Lung Cancer Small Cell Lung Cancer (SCLC)

Also known as: Small-cell Lung Cancer / Small Cell Lung Cancer / Small Cell Lung Cancer (SCLC) / Small Cell Carcinoma of the Lung / SCLC / Small Cell Lung Cancer ( SCLC ) / Small Cell Lung Cancers / Small-Cell-Lung Cancer / Lung Cancer, Small Cell / Small- Cell Lung Cancer / Small Cell Lung Carcinoma / Oat cell carcinoma of lung / Small cell lung cancer stage unspecified

DrugDrug NameDrug Description
DB00515CisplatinCisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also includes carboplatin and oxaliplatin.
DB01248DocetaxelDocetaxel is a clinically well established anti-mitotic chemotherapy medication used mainly for the treatment of breast, ovarian, and non-small cell lung cancer. Docetaxel binds to microtubules reversibly with high affinity and has a maximum stoichiometry of one mole docetaxel per mole tubulin in microtubules.
DB00773EtoposideA semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle. [PubChem]
DB01181IfosfamideIfosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppresive agent.
DB00762IrinotecanIrinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cell death. It is a derivative of camptothecin. Irinotecan was approved for the treatment of advanced pancreatic cancer in October, 2015 (irinotecan liposome injection, trade name Onivyde).
DB00563MethotrexateAn antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofolate dehydrogenase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
DrugDrug NameTargetType
DB00515CisplatinDNAtarget
DB00515CisplatinCanalicular multispecific organic anion transporter 2transporter
DB00515CisplatinMultidrug resistance-associated protein 5transporter
DB00515CisplatinCanalicular multispecific organic anion transporter 1transporter
DB00515CisplatinSolute carrier family 22 member 2transporter
DB00515CisplatinHigh affinity copper uptake protein 1transporter
DB00515CisplatinProbable low affinity copper uptake protein 2transporter
DB00515CisplatinMultidrug resistance-associated protein 6transporter
DB00515CisplatinMultidrug resistance protein 1transporter
DB00515CisplatinCopper-transporting ATPase 2transporter
DB00515CisplatinCopper-transporting ATPase 1transporter
DB00515CisplatinProstaglandin G/H synthase 2enzyme
DB00515CisplatinMyeloperoxidaseenzyme
DB00515CisplatinXanthine dehydrogenase/oxidaseenzyme
DB00515CisplatinArylamine N-acetyltransferaseenzyme
DB00515CisplatinCytochrome P450 2C9enzyme
DB00515CisplatinCytochrome P450 2B6enzyme
DB00515CisplatinCholinesteraseenzyme
DB00515CisplatinCytochrome P450 4A11enzyme
DB00515CisplatinATP-binding cassette sub-family G member 2transporter
DB00515CisplatinGlutathione S-transferase theta-1enzyme
DB00515CisplatinMetallothionein-1Aenzyme
DB00515CisplatinMetallothionein-2enzyme
DB00515CisplatinSuperoxide dismutase [Cu-Zn]enzyme
DB00515CisplatinGlutathione S-transferase Penzyme
DB00515CisplatinNAD(P)H dehydrogenase [quinone] 1enzyme
DB00515CisplatinGlutathione S-transferase Mu 1enzyme
DB00515CisplatinDNA-3-methyladenine glycosylasetarget
DB00515CisplatinAlpha-2-macroglobulintarget
DB00515CisplatinSerum albumincarrier
DB00515CisplatinSerotransferrintarget
DB00515CisplatinCopper transport protein ATOX1target
