Hypertensive

Also known as: Hypertension / Blood pressure high / Essential (primary) hypertension / HT / HBP / Hypertension NOS / Hypertension arterial

DrugDrug NameDrug Description
DB01193AcebutololA cardioselective beta-adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm as well as weak inherent sympathomimetic action.
DB09026AliskirenAliskiren is the first in a class of drugs called direct renin inhibitors. Its current licensed indication is essential (primary) hypertension. While used for high blood pressure, other better studied medications are typically recommended due to concerns of higher side effects and less evidence of benefit. In December 2011, Novartis halted a clinical trial of the drug after discovering increased incidence of nonfatal stroke, kidney complications, high blood potassium, and low blood pressure in people with diabetes and kidney impairment.
DB00594AmilorideA pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with diuretics to spare potassium loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)
DB00381AmlodipineAmlodipine is a long-acting 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, amlodipine prevents calcium-dependent myocyte contraction and vasoconstriction. A second proposed mechanism for the drug’s vasodilatory effects involves pH-dependent inhibition of calcium influx via inhibition of smooth muscle carbonic anhydrase. Some studies have shown that amlodipine also exerts inhibitory effects on voltage-gated N-type calcium channels. N-type calcium channels located in the central nervous system may be involved in nociceptive signaling and pain sensation. Amlodipine is used to treat hypertension and chronic stable angina.
DB00335AtenololA cardioselective beta-adrenergic blocker possessing properties and potency similar to propranolol, but without a negative inotropic effect.
DB08822Azilsartan medoxomilAzilsartan medoxomil is an angiotensin II receptor antagonist indicated for the treatment of mild to moderate essential hypertension. Azilsartan medoxomil is a prodrug of Azilsartan marketed as "Edarbi" by Takeda. Azilsartan medoxomil has so far been shown to be superior to olmesartan and valsartan in lowering blood pressure.
DB00542BenazeprilBenazepril, brand name Lotensin, is a medication used to treat high blood pressure (hypertension), congestive heart failure, and chronic renal failure. Upon cleavage of its ester group by the liver, benazepril is converted into its active form benazeprilat, a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor.
DB00436BendroflumethiazideA thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810)
DB00195BetaxololA cardioselective beta-1-adrenergic antagonist with no partial agonist activity.
DB00612BisoprololBisoprolol is a cardioselective β1-adrenergic blocking agent used for secondary prevention of myocardial infarction (MI), heart failure, angina pectoris and mild to moderate hypertension. Bisoprolol is structurally similar to metoprolol, acebutolol and atenolol in that it has two substituents in the para position of the benzene ring. The β1-selectivity of these agents is thought to be due in part to the large substituents in the para position. At lower doses (less than 20 mg daily), bisoprolol selectively blocks cardiac β1-adrenergic receptors with little activity against β2-adrenergic receptors of the lungs and vascular smooth muscle. Receptor selectivity decreases with daily doses of 20 mg or greater. Unlike propranolol and pindolol, bisoprolol does not exhibit membrane-stabilizing or sympathomimetic activity. Bisoprolol possesses a single chiral centre and is administered as a racemic mixture. Only l-bisoprolol exhibits significant β-blocking activity.
DB00796CandesartanCandesartan is an angiotensin-receptor blocker (ARB) that may be used alone or with other agents to treat hypertension. It is administered orally as the prodrug, candesartan cilexetil, which is rapidly converted to its active metabolite, candesartan, during absorption in the gastrointestinal tract. Candesartan lowers blood pressure by antagonizing the renin-angiotensin-aldosterone system (RAAS); it competes with angiotensin II for binding to the type-1 angiotensin II receptor (AT1) subtype and prevents the blood pressure increasing effects of angiotensin II. Unlike angiotensin-converting enzyme (ACE) inhibitors, ARBs do not have the adverse effect of dry cough. Candesartan may be used to treat hypertension, isolated systolic hypertension, left ventricular hypertrophy and diabetic nephropathy. It may also be used as an alternative agent for the treatment of heart failure, systolic dysfunction, myocardial infarction and coronary artery disease.
DB01197CaptoprilCaptopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment of hypertension.
DB01136CarvedilolCarvedilol is a non-selective beta blocker indicated in the treatment of mild to moderate congestive heart failure (CHF). It blocks beta-1 and beta-2 adrenergic receptors as well as the alpha-1 adrenergic receptors.
DB00880ChlorothiazideA thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812)
DB04920ClevidipineClevidipine is a dihydropyridine L-type calcium channel blocker that is selective for vascular smooth muscle and is indicated for blood pressure reduction when oral therapy is not an option.
DB00575ClonidineClonidine, an imidazoline-derivative hypotensive agent is a centrally-acting α2-adrenergic agonist. It crosses the blood-brain barrier and acts in the hypothalamus to induce a decrease in blood pressure. It may also be administered as an epidural infusion as an adjunct treatment in the management of severe cancer pain that is not relieved by opiate analgesics alone. Clonidine may be used for differential diagnosis of pheochromocytoma in hypertensive patients. Other uses for clonidine include prophylaxis of vascular migraine headaches, treatment of severe dysmenorrhea, management of vasomotor symptoms associated with menopause, rapid detoxification in the management of opiate withdrawal, treatment of alcohol withdrawal used in conjunction with benzodiazepines, management of nicotine dependence, topical use to reduce intraocular pressure in the treatment of open-angle and secondary glaucoma and hemorrhagic glaucoma associated with hypertension, and in the treatment of attention-deficit hyperactivity disorder (ADHD). Clonidine also exhibits some peripheral activity.
DB00343DiltiazemA benzothiazepine derivative with vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions. It is also teratogenic. [PubChem]
DB00590DoxazosinDoxazosin is a quinazoline-derivative that selectively antagonizes postsynaptic α1-adrenergic receptors. It may be used to mild to moderate hypertension and in the management of symptomatic benign prostatic hyperplasia (BPH). α1-Receptors mediate contraction and hypertrophic growth of smooth muscle cells. Antagonism of these receptors leads to smooth muscle relaxation in the peripheral vasculature and prostate gland.
DB00584EnalaprilEnalapril is a prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to enalaprilat following oral administration. Enalaprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Enalapril may be used to treat essential or renovascular hypertension and symptomatic congestive heart failure.
DB09477EnalaprilatEnalaprilat is the active metabolite of the orally available pro-drug, enalapril. Used in the treatment of hypertension, enalapril is an ACE inhibitor that prevents Angiotensin Converting Enzyme (ACE) from transforming angiotensin I into angiotensin II. As angiotensin II is responsible for vasoconstriction and sodium reabsorption in the proximal tubule of the kidney, down-regulation of this protein results in reduced blood pressure and blood fluid volume. Enalaprilat was originally created to overcome the limitations of the first ACE inhibitor, captopril, which had numerous side effects and left a metallic taste in the mouth. Removal of the problematic thiol group from captopril resulted in enalaprilat, which was then modified further with an ester to create the orally available pro-drug enalapril. Enalaprilat is poorly orally available and is therefore only available as an intravenous injection for the treatment of hypertension when oral therapy is not possible.
DB00700EplerenoneEplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone circulating levels do not overcome the effects of eplerenone. Eplerenone selectively binds to recombinant human mineralocorticoid receptors relative to its binding to recombinant human glucocorticoid, progesterone and androgen receptors.
