Venous Thromboembolism (VTE)

Also known as: VTE / VTE (Venous Thromboembolism) / Venous Thromboembolism / Venous thromboembolisms / Venous embolism / Embolism venous / Embolism of vein NOS / Venous embolism NOS

DrugDrug NameDrug Description
DB12364BetrixabanBetrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa [A7708]. It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity [A27286]. Betrixaban, now developed by Portola Pharmaceuticals Inc., is prescribed as a venous thromboembolism (VTE) prophylactic for adult patients with moderate to severe restricted motility or with other risks for VTE [A27285]. VTE can be manifested as deep vein thrombosis or pulmonary embolism and it is a leading cause of preventable death in hospitalized patients [A27287].
DB06779DalteparinDalteparin, a low molecular weight heparin (LMWH) prepared by nitrous acid degradation of unfractionated heparin of porcine intestinal mucosa origin, is an anticoagulant. It is composed of strongly acidic sulphated polysaccharide chains with an average molecular weight of 5000 and about 90% of the material within the range of 2000-9000. LMWHs have a more predictable response, a greater bioavailability, and a longer anti-Xa half life than unfractionated heparin. Dalteparin can also be safely used in most pregnant women. Low molecular weight heparins are less effective at inactivating factor IIa due to their shorter length compared to unfractionated heparin.
DB01109HeparinUnfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated heparin is more specific than LMWH for thrombin. Furthermore, the effects of UH can typically be reversed by using protamine sulfate.
DB08813NadroparinNadroparin is a low molecular weight heparin (LMWH) which, when bound to antithrombin III (ATIII), accelerates the inactivation of factor II and factor Xa. Nadroparin halts the coagulation pathway by inhibiting the activation of thrombin (factor IIa) by factor Xa. The amplification of the fibrin clotting cascade is stopped once factors Xa and IIa are inactivated. It is derived from porcine sources and has a mean molecular size of 5000 daltons. Low molecular weight heparins are less effective at inactivating factor IIa due to their shorter length compared to unfractionated heparin.
DB06822TinzaparinTinzaparin is a low molecular weight heparin (LMWH), produced by enzymatic depolymerization of unfractionated heparin from porcine intestinal mucosa. It is a heterogeneous mixture of with an average molecular weight between 5500 and 7500 daltons. Tinzaparin is composed of molecules with and without a special site for high affinity binding to antithrombin III (ATIII). This complex greatly accelerates the inhibition of factor Xa. It is an anticoagulant and considered an antithrombotic. Tinzaparin must be given either subcutaneously or parenterally. LMWHs are less effective at inactivating factor IIa due to their shorter length compared to unfractionated heparin.
DrugDrug NamePhaseStatusCount
DB06605Apixaban1Completed2
DB06605Apixaban1Terminated1
DB00091Ciclosporin1Completed1
DB01211Clarithromycin1Completed1
DB09075Edoxaban1Recruiting1
DB01225Enoxaparin1Completed2
DB01225Enoxaparin1Recruiting1
DB01225Enoxaparin1Unknown Status1
DB11728Fondaparinux1Completed1
DB00864Tacrolimus1Completed1
DB01076Atorvastatin1 / 2Recruiting1
DB06779Dalteparin1 / 2Completed1
DB00682Warfarin1 / 2Recruiting1
DB00945Acetylsalicylic acid2Completed1
DB00945Acetylsalicylic acid2Recruiting1
DB06605Apixaban2Completed1
DB06605Apixaban2Recruiting2
DB00407Ardeparin2Completed1
DB01076Atorvastatin2Terminated1
DB11121Chloroxylenol2Recruiting1
DB06695Dabigatran etexilate2Completed6
DB06695Dabigatran etexilate2Withdrawn1
DB06779Dalteparin2Completed1
DB06779Dalteparin2Recruiting1
DB06779Dalteparin2Terminated1
DB09075Edoxaban2Completed2
DB01225Enoxaparin2Completed8
DB01225Enoxaparin2Recruiting2
DB01225Enoxaparin2Terminated1
DB11984Letaxaban2Completed1
DB06609Odiparcil2Completed1
DB06228Rivaroxaban2Completed6