DB01248DocetaxelApoptosis regulator Bcl-2target
DB01248DocetaxelTubulin beta-1 chaintarget
DB01248DocetaxelCytochrome P450 3A4enzyme
DB01248DocetaxelCytochrome P450 3A5enzyme
DB01248DocetaxelCytochrome P450 3A7enzyme
DB01248DocetaxelMultidrug resistance protein 1transporter
DB01248DocetaxelMultidrug resistance-associated protein 7transporter
DB01248DocetaxelCytochrome P450 1B1enzyme
DB01248DocetaxelMicrotubule-associated protein 2target
DB01248DocetaxelMicrotubule-associated protein 4target
DB01248DocetaxelMicrotubule-associated protein tautarget
DB01248DocetaxelSolute carrier organic anion transporter family member 1B3transporter
DB01248DocetaxelSolute carrier family 22 member 7transporter
DB01248DocetaxelATP-binding cassette sub-family G member 2transporter
DB01248DocetaxelCanalicular multispecific organic anion transporter 1transporter
DB01248DocetaxelMultidrug resistance-associated protein 1transporter
DB01248DocetaxelNuclear receptor subfamily 1 group I member 2target
DB00773EtoposideDNA topoisomerase 2-alphatarget
DB00773EtoposideCytochrome P450 3A4enzyme
DB00773EtoposideCanalicular multispecific organic anion transporter 2transporter
DB00773EtoposideMultidrug resistance-associated protein 6transporter
DB00773EtoposideMultidrug resistance protein 1transporter
DB00773EtoposideMultidrug resistance-associated protein 1transporter
DB00773EtoposideMultidrug resistance-associated protein 7transporter
DB00773EtoposideCanalicular multispecific organic anion transporter 1transporter
DB00773EtoposideATP-binding cassette sub-family G member 2transporter
DB00773EtoposideCytochrome P450 1A2enzyme
DB00773EtoposideCytochrome P450 2C8enzyme
DB00773EtoposideCytochrome P450 2E1enzyme
DB00773EtoposideCytochrome P450 3A5enzyme
DB00773EtoposideUDP-glucuronosyltransferase 1-1enzyme
DB00773EtoposideDNA topoisomerase 2-betatarget
DB00773EtoposideGlutathione S-transferase theta-1enzyme
DB00773EtoposideGlutathione S-transferase Penzyme
DB00773EtoposideProstaglandin G/H synthase 2enzyme
DB00773EtoposideProstaglandin G/H synthase 1enzyme
DB01181IfosfamideCytochrome P450 2B6enzyme
DB01181IfosfamideDNAtarget
DB01181IfosfamideCytochrome P450 3A4enzyme
DB01181IfosfamideCytochrome P450 3A5enzyme
DB01181IfosfamideCytochrome P450 2C9enzyme
DB01181IfosfamideCytochrome P450 2C8enzyme
DB01181IfosfamideCytochrome P450 2A6enzyme
DB01181IfosfamideCytochrome P450 2C19enzyme
DB01181IfosfamideCytochrome P450 2C18enzyme
DB01181IfosfamideProstaglandin G/H synthase 1enzyme
DB01181IfosfamideCytochrome P450 3A7enzyme
DB01181IfosfamideNuclear receptor subfamily 1 group I member 2target
DB00762IrinotecanDNA topoisomerase I, mitochondrialtarget
DB00762IrinotecanDNA topoisomerase 1target
DB00762IrinotecanCytochrome P450 3A4enzyme
DB00762IrinotecanCytochrome P450 3A5enzyme
DB00762IrinotecanUDP-glucuronosyltransferase 1-1enzyme
DB00762IrinotecanUDP-glucuronosyltransferase 1-9enzyme
DB00762IrinotecanLiver carboxylesterase 1enzyme
DB00762IrinotecanCytochrome P450 3A7enzyme
DB00762IrinotecanCytochrome P450 2B6enzyme
DB00762IrinotecanSolute carrier family 22 member 3transporter
DB00762IrinotecanSolute carrier organic anion transporter family member 1B1transporter