DB00876EprosartanEprosartan is an angiotensin II receptor antagonist used for the treatment of high blood pressure. It acts on the renin-angiotensin system in two ways to decrease total peripheral resistance. First, it blocks the binding of angiotensin II to AT1 receptors in vascular smooth muscle, causing vascular dilatation. Second, it inhibits sympathetic norepinephrine production, further reducing blood pressure.
DB01023FelodipineFelodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte contraction and vasoconstriction. Felodipine is the most potent CCB in use and is unique in that it exhibits fluorescent activity. In addition to binding to L-type calcium channels, felodipine binds to a number of calcium-binding proteins, exhibits competitive antagonism of the mineralcorticoid receptor, inhibits the activity of calmodulin-dependent cyclic nucleotide phosphodiesterase, and blocks calcium influx through voltage-gated T-type calcium channels. Felodipine is used to treat mild to moderate essential hypertension.
DB00492FosinoprilFosinopril is a phosphinic acid-containing ester prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly hydrolyzed to fosinoprilat, its principle active metabolite. Fosinoprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Fosinopril may be used to treat mild to moderate hypertension, as an adjunct in the treatment of congestive heart failure, and to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy.
DB00695FurosemideA benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for edema and chronic renal insufficiency. [PubChem]
DB01018GuanfacineA centrally acting antihypertensive agent. The drug lowers both systolic and diastolic blood pressure by activating the central nervous system alpha-2 adrenoreceptors, which results in reduced sympathetic outflow leading to reduced vascular tone. Its adverse reactions include dry mouth, sedation, and constipation. [PubChem]
DB00999HydrochlorothiazideA thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It has been used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism. [PubChem]
DB00808IndapamideA benzamide-sulfonamide-indole. It is called a thiazide-like diuretic but structure is different enough (lacking the thiazo-ring) so it is not clear that the mechanism is comparable. [PubChem]
DB01029IrbesartanIrbesartan is an angiotensin receptor blocker (ARB) used mainly for the treatment of hypertension. It competes with angiotensin II for binding at the AT1 receptor subtype. Unlike ACE inhibitors, ARBs do not have the adverse effect of dry cough. The use of ARBs is pending revision due to findings from several clinical trials suggesting that this class of drugs may be associated with a small increased risk of cancer.
DB00270IsradipineIsradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. It is structurally related to felodipine, nifedipine, and nimodipine and is the most potent calcium-channel blocking agent of the DHP class. Isradipine binds to calcium channels with high affinity and specificity and inhibits calcium flux into cardiac and arterial smooth muscle cells. It exhibits greater selectivity towards arterial smooth muscle cells owing to alternative splicing of the alpha-1 subunit of the channel and increased prevalence of inactive channels in smooth muscle cells. Isradipine may be used to treat mild to moderate essential hypertension.
DB00598LabetalolBlocker of both alpha- and beta-adrenergic receptors that is used as an antihypertensive. [PubChem]
DB00722LisinoprilLisinopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Lisinopril may be used to treat hypertension and symptomatic congestive heart failure, to improve survival in certain individuals following myocardial infarction, and to prevent progression of renal disease in hypertensive patients with diabetes mellitus and microalbuminuria or overt nephropathy.
DB00678LosartanLosartan is an angiotensin-receptor blocker (ARB) that may be used alone or with other agents to treat hypertension. Losartan and its longer acting metabolite, E-3174, lower blood pressure by antagonizing the renin-angiotensin-aldosterone system (RAAS); they compete with angiotensin II for binding to the type-1 angiotensin II receptor (AT1) subtype and prevents the blood pressure increasing effects of angiotensin II. Unlike angiotensin-converting enzyme (ACE) inhibitors, ARBs do not have the adverse effect of dry cough. Losartan may be used to treat hypertension, isolated systolic hypertension, left ventricular hypertrophy and diabetic nephropathy. It may also be used as an alternative agent for the treatment of systolic dysfunction, myocardial infarction, coronary artery disease, and heart failure.
DB00232MethyclothiazideA thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p825)
DB00968MethyldopaAn alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. [PubChem]
DB00264MetoprololMetoprolol is a cardioselective β1-adrenergic blocking agent used for acute myocardial infarction (MI), heart failure, angina pectoris and mild to moderate hypertension. It may also be used for supraventricular and tachyarrhythmias and prophylaxis for migraine headaches. Metoprolol is structurally similar to bisoprolol, acebutolol and atenolol in that it has two substituents in the para position of the benzene ring. The β1-selectivity of these agents is thought to be due in part to the large substituents in the para position. At low doses, metoprolol selectively blocks cardiac β1-adrenergic receptors with little activity against β2-adrenergic receptors of the lungs and vascular smooth muscle. Receptor selectivity decreases with higher doses. Unlike propranolol and pindolol, metoprolol does not exhibit membrane-stabilizing or intrinsic sympathomimetic activity. Membrane-stabilizing effects are only observed at doses much higher than those needed for β-adrenergic blocking activity. Metoprolol possesses a single chiral centre and is administered as a racemic mixture.
DB00691MoexiprilMoexipril is a non-sulfhydryl containing precursor of the active angiotensin-converting enzyme (ACE) inhibitor moexiprilat. It is used to treat high blood pressure (hypertension). It works by relaxing blood vessels, causing them to widen. Lowering high blood pressure helps prevent strokes, heart attacks and kidney problems.
DB01203NadololA non-selective beta-adrenergic antagonist with a long half-life, used in cardiovascular disease to treat arrhythmias, angina pectoris, and hypertension. Nadolol is also used for migraine disorders and for tremor. [PubChem]
DB04861NebivololNebivolol is a highly cardioselective vasodilatory beta1 receptor blocker used in treatment of hypertension. In most countries, this medication is available only by prescription. [Wikipedia]
DB00622NicardipineA potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents. [PubChem]
DB01115NifedipineNifedipine has been formulated as both a long- and short-acting 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nifedipine prevents calcium-dependent myocyte contraction and vasoconstriction. A second proposed mechanism for the drug’s vasodilatory effects involves pH-dependent inhibition of calcium influx via inhibition of smooth muscle carbonic anhydrase. Nifedipine is used to treat hypertension and chronic stable angina.
DB00401NisoldipineNisoldipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth muscle contraction and subsequent vasoconstriction. Nisoldipine may be used in alone or in combination with other agents in the management of hypertension.
DB00275OlmesartanOlmesartan is an antihypertensive agent, which belongs to the class of medications called angiotensin II receptor blockers. It is indicated for the treatment of high blood pressure and is marketed under the name Olmetec®. The FDA label includes a black-box warning of injury and death to the fetus, so women of child-bearing age need to be warned and take the necessary precautions. Olmesartan is also contraindicated in diabetes mellitus patients taking aliskiren.
DB00960PindololA moderately lipophilic beta blocker (adrenergic beta-antagonists). It is non-cardioselective and has intrinsic sympathomimetic actions, but little membrane-stabilizing activity. (From Martindale, The Extra Pharmocopoeia, 30th ed, p638)
DB00457PrazosinPrazosin is a selective α-1-adrenergic receptor antagonist used to treat hypertension. It has also been used to decrease urinary obstruction and relieve symptoms associated with symptomatic benign prostatic hyperplasia. α1-Receptors mediate contraction and hypertrophic growth of smooth muscle cells. Antagonism of these receptors leads to smooth muscle relaxation in the peripheral vasculature and prostate gland. Prazosin has also been used in conjunction with cardiac glycosides and diuretics in the management of severe congestive heart failure. It has also been used alone or in combination with β-blockers in the preoperative management of signs and symptoms of pheochromocytoma.
