Hypertriglyceridemias

Also known as: Hypertriglyceridemia / Hypertriglyceridaemia / Triglyceride increased / Elevated triglycerides / Hyperglyceridaemia / Hyperglyceridemia / Triglycerides high / Raised triglycerides / Raised TG

DrugDrug NameDrug Description
DB01076AtorvastatinAtorvastatin is a member of the statins firstly synthesized in 1985 by Dr. Bruce Roth and FDA approved in 1996.[T568] It is a pentasubstituted pyrrole[A177415] formed by two contrasting moieties with an achiral heterocyclic core unit and a 3,5-dihydroxypentanoyl side chain identical to its parent compound.[T571] Unlike other members of the statin group, atorvastatin is an active compound and hence, it does not require activation.[A177436] It is the most widely used and potent member of the statin group.[T568]
DB01098RosuvastatinRosuvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reducuase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Rosuvastatin belongs to a class of medications called statins and is used to reduce plasma cholesterol levels and prevent cardiovascular disease.
DrugDrug NameTargetType
DB01076Atorvastatin3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
DB01076AtorvastatinCytochrome P450 3A4enzyme
DB01076AtorvastatinDipeptidyl peptidase 4target
DB01076AtorvastatinCytochrome P450 2D6enzyme
DB01076AtorvastatinCytochrome P450 2C9enzyme
DB01076AtorvastatinCytochrome P450 2C19enzyme
DB01076AtorvastatinCytochrome P450 3A5enzyme
DB01076AtorvastatinCytochrome P450 3A7enzyme
DB01076AtorvastatinMultidrug resistance protein 1transporter
DB01076AtorvastatinSolute carrier organic anion transporter family member 1A2transporter
DB01076AtorvastatinSolute carrier organic anion transporter family member 1B1transporter
DB01076AtorvastatinMultidrug resistance-associated protein 4transporter
DB01076AtorvastatinMultidrug resistance-associated protein 5transporter
DB01076AtorvastatinMultidrug resistance-associated protein 1transporter
DB01076AtorvastatinCytochrome P450 2B6enzyme
DB01076AtorvastatinCytochrome P450 2C8enzyme
DB01076AtorvastatinAryl hydrocarbon receptortarget
DB01076AtorvastatinSolute carrier organic anion transporter family member 2B1transporter
DB01076AtorvastatinSolute carrier organic anion transporter family member 1B3transporter
DB01076AtorvastatinUDP-glucuronosyltransferase 1-1enzyme
DB01076AtorvastatinUDP-glucuronosyltransferase 1-3enzyme
DB01076AtorvastatinCanalicular multispecific organic anion transporter 1transporter
DB01076AtorvastatinBile salt export pumptransporter
DB01076AtorvastatinSerum albumincarrier
DB01098Rosuvastatin3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
DB01098RosuvastatinCytochrome P450 2C9enzyme
DB01098RosuvastatinMultidrug resistance-associated protein 4transporter
DB01098RosuvastatinMultidrug resistance-associated protein 1transporter
DB01098RosuvastatinCytochrome P450 2C19enzyme
DB01098RosuvastatinCytochrome P450 3A4enzyme
DB01098RosuvastatinCytochrome P450 3A5enzyme
DB01098RosuvastatinSolute carrier organic anion transporter family member 1A2transporter
DB01098RosuvastatinSolute carrier organic anion transporter family member 1B3transporter
DB01098RosuvastatinSolute carrier organic anion transporter family member 2B1transporter
DB01098RosuvastatinCystine/glutamate transportertransporter
