Disseminated Sclerosis

Also known as: MS (Multiple Sclerosis) / MS / Multiple Sclerosis (MS) / Multiple Sclerosis / Multiple Sclerosis, MS / Generalized multiple sclerosis / Disseminated multiple sclerosis / Sclerosis multiple

DrugDrug NameDrug Description
DB00915AmantadineAn antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake. [PubChem]
DB00993AzathioprineAn immunosuppressive antimetabolite pro-drug. It is an imidazolyl derivative of 6-mercaptopurine and many of its biological effects are similar to those of the parent compound. Azathioprine is converted into 6-mercaptopurine in the body where it blocks purine metabolism and DNA synthesis.
DB00181BaclofenBaclofen is a gamma-amino-butyric acid (GABA) derivative used as a skeletal muscle relaxant. Baclofen stimulates GABA-B receptors leading to decreased frequency and amplitude of muscle spasms. It is especially useful in treating muscle spasticity associated with spinal cord injury. It appears to act primarily at the spinal cord level by inhibiting spinal polysynaptic afferent pathways and, to a lesser extent, monosynaptic afferent pathways.
DB09061CannabidiolCannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical implications are currently being investigated, CBD has shown promise as a therapeutic and pharmaceutical drug target. In particular, CBD has shown promise as an analgesic, anticonvulsant, muscle relaxant, anxiolytic, antipsychotic and has shown neuroprotective, anti-inflammatory, and antioxidant activity, among other currently investigated uses [A32477, A32469]. CBD's exact place within medical practice is still currently hotly debated, however as the body of evidence grows and legislation changes to reflect its wide-spread use, public and medical opinion have changed significantly with regards to its usefulness in a number of medical conditions ranging from anxiety to epilepsy. From a pharmacological perspective, Cannabis' (and CBD's) diverse receptor profile explains its potential application for such a wide variety of medical conditions. Cannabis contains more than 400 different chemical compounds, of which 61 are considered cannabinoids, a class of compounds that act upon endogenous cannabinoid receptors of the body [A32584]. Cannabinoid receptors are utilized endogenously by the body through the endocannabinoid system, which includes a group of lipid proteins, enzymes, and receptors that are involved in many physiological processes. Through its modulation of neurotransmitter release, the endocannabinoid system regulates cognition, pain sensation, appetite, memory, sleep, immune function, and mood among many other bodily systems. These effects are largely mediated through two members of the G-protein coupled receptor family, cannabinoid receptors 1 and 2 (CB1 and CB2)[A32585,A32824]. CB1 receptors are found in both the central and peripheral nervous systems, with the majority of receptors localized to the hippocampus and amygdala of the brain. Physiological effects of using cannabis make sense in the context of its receptor activity as the hippocampus and amygdala are primarily involved with regulation of memory, fear, and emotion. In contrast, CB2 receptors are mainly found peripherally in immune cells, lymphoid tissue, and peripheral nerve terminals [A32676]. Tetrahydrocannabinol (THC) and cannabidiol (CBD) are two types of cannabinoids found naturally in the resin of the marijuana plant, both of which interact with the cannabinoid receptors that are found throughout the body. Although THC and CBD have been the most studied cannabinoids, there are many others identified to date including cannabinol (CBN), cannabigerol (CBG), [DB14050] (CBDV), and [DB11755] (THCV) that can be found within the medical cannabis [A32830]. While both CBD and THC are used for medicinal purposes, they have different receptor activity, function, and physiological effects. If not provided in their activated form (such as through synthetic forms of THC like [DB00470] or [DB00486]), THC and CBD are obtained through conversion from their precursors, tetrahydrocannabinolic acid-A (THCA-A) and cannabidiolic acid (CBDA), through decarboxylation reactions. This can be achieved through heating, smoking, vaporization, or baking of dried unfertilized female cannabis flowers. The primary psychoactive component of Cannabis, delta 9-tetrahydrocannabinol (Δ9-THC), demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors. This activity results in the well-known effects of smoking cannabis such as increased appetite, reduced pain, and changes in emotional and cognitive processes. In contrast to THC's weak agonist activity, CBD has been shown to act as a negative allosteric modulator of the cannabinoid CB1 receptor, the most abundant G-Protein Coupled Receptor (GPCR) in the body [A32469]. Allosteric regulation is achieved through the modulation of receptor activity on a functionally distinct site from the agonist or antagonist binding site which is clinically significant as direct agonists (such as THC) are limited by their psychomimetic effects such as changes to mood, memory, and anxiety[A32469]. In addition to the well-known activity on CB1 and CB2 receptors, there is further evidence that CBD also activates 5-HT1A/2A/3A serotonergic and TRPV1–2 vanilloid receptors, antagonizes alpha-1 adrenergic and µ-opioid receptors, inhibits synaptosomal uptake of noradrenaline, dopamine, serotonin and gamma-aminobutyric acid (GABA), and cellular uptake of anandamide, acts on mitochondria Ca2+ stores, blocks low-voltage-activated (T-type) Ca2+ channels, stimulates activity of the inhibitory glycine-receptor, and inhibits activity of fatty amide hydrolase (FAAH) [A31555, A31574]. CBD is currently available in Canada within a 1:1 formulation with tetrahydrocannbinol (THC) (as the formulation known as "nabiximols") as the brand name product Sativex. It is approved for use as adjunctive treatment for symptomatic relief of spasticity in adult patients with multiple sclerosis (MS). Sativex was also given a conditional Notice of Compliance (NOC/c) for use as adjunctive treatment for the symptomatic relief of neuropathic pain in adult patients with multiple sclerosis and as adjunctive analgesic treatment for moderate to severe pain in adult patients with advanced cancer [L886]. In April 2018, a Food and Drug Administration advisory panel unanimously recommended approval of Epidiolex (cannabidiol oral solution) for the treatment of two rare forms of epilepsy - Lennox-Gastaut syndrome and Dravet syndrome, which are among the two most difficult types of epilepsy to treat [L2721, L2719]. Epidiolex was granted Orphan Drug designation as well as Fast Track Approval from the FDA for further study in these hard to treat conditions. Notably, phase 3 clinical trials of Epidiolex have demonstrated clinically significant improvement in Lennox-Gastaut syndrome and Dravet syndrome [L2720]. On June 25th, 2018, Epidiolex was approved by the FDA to be the first CBD-based product available on the US market.