DB00571PropranololA widely used non-cardioselective beta-adrenergic antagonist. Propranolol is used in the treatment or prevention of many disorders including acute myocardial infarction, arrhythmias, angina pectoris, hypertension, hypertensive emergencies, hyperthyroidism, migraine, pheochromocytoma, menopause, and anxiety. [PubChem]
DB00881QuinaprilQuinapril is a prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to quinaprilat (quinapril diacid) following oral administration. Quinaprilat is a competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Quinapril may be used to treat essential hypertension and congestive heart failure.
DB00178RamiprilRamipril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to ramiprilat in the liver and, to a lesser extent, kidneys. Ramiprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Ramipril may be used in the treatment of hypertension, congestive heart failure, nephropathy, and to reduce the rate of death, myocardial infarction and stroke in individuals at high risk of cardiovascular events.
DB00206ReserpineAn alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use. [PubChem]
DB00421SpironolactoneA potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
DB00966TelmisartanTelmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. Generally, angiotensin II receptor blockers (ARBs) such as telmisartan bind to the angiotensin II type 1 (AT1) receptors with high affinity, causing inhibition of the action of angiotensin II on vascular smooth muscle, ultimately leading to a reduction in arterial blood pressure. Recent studies suggest that telmisartan may also have PPAR-gamma agonistic properties that could potentially confer beneficial metabolic effects.
DB01162TerazosinTerazosin is a selective alpha1-antagonist used for treatment of symptoms of benign prostatic hyperplasia (BPH). It also acts to lower blood pressure, so it is a drug of choice for men with hypertension and prostate enlargement. It works by blocking the action of adrenaline on smooth muscle of the bladder and the blood vessel walls.
DB00214TorasemideTorasemide (rINN) or torsemide (USAN) is a pyridine-sulfonylurea type loop diuretic mainly used in the management of edema associated with congestive heart failure. It is also used at low doses for the management of hypertension. It is marketed under the brand name Demadex. [Wikipedia]
DB00519TrandolaprilTrandolapril is a non-sulhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to its biologically active diacid form, trandolaprilat, in the liver. Trandolaprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Trandolapril may be used to treat mild to moderate hypertension, to improve survival following myocardial infarction in clinically stable patients with left ventricular dysfunction, as an adjunct treatment for congestive heart failure, and to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy.
DB00384TriamtereneA pteridine that is used as a mild diuretic. [PubChem]
DB00177ValsartanValsartan is an angiotensin-receptor blocker (ARB) that may be used to treat a variety of cardiac conditions including hypertension, diabetic nephropathy and heart failure. Valsartan lowers blood pressure by antagonizing the renin-angiotensin-aldosterone system (RAAS); it competes with angiotensin II for binding to the type-1 angiotensin II receptor (AT1) subtype and prevents the blood pressure increasing effects of angiotensin II. Unlike angiotensin-converting enzyme (ACE) inhibitors, ARBs do not have the adverse effect of dry cough. Valsartan may be used to treat hypertension, isolated systolic hypertension, left ventricular hypertrophy and diabetic nephropathy. It may also be used as an alternative agent for the treatment of heart failure, systolic dysfunction, myocardial infarction and coronary artery disease.
DB00661VerapamilA calcium channel blocker that is a class IV anti-arrhythmia agent.
DrugDrug NameTargetType
DB01193AcebutololBeta-1 adrenergic receptortarget
DB01193AcebutololCytochrome P450 2D6enzyme
DB01193AcebutololBeta-2 adrenergic receptortarget
DB01193AcebutololSolute carrier family 22 member 1transporter
DB01193AcebutololMultidrug resistance protein 1transporter
DB09026AliskirenRenintarget
DB09026AliskirenCytochrome P450 3A4enzyme
DB00594AmilorideAmiloride-sensitive sodium channel subunit betatarget
DB00594AmilorideAcid-sensing ion channel 1target
DB00594AmilorideAmiloride-sensitive amine oxidase [copper-containing]target
DB00594AmilorideAmiloride-sensitive sodium channel subunit alphatarget
DB00594AmilorideAmiloride-sensitive sodium channel subunit gammatarget
DB00594AmilorideSodium/hydrogen exchanger 1target
DB00594AmilorideAcid-sensing ion channel 2target
DB00594AmilorideAmiloride-sensitive sodium channel subunit deltatarget
DB00594AmilorideUrokinase-type plasminogen activatortarget
DB00594AmilorideSolute carrier family 22 member 2transporter
DB00594AmilorideSolute carrier family 22 member 1transporter
DB00594AmilorideSolute carrier family 22 member 4transporter
DB00594AmilorideAmiloride-sensitive amine oxidase [copper-containing]enzyme
DB00594AmilorideAmiloride-sensitive amine oxidase [copper-containing]enzyme
DB00381AmlodipineCarbonic anhydrase 1target
DB00381AmlodipineCytochrome P450 3A4enzyme
DB00381AmlodipineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB00381AmlodipineVoltage-dependent L-type calcium channel subunit beta-2target
DB00381AmlodipineCytochrome P450 1A1enzyme
DB00381AmlodipineCytochrome P450 2B6enzyme
DB00381AmlodipineVoltage-dependent N-type calcium channel subunit alpha-1Btarget
DB00381AmlodipineVoltage-dependent calcium channel subunit alpha-2/delta-1target
DB00381AmlodipineVoltage-gated calcium channel beta 1 subunit splice variant CavB1dtarget
DB00381AmlodipineVoltage-dependent calcium channel subunit alpha-2/delta-3target
DB00381AmlodipineVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
DB00381AmlodipineVoltage-dependent L-type calcium channel subunit alpha-1Starget
DB00381AmlodipineCytochrome P450 3A5enzyme
DB00381AmlodipineCytochrome P450 3A7enzyme
DB00381AmlodipineCytochrome P450 1A2enzyme
DB00381AmlodipineMultidrug resistance protein 1transporter
DB00381AmlodipineCytochrome P450 2A6enzyme
DB00381AmlodipineCytochrome P450 2C8enzyme
DB00381AmlodipineCytochrome P450 2C9enzyme
DB00381AmlodipineCytochrome P450 2D6enzyme
DB00381AmlodipineSphingomyelin phosphodiesterasetarget
