Surgical Site Infections

Also known as: SURGICAL SITE INFECTION / Incision site infection / Post-operative wound infection / Postoperative wound infection / Surgical wound infection / Post procedural site wound infection

DrugDrug NameDrug Description
DB01327CefazolinA semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.
DB01597CilastatinA renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, imipenem, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4. [PubChem]
DB00303ErtapenemErtapenem is a carbapenem antibiotic marketed by Merck as Invanz®. It is structurally very similar to meropenem in that it possess a 1-beta-methyl group. [Wikipedia]
DB00713OxacillinAn antibiotic similar to flucloxacillin used in resistant staphylococci infections. [PubChem]
DB00319PiperacillinSemisynthetic, broad-spectrum, ampicillin derived ureidopenicillin antibiotic proposed for pseudomonas infections. It is also used in combination with other antibiotics. [PubChem]
DB01015SulfamethoxazoleA bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. Its broad spectrum of activity has been limited by the development of resistance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p208)
DB01606TazobactamTazobactam is a antibacterial penicillin derivative which inhibits the action of bacterial beta-lactamases.
DrugDrug NameTargetType
DB01327CefazolinSerum paraoxonase/arylesterase 1target
DB01327CefazolinSerum albumincarrier
DB01327CefazolinSolute carrier family 22 member 6transporter
DB01327CefazolinSolute carrier family 22 member 8transporter
DB01327CefazolinSolute carrier family 22 member 11transporter
DB01327CefazolinPenicillin-binding protein 1Atarget
DB01327CefazolinPenicillin-binding protein 1Btarget
DB01327CefazolinPenicillin-binding protein 2target
DB01327CefazolinPenicillin-binding protein 1Ctarget
DB01327CefazolinPeptidoglycan synthase FtsItarget
DB01327CefazolinMultidrug resistance-associated protein 4transporter
DB01327CefazolinThiopurine S-methyltransferaseenzyme
DB01327CefazolinInterleukin-15target
DB01327CefazolinInterleukin-2target
DB01597CilastatinDipeptidase 1target
DB01597CilastatinSolute carrier family 22 member 6transporter
DB01597CilastatinSolute carrier family 22 member 8transporter
DB00303ErtapenemPenicillin-binding protein 2target
DB00303ErtapenemPeptidoglycan synthase FtsItarget
DB00303ErtapenemPenicillin-binding protein 1Atarget
DB00303ErtapenemD-alanyl-D-alanine carboxypeptidase DacCtarget
DB00303ErtapenemD-alanyl-D-alanine carboxypeptidase DacBtarget
DB00303ErtapenemPenicillin-binding protein 1Btarget
DB00303ErtapenemPeptidoglycan synthase FtsItarget
DB00303ErtapenemPenicillin-binding protein 2target
DB00713OxacillinPenicillin-binding protein 1Atarget
DB00713OxacillinSolute carrier family 15 member 1transporter
DB00713OxacillinSolute carrier family 15 member 2transporter
DB00713OxacillinPenicillin-binding protein 3target
DB00713OxacillinPenicillin-binding protein 2atarget
DB00713OxacillinPenicillin-binding protein 1Atarget
DB00713OxacillinPenicillin-binding protein 2Btarget
DB00713OxacillinPenicillin-binding protein 1btarget
DB00713OxacillinSolute carrier family 15 member 1target
DB00713OxacillinPenicillin-binding protein 2target
DB00713OxacillinSolute carrier family 15 member 2target
DB00319PiperacillinSolute carrier family 22 member 6transporter
DB00319PiperacillinPenicillin-binding protein 3target
