Hairy Cell Leukemia (HCL)

Also known as: Leukemia, Hairy Cell / Hairy cell leukaemia / Hairy Cell Leukemia / Leukemias, Hairy Cell / Leukemic reticuloendotheliosis / Leukaemic reticuloendotheliosis

Drug	Drug Name	Drug Description
DB00242	Cladribine	A purine antimetabolite used for the management of relapsing forms of Multiple Sclerosis (MS), used in patients who have not responded to or who were unable to tolerate alternative MS drugs.
DB00105	Interferon alfa-2b	A form of recombinant human interferon used to treat hepatitis B and C infection, genital warts, hairy cell leukemia, follicular lymphoma, malignant melanoma, and AIDs-related Kaposi's sarcoma.
DB12688	Moxetumomab Pasudotox	A CD22-specific antibody conjugated to a truncated exotoxin used to treat relapsed or refractory hairy cell leukemia in patients who have already been treated with a purine nucleoside analog and one other treatment.
DB00552	Pentostatin	An adenosine deaminase inhibitor used to treat hairy cell leukemia.

Drug	Drug Name	Target	Type
DB00242	Cladribine	Purine nucleoside phosphorylase	target
DB00242	Cladribine	DNA	target
DB00242	Cladribine	Deoxycytidine kinase	enzyme
DB00242	Cladribine	Ribonucleoside-diphosphate reductase large subunit	target
DB00242	Cladribine	Ribonucleoside-diphosphate reductase subunit M2	target
DB00242	Cladribine	Ribonucleoside-diphosphate reductase subunit M2 B	target
DB00242	Cladribine	DNA polymerase alpha catalytic subunit	target
DB00242	Cladribine	DNA polymerase epsilon catalytic subunit A	target
DB00242	Cladribine	DNA polymerase epsilon subunit 2	target
DB00242	Cladribine	DNA polymerase epsilon subunit 3	target
DB00242	Cladribine	DNA polymerase epsilon subunit 4	target
DB00242	Cladribine	ATP-binding cassette sub-family G member 2	transporter
DB00242	Cladribine	Solute carrier family 28 member 3	transporter
DB00105	Interferon alfa-2b	Interferon alpha/beta receptor 2	target
DB00105	Interferon alfa-2b	Interferon alpha/beta receptor 1	target
DB00105	Interferon alfa-2b	Cytochrome P450 1A2	enzyme
DB12688	Moxetumomab Pasudotox	B-cell receptor CD22	target
DB12688	Moxetumomab Pasudotox	Elongation factor 2	target
DB00552	Pentostatin	Adenosine deaminase	target

Drug	Drug Name	Phase	Status	Count
DB12688	Moxetumomab Pasudotox	1	Completed	1
DB12688	Moxetumomab Pasudotox	1	Recruiting	1
DB12688	Moxetumomab Pasudotox	1	Unknown Status	1
DB12146	Rigosertib	1	Completed	1
DB00073	Rituximab	1	Recruiting	1
DB12121	Entospletinib	1 / 2	Recruiting	1
DB08935	Obinutuzumab	1 / 2	Recruiting	1
DB06769	Bendamustine	2	Recruiting	1
DB00242	Cladribine	2	Completed	1
DB00242	Cladribine	2	Recruiting	2
DB15223	Flotetuzumab	2	Not Yet Recruiting	1
DB09053	Ibrutinib	2	Recruiting	1
DB00034	Interferon alfa-2a, Recombinant	2	Completed	1
DB08935	Obinutuzumab	2	Recruiting	1
DB00552	Pentostatin	2	Recruiting	1
DB00073	Rituximab	2	Completed	1
DB00073	Rituximab	2	Recruiting	3
DB08881	Vemurafenib	2	Active Not Recruiting	1
DB08881	Vemurafenib	2	Recruiting	1
DB00242	Cladribine	2 / 3	Recruiting	1
DB12688	Moxetumomab Pasudotox	3	Completed	1