DB00335AtenololBeta-1 adrenergic receptortarget
DB00335AtenololMultidrug resistance protein 1transporter
DB00335AtenololBeta-2 adrenergic receptortarget
DB08822Azilsartan medoxomilType-1 angiotensin II receptortarget
DB00542BenazeprilAngiotensin-converting enzymetarget
DB00542BenazeprilMethylenetetrahydrofolate reductaseenzyme
DB00542BenazeprilSolute carrier family 15 member 1transporter
DB00542BenazeprilSolute carrier family 15 member 2transporter
DB00436BendroflumethiazideSolute carrier family 12 member 3target
DB00436BendroflumethiazideCarbonic anhydrase 1target
DB00436BendroflumethiazideCarbonic anhydrase 2target
DB00436BendroflumethiazideCarbonic anhydrase 4target
DB00436BendroflumethiazideCalcium-activated potassium channel subunit alpha-1target
DB00436BendroflumethiazideThiopurine S-methyltransferaseenzyme
DB00195BetaxololBeta-1 adrenergic receptortarget
DB00195BetaxololBeta-2 adrenergic receptortarget
DB00195BetaxololCytochrome P450 1A2enzyme
DB00195BetaxololCytochrome P450 2D6enzyme
DB00612BisoprololBeta-1 adrenergic receptortarget
DB00612BisoprololBeta-2 adrenergic receptortarget
DB00612BisoprololCytochrome P450 2D6enzyme
DB00612BisoprololCytochrome P450 3A4enzyme
DB00796CandesartanType-1 angiotensin II receptortarget
DB00796CandesartanCytochrome P450 2C8enzyme
DB00796CandesartanCytochrome P450 2C9enzyme
DB00796CandesartanMultidrug resistance protein 1transporter
DB00796CandesartanUDP-glucuronosyltransferase 1-3enzyme
DB00796CandesartanProstaglandin G/H synthase 1enzyme
DB01197CaptoprilSerum albumincarrier
DB01197CaptoprilCytochrome P450 2D6enzyme
DB01197CaptoprilAngiotensin-converting enzymetarget
DB01197Captopril72 kDa type IV collagenasetarget
DB01197CaptoprilMatrix metalloproteinase-9target
DB01197CaptoprilLeukotriene A-4 hydrolasetarget
DB01197CaptoprilB1 bradykinin receptortarget
DB01197CaptoprilMultidrug resistance protein 1transporter
DB01197CaptoprilSolute carrier family 15 member 1transporter
DB01197CaptoprilSolute carrier family 22 member 6transporter
DB01136CarvedilolAlpha-1A adrenergic receptortarget
DB01136CarvedilolBeta-1 adrenergic receptortarget
DB01136CarvedilolNADH dehydrogenase [ubiquinone] 1 subunit C2target
DB01136CarvedilolBeta-2 adrenergic receptortarget
DB01136CarvedilolVascular endothelial growth factor Atarget
DB01136CarvedilolNatriuretic peptides Btarget
DB01136CarvedilolGap junction alpha-1 proteintarget
DB01136CarvedilolPotassium voltage-gated channel subfamily H member 2target
DB01136CarvedilolVascular cell adhesion protein 1target
DB01136CarvedilolCytochrome P450 2C9enzyme
DB01136CarvedilolCytochrome P450 2D6enzyme
DB01136CarvedilolXanthine dehydrogenase/oxidaseenzyme
DB01136CarvedilolMultidrug resistance protein 1transporter
DB01136CarvedilolCytochrome P450 1A2enzyme
DB01136CarvedilolCytochrome P450 3A4enzyme
DB01136CarvedilolCytochrome P450 1A1enzyme
DB01136CarvedilolCytochrome P450 2E1enzyme
DB01136CarvedilolProstaglandin G/H synthase 1enzyme
DB01136CarvedilolAlpha-1D adrenergic receptortarget
DB01136CarvedilolAlpha-1B adrenergic receptortarget
DB01136CarvedilolAlpha-2C adrenergic receptortarget
DB01136CarvedilolAlpha-2B adrenergic receptortarget
DB01136CarvedilolAlpha-2A adrenergic receptortarget
DB01136CarvedilolE-selectintarget
DB01136CarvedilolHypoxia-inducible factor 1-alphatarget
DB01136CarvedilolInward rectifier potassium channel 4target
DB00880ChlorothiazideSolute carrier family 12 member 3target
DB00880ChlorothiazideCarbonic anhydrase 1target
DB00880ChlorothiazideCarbonic anhydrase 2target
DB00880ChlorothiazideCarbonic anhydrase 4target
DB00880ChlorothiazideSolute carrier family 22 member 6transporter
DB04920ClevidipineVoltage-dependent L-type calcium channel subunit alpha-1Ftarget
DB04920ClevidipineVoltage-dependent L-type calcium channel subunit alpha-1Starget
DB04920ClevidipineVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
DB04920ClevidipineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB04920ClevidipineCytochrome P450 2C9enzyme
DB04920ClevidipineCytochrome P450 2D6enzyme
DB04920ClevidipineCytochrome P450 2E1enzyme
DB04920ClevidipineCytochrome P450 2C19enzyme
DB04920ClevidipineCytochrome P450 1A2enzyme
DB04920ClevidipineCytochrome P450 3A4enzyme
DB04920ClevidipineCholinesteraseenzyme
DB00575ClonidineAlpha-2A adrenergic receptortarget
DB00575ClonidineCytochrome P450 2D6enzyme
DB00575ClonidineAlpha-2B adrenergic receptortarget
DB00575ClonidineAlpha-2C adrenergic receptortarget
DB00575ClonidineSolute carrier family 22 member 1transporter
DB00575ClonidineSolute carrier family 22 member 3transporter
DB00575ClonidineSolute carrier family 22 member 5transporter
DB00575ClonidineSolute carrier family 22 member 4transporter
DB00575ClonidineMultidrug resistance protein 1transporter
DB00575ClonidineCytochrome P450 1A2enzyme
DB00575ClonidineCytochrome P450 3A4enzyme
DB00575ClonidineCytochrome P450 1A1enzyme
DB00575ClonidineCytochrome P450 3A5enzyme
DB00575ClonidineAlpha-1A adrenergic receptortarget
DB00575ClonidineAlpha-1B adrenergic receptortarget
DB00575ClonidineAlpha-1D adrenergic receptortarget
DB00343DiltiazemVoltage-dependent calcium channel gamma-1 subunittarget
DB00343DiltiazemCytochrome P450 3A4enzyme
DB00343DiltiazemCytochrome P450 2C19enzyme
DB00343DiltiazemCytochrome P450 2D6enzyme
DB00343DiltiazemCytochrome P450 3A5enzyme
DB00343DiltiazemCytochrome P450 3A7enzyme
DB00343DiltiazemMultidrug resistance protein 1transporter
DB00343DiltiazemCytochrome P450 2C8enzyme
DB00343DiltiazemCytochrome P450 2C9enzyme
DB00590DoxazosinAlpha-1A adrenergic receptortarget
DB00590DoxazosinAlpha-1B adrenergic receptortarget
DB00590DoxazosinAlpha-1D adrenergic receptortarget
DB00590DoxazosinPotassium voltage-gated channel subfamily H member 2target
DB00590DoxazosinPotassium voltage-gated channel subfamily H member 6target
DB00590DoxazosinPotassium voltage-gated channel subfamily H member 7target
DB00590DoxazosinAlpha-1-acid glycoprotein 1carrier
DB00590DoxazosinMultidrug resistance protein 1transporter
DB00590DoxazosinCytochrome P450 2C19enzyme
DB00590DoxazosinCytochrome P450 2D6enzyme
DB00584EnalaprilAngiotensin-converting enzymetarget
DB00584EnalaprilCytochrome P450 3A4enzyme
DB00584EnalaprilMultidrug resistance protein 1transporter
DB00584EnalaprilSolute carrier family 15 member 1transporter
DB00584EnalaprilSolute carrier family 22 member 6transporter
DB00584EnalaprilSolute carrier family 22 member 8transporter
DB00584EnalaprilSolute carrier family 22 member 7transporter