DB06637DalfampridineDalfampridine is a potassium channel blocker used to help multiple sclerosis patients walk. This is the first drug that was specifically approved to help with mobility in these patients. FDA approved on January 22, 2010.
DB01219DantroleneChemically, dantrolene is a hydantoin derivative, but does not exhibit antiepileptic activity like other hydantoin derivates such as phenytoin.
DB08908Dimethyl fumarateDimethyl fumarate is an anti-inflammatory. It is indicated for multiple sclerosis patients with relapsing forms and is also being investigated for the treatment of psoriasis. The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MMF up-regulates the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway that is activated in response to oxidative stress. Dimethyl fumarate is marketed under the brand name Tecfidera.
DB08868FingolimodFingolimod is a sphingosine 1-phosphate receptor modulator indicated and approved for the treatment of relapsing-remitting multiple sclerosis.
DB05259GlatiramerGlatiramer acetate consists of the acetate salts of synthetic polypeptides, containing four naturally occurring amino acids: L-glutamic acid, L-alanine, L-tyrosine, and L-lysine with an average molar fraction of 0.141, 0.427, 0.095, and 0.338, respectively. The average molecular weight of glatiramer acetate is 5,000-9,000 daltons. It is an immunomodulator, licensed in much of the world for reduced frequency of relapses in relapsing-remitting multiple sclerosis.
DB00563MethotrexateAn antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofolate dehydrogenase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
DB00745ModafinilModafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron activation is associated with psychoactivation and euphoria. The exact mechanism of action is unclear, although in vitro studies have shown it to inhibit the reuptake of dopamine by binding to the dopamine reuptake pump, and lead to an increase in extracellular dopamine. Modafinil activates glutamatergic circuits while inhibiting GABA.
DB09122Peginterferon beta-1aPeginterferon beta-1a is an interferon beta-1a to which a single, linear 20,000 dalton (Da) methoxy poly(ethyleneglycol)-O-2-methylpropionaldehyde (PEG) molecule is covalently attached to the alpha amino group of the N-terminal amino acid residue. The amino acid sequence of the recombinant interferon beta-1a is identical to that of the human interferon beta counterpart. Although it's mechanism of action is unknown, peginterferon beta-1a is indicated for use in relapsing forms of Multiple Sclerosis (MS). Interferon beta was the first drug to alter the course of MS, however multiple side effects and the need for weekly subcutaneous injection make it difficult to use. Interferon beta was subsequently PEGylated (covalently attached to polyethylene glycol) to extend its duration of action to every 14 days. It is currently available as peginterferon beta-1a as the FDA-approved product Plegridy.
DB08880TeriflunomideTeriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of hepatoxicity and teratogenicity for patients using teriflunomide.
