Hairy Cell Leukemia (HCL)

Also known as: Leukemia, Hairy Cell / Hairy cell leukaemia / Hairy Cell Leukemia / Leukemias, Hairy Cell / Leukemic reticuloendotheliosis / Leukaemic reticuloendotheliosis

Drug	Drug Name	Drug Description
DB00242	Cladribine	An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. [PubChem]
DB00105	Interferon Alfa-2b, Recombinant	Interferon alpha 2b (human leukocyte clone hif-sn 206 protein moiety reduced). A type I interferon consisting of 165 amino acid residues with arginine in position 23. This protein is produced by recombinant DNA technology and resembles interferon secreted by leukocytes. It is used extensively as an antiviral or antineoplastic agent.
DB00552	Pentostatin	A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity. [PubChem]

Drug	Drug Name	Target	Type
DB00242	Cladribine	Purine nucleoside phosphorylase	target
DB00242	Cladribine	DNA	target
DB00242	Cladribine	Deoxycytidine kinase	enzyme
DB00242	Cladribine	Ribonucleoside-diphosphate reductase large subunit	target
DB00242	Cladribine	Ribonucleoside-diphosphate reductase subunit M2	target
DB00242	Cladribine	Ribonucleoside-diphosphate reductase subunit M2 B	target
DB00242	Cladribine	DNA polymerase alpha catalytic subunit	target
DB00242	Cladribine	DNA polymerase epsilon catalytic subunit A	target
DB00242	Cladribine	DNA polymerase epsilon subunit 2	target
DB00242	Cladribine	DNA polymerase epsilon subunit 3	target
DB00242	Cladribine	DNA polymerase epsilon subunit 4	target
DB00242	Cladribine	Solute carrier family 22 member 2	transporter
DB00242	Cladribine	Solute carrier family 22 member 1	transporter
DB00242	Cladribine	ATP-binding cassette sub-family G member 2	transporter
DB00242	Cladribine	Solute carrier family 28 member 3	transporter
DB00105	Interferon Alfa-2b, Recombinant	Interferon alpha/beta receptor 2	target
DB00105	Interferon Alfa-2b, Recombinant	Interferon alpha/beta receptor 1	target
DB00105	Interferon Alfa-2b, Recombinant	Cytochrome P450 1A2	enzyme
DB00552	Pentostatin	Adenosine deaminase	target

Drug	Drug Name	Phase	Status	Count
DB12688	Moxetumomab Pasudotox	1	Completed	1
DB12121	Entospletinib	1 / 2	Recruiting	1
DB08935	Obinutuzumab	1 / 2	Recruiting	1
DB06769	Bendamustine	2	Recruiting	1
DB00242	Cladribine	2	Completed	1
DB00242	Cladribine	2	Recruiting	1
DB09053	Ibrutinib	2	Recruiting	1
DB08935	Obinutuzumab	2	Recruiting	1
DB00552	Pentostatin	2	Recruiting	1
DB00073	Rituximab	2	Recruiting	2
DB08881	Vemurafenib	2	Active Not Recruiting	1
DB08881	Vemurafenib	2	Recruiting	1
DB00242	Cladribine	2 / 3	Recruiting	1
DB00125	L-Arginine	2 / 3	Recruiting	1
DB12688	Moxetumomab Pasudotox	3	Active Not Recruiting	1