DB00584EnalaprilSolute carrier organic anion transporter family member 1A2transporter
DB09477EnalaprilatAngiotensin-converting enzymetarget
DB09477EnalaprilatB1 bradykinin receptortarget
DB00700EplerenoneCytochrome P450 3A4enzyme
DB00700EplerenoneCytochrome P450 3A5enzyme
DB00700EplerenoneCytochrome P450 3A7enzyme
DB00700EplerenoneCytochrome P450 11B2, mitochondrialenzyme
DB00700EplerenoneMineralocorticoid receptortarget
DB00876EprosartanType-1 angiotensin II receptortarget
DB00876EprosartanCanalicular multispecific organic anion transporter 1transporter
DB00876EprosartanCytochrome P450 2C9enzyme
DB01023FelodipineVoltage-dependent calcium channel subunit alpha-2/delta-1target
DB01023FelodipineCalmodulintarget
DB01023FelodipineCytochrome P450 3A4enzyme
DB01023FelodipineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB01023FelodipineVoltage-dependent L-type calcium channel subunit beta-2target
DB01023FelodipineCytochrome P450 2C8enzyme
DB01023FelodipineCalcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1Btarget
DB01023FelodipineCalcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1Atarget
DB01023FelodipineVoltage-dependent T-type calcium channel subunit alpha-1Htarget
DB01023FelodipineVoltage-dependent calcium channel subunit alpha-2/delta-2target
DB01023FelodipineTroponin C, skeletal muscletarget
DB01023FelodipineTroponin C, slow skeletal and cardiac musclestarget
DB01023FelodipineMineralocorticoid receptortarget
DB01023FelodipineVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
DB01023FelodipineVoltage-dependent L-type calcium channel subunit alpha-1Starget
DB01023FelodipineCytochrome P450 3A5enzyme
DB01023FelodipineCytochrome P450 3A7enzyme
DB01023FelodipineMultidrug resistance protein 1transporter
DB01023FelodipineCytochrome P450 2C9enzyme
DB01023FelodipineCytochrome P450 2D6enzyme
DB00492FosinoprilAngiotensin-converting enzymetarget
DB00492FosinoprilSolute carrier family 15 member 1transporter
DB00492FosinoprilSolute carrier family 15 member 2transporter
DB00695FurosemideSolute carrier family 12 member 1target
DB00695FurosemideSerum albumincarrier
DB00695FurosemideSolute carrier family 22 member 6transporter
DB00695FurosemideSolute carrier family 22 member 5transporter
DB00695FurosemideSolute carrier family 22 member 8transporter
DB00695FurosemideCanalicular multispecific organic anion transporter 1transporter
DB00695FurosemideSolute carrier organic anion transporter family member 2A1transporter
DB00695FurosemideSolute carrier family 22 member 11transporter
DB00695Furosemide6-phosphogluconate dehydrogenase, decarboxylatingenzyme
DB00695FurosemideCarbonic anhydrase 2target
DB01018GuanfacineAlpha-2A adrenergic receptortarget
DB01018GuanfacineCytochrome P450 2C9enzyme
DB01018GuanfacineCytochrome P450 2C19enzyme
DB01018GuanfacineCytochrome P450 3A4enzyme
DB01018GuanfacineAlpha-2B adrenergic receptortarget
DB00999HydrochlorothiazideSolute carrier family 12 member 3target
DB00999HydrochlorothiazideCarbonic anhydrase 1target
DB00999HydrochlorothiazideCarbonic anhydrase 2target
DB00999HydrochlorothiazideCarbonic anhydrase 4target
DB00999HydrochlorothiazideCarbonic anhydrase 9target
DB00999HydrochlorothiazideCarbonic anhydrase 12target
DB00999HydrochlorothiazideSolute carrier family 22 member 6transporter
DB00999HydrochlorothiazideCalcium-activated potassium channel subunit alpha-1target
DB00808IndapamidePotassium voltage-gated channel subfamily KQT member 1target
DB00808IndapamidePotassium voltage-gated channel subfamily E member 1target
DB00808IndapamideCytochrome P450 3A4enzyme
DB01029IrbesartanType-1 angiotensin II receptortarget
DB01029IrbesartanTranscription factor AP-1target
DB01029IrbesartanCytochrome P450 2C9enzyme
DB01029IrbesartanCytochrome P450 2C8enzyme
DB01029IrbesartanUDP-glucuronosyltransferase 1-3enzyme
DB01029IrbesartanProstaglandin G/H synthase 1enzyme
DB01029IrbesartanCytochrome P450 1A2enzyme
DB01029IrbesartanCytochrome P450 2D6enzyme
DB01029IrbesartanCytochrome P450 3A4enzyme
DB00270IsradipineVoltage-dependent calcium channel subunit alpha-2/delta-1target
DB00270IsradipineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB00270IsradipineCytochrome P450 3A4enzyme
DB00270IsradipineVoltage-dependent T-type calcium channel subunit alpha-1Htarget
DB00270IsradipineVoltage-dependent calcium channel subunit alpha-2/delta-2target
DB00270IsradipineVoltage-dependent L-type calcium channel subunit beta-2target
DB00270IsradipineVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
DB00270IsradipineVoltage-dependent L-type calcium channel subunit alpha-1Starget
DB00598LabetalolAlpha-1 adrenergic receptorstarget
DB00598LabetalolBeta-1 adrenergic receptortarget
DB00598LabetalolBeta-2 adrenergic receptortarget
DB00598LabetalolCytochrome P450 2D6enzyme
DB00722LisinoprilAngiotensin-converting enzymetarget
DB00678LosartanType-1 angiotensin II receptortarget
DB00678LosartanCytochrome P450 3A4enzyme
DB00678LosartanCytochrome P450 2C9enzyme
DB00678LosartanCytochrome P450 2C8enzyme
DB00678LosartanMultidrug resistance protein 1transporter
DB00678LosartanSolute carrier family 22 member 6transporter
DB00678LosartanUDP-glucuronosyltransferase 1-1enzyme
DB00678LosartanUDP-glucuronosyltransferase 1-3enzyme
DB00678LosartanUDP-glucuronosyltransferase 1-10enzyme
DB00678LosartanUDP-glucuronosyltransferase 2B7enzyme
DB00678LosartanUDP-glucuronosyltransferase 2B17enzyme
DB00678LosartanCytochrome P450 1A2enzyme
DB00678LosartanCytochrome P450 2C19enzyme
DB00678LosartanCytochrome P450 3A5enzyme
DB00678LosartanSerum albumincarrier
DB00678LosartanSolute carrier family 22 member 12transporter
DB00678LosartanSolute carrier family 2, facilitated glucose transporter member 9transporter
DB00232MethyclothiazideSolute carrier family 12 member 1target
DB00232MethyclothiazideCarbonic anhydrase 4target
DB00232MethyclothiazideCarbonic anhydrase 2target
DB00232MethyclothiazideCarbonic anhydrase 1target
DB00968MethyldopaAlpha-2A adrenergic receptortarget
DB00968MethyldopaCatechol O-methyltransferaseenzyme
DB00968MethyldopaSolute carrier family 15 member 1transporter
DB00968MethyldopaAromatic-L-amino-acid decarboxylasetarget
DB00264MetoprololBeta-1 adrenergic receptortarget
DB00264MetoprololCytochrome P450 2D6enzyme
DB00264MetoprololBeta-2 adrenergic receptortarget
DB00264MetoprololSolute carrier family 22 member 2transporter
DB00264MetoprololMultidrug resistance protein 1transporter
