Open Angle Glaucoma (OAG)

Also known as: Open angle glaucoma / Glaucoma, Open Angle / Open angle glaucoma NOS / Pigmentary glaucoma / Open-angle glaucoma NOS / Open-angle glaucoma / Glaucoma, Open-Angle / Open-angle glaucoma, unspecified / Glaucoma simplex

DrugDrug NameDrug Description
DB00819AcetazolamideA cardiac anhydrase inhibitor used to treat edema from heart failure or medications, certain types of epilepsy, and glaucoma.
DB00905BimatoprostA prostaglandin analog used to treat hypotrichosis of the eyelashes and intraocular pressure in open angle glaucoma or ocular hypertension.
DB00411CarbamoylcholineA direct acting miotic agent administered ophthalmically to decrease intraocular pressure in glaucoma or after eye surgery, and to induce miosis during surgery.
DB00869DorzolamideA carbonic anhydrase inhibitor used to treat high intraocular pressure in ocular hypertension and open angle glaucoma.
DB00668EpinephrineA hormone and neurotransmitter used to treat allergic reactions, to restore cardiac rhythm, and to control mucosal congestion, glaucoma, and asthma.
DB01214MetipranololA beta-adrenergic antagonist used for the reduction of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.
DrugDrug NameTargetType
DB00819AcetazolamideCarbonic anhydrase 1target
DB00819AcetazolamideAquaporin-1target
DB00819AcetazolamideCarbonic anhydrase 14target
DB00819AcetazolamideSolute carrier family 22 member 6transporter
DB00819AcetazolamideCarbonic anhydrase 2target
DB00819AcetazolamideCarbonic anhydrase 3target
DB00819AcetazolamideCarbonic anhydrase 4target
DB00819AcetazolamideCytochrome P450 3A4enzyme
DB00819AcetazolamideCarbonic anhydrase 7target
DB00819AcetazolamideCarbonic anhydrase 12target
DB00905BimatoprostProstaglandin F2-alpha receptortarget
DB00905BimatoprostProstaglandin E2 receptor EP1 subtypetarget
DB00905BimatoprostProstaglandin E2 receptor EP3 subtypetarget
DB00905BimatoprostCytochrome P450 3A4enzyme
DB00905BimatoprostCytochrome P450 3A5enzyme
DB00411CarbamoylcholineMuscarinic acetylcholine receptor M1target
DB00411CarbamoylcholineMuscarinic acetylcholine receptor M2target
DB00411CarbamoylcholineNeuronal acetylcholine receptor subunit alpha-2target
DB00411CarbamoylcholineCytosolic phospholipase A2enzyme
DB00411CarbamoylcholineAcetylcholinesterasetarget
DB00411CarbamoylcholineMuscarinic acetylcholine receptor M3target
DB00411CarbamoylcholineMuscarinic acetylcholine receptor M4target
DB00869DorzolamideCarbonic anhydrase 2target
DB00869DorzolamideCarbonic anhydrase 1target
DB00869DorzolamideCarbonic anhydrase 4target
DB00869DorzolamideCytochrome P450 2C9enzyme
DB00869DorzolamideCarbonic anhydrase 3target
DB00668EpinephrineAlpha-1A adrenergic receptortarget
DB00668EpinephrineBeta-1 adrenergic receptortarget
DB00668EpinephrineBeta-2 adrenergic receptortarget
DB00668EpinephrineSolute carrier family 22 member 2transporter
DB00668EpinephrineSolute carrier family 22 member 1transporter
DB00668EpinephrineCytochrome P450 2C9enzyme
DB00668EpinephrineCytochrome P450 3A4enzyme
DB00668EpinephrineAlpha-1B adrenergic receptortarget
DB00668EpinephrineAlpha-1D adrenergic receptortarget
DB00668EpinephrineAlpha-2A adrenergic receptortarget
DB00668EpinephrineAlpha-2B adrenergic receptortarget
DB00668EpinephrineTumor necrosis factortarget
DB00668EpinephrineCatechol O-methyltransferaseenzyme
DB00668EpinephrineMonoamine oxidaseenzyme
DB01214MetipranololBeta-1 adrenergic receptortarget
DB01214MetipranololBeta-2 adrenergic receptortarget
DB01214MetipranololCytochrome P450 2D6enzyme
DrugDrug NamePhaseStatusCount
DB00654Latanoprost1Not Yet Recruiting1
DB00654Latanoprost1 / 2Completed1
DB12256Bamosiran2Completed2
DB00443Betamethasone2Completed1
DB00484Brimonidine2Completed1
DB00091Cyclosporine2Completed1
DB00654Latanoprost2Completed3
DB11660Latanoprostene bunod2Completed1
DB13931Netarsudil2Completed5
DB00692Phentolamine2Completed1
DB00373Timolol2Completed3
DB00287Travoprost2Completed1
DB00905Bimatoprost3Withdrawn1
DB00484Brimonidine3Recruiting1
DB01194Brinzolamide3Withdrawn1
DB00869Dorzolamide3Completed1
DB00654Latanoprost3Completed7
DB00654Latanoprost3Recruiting1
DB00654Latanoprost3Terminated1
DB00654Latanoprost3Withdrawn1
DB13931Netarsudil3Recruiting1
DB01165Ofloxacin3Recruiting1
DB01085Pilocarpine3Recruiting1
DB00860Prednisolone3Recruiting1
DB08819Tafluprost3Completed1
DB00373Timolol3Completed8
DB00373Timolol3Terminated1
DB00287Travoprost3Completed3
DB00287Travoprost3Withdrawn1
DB00905Bimatoprost4Completed2
DB00484Brimonidine4Completed2
DB01194Brinzolamide4Completed3
DB00869Dorzolamide4Completed2
DB00869Dorzolamide4Unknown Status1
DB00654Latanoprost4Completed4
DB00305Mitomycin4Completed1
DB00305Mitomycin4Recruiting1
DB00373Timolol4Completed5
DB00373Timolol4Unknown Status1
DB00287Travoprost4Completed4
DB00484BrimonidineNot AvailableCompleted1
DB01194BrinzolamideNot AvailableCompleted1
DB00869DorzolamideNot AvailableUnknown Status1
DB00465KetorolacNot AvailableTerminated1
DB00654LatanoprostNot AvailableUnknown Status1
DB15566Prednisolone acetateNot AvailableTerminated1
DB00373TimololNot AvailableUnknown Status1
DB00287TravoprostNot AvailableCompleted1