DrugDrug NameTargetType
DB00915AmantadineD(2) dopamine receptortarget
DB00915AmantadineMatrix protein 2target
DB00915AmantadineAromatic-L-amino-acid decarboxylaseenzyme
DB00915AmantadineAmine oxidase [flavin-containing] Benzyme
DB00915AmantadineSolute carrier family 22 member 2transporter
DB00915AmantadineSolute carrier family 22 member 1transporter
DB00915AmantadineGlutamate receptor ionotropic, NMDA 3Atarget
DB00915AmantadineNeuronal acetylcholine receptor subunit alpha-7target
DB00915AmantadineNeuronal acetylcholine receptor subunit alpha-4target
DB00915AmantadineNeuronal acetylcholine receptor subunit alpha-3target
DB00993AzathioprineHypoxanthine-guanine phosphoribosyltransferasetarget
DB00993AzathioprineThiopurine S-methyltransferaseenzyme
DB00993AzathioprineXanthine dehydrogenase/oxidaseenzyme
DB00993AzathioprineGlutathione S-transferase A1enzyme
DB00993AzathioprineGlutathione S-transferase A2enzyme
DB00993AzathioprineGlutathione S-transferase Mu 1enzyme
DB00993AzathioprineRas-related C3 botulinum toxin substrate 1target
DB00993AzathioprineCytochrome P450 1A2enzyme
DB00181BaclofenGamma-aminobutyric acid type B receptor subunit 1target
DB00181BaclofenGamma-aminobutyric acid type B receptor subunit 2target
DB00181BaclofenSolute carrier family 22 member 8transporter
DB09061CannabidiolCytochrome P450 2C9enzyme
DB09061CannabidiolCytochrome P450 2C19enzyme
DB09061CannabidiolCytochrome P450 2D6enzyme
DB09061CannabidiolCytochrome P450 3A4enzyme
DB09061CannabidiolCannabinoid receptor 1target
DB09061CannabidiolCannabinoid receptor 2target
DB09061CannabidiolG-protein coupled receptor 12target
DB09061CannabidiolGlycine receptor subunit alpha-1target
DB09061CannabidiolGlycine receptor (alpha-1/beta)target
DB09061CannabidiolGlycine receptor subunit alpha-3target
DB09061CannabidiolN-arachidonyl glycine receptortarget
DB09061CannabidiolG-protein coupled receptor 55target
DB09061Cannabidiol5-hydroxytryptamine receptor 1Atarget
DB09061Cannabidiol5-hydroxytryptamine receptor 2Atarget
DB09061CannabidiolNeuronal acetylcholine receptor subunit alpha-7target
DB09061CannabidiolDelta-type opioid receptortarget
DB09061CannabidiolMu-type opioid receptortarget
DB09061CannabidiolPeroxisome proliferator-activated receptor gammatarget
DB09061CannabidiolCytochrome P450 3A5enzyme
DB09061CannabidiolAcetyl-CoA acetyltransferase, mitochondrialenzyme
DB09061CannabidiolArylalkylamine N-acetyltransferaseenzyme
DB09061CannabidiolCatalaseenzyme
DB09061CannabidiolProstaglandin G/H synthase 1enzyme
DB09061CannabidiolProstaglandin G/H synthase 2enzyme
DB09061CannabidiolCytochrome P450 3A7enzyme
DB09061CannabidiolCytochrome P450 1A1enzyme
DB09061CannabidiolCytochrome P450 1A2enzyme
DB09061CannabidiolCytochrome P450 1B1enzyme
DB09061CannabidiolSn1-specific diacylglycerol lipase alphaenzyme
DB09061CannabidiolFatty-acid amide hydrolase 1enzyme
DB09061CannabidiolGlutathione reductase, mitochondrialenzyme
DB09061CannabidiolGlutathione peroxidase 1enzyme
DB09061Cannabidiol3-hydroxy-3-methylglutaryl-coenzyme A reductaseenzyme
DB09061CannabidiolIndoleamine 2,3-dioxygenase 1enzyme
DB09061CannabidiolArachidonate 5-lipoxygenaseenzyme
DB09061CannabidiolArachidonate 15-lipoxygenaseenzyme
DB09061CannabidiolN-acylethanolamine-hydrolyzing acid amidaseenzyme
DB09061CannabidiolQuinone oxidoreductaseenzyme
DB09061CannabidiolN-acyl-phosphatidylethanolamine-hydrolyzing phospholipase Denzyme
DB09061CannabidiolPhospholipase A2enzyme
DB09061CannabidiolSteroid 17-alpha-hydroxylase/17,20 lyaseenzyme
DB09061CannabidiolSuperoxide dismutase [Cu-Zn]enzyme
DB09061CannabidiolSphingomyelin phosphodiesteraseenzyme
DB09061CannabidiolMultidrug resistance-associated protein 1transporter
DB09061CannabidiolATP-binding cassette sub-family G member 2transporter
DB09061CannabidiolEquilibrative nucleoside transporter 1transporter
DB09061CannabidiolTransient receptor potential cation channel subfamily V member 1target