DB00264MetoprololCytochrome P450 2C19enzyme
DB00691MoexiprilAngiotensin-converting enzymetarget
DB00691MoexiprilSolute carrier family 15 member 1transporter
DB00691MoexiprilSolute carrier family 15 member 2transporter
DB00691MoexiprilAngiotensin-converting enzyme 2target
DB01203NadololBeta-1 adrenergic receptortarget
DB01203NadololBeta-2 adrenergic receptortarget
DB01203NadololMultidrug resistance protein 1transporter
DB04861NebivololBeta-1 adrenergic receptortarget
DB04861NebivololCytochrome P450 2D6enzyme
DB04861NebivololBeta-2 adrenergic receptortarget
DB00622NicardipineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB00622NicardipineCytochrome P450 3A4enzyme
DB00622NicardipineCytochrome P450 2C9enzyme
DB00622NicardipineCytochrome P450 2C19enzyme
DB00622NicardipineCytochrome P450 2C8enzyme
DB00622NicardipineCytochrome P450 2D6enzyme
DB00622NicardipineCalcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1Btarget
DB00622NicardipineCalcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1Atarget
DB00622NicardipineAlpha-1A adrenergic receptortarget
DB00622NicardipineAlpha-1D adrenergic receptortarget
DB00622NicardipineAlpha-1B adrenergic receptortarget
DB00622NicardipineMuscarinic acetylcholine receptor M1target
DB00622NicardipineMuscarinic acetylcholine receptor M2target
DB00622NicardipineMuscarinic acetylcholine receptor M3target
DB00622NicardipineMuscarinic acetylcholine receptor M4target
DB00622NicardipineMuscarinic acetylcholine receptor M5target
DB00622NicardipineVoltage-dependent calcium channel subunit alpha-2/delta-1target
DB00622NicardipineVoltage-dependent L-type calcium channel subunit beta-2target
DB00622NicardipineVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
DB00622NicardipineCalmodulintarget
DB00622NicardipineMultidrug resistance protein 1transporter
DB00622NicardipineCytochrome P450 2B6enzyme
DB00622NicardipineCytochrome P450 2E1enzyme
DB00622NicardipineCytochrome P450 3A5enzyme
DB01115NifedipineVoltage-dependent calcium channel subunit alpha-2/delta-1target
DB01115NifedipineCytochrome P450 3A4enzyme
DB01115NifedipineCytochrome P450 2E1enzyme
DB01115NifedipineCytochrome P450 2D6enzyme
DB01115NifedipineCalmodulintarget
DB01115NifedipineVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
DB01115NifedipineVoltage-dependent L-type calcium channel subunit alpha-1Starget
DB01115NifedipineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB01115NifedipineVoltage-dependent L-type calcium channel subunit beta-2target
DB01115NifedipinePotassium voltage-gated channel subfamily A member 1target
DB01115NifedipineVoltage-dependent T-type calcium channel subunit alpha-1Htarget
DB01115NifedipineCytochrome P450 1A2enzyme
DB01115NifedipineCytochrome P450 2A6enzyme
DB01115NifedipineCytochrome P450 2C8enzyme
DB01115NifedipineCytochrome P450 3A5enzyme
DB01115NifedipineCytochrome P450 3A7enzyme
DB01115NifedipineCanalicular multispecific organic anion transporter 2transporter
DB01115NifedipineMultidrug resistance protein 1transporter
DB01115NifedipineCanalicular multispecific organic anion transporter 1transporter
DB01115NifedipineCytochrome P450 1A1enzyme
DB01115NifedipineCytochrome P450 2B6enzyme
DB01115NifedipineCytochrome P450 2C9enzyme
DB01115NifedipineNuclear receptor subfamily 1 group I member 2target
DB00401NisoldipineCytochrome P450 3A4enzyme
DB00401NisoldipineVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
DB00401NisoldipineVoltage-dependent L-type calcium channel subunit alpha-1Starget
DB00401NisoldipineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB00401NisoldipineVoltage-dependent calcium channel subunit alpha-2/delta-1target
DB00401NisoldipineVoltage-dependent L-type calcium channel subunit beta-2target
DB00401NisoldipineCytochrome P450 3A5enzyme
DB00401NisoldipineCytochrome P450 3A7enzyme
DB00401NisoldipineMultidrug resistance protein 1transporter
DB00401NisoldipineCytochrome P450 1A2enzyme
DB00275OlmesartanType-1 angiotensin II receptortarget
DB00275OlmesartanCanalicular multispecific organic anion transporter 1transporter
DB00275OlmesartanSolute carrier organic anion transporter family member 1B3transporter
DB00275OlmesartanSolute carrier organic anion transporter family member 1B1transporter
DB00960PindololBeta-1 adrenergic receptortarget
DB00960PindololBeta-2 adrenergic receptortarget
DB00960Pindolol5-hydroxytryptamine receptor 1Atarget
DB00960Pindolol5-hydroxytryptamine receptor 1Btarget
DB00960PindololCytochrome P450 2D6enzyme
DB00960PindololBeta-3 adrenergic receptortarget
DB00457PrazosinAlpha-1A adrenergic receptortarget
DB00457PrazosinAlpha-1B adrenergic receptortarget
DB00457PrazosinAlpha-1D adrenergic receptortarget
DB00457PrazosinPotassium voltage-gated channel subfamily H member 2target
DB00457PrazosinPotassium voltage-gated channel subfamily H member 6target
DB00457PrazosinPotassium voltage-gated channel subfamily H member 7target
DB00457PrazosinAlpha-1-acid glycoprotein 1carrier
DB00457PrazosinSolute carrier family 22 member 2transporter
DB00457PrazosinSolute carrier family 22 member 1transporter
DB00457PrazosinSolute carrier family 22 member 3transporter
DB00457PrazosinMultidrug resistance protein 1transporter
DB00457PrazosinATP-binding cassette sub-family G member 2transporter
DB00457PrazosinCytochrome P450 1A1enzyme
DB00457PrazosinAlpha-2A adrenergic receptortarget
DB00457PrazosinAlpha-2B adrenergic receptortarget
DB00571PropranololBeta-1 adrenergic receptortarget
DB00571PropranololBeta-2 adrenergic receptortarget
DB00571PropranololBeta-3 adrenergic receptortarget
DB00571Propranolol5-hydroxytryptamine receptor 1Atarget
DB00571Propranolol5-hydroxytryptamine receptor 1Btarget
DB00571PropranololCytochrome P450 1A2enzyme
DB00571PropranololCytochrome P450 2D6enzyme
DB00571PropranololAlpha-1-acid glycoprotein 1carrier
DB00571PropranololCytochrome P450 2C19enzyme
DB00571PropranololCytochrome P450 3A4enzyme
DB00571PropranololCytochrome P450 3A5enzyme
DB00571PropranololCytochrome P450 3A7enzyme
DB00571PropranololSolute carrier family 22 member 2transporter
DB00571PropranololMultidrug resistance protein 1transporter
DB00571PropranololCytochrome P450 1A1enzyme
DB00881QuinaprilAngiotensin-converting enzymetarget
DB00881QuinaprilSolute carrier family 15 member 1transporter
DB00881QuinaprilSolute carrier family 15 member 2transporter
DB00178RamiprilAngiotensin-converting enzymetarget
DB00178RamiprilSolute carrier family 15 member 1transporter