DB00762IrinotecanMultidrug resistance-associated protein 1transporter
DB00762IrinotecanATP-binding cassette sub-family G member 2transporter
DB00762IrinotecanSerum albumincarrier
DB00762IrinotecanCocaine esteraseenzyme
DB00762IrinotecanCholinesteraseenzyme
DB00762IrinotecanMultidrug resistance protein 1transporter
DB00762IrinotecanCanalicular multispecific organic anion transporter 1transporter
DB00563MethotrexateDihydrofolate reductasetarget
DB00563MethotrexateAldehyde oxidaseenzyme
DB00563MethotrexateMethylenetetrahydrofolate reductaseenzyme
DB00563MethotrexateSerum albumincarrier
DB00563MethotrexateCanalicular multispecific organic anion transporter 2transporter
DB00563MethotrexateMultidrug resistance-associated protein 4transporter
DB00563MethotrexateMultidrug resistance-associated protein 1transporter
DB00563MethotrexateSolute carrier family 22 member 6transporter
DB00563MethotrexateMultidrug resistance-associated protein 7transporter
DB00563MethotrexateSolute carrier family 22 member 8transporter
DB00563MethotrexateCanalicular multispecific organic anion transporter 1transporter
DB00563MethotrexateMultidrug resistance protein 1transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 1A2transporter
DB00563MethotrexateMonocarboxylate transporter 1transporter
DB00563MethotrexateATP-binding cassette sub-family C member 11transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 1B3transporter
DB00563MethotrexateSolute carrier family 22 member 11transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 1C1transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 3A1transporter
DB00563MethotrexateATP-binding cassette sub-family G member 2transporter
DB00563MethotrexateSolute carrier family 22 member 7transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 1B1transporter
DB00563Methotrexate6-phosphogluconate dehydrogenase, decarboxylatingenzyme
DB00563MethotrexateProton-coupled folate transportertransporter
DB00563MethotrexateFolylpolyglutamate synthase, mitochondrialenzyme
DB00563MethotrexateGamma-glutamyl hydrolaseenzyme
DB00563MethotrexateDihydrofolate reductaseenzyme
DB00563MethotrexateThymidylate synthaseenzyme
DB00563MethotrexateBifunctional purine biosynthesis protein PURHenzyme
DB00563MethotrexateSolute carrier organic anion transporter family member 4C1transporter
DB00563MethotrexateFolate transporter 1transporter
DB00563MethotrexateFolate receptor alphatransporter
DrugDrug NamePhaseStatusCount
DB05220Alisertib1Completed1
DB00928Azacitidine1Recruiting1
DB00188Bortezomib1Completed1
DB00958Carboplatin1Recruiting1
DB00608Chloroquine1Completed1
DB00608Chloroquine1Recruiting1
DB00515Cisplatin1Active Not Recruiting1
DB00515Cisplatin1Recruiting1
DB00851Dacarbazine1Completed1
DB00773Etoposide1Active Not Recruiting1
DB00773Etoposide1Recruiting2
DB01590Everolimus1Completed1
DB11896Gedatolisib1Recruiting1
DB06186Ipilimumab1Recruiting2
DB12154Itacitinib1Recruiting1
DB12089Lorvotuzumab mertansine1Completed1
DB09035Nivolumab1Recruiting1
DB01229Paclitaxel1Completed1
DB01229Paclitaxel1Recruiting2
DB06603Panobinostat1Terminated1
DB09037Pembrolizumab1Recruiting2
DB13017Rovalpituzumab Tesirine1Recruiting3
DB01030Topotecan1Completed4