DB09061CannabidiolVoltage-dependent T-type calcium channel subunit alpha-1Gtarget
DB09061CannabidiolVoltage-dependent T-type calcium channel subunit alpha-1Htarget
DB09061CannabidiolVoltage-dependent T-type calcium channel subunit alpha-1Itarget
DB09061CannabidiolTransient receptor potential cation channel subfamily A member 1target
DB09061CannabidiolTransient receptor potential cation channel subfamily M member 8target
DB09061CannabidiolTransient receptor potential cation channel subfamily V member 2target
DB09061CannabidiolTransient receptor potential cation channel subfamily V member 3target
DB09061CannabidiolTransient receptor potential cation channel subfamily V member 4target
DB09061CannabidiolVoltage-dependent anion-selective channel protein 1target
DB09061Cannabidiol5-hydroxytryptamine receptor 3Atarget
DB09061CannabidiolAdenosine receptor A1target
DB06637DalfampridineCytochrome P450 2E1enzyme
DB06637DalfampridinePotassium voltage-gated channel subfamily D member 2target
DB06637DalfampridinePotassium voltage-gated channel subfamily D member 3target
DB06637DalfampridinePotassium voltage-gated channel subfamily A member 1target
DB06637DalfampridinePotassium voltage-gated channel subfamily A member 4target
DB06637DalfampridinePotassium voltage-gated channel subfamily A member 2target
DB06637DalfampridinePotassium voltage-gated channel subfamily A member 3target
DB06637DalfampridinePotassium voltage-gated channel subfamily A member 5target
DB06637DalfampridinePotassium voltage-gated channel subfamily A member 6target
DB06637DalfampridinePotassium voltage-gated channel subfamily A member 7target
DB06637DalfampridinePotassium voltage-gated channel subfamily A member 10target
DB06637DalfampridinePotassium voltage-gated channel subfamily B member 1target
DB06637DalfampridinePotassium voltage-gated channel subfamily B member 2target
DB06637DalfampridinePotassium voltage-gated channel subfamily C member 1target
DB06637DalfampridinePotassium voltage-gated channel subfamily C member 2target
DB06637DalfampridinePotassium voltage-gated channel subfamily C member 3target
DB06637DalfampridinePotassium voltage-gated channel subfamily D member 1target
DB06637DalfampridineSolute carrier family 22 member 2transporter
DB01219DantroleneRyanodine receptor 1target
DB01219DantroleneCytochrome P450 3A4enzyme
DB08908Dimethyl fumarateKelch-like ECH-associated protein 1target
DB08908Dimethyl fumarateTranscription factor p65target
DB08868FingolimodLeukotriene-B(4) omega-hydroxylase 1enzyme
DB08868FingolimodSphingosine 1-phosphate receptor 5target
DB08868FingolimodSphingosine kinase 1enzyme
DB08868FingolimodCytochrome P450 2D6enzyme
DB08868FingolimodCytochrome P450 2E1enzyme
DB08868FingolimodCytochrome P450 4F12enzyme
DB08868FingolimodHistone deacetylase 1target
DB05259GlatiramerHLA class II histocompatibility antigen, DRB1-1 beta chaintarget
DB00563MethotrexateSerum albumincarrier
DB00563MethotrexateAldehyde oxidaseenzyme
DB00563MethotrexateMethylenetetrahydrofolate reductaseenzyme
DB00563Methotrexate6-phosphogluconate dehydrogenase, decarboxylatingenzyme
DB00563MethotrexateFolylpolyglutamate synthase, mitochondrialenzyme
DB00563MethotrexateGamma-glutamyl hydrolaseenzyme
DB00563MethotrexateDihydrofolate reductaseenzyme
DB00563MethotrexateThymidylate synthaseenzyme
DB00563MethotrexateBifunctional purine biosynthesis protein PURHenzyme
DB00563MethotrexateCytochrome P450 3A4enzyme
DB00563MethotrexateDihydrofolate reductasetarget
DB00563MethotrexateCanalicular multispecific organic anion transporter 2transporter
DB00563MethotrexateMultidrug resistance-associated protein 4transporter
DB00563MethotrexateMultidrug resistance-associated protein 1transporter
DB00563MethotrexateSolute carrier family 22 member 6transporter
DB00563MethotrexateMultidrug resistance-associated protein 7transporter
DB00563MethotrexateSolute carrier family 22 member 8transporter
DB00563MethotrexateCanalicular multispecific organic anion transporter 1transporter