DB00178RamiprilSolute carrier family 15 member 2transporter
DB00178RamiprilCholinesteraseenzyme
DB00178RamiprilB1 bradykinin receptortarget
DB00206ReserpineSynaptic vesicular amine transportertarget
DB00206ReserpineMultidrug resistance protein 1transporter
DB00206ReserpineSolute carrier family 22 member 1transporter
DB00206ReserpineBile salt export pumptransporter
DB00206ReserpineCanalicular multispecific organic anion transporter 1transporter
DB00206ReserpineSolute carrier family 22 member 2transporter
DB00206ReserpineCytochrome P450 3A5enzyme
DB00206ReserpineChromaffin granule amine transportertarget
DB00206ReserpineBaculoviral IAP repeat-containing protein 5target
DB00421SpironolactoneMineralocorticoid receptortarget
DB00421SpironolactoneCytochrome P450 2C8enzyme
DB00421SpironolactoneCanalicular multispecific organic anion transporter 1transporter
DB00421SpironolactoneMultidrug resistance protein 1transporter
DB00421SpironolactoneSolute carrier organic anion transporter family member 1A2transporter
DB00421SpironolactoneCytochrome P450 11B1, mitochondrialenzyme
DB00421SpironolactoneAndrogen receptortarget
DB00421SpironolactoneProgesterone receptortarget
DB00421SpironolactoneGlucocorticoid receptortarget
DB00421SpironolactoneCytochrome P450 11B2, mitochondrialtarget
DB00421Spironolactone17alpha-hydroxylasetarget
DB00421Spironolactone17,20-desmolasetarget
DB00421Spironolactone3-oxo-5-alpha-steroid 4-dehydrogenasetarget
DB00421SpironolactoneSex hormone-binding globulintarget
DB00421SpironolactoneVoltage-dependent calcium channeltarget
DB00421SpironolactoneDihydrotestosterone receptortarget
DB00421SpironolactoneNuclear receptor subfamily 1 group I member 2target
DB00966TelmisartanType-1 angiotensin II receptortarget
DB00966TelmisartanPeroxisome proliferator-activated receptor gammatarget
DB00966TelmisartanMultidrug resistance protein 1transporter
DB00966TelmisartanCanalicular multispecific organic anion transporter 1transporter
DB00966TelmisartanATP-binding cassette sub-family G member 2transporter
DB00966TelmisartanCytochrome P450 2C19enzyme
DB01162TerazosinAlpha-1A adrenergic receptortarget
DB01162TerazosinAlpha-1B adrenergic receptortarget
DB01162TerazosinAlpha-1D adrenergic receptortarget
DB01162TerazosinPotassium voltage-gated channel subfamily H member 2target
DB01162TerazosinPotassium voltage-gated channel subfamily H member 6target
DB01162TerazosinPotassium voltage-gated channel subfamily H member 7target
DB01162TerazosinMultidrug resistance protein 1transporter
DB00214TorasemideSolute carrier family 12 member 1target
DB00214TorasemideCytochrome P450 2C8enzyme
DB00214TorasemideCytochrome P450 2C9enzyme
DB00214TorasemideProstaglandin G/H synthase 1enzyme
DB00214TorasemideCytochrome P450 2C19enzyme
DB00519TrandolaprilAngiotensin-converting enzymetarget
DB00519TrandolaprilSolute carrier family 15 member 1transporter
DB00519TrandolaprilSolute carrier family 15 member 2transporter
DB00519TrandolaprilLiver carboxylesterase 1enzyme
DB00384TriamtereneAmiloride-sensitive sodium channel subunit gammatarget
DB00384TriamtereneAmiloride-sensitive sodium channel subunit alphatarget
DB00384TriamtereneAmiloride-sensitive sodium channel subunit betatarget
DB00384TriamtereneAmiloride-sensitive sodium channel subunit deltatarget
DB00384TriamtereneCytochrome P450 1A2enzyme
DB00177ValsartanType-1 angiotensin II receptortarget
DB00177ValsartanCytochrome P450 2C9enzyme
DB00177ValsartanSolute carrier organic anion transporter family member 1B3transporter
DB00177ValsartanSolute carrier organic anion transporter family member 1B1transporter
DB00177ValsartanSerum albumincarrier
DB00661VerapamilCytochrome P450 1A2enzyme
DB00661VerapamilCytochrome P450 3A5enzyme
DB00661VerapamilCytochrome P450 3A4enzyme
DB00661VerapamilCytochrome P450 3A7enzyme
DB00661VerapamilCytochrome P450 2C8enzyme
DB00661VerapamilCytochrome P450 2C9enzyme
DB00661VerapamilCytochrome P450 2C18enzyme
DB00661VerapamilCytochrome P450 2B6enzyme
DB00661VerapamilCytochrome P450 2C19enzyme
DB00661VerapamilCytochrome P450 2D6enzyme
DB00661VerapamilSodium channel protein type 5 subunit alphatarget
DB00661VerapamilATP-sensitive inward rectifier potassium channel 11target
DB00661VerapamilVoltage-dependent L-type calcium channel subunit beta-4target
DB00661VerapamilVoltage-dependent T-type calcium channel subunit alpha-1Gtarget
DB00661VerapamilVoltage-dependent L-type calcium channel subunit alpha-1Ftarget
DB00661VerapamilVoltage-dependent L-type calcium channel subunit beta-3target
DB00661VerapamilVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
DB00661VerapamilVoltage-dependent L-type calcium channel subunit beta-1target
DB00661VerapamilVoltage-dependent L-type calcium channel subunit beta-2target
DB00661VerapamilPotassium voltage-gated channel subfamily H member 2target
DB00661VerapamilVoltage-dependent L-type calcium channel subunit alpha-1Starget
DB00661VerapamilVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB00661VerapamilVoltage-dependent T-type calcium channel subunit alpha-1Itarget
DB00661VerapamilVoltage-dependent N-type calcium channel subunit alpha-1Btarget
DB00661VerapamilVoltage-dependent P/Q-type calcium channel subunit alpha-1Atarget
DB00661VerapamilSodium-dependent serotonin transportertarget
DB00661VerapamilAlpha-1A adrenergic receptortarget
DB00661VerapamilAlpha-1B adrenergic receptortarget
DB00661VerapamilAlpha-1D adrenergic receptortarget
DB00661VerapamilMultidrug resistance protein 1transporter
DB00661VerapamilSolute carrier family 22 member 1transporter
DB00661VerapamilCanalicular multispecific organic anion transporter 2transporter
DB00661VerapamilMultidrug resistance-associated protein 4transporter
DB00661VerapamilSolute carrier family 22 member 5transporter
DB00661VerapamilBile salt export pumptransporter
DB00661VerapamilMultidrug resistance-associated protein 1transporter
DB00661VerapamilSolute carrier organic anion transporter family member 1A2transporter
DB00661VerapamilMultidrug resistance-associated protein 7transporter
DB00661VerapamilCanalicular multispecific organic anion transporter 1transporter
DB00661VerapamilSolute carrier family 22 member 4transporter
DB00661VerapamilATP-binding cassette sub-family G member 2transporter
DB00661VerapamilSolute carrier organic anion transporter family member 1B1transporter
DrugDrug NamePhaseStatusCount
DB00316Acetaminophen0Enrolling by Invitation1
DB00594Amiloride0Terminated1