DB00319PiperacillinPenicillin-binding protein 2Btarget
DB00319PiperacillinPenicillin-binding protein 2atarget
DB00319PiperacillinPenicillin-binding protein 1btarget
DB00319PiperacillinSolute carrier family 22 member 8transporter
DB01015SulfamethoxazoleBifunctional protein FolCtarget
DB01015SulfamethoxazoleCytochrome P450 2C9enzyme
DB01015SulfamethoxazoleSerum albumincarrier
DB01015SulfamethoxazoleArylamine N-acetyltransferase 1enzyme
DB01015SulfamethoxazoleArylamine N-acetyltransferase 2enzyme
DB01015SulfamethoxazoleProstaglandin G/H synthase 1enzyme
DB01015SulfamethoxazoleUDP-glucuronosyltransferase 1-9enzyme
DB01015SulfamethoxazoleDihydropteroate synthasetarget
DB01015SulfamethoxazoleCytochrome P450 2C8enzyme
DB01015SulfamethoxazoleCytochrome P450 3A4enzyme
DB01015SulfamethoxazoleGlutathione S-transferase Ptarget
DB01015SulfamethoxazoleBile salt export pumptransporter
DB01606TazobactamBeta-lactamase SHV-1target
DB01606TazobactamBeta-lactamase TEMtarget
DB01606TazobactamSolute carrier family 22 member 6transporter
DB01606TazobactamSolute carrier family 22 member 8transporter
DrugDrug NamePhaseStatusCount
DB00898Ethanol0Recruiting1
DB00916Metronidazole0Recruiting1
DB00994Neomycin0Recruiting1
DB09287Polyethylene glycol0Recruiting1
DB11077Polyethylene glycol 4000Recruiting1
DB00567Cephalexin1Recruiting1
DB00878Chlorhexidine1Completed2
DB00916Metronidazole1Recruiting1
DB11933Riboprine1Completed2
DB00815Sodium lauryl sulfate1Completed1
DB00512Vancomycin1Terminated1
DB09096Benzoyl peroxide2Completed1
DB00567Cephalexin2Completed1
DB00878Chlorhexidine2Recruiting1
DB01190Clindamycin2Completed1
DB14135Hypochlorous acid2Unknown Status1
DB02325Isopropyl Alcohol2Completed1
DB02325Isopropyl Alcohol2Terminated1
DB06812Povidone-iodine2Recruiting1
DB06812Povidone-iodine2Terminated1
DB09153Sodium Chloride2Terminated1
DB00878Chlorhexidine2 / 3Completed1
DB00668Epinephrine2 / 3Not Yet Recruiting1
DB00303Ertapenem2 / 3Completed1
DB00916Metronidazole2 / 3Not Yet Recruiting1
DB01212Ceftriaxone3Completed1
DB00878Chlorhexidine3Completed1
DB06219Dalbavancin3Completed3
DB00080Daptomycin3Completed1
DB00303Ertapenem3Completed1
DB00601Linezolid3Completed2
DB00916Metronidazole3Completed1
DB00410Mupirocin3Completed1
DB06812Povidone-iodine3Completed1
DB11933Riboprine3Completed1
DB00512Vancomycin3Completed2
DB00163Vitamin E3Recruiting1
DB00626Bacitracin4Recruiting1
DB01327Cefazolin4Not Yet Recruiting1
DB01327Cefazolin4Recruiting1
DB06590Ceftaroline fosamil4Recruiting1
DB01112Cefuroxime4Completed1
DB00199Erythromycin4Recruiting1
DB00410Mupirocin4Completed1
DB00994Neomycin4Recruiting1
DB03088Pidolic Acid4Completed1
DB06812Povidone-iodine4Completed1
DB06812Povidone-iodine4Not Yet Recruiting1
DB06812Povidone-iodine4Terminated1
DB00684Tobramycin4Recruiting1
DB00512Vancomycin4Completed1
DB00512Vancomycin4Not Yet Recruiting1
DB00512Vancomycin4Recruiting2
DB01060AmoxicillinNot AvailableCompleted1
DB00207AzithromycinNot AvailableCompleted1
DB01327CefazolinNot AvailableRecruiting2
DB00878ChlorhexidineNot AvailableRecruiting2
DB00766ClavulanateNot AvailableCompleted1
DB00030Insulin HumanNot AvailableCompleted1
DB00410MupirocinNot AvailableCompleted1
DB00410MupirocinNot AvailableRecruiting1
DB06812Povidone-iodineNot AvailableCompleted2
DB06812Povidone-iodineNot AvailableWithdrawn1
DB09153Sodium ChlorideNot AvailableRecruiting1
DB00512VancomycinNot AvailableRecruiting1