DB00563MethotrexateMultidrug resistance protein 1transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 1A2transporter
DB00563MethotrexateMonocarboxylate transporter 1transporter
DB00563MethotrexateATP-binding cassette sub-family C member 11transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 1B3transporter
DB00563MethotrexateSolute carrier family 22 member 11transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 1C1transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 3A1transporter
DB00563MethotrexateATP-binding cassette sub-family G member 2transporter
DB00563MethotrexateSolute carrier family 22 member 7transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 1B1transporter
DB00563MethotrexateProton-coupled folate transportertransporter
DB00563MethotrexateSolute carrier organic anion transporter family member 4C1transporter
DB00563MethotrexateFolate transporter 1transporter
DB00563MethotrexateFolate receptor alphatransporter
DB00745ModafinilSodium-dependent dopamine transportertarget
DB00745ModafinilAlpha-1B adrenergic receptortarget
DB00745ModafinilCytochrome P450 3A4enzyme
DB00745ModafinilCytochrome P450 2C19enzyme
DB00745ModafinilCytochrome P450 1A2enzyme
DB00745ModafinilCytochrome P450 2B6enzyme
DB00745ModafinilCytochrome P450 2C9enzyme
DB00745ModafinilCytochrome P450 3A5enzyme
DB08880TeriflunomideATP-binding cassette sub-family G member 2transporter
DB08880TeriflunomideDihydroorotate dehydrogenase (quinone), mitochondrialtarget
DB08880TeriflunomideCytochrome P450 2C8enzyme
DB08880TeriflunomideSolute carrier organic anion transporter family member 1B1transporter
DrugDrug NamePhaseStatusCount
DB06215Ferumoxytol0Enrolling by Invitation1
DB00060Interferon beta-1a0Completed1
DB00688Mycophenolate mofetil0Completed1
DB01281Abatacept1Completed1
DB00087Alemtuzumab1Active Not Recruiting1
DB01076Atorvastatin1Completed1
DB00190Carbidopa1Recruiting1
DB00262Carmustine1Recruiting1
DB00169Cholecalciferol1Completed1
DB01432Cholestyramine1Completed1
DB00242Cladribine1Completed1
DB00257Clotrimazole1Completed1
DB01285Corticotropin1Completed1
DB00531Cyclophosphamide1Completed2
DB00987Cytarabine1Recruiting1
DB09341Dextrose, unspecified form1Terminated1
DB12116Epigallocatechin gallate1Completed1
DB00773Etoposide1Recruiting1
DB00099Filgrastim1Completed2
DB08868Fingolimod1Completed1
DB12732Firategrast1Completed1
DB11987GSK-20186821Completed1
DB05259Glatiramer1Completed1
DB00629Guanabenz1Terminated1
DB05106IR2081Not Yet Recruiting1
DB00060Interferon beta-1a1Completed4
DB00068Interferon beta-1b1Completed1
DB01026Ketoconazole1Completed1
DB00279Liothyronine1Recruiting1
DB00166Lipoic Acid1Completed1
DB00166Lipoic Acid1Recruiting1
DB06796Mangafodipir1Recruiting1
DB01042Melphalan1Recruiting1
DB00959Methylprednisolone1Completed2
DB00959Methylprednisolone1Terminated1
DB01110Miconazole1Completed1
DB09035Nivolumab1Not Yet Recruiting1
DB12891Ozanezumab1Terminated1
DB12612Ozanimod1Active Not Recruiting1
DB00213Pantoprazole1Completed1
DB09122Peginterferon beta-1a1Completed1
DB00635Prednisone1Completed1
DB06815Pyrithione1Completed1
DB09153Sodium Chloride1Completed1
DB14329Sunflower oil1Terminated1
DB00857Terbinafine1Completed1
DB00759Tetracycline1Completed1
DB00525Tolnaftate1Completed1
DB11117Undecylenic acid1Completed1
DB09145Water1Completed2
DB00087Alemtuzumab1 / 2Recruiting1
DB00470Dronabinol1 / 2Terminated1
DB01381Ginkgo biloba1 / 2Completed1
DB01611Hydroxychloroquine1 / 2Recruiting1
DB09081Idebenone1 / 2Enrolling by Invitation1
DB01221Ketamine1 / 2Recruiting1
DB00166Lipoic Acid1 / 2Completed1
DB01356Lithium cation1 / 2Completed1
DB00678Losartan1 / 2Recruiting1
DB14009Medical Cannabis1 / 2Completed1
DB14009Medical Cannabis1 / 2Terminated1
DB05914Mesenchymal Stem Cells1 / 2Completed2
DB05914Mesenchymal Stem Cells1 / 2Recruiting1
DB00683Midazolam1 / 2Recruiting1
DB05063Mitoquinone1 / 2Recruiting1
DB00471Montelukast1 / 2Recruiting1
DB11133Omega-3 fatty acids1 / 2Unknown Status1
