yet Recruiting2
DB00515Cisplatin2Completed1
DB00515Cisplatin2Suspended1
DB00515Cisplatin2Terminated1
DB00531Cyclophosphamide2Recruiting1
DB01248Docetaxel2Completed2
DB01248Docetaxel2Recruiting1
DB01248Docetaxel2Suspended1
DB11714Durvalumab2Active Not Recruiting1
DB11714Durvalumab2Not Yet Recruiting1
DB11717Epacadostat2Active Not Recruiting2
DB00530Erlotinib2Completed2
DB01073Fludarabine2Recruiting1
DB00441Gemcitabine2Completed2
DB00441Gemcitabine2Terminated1
DB01167Itraconazole2Terminated1
DB12167LY-30234142Terminated1
DB00331Metformin2Terminated1
DB05774Necitumumab2Terminated1
DB09559Necitumumab2Terminated1
DB06192Nimotuzumab2Terminated1
DB09035Nivolumab2Withdrawn1
DB09074Olaparib2Active Not Recruiting1
DB01229Paclitaxel2Completed1
DB01229Paclitaxel2Not Yet Recruiting1
DB09037Pembrolizumab2Active Not Recruiting2
DB09037Pembrolizumab2Not Yet Recruiting1
DB09037Pembrolizumab2Recruiting3
DB00642Pemetrexed2Active Not Recruiting1
DB00642Pemetrexed2Completed3
DB00642Pemetrexed2Not Yet Recruiting2
DB00642Pemetrexed2Recruiting1
DB12257Platinum2Active Not Recruiting1
DB05578Ramucirumab2Completed1
DB12183Sapitinib2Active Not Recruiting1
DB12048Savolitinib2Active Not Recruiting1
DB11689Selumetinib2Active Not Recruiting1
DB04900Thymalfasin2Withdrawn1
DB12200Tivantinib2Completed1
DB00577Valaciclovir2Recruiting1
DB05294Vandetanib2Active Not Recruiting1
DB00361Vinorelbine2Recruiting1
DB11925Vistusertib2Active Not Recruiting1
DB01248Docetaxel2 / 3Terminated1
DB12047Ganetespib2 / 3Terminated1
DB00112Bevacizumab3Completed1
DB00112Bevacizumab3Terminated1
DB00958Carboplatin3Completed1
DB00515Cisplatin3Active Not Recruiting2
DB00515Cisplatin3Terminated1
DB01248Docetaxel3Recruiting2
DB01248Docetaxel3Terminated1
DB00530Erlotinib3Active Not Recruiting1
DB12047Ganetespib3Terminated1
DB00317Gefitinib3Active Not Recruiting1
DB00441Gemcitabine3Active Not Recruiting2
DB06186Ipilimumab3Recruiting1
DB09078Lenvatinib3Recruiting1
DB09035Nivolumab3Recruiting1
DB09330Osimertinib3Active Not Recruiting1
DB01229Paclitaxel3Completed1
DB09037Pembrolizumab3Recruiting1
DB00642Pemetrexed3Active Not Recruiting1
DB00642Pemetrexed3Terminated1
DB05578Ramucirumab3Active Not Recruiting1
DB00958Carboplatin4Terminated1
DB00530Erlotinib4Suspended1
DB00317Gefitinib4Terminated1
DB00441Gemcitabine4Terminated1
DB00361Vinorelbine4Completed1
DB00135TyrosineNot AvailableRecruiting1