DB06228Rivaroxaban2Unknown Status1
DB01098Rosuvastatin2Completed1
DB01098Rosuvastatin2Recruiting2
DB05131TTP8892Completed1
DB06822Tinzaparin2Terminated2
DB00682Warfarin2Completed2
DB00945Acetylsalicylic acid2 / 3Unknown Status1
DB06605Apixaban2 / 3Recruiting1
DB12289Darexaban2 / 3Completed3
DB01225Enoxaparin2 / 3Completed3
DB00668Epinephrine2 / 3Not Yet Recruiting1
DB00569Fondaparinux2 / 3Completed1
DB00916Metronidazole2 / 3Not Yet Recruiting1
DB06228Rivaroxaban2 / 3Recruiting1
DB01418Acenocoumarol3Terminated1
DB00945Acetylsalicylic acid3Completed3
DB00009Alteplase3Completed1
DB06605Apixaban3Active Not Recruiting1
DB06605Apixaban3Not Yet Recruiting1
DB06605Apixaban3Recruiting2
DB00407Ardeparin3Completed6
DB00407Ardeparin3Terminated1
DB00278Argatroban3Recruiting1
DB09258Bemiparin3Completed1
DB09258Bemiparin3Terminated1
DB12364Betrixaban3Completed1
DB09261Certoparin3Terminated1
DB06695Dabigatran etexilate3Completed2
DB06695Dabigatran etexilate3Recruiting3
DB06779Dalteparin3Active Not Recruiting1
DB06779Dalteparin3Completed4
DB06779Dalteparin3Recruiting1
DB06779Dalteparin3Terminated2
DB12289Darexaban3Completed4
DB09075Edoxaban3Completed6
DB09075Edoxaban3Recruiting1
DB01225Enoxaparin3Completed18
DB01225Enoxaparin3Recruiting3
DB01225Enoxaparin3Terminated3
DB00569Fondaparinux3Completed2
DB11728Fondaparinux3Completed2
DB11728Fondaparinux3Recruiting1
DB00569Fondaparinux3Terminated1
DB11728Fondaparinux3Terminated1
DB01109Heparin3Completed3
DB01109Heparin3Recruiting1
DB08813Nadroparin3Completed1
DB08813Nadroparin3Terminated1
DB00946Phenprocoumon3Terminated1
DB09259Reviparin3Terminated1
DB06228Rivaroxaban3Active Not Recruiting1
DB06228Rivaroxaban3Completed12
DB06228Rivaroxaban3Not Yet Recruiting1
DB06228Rivaroxaban3Recruiting1
DB06822Tinzaparin3Completed1
DB06822Tinzaparin3Recruiting2
DB06822Tinzaparin3Terminated1
DB00682Warfarin3Completed4
DB00682Warfarin3Not Yet Recruiting1
DB00682Warfarin3Recruiting1
DB00682Warfarin3Terminated1
DB01418Acenocoumarol4Completed1
DB00945Acetylsalicylic acid4Recruiting1
DB06605Apixaban4Active Not Recruiting1
DB06605Apixaban4Completed1
DB06605Apixaban4Recruiting4
DB06695Dabigatran etexilate4Completed1
DB06779Dalteparin4Completed1
DB06779Dalteparin4Terminated2
DB01225Enoxaparin4Completed3
DB01225Enoxaparin4Not Yet Recruiting1
DB01225Enoxaparin4Recruiting2
DB01225Enoxaparin4Suspended1
DB00569Fondaparinux4Completed1
DB11728Fondaparinux4Completed1
DB01109Heparin4Completed1
DB01109Heparin4Recruiting2
DB01109Heparin4Suspended1
DB01109Heparin4Terminated2
DB08813Nadroparin4Terminated1
DB06228Rivaroxaban4Completed2
DB06228Rivaroxaban4Recruiting1
DB06822Tinzaparin4Completed2
DB06605ApixabanNot AvailableCompleted2
DB06605ApixabanNot AvailableRecruiting4
DB09258BemiparinNot AvailableCompleted1
DB11121ChloroxylenolNot AvailableUnknown Status1
DB06695Dabigatran etexilateNot AvailableCompleted1
DB06695Dabigatran etexilateNot AvailableRecruiting1
DB06695Dabigatran etexilateNot AvailableTerminated1
DB06779DalteparinNot AvailableCompleted2
DB06779DalteparinNot AvailableRecruiting1
DB09075EdoxabanNot AvailableActive Not Recruiting1
DB09075EdoxabanNot AvailableRecruiting3
DB01225EnoxaparinNot AvailableCompleted1
DB01225EnoxaparinNot AvailableNot Yet Recruiting1
DB01225EnoxaparinNot AvailableRecruiting1
DB00569FondaparinuxNot AvailableCompleted1
DB11728FondaparinuxNot AvailableCompleted2
DB00569FondaparinuxNot AvailableRecruiting1
DB11728FondaparinuxNot AvailableRecruiting1
DB11728FondaparinuxNot AvailableUnknown Status1
DB01109HeparinNot AvailableUnknown Status1
DB01109HeparinNot AvailableWithdrawn1
DB00959MethylprednisoloneNot AvailableCompleted1
DB08813NadroparinNot AvailableCompleted1
DB06228RivaroxabanNot AvailableCompleted5
DB06228RivaroxabanNot AvailableNot Yet Recruiting1
DB06228RivaroxabanNot AvailableRecruiting3
DB06822TinzaparinNot AvailableUnknown Status1
DB00682WarfarinNot AvailableCompleted1
DB00682WarfarinNot AvailableRecruiting2
DB00682WarfarinNot AvailableTerminated1