DB01098RosuvastatinSolute carrier organic anion transporter family member 1B1transporter
DB01098RosuvastatinBile salt export pumptransporter
DB01098RosuvastatinATP-binding cassette sub-family G member 2transporter
DB01098RosuvastatinSerum albumincarrier
DB01098RosuvastatinCanalicular multispecific organic anion transporter 1transporter
DB01098RosuvastatinSolute carrier family 22 member 8transporter
DrugDrug NamePhaseStatusCount
DB01394Colchicine0Completed1
DB00945Acetylsalicylic acid1Completed1
DB15354Evinacumab1Completed1
DB01039Fenofibrate1Completed1
DB01241Gemfibrozil1Completed1
DB08887Icosapent ethyl1Completed1
DB08887Icosapent ethyl1Unknown Status1
DB01601Lopinavir1Completed1
DB04835Maraviroc1Completed1
DB00331Metformin1Unknown Status1
DB09539Omega-3-acid ethyl esters1Completed1
DB09568Omega-3-carboxylic acids1Completed3
DB00503Ritonavir1Completed1
DB01098Rosuvastatin1Completed1
DB00641Simvastatin1Completed1
DB00682Warfarin1Completed1
DB06774Capsaicin1 / 2Recruiting1
DB05123Gemcabene1 / 2Active Not Recruiting1
DB11133Omega-3 fatty acids1 / 2Completed1
DB09539Omega-3-acid ethyl esters1 / 2Completed1
DB00140Riboflavin1 / 2Completed1
DB09145Water1 / 2Completed1
DB09055Acipimox2Completed1
DB01039Fenofibrate2Completed3
DB13961Fish oil2Completed1
DB05123Gemcabene2Completed1
DB04852Implitapide2Terminated1
DB09539Omega-3-acid ethyl esters2Terminated1
DB01083Orlistat2Active Not Recruiting1
DB12866Pradigastat2Terminated1
DB05678SLx-40902Completed1
DB12435Tipelukast2Completed1
DB09539Omega-3-acid ethyl esters2 / 3Completed1
DB01076Atorvastatin3Completed2
DB01076Atorvastatin3Withdrawn1
DB00973Ezetimibe3Completed2
DB01039Fenofibrate3Withdrawn1
DB00159Icosapent3Completed1
DB00159Icosapent3Recruiting1
DB06291Icosapent ethyl3Completed2
DB09567Olive oil3Completed3
DB09539Omega-3-acid ethyl esters3Completed5
DB09568Omega-3-carboxylic acids3Completed3
DB06817Raltegravir3Completed1
DB01098Rosuvastatin3Not Yet Recruiting1
DB00641Simvastatin3Completed2
DB00966Telmisartan3Completed1
DB00273Topiramate3Terminated1
DB06281Torcetrapib3Completed1
DB15067Volanesorsen3Completed1
DB01076Atorvastatin4Completed1
DB09064Ciprofibrate4Unknown Status1
DB11874Crocin4Completed1
DB01039Fenofibrate4Active Not Recruiting1
DB01039Fenofibrate4Completed6
DB01319Fosamprenavir4Completed1
DB08887Icosapent ethyl4Active Not Recruiting1
DB00627Niacin4Completed1
DB11133Omega-3 fatty acids4Completed1
DB11133Omega-3 fatty acids4Recruiting1
DB09539Omega-3-acid ethyl esters4Completed3
DB09539Omega-3-acid ethyl esters4Unknown Status2
DB09539Omega-3-acid ethyl esters4Withdrawn1
DB00503Ritonavir4Completed1
DB01098Rosuvastatin4Completed1
DB06335Saxagliptin4Enrolling by Invitation1
DB00641Simvastatin4Active Not Recruiting1
DB09055AcipimoxNot AvailableCompleted1
DB01393BezafibrateNot AvailableCompleted1
DB01039FenofibrateNot AvailableCompleted2
DB13961Fish oilNot AvailableCompleted1
DB00627NiacinNot AvailableCompleted2
DB09539Omega-3-acid ethyl estersNot AvailableActive Not Recruiting1
DB09539Omega-3-acid ethyl estersNot AvailableCompleted2
DB01132PioglitazoneNot AvailableCompleted1
DB00412RosiglitazoneNot AvailableCompleted1
DB11700SetmelanotideNot AvailableNo Longer Available1
DB09422Soybean oilNot AvailableTerminated2
DB00300Tenofovir disoproxilNot AvailableCompleted1