DB01217Anastrozole0Withdrawn1
DB11720Angiotensin 1-70Active Not Recruiting1
DB00335Atenolol0Not Yet Recruiting1
DB00136Calcitriol0Terminated1
DB00575Clonidine0Not Yet Recruiting1
DB00115Cyanocobalamin0Completed1
DB00999Hydrochlorothiazide0Terminated1
DB01050Ibuprofen0Enrolling by Invitation1
DB00007Leuprolide0Withdrawn1
DB00678Losartan0Not Yet Recruiting1
DB01065Melatonin0Not Yet Recruiting2
DB00191Phentermine0Completed1
DB00360Sapropterin0Completed1
DB01392Yohimbine0Not Yet Recruiting1
DB00945Acetylsalicylic acid1Completed1
DB09026Aliskiren1Completed4
DB09026Aliskiren1Withdrawn1
DB00594Amiloride1Completed1
DB00345Aminohippuric acid1Active Not Recruiting1
DB00381Amlodipine1Completed19
DB00381Amlodipine1Not Yet Recruiting1
DB00381Amlodipine1Recruiting1
DB00381Amlodipine1Terminated1
DB00381Amlodipine1Withdrawn1
DB11842Angiotensin Ii1Active Not Recruiting1
DB00335Atenolol1Completed3
DB01076Atorvastatin1Completed3
DB08822Azilsartan medoxomil1Not Yet Recruiting1
DB05358Azilsartan medoxomil1Terminated1
DB08822Azilsartan medoxomil1Terminated1
DB12054BQ-1231Recruiting2
DB00559Bosentan1Completed1
DB01373Calcium1Completed1
DB00796Candesartan1Completed9
DB00796Candesartan1Not Yet Recruiting1
DB01197Captopril1Completed2
DB00190Carbidopa1Completed1
DB01136Carvedilol1Completed4
DB00310Chlorthalidone1Completed3
DB09232Cilnidipine1Completed1
DB00575Clonidine1Completed1
DB11086Cocoa butter1Recruiting1
DB00035Desmopressin1Completed1
DB00343Diltiazem1Completed2
DB00343Diltiazem1Withdrawn1
DB00975Dipyridamole1Completed1
DB00584Enalapril1Completed1
DB00700Eplerenone1Completed1
DB00153Ergocalciferol1Completed1
DB00800Fenoldopam1Unknown Status1
DB00950Fexofenadine1Recruiting1
DB09279Fimasartan1Completed9
DB01018Guanfacine1Completed1
DB01275Hydralazine1Completed1
DB00999Hydrochlorothiazide1Completed5
DB00224Indinavir1Completed1
DB01020Isosorbide Mononitrate1Completed3
DB09237Levamlodipine1Completed3
DB00722Lisinopril1Completed6
DB00678Losartan1Completed7
DB11968MK-71451Completed1
DB00264Metoprolol1Completed3
DB01017Minocycline1Recruiting1
DB05063Mitoquinone1Recruiting1
DB00218Moxifloxacin1Completed1
DB04861Nebivolol1Completed2
DB11589Neon1Active Not Recruiting1
DB04899Nesiritide1Completed1
DB00622Nicardipine1Completed1
DB02701Nicotinamide1Completed1
DB01115Nifedipine1Completed1
DB00727Nitroglycerin1Completed1
DB00727Nitroglycerin1Recruiting1
DB00368Norepinephrine1Active Not Recruiting1
DB00275Olmesartan1Completed1
DB00692Phentolamine1Recruiting1
DB00388Phenylephrine1Recruiting1
DB08860Pitavastatin1Completed2
DB01345Potassium1Completed1
DB00457Prazosin1Completed1
DB00852Pseudoephedrine1Completed1
DB04216Quercetin1Active Not Recruiting1
DB00178Ramipril1Completed1
DB00178Ramipril1Withdrawn1
DB00863Ranitidine1Recruiting1
DB02709Resveratrol1Active Not Recruiting1
DB00503Ritonavir1Completed1
DB01098Rosuvastatin1Completed11
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DB00678LosartanNot AvailableNot Yet Recruiting1
DB00678LosartanNot AvailableUnknown Status2
DB08815LurasidoneNot AvailableRecruiting1
DB00760MeropenemNot AvailableRecruiting1
DB00331MetforminNot AvailableNot Yet Recruiting1
DB00331MetforminNot AvailableWithdrawn1
DB00968MethyldopaNot AvailableTerminated1
DB00959MethylprednisoloneNot AvailableRecruiting1
DB00264MetoprololNot AvailableCompleted5
DB00264MetoprololNot AvailableRecruiting1
DB00264MetoprololNot AvailableTerminated3
DB00264MetoprololNot AvailableUnknown Status2
DB00683MidazolamNot AvailableRecruiting1
DB01618MolindoneNot AvailableRecruiting1
DB00295MorphineNot AvailableRecruiting1
DB04861NebivololNot AvailableCompleted5
DB04861NebivololNot AvailableTerminated2
DB04861NebivololNot AvailableUnknown Status2
DB04861NebivololNot AvailableWithdrawn1
DB11589NeonNot AvailableActive Not Recruiting1
DB04899NesiritideNot AvailableCompleted1
DB04899NesiritideNot AvailableWithdrawn1
DB00622NicardipineNot AvailableRecruiting1
DB09220NicorandilNot AvailableTerminated1
DB01115NifedipineNot AvailableCompleted3
DB01115NifedipineNot AvailableRecruiting1
DB01115NifedipineNot AvailableWithdrawn1
DB00727NitroglycerinNot AvailableCompleted1
DB00325NitroprussideNot AvailableCompleted1
DB00368NorepinephrineNot AvailableActive Not Recruiting1
DB00334OlanzapineNot AvailableRecruiting1
DB00275OlmesartanNot AvailableCompleted3
DB00275OlmesartanNot AvailableUnknown Status1
DB11133Omega-3 fatty acidsNot AvailableActive Not Recruiting1
DB00198OseltamivirNot AvailableRecruiting1
DB00910ParicalcitolNot AvailableCompleted1
DB00312PentobarbitalNot AvailableRecruiting1
DB00790PerindoprilNot AvailableCompleted1
DB00790PerindoprilNot AvailableNot Yet Recruiting1
DB00960PindololNot AvailableTerminated1
DB01345PotassiumNot AvailableCompleted1
DB00761Potassium ChlorideNot AvailableRecruiting1
DB09345PramocaineNot AvailableCompleted1
DB00175PravastatinNot AvailableTerminated1
DB00818PropofolNot AvailableRecruiting1
DB00571PropranololNot AvailableCompleted1
DB01224QuetiapineNot AvailableRecruiting1
DB00881QuinaprilNot AvailableCompleted2
DB00178RamiprilNot AvailableCompleted2
DB00734RisperidoneNot AvailableRecruiting1
DB01098RosuvastatinNot AvailableTerminated1
DB12418SaccharinNot AvailableWithdrawn1
DB01399SalsalateNot AvailableCompleted1
DB00203SildenafilNot AvailableCompleted3
DB00641SimvastatinNot AvailableCompleted1
DB01261SitagliptinNot AvailableCompleted1
DB01261SitagliptinNot AvailableRecruiting1
DB09422Soybean oilNot AvailableCompleted2
DB00421SpironolactoneNot AvailableWithdrawn1
DB00820TadalafilNot AvailableCompleted1
DB00966TelmisartanNot AvailableCompleted34
DB00966TelmisartanNot AvailableNot Yet Recruiting1
DB00966TelmisartanNot AvailableTerminated1
DB00966TelmisartanNot AvailableUnknown Status2
DB01162TerazosinNot AvailableCompleted1
DB00624TestosteroneNot AvailableWithdrawn1
DB11815TilarginineNot AvailableCompleted1
DB00373TimololNot AvailableRecruiting1
DB00684TobramycinNot AvailableRecruiting1
DB00273TopiramateNot AvailableRecruiting1
DB00384TriamtereneNot AvailableUnknown Status1
DB08604TriclosanNot AvailableCompleted1
DB01116TrimethaphanNot AvailableCompleted1
DB00313Valproic AcidNot AvailableRecruiting1
DB00177ValsartanNot AvailableTerminated1
DB00177ValsartanNot AvailableUnknown Status1
DB11094Vitamin DNot AvailableRecruiting1
DB11094Vitamin DNot AvailableWithdrawn1
DB00682WarfarinNot AvailableRecruiting1
DB09145WaterNot AvailableTerminated1
DB00246ZiprasidoneNot AvailableRecruiting1
DB05875substance PNot AvailableCompleted1