DB11581Venetoclax1Recruiting1
DB06069XMT-10011Completed1
DB05220Alisertib1 / 2Completed1
DB11595Atezolizumab1 / 2Terminated1
DB12459Belotecan1 / 2Recruiting1
DB00958Carboplatin1 / 2Active Not Recruiting2
DB00958Carboplatin1 / 2Completed4
DB00958Carboplatin1 / 2Terminated2
DB08889Carfilzomib1 / 2Active Not Recruiting1
DB00515Cisplatin1 / 2Active Not Recruiting1
DB00515Cisplatin1 / 2Completed2
DB00515Cisplatin1 / 2Recruiting1
DB00515Cisplatin1 / 2Terminated1
DB01234Dexamethasone1 / 2Active Not Recruiting1
DB01248Docetaxel1 / 2Active Not Recruiting1
DB00997Doxorubicin1 / 2Active Not Recruiting1
DB00997Doxorubicin1 / 2Terminated1
DB11714Durvalumab1 / 2Active Not Recruiting1
DB00773Etoposide1 / 2Active Not Recruiting2
DB00773Etoposide1 / 2Completed4
DB00773Etoposide1 / 2Recruiting1
DB00773Etoposide1 / 2Terminated2
DB12047Ganetespib1 / 2Terminated1
DB00441Gemcitabine1 / 2Active Not Recruiting1
DB00441Gemcitabine1 / 2Completed1
DB01181Ifosfamide1 / 2Recruiting1
DB06186Ipilimumab1 / 2Recruiting1
DB00762Irinotecan1 / 2Active Not Recruiting1
DB00762Irinotecan1 / 2Completed1
DB12085LCL-1611 / 2Recruiting1
DB12089Lorvotuzumab mertansine1 / 2Completed1
DB05764Navitoclax1 / 2Completed1
DB09035Nivolumab1 / 2Active Not Recruiting1
DB09035Nivolumab1 / 2Recruiting1
DB09074Olaparib1 / 2Active Not Recruiting2
DB01229Paclitaxel1 / 2Active Not Recruiting1
DB09037Pembrolizumab1 / 2Active Not Recruiting1
DB09037Pembrolizumab1 / 2Withdrawn1
DB00642Pemetrexed1 / 2Terminated1
DB12257Platinum1 / 2Active Not Recruiting1
DB11972Rilotumumab1 / 2Completed1
DB12893Sacituzumab govitecan1 / 2Recruiting1
DB00853Temozolomide1 / 2Active Not Recruiting1
DB01030Topotecan1 / 2Completed1
DB01030Topotecan1 / 2Recruiting2
DB01030Topotecan1 / 2Terminated1
DB01030Topotecan1 / 2Withdrawn1
DB00361Vinorelbine1 / 2Active Not Recruiting1
DB00361Vinorelbine1 / 2Completed1
DB02546Vorinostat1 / 2Terminated2
DB125527-ethyl-10-hydroxycamptothecin2Completed1
DB05220Alisertib2Active Not Recruiting1
DB06263Amrubicin2Completed3
DB06263Amrubicin2Terminated1
DB11885Anlotinib2Recruiting1
DB11595Atezolizumab2Recruiting2
DB12459Belotecan2Recruiting1
DB00112Bevacizumab2Completed2
DB00112Bevacizumab2Withdrawn1
DB06772Cabazitaxel2Completed1
DB00958Carboplatin2Completed3
DB00958Carboplatin2Not Yet Recruiting3
DB00958Carboplatin2Recruiting3
DB00958Carboplatin2Terminated2
DB00958Carboplatin2Unknown Status1
DB00515Cisplatin2Completed3
DB00515Cisplatin2Not Yet Recruiting1
DB00515Cisplatin2Terminated1
DB00515Cisplatin2Unknown Status2
DB00515Cisplatin2Withdrawn1
DB01151Desipramine2Terminated1
DB01248Docetaxel2Unknown Status1
DB01248Docetaxel2Withdrawn1
DB00997Doxorubicin2Active Not Recruiting1
DB11727Endostar2Completed1
DB01225Enoxaparin2Withdrawn1
DB00773Etoposide2Completed2
DB00773Etoposide2Not Yet Recruiting3
DB00773Etoposide2Recruiting3
DB00773Etoposide2Withdrawn1
DB01590Everolimus2Completed1
DB12047Ganetespib2Active Not Recruiting1
DB00317Gefitinib2Completed1
DB00441Gemcitabine2Not Yet Recruiting1
DB00441Gemcitabine2Recruiting2
DB00441Gemcitabine2Unknown Status1
DB01611Hydroxychloroquine2Not Yet Recruiting1
DB05325INGN 2252Active Not Recruiting1
DB00619Imatinib2Completed1
DB06186Ipilimumab2Completed1