DB06303Otilimab1 / 2Completed1
DB00039Palifermin1 / 2Recruiting1
DB01132Pioglitazone1 / 2Recruiting1
DB01224Quetiapine1 / 2Recruiting1
DB00073Rituximab1 / 2Terminated1
DB00877Sirolimus1 / 2Terminated1
DB00624Testosterone1 / 2Completed1
DB01281Abatacept2Terminated1
DB00819Acetazolamide2Not Yet Recruiting1
DB00087Alemtuzumab2Terminated1
DB00915Amantadine2Completed1
DB00594Amiloride2Completed1
DB00289Atomoxetine2Completed1
DB01076Atorvastatin2Completed2
DB00207Azithromycin2Completed1
DB00181Baclofen2Completed1
DB06401Bazedoxifene2Recruiting1
DB09020Bisacodyl2Recruiting1
DB05092CDP3232Terminated1
DB09061Cannabidiol2Unknown Status1
DB00262Carmustine2Completed1
DB00169Cholecalciferol2Terminated1
DB00242Cladribine2Completed1
DB09110Coenzyme M2Completed1
DB00286Conjugated estrogens2Recruiting1
DB01285Corticotropin2Terminated1
DB11672Curcumin2Completed1
DB00531Cyclophosphamide2Completed1
DB00531Cyclophosphamide2Terminated1
DB00531Cyclophosphamide2Withdrawn1
DB00987Cytarabine2Completed1
DB00111Daclizumab2Completed2
DB06637Dalfampridine2Active Not Recruiting2
DB06637Dalfampridine2Completed3
DB06637Dalfampridine2Recruiting1
DB00496Darifenacin2Terminated1
DB00380Dexrazoxane2Unknown Status1
DB00514Dextromethorphan2Completed1
DB08908Dimethyl fumarate2Completed2
DB11089Docusate2Recruiting1
DB00470Dronabinol2Unknown Status1
DB12116Epigallocatechin gallate2Terminated1
DB00773Etoposide2Completed1
DB08868Fingolimod2Completed3
DB12732Firategrast2Completed2
DB01073Fludarabine2Terminated1
DB01381Ginkgo biloba2Completed1
DB05259Glatiramer2Completed3
DB05106IR2082Not Yet Recruiting1
DB00060Interferon beta-1a2Completed9
DB00060Interferon beta-1a2Unknown Status1
DB00068Interferon beta-1b2Completed5
DB00068Interferon beta-1b2Unknown Status1
DB00174L-Asparagine2Completed1
DB00128L-Aspartic Acid2Completed1
DB00166Lipoic Acid2Recruiting1
DB01255Lisdexamfetamine2Completed1
DB12583Maltodextrin2Recruiting1
DB11526Masitinib2Completed1
DB01042Melphalan2Completed1
DB01043Memantine2Terminated1
DB05914Mesenchymal Stem Cells2Recruiting2
DB00422Methylphenidate2Recruiting1
DB00959Methylprednisolone2Enrolling by Invitation1
DB00959Methylprednisolone2Withdrawn1
DB01017Minocycline2Terminated1
DB01204Mitoxantrone2Unknown Status1
DB00688Mycophenolate mofetil2Completed1
DB00108Natalizumab2Completed2
DB12714Nerispirdine2Completed2
DB06650Ofatumumab2Completed1
DB00776Oxcarbazepine2Completed1
DB00252Phenytoin2Completed1
DB12520Plozalizumab2Completed1
DB12016Ponesimod2Active Not Recruiting1
DB00635Prednisone2Completed1
DB00908Quinidine2Completed1
DB01045Rifampicin2Completed1
DB00740Riluzole2Completed2
DB00073Rituximab2Completed2
DB01954Rolipram2Completed1
DB09029Secukinumab2Completed1
DB09029Secukinumab2Terminated1
DB09153Sodium Chloride2Completed1
DB09153Sodium Chloride2Terminated1
DB09325Sodium fluoride2Completed1
DB00864Tacrolimus2Unknown Status1
DB08880Teriflunomide2Completed6
DB00624Testosterone2Not Yet Recruiting1
DB00624Testosterone2Terminated1
DB00624Testosterone2Withdrawn1
DB12738Tiplimotide2Completed1
DB00273Topiramate2Unknown Status1
DB02891Tricyclazole2Completed1
DB11850Ublituximab2Active Not Recruiting1
DB05679Ustekinumab2Completed1
DB09145Water2Completed2
DB00346Alfuzosin2 / 3Terminated1
DB00182Amphetamine2 / 3Completed1
DB00182Amphetamine2 / 3Recruiting1
DB06413Armodafinil2 / 3Completed1
DB09061Cannabidiol2 / 3Withdrawn1
DB11121Chloroxylenol2 / 3Completed1
DB00169Cholecalciferol2 / 3Completed1
DB01285Corticotropin2 / 3Terminated1
DB06637Dalfampridine2 / 3Completed2
DB01576Dextroamphetamine2 / 3Completed1
DB01576Dextroamphetamine2 / 3Recruiting1
DB08908Dimethyl fumarate2 / 3Recruiting1
DB00470Dronabinol2 / 3Withdrawn1
DB00476Duloxetine2 / 3Completed1
DB08868Fingolimod2 / 3Completed1
DB08868Fingolimod2 / 3Recruiting1
DB08868Fingolimod2 / 3Terminated1
DB05259Glatiramer2 / 3Recruiting1
DB01005Hydroxyurea2 / 3Terminated1
DB05106IR2082 / 3Not Yet Recruiting1
DB00060Interferon beta-1a2 / 3Active Not Recruiting1
DB00060Interferon beta-1a2 / 3Recruiting1
DB00068Interferon beta-1b2 / 3Recruiting1
DB00068Interferon beta-1b2 / 3Terminated1
DB00125L-Arginine2 / 3Completed1
DB01043Memantine2 / 3Unknown Status1
DB00422Methylphenidate2 / 3Completed1
DB00959Methylprednisolone2 / 3Terminated1
DB00688Mycophenolate mofetil2 / 3Completed1
DB00108Natalizumab2 / 3Completed1
DB00108Natalizumab2 / 3Recruiting1
DB00073Rituximab2 / 3Completed1
DB00316Acetaminophen3Recruiting1
DB00945Acetylsalicylic acid3Terminated1
DB09278Activated charcoal3Completed1
DB00787Acyclovir3Recruiting1
DB00087Alemtuzumab3Recruiting2
DB00087Alemtuzumab3Unknown Status1
DB00915Amantadine3Recruiting2
DB08891Arbaclofen3Completed2
DB08891Arbaclofen3Recruiting3
DB00181Baclofen3Completed3
DB00121Biotin3Active Not Recruiting1
DB00083Botulinum Toxin Type A3Completed2
DB00083Botulinum Toxin Type A3Recruiting1
DB09061Cannabidiol3Completed13
DB09061Cannabidiol3Withdrawn1
DB00169Cholecalciferol3Recruiting1
DB01432Cholestyramine3Completed1
DB00242Cladribine3Completed1
DB01285Corticotropin3Enrolling by Invitation1
DB10631Cranberry3Completed1
DB00531Cyclophosphamide3Recruiting1
DB00111Daclizumab3Active Not Recruiting1
DB06637Dalfampridine3Completed9
DB13679Dexchlorpheniramine3Recruiting1
DB09341Dextrose, unspecified form3Withdrawn1
DB08908Dimethyl fumarate3Active Not Recruiting1
DB08908Dimethyl fumarate3Completed1
DB08908Dimethyl fumarate3Terminated1
DB00843Donepezil3Withdrawn1
DB00470Dronabinol3Completed13
DB00470Dronabinol3Withdrawn1
DB00476Duloxetine3Completed1
DB00153Ergocalciferol3Recruiting1
DB00153Ergocalciferol3Unknown Status1
DB01175Escitalopram3Completed1
DB00783Estradiol3Unknown Status1
DB08868Fingolimod3Active Not Recruiting1
DB08868Fingolimod3Completed4
DB05259Glatiramer3Completed3
DB05259Glatiramer3Recruiting1
DB00060Interferon beta-1a3Active Not Recruiting1
DB00060Interferon beta-1a3Completed7
DB00060Interferon beta-1a3Terminated1
DB00068Interferon beta-1b3Completed2
DB00068Interferon beta-1b3Withdrawn1
DB00583L-Carnitine3Unknown Status1
DB06685Laquinimod3Completed3
DB01043Memantine3Completed1
DB00563Methotrexate3Completed1
DB00959Methylprednisolone3Recruiting1
DB00959Methylprednisolone3Terminated1
DB00959Methylprednisolone3Unknown Status1
DB01204Mitoxantrone3Active Not Recruiting1
DB00704Naltrexone3Completed1
DB00108Natalizumab3Completed1
DB13981Nomegestrol acetate3Unknown Status1
DB11988Ocrelizumab3Recruiting2
DB12612Ozanimod3Completed1
DB12612Ozanimod3Enrolling by Invitation1
DB00715Paroxetine3Completed1
DB12016Ponesimod3Active Not Recruiting1
DB12016Ponesimod3Enrolling by Invitation1
DB12016Ponesimod3Recruiting1
DB00860Prednisolone3Recruiting1
DB00635Prednisone3Unknown Status1
DB00230Pregabalin3Completed1
DB00863Ranitidine3Recruiting1
DB00073Rituximab3Recruiting1
DB00641Simvastatin3Unknown Status1
DB12371Siponimod3Not Yet Recruiting1
DB09153Sodium Chloride3Completed1
DB08880Teriflunomide3Active Not Recruiting3
DB08880Teriflunomide3Completed5
DB08880Teriflunomide3Recruiting1
DB00697Tizanidine3Completed1
DB11094Vitamin D3Recruiting1
DB11094Vitamin D3Unknown Status1
DB09145Water3Completed3
DB09145Water3Terminated1
DB00399Zoledronic acid3Terminated1
DB00316Acetaminophen4Recruiting1
DB00087Alemtuzumab4Active Not Recruiting2
DB00083Botulinum Toxin Type A4Completed1
DB09061Cannabidiol4Completed1
DB00341Cetirizine4Completed1
DB11121Chloroxylenol4Recruiting1
DB00169Cholecalciferol4Unknown Status1
DB00242Cladribine4Recruiting2
DB01285Corticotropin4Completed1
DB01285Corticotropin4Not Yet Recruiting1
DB09547Corticotropin4Not Yet Recruiting1
DB01285Corticotropin4Recruiting1
DB01285Corticotropin4Terminated1
DB01285Corticotropin4Unknown Status1
DB06637Dalfampridine4Completed5
DB06637Dalfampridine4Recruiting1
DB06637Dalfampridine4Unknown Status1
DB00586Diclofenac4Completed1
DB00804Dicyclomine4Completed1
DB08908Dimethyl fumarate4Active Not Recruiting2
DB08908Dimethyl fumarate4Completed1
DB08908Dimethyl fumarate4Recruiting1