DB06186Ipilimumab2Recruiting1
DB00762Irinotecan2Completed2
DB00762Irinotecan2Recruiting1
DB00762Irinotecan2Terminated1
DB00762Irinotecan2Unknown Status1
DB00125L-Arginine2Completed1
DB11861Litronesib2Completed1
DB11845Lucitanib2Completed1
DB09079Nintedanib2Completed1
DB09079Nintedanib2Recruiting1
DB09079Nintedanib2Withdrawn1
DB09035Nivolumab2Recruiting1
DB09074Olaparib2Recruiting1
DB00526Oxaliplatin2Terminated1
DB01229Paclitaxel2Active Not Recruiting3
DB01229Paclitaxel2Completed2
DB01229Paclitaxel2Recruiting1
DB01229Paclitaxel2Terminated1
DB06663Pasireotide2Unknown Status1
DB06589Pazopanib2Active Not Recruiting1
DB06589Pazopanib2Completed2
DB06589Pazopanib2Terminated2
DB09037Pembrolizumab2Active Not Recruiting1
DB09037Pembrolizumab2Not Yet Recruiting2
DB09037Pembrolizumab2Recruiting1
DB00642Pemetrexed2Terminated4
DB04874Picoplatin2Completed1
DB00635Prednisone2Recruiting1
DB12008Prexasertib2Recruiting1
DB13017Rovalpituzumab Tesirine2Active Not Recruiting1
DB00641Simvastatin2Completed1
DB00398Sorafenib2Terminated1
DB01268Sunitinib2Completed1
DB08937TAS-1022Terminated1
DB00853Temozolomide2Enrolling by Invitation1
DB04900Thymalfasin2Not Yet Recruiting1
DB01030Topotecan2Completed5
DB01030Topotecan2Not Yet Recruiting1
DB01030Topotecan2Recruiting3
DB01030Topotecan2Terminated1
DB01030Topotecan2Unknown Status1
DB00755Tretinoin2Active Not Recruiting1
DB05294Vandetanib2Completed1
DB07232Veliparib2Recruiting1
DB11925Vistusertib2Recruiting1
DB11999Vosaroxin2Completed1
DB09077Dinutuximab2 / 3Recruiting1
DB00762Irinotecan2 / 3Recruiting1
DB01030Topotecan2 / 3Recruiting1
DB06263Amrubicin3Completed1
DB06263Amrubicin3Terminated1
DB11595Atezolizumab3Recruiting1
DB00958Carboplatin3Completed2
DB00958Carboplatin3Recruiting3
DB00958Carboplatin3Terminated1
DB00493Cefotaxime3Recruiting1
DB00515Cisplatin3Active Not Recruiting1
DB00515Cisplatin3Completed3
DB00515Cisplatin3Not Yet Recruiting1
DB00515Cisplatin3Recruiting1
DB00515Cisplatin3Terminated2
DB00531Cyclophosphamide3Recruiting1
DB00012Darbepoetin alfa3Completed1
DB01234Dexamethasone3Recruiting1
DB00997Doxorubicin3Recruiting1
DB01225Enoxaparin3Completed1
DB00773Etoposide3Active Not Recruiting1
DB00773Etoposide3Completed5
DB00773Etoposide3Not Yet Recruiting1
DB00773Etoposide3Recruiting3
DB00773Etoposide3Terminated1
DB00762Irinotecan3Completed2
DB00762Irinotecan3Not Yet Recruiting1
DB12674Lurbinectedin3Recruiting1
DB09037Pembrolizumab3Recruiting1
DB00642Pemetrexed3Completed1
DB04874Picoplatin3Unknown Status1
DB13017Rovalpituzumab Tesirine3Recruiting2
DB01030Topotecan3Completed4
DB01030Topotecan3Not Yet Recruiting1
DB01030Topotecan3Recruiting3
DB01030Topotecan3Terminated1
DB00541Vincristine3Recruiting1
DB00515Cisplatin4Recruiting1
DB00773Etoposide4Recruiting1
DB00762Irinotecan4Recruiting1
DB00515CisplatinNot AvailableCompleted1
DB01254DasatinibNot AvailableCompleted1
DB01142DoxepinNot AvailableActive Not Recruiting1
DB00773EtoposideNot AvailableCompleted1
DB01181IfosfamideNot AvailableCompleted1
DB01362IohexolNot AvailableActive Not Recruiting1
DB00762IrinotecanNot AvailableUnknown Status1
DB00722LisinoprilNot AvailableActive Not Recruiting1
DB01356LithiumNot AvailableTerminated1
DB01030TopotecanNot AvailableCompleted2