DB08908Dimethyl fumarate4Terminated1
DB08908Dimethyl fumarate4Withdrawn2
DB00470Dronabinol4Completed1
DB00153Ergocalciferol4Unknown Status1
DB08868Fingolimod4Completed4
DB08868Fingolimod4Recruiting1
DB08868Fingolimod4Withdrawn1
DB06703Gadobutrol4Recruiting1
DB05259Glatiramer4Active Not Recruiting1
DB05259Glatiramer4Completed4
DB05259Glatiramer4Unknown Status2
DB00060Interferon beta-1a4Completed8
DB00060Interferon beta-1a4Terminated1
DB00060Interferon beta-1a4Withdrawn1
DB00068Interferon beta-1b4Completed1
DB00068Interferon beta-1b4Unknown Status1
DB01202Levetiracetam4Completed1
DB00281Lidocaine4Completed1
DB00281Lidocaine4Terminated1
DB01046Lubiprostone4Completed1
DB01043Memantine4Completed1
DB00563Methotrexate4Completed1
DB00563Methotrexate4Withdrawn1
DB00959Methylprednisolone4Completed1
DB00959Methylprednisolone4Recruiting1
DB00959Methylprednisolone4Withdrawn1
DB08893Mirabegron4Recruiting1
DB00745Modafinil4Not Yet Recruiting1
DB00471Montelukast4Completed1
DB00486Nabilone4Completed2
DB00108Natalizumab4Active Not Recruiting1
DB00108Natalizumab4Completed3
DB00108Natalizumab4Recruiting2
DB11988Ocrelizumab4Recruiting1
DB00497Oxycodone4Terminated1
DB09122Peginterferon beta-1a4Recruiting1
DB00635Prednisone4Recruiting1
DB00635Prednisone4Terminated1
DB00073Rituximab4Completed1
DB00989Rivastigmine4Terminated1
DB00641Simvastatin4Completed2
DB09153Sodium Chloride4Completed1
DB01591Solifenacin4Completed1
DB09034Suvorexant4Recruiting1
DB08880Teriflunomide4Active Not Recruiting1
DB08880Teriflunomide4Completed1
DB09085Tetracaine4Completed1
DB11094Vitamin D4Unknown Status1
DB09145Water4Completed2
DB05299keyhole limpet hemocyanin4Completed1
DB00087AlemtuzumabNot AvailableNot Yet Recruiting1
DB01076AtorvastatinNot AvailableUnknown Status1
DB00083Botulinum Toxin Type ANot AvailableRecruiting1
DB09061CannabidiolNot AvailableCompleted1
DB00242CladribineNot AvailableActive Not Recruiting1
DB01285CorticotropinNot AvailableRecruiting1
DB01285CorticotropinNot AvailableUnknown Status1
DB00531CyclophosphamideNot AvailableNot Yet Recruiting1
DB06637DalfampridineNot AvailableActive Not Recruiting2
DB06637DalfampridineNot AvailableRecruiting1
DB06637DalfampridineNot AvailableTerminated1
DB08908Dimethyl fumarateNot AvailableCompleted2
DB08908Dimethyl fumarateNot AvailableRecruiting3
DB08908Dimethyl fumarateNot AvailableTerminated2
DB08908Dimethyl fumarateNot AvailableWithdrawn1
DB00470DronabinolNot AvailableCompleted1
DB06215FerumoxytolNot AvailableWithdrawn1
DB08868FingolimodNot AvailableCompleted2
DB08868FingolimodNot AvailableRecruiting3
DB09149Florbetapir (18F)Not AvailableUnknown Status1
DB01073FludarabineNot AvailableNot Yet Recruiting1
DB00743Gadobenic acidNot AvailableTerminated1
DB06703GadobutrolNot AvailableTerminated1
DB12091GadoliniumNot AvailableWithdrawn1
DB00597GadoteridolNot AvailableNot Yet Recruiting1
DB00597GadoteridolNot AvailableRecruiting1
DB05259GlatiramerNot AvailableCompleted5
DB05259GlatiramerNot AvailableRecruiting1
DB05259GlatiramerNot AvailableUnknown Status1
DB00060Interferon beta-1aNot AvailableCompleted12
DB00060Interferon beta-1aNot AvailableTerminated1
DB00060Interferon beta-1aNot AvailableWithdrawn1
DB00068Interferon beta-1bNot AvailableActive Not Recruiting1
DB00068Interferon beta-1bNot AvailableCompleted22
DB01065MelatoninNot AvailableCompleted1
DB00959MethylprednisoloneNot AvailableTerminated1
DB00959MethylprednisoloneNot AvailableUnknown Status1
DB00745ModafinilNot AvailableCompleted1
DB00108NatalizumabNot AvailableCompleted6
DB11988OcrelizumabNot AvailableEnrolling by Invitation1
DB11988OcrelizumabNot AvailableNo Longer Available1
DB11988OcrelizumabNot AvailableNot Yet Recruiting2
DB11988OcrelizumabNot AvailableRecruiting1
DB09122Peginterferon beta-1aNot AvailableRecruiting1
DB00635PrednisoneNot AvailableUnknown Status1
DB01001SalbutamolNot AvailableCompleted1
DB09153Sodium ChlorideNot AvailableCompleted2
DB09145WaterNot AvailableCompleted3