Sleeplessness

Also known as: Insomnia / Insomnia NOS

DrugDrug NameDrug Description
DB00321AmitriptylineA tricyclic antidepressant indicated in the treatment of depressive illness, either endogenous or psychotic, and to relieve depression associated anxiety.
DB00237ButabarbitalA barbiturate drug used as a sedative and hypnotic.
DB01151DesipramineA tricyclic antidepressant used in the treatment of depression.
DB01075DiphenhydramineA H1 receptor antihistamine used in the treatment of seasonal allergies, and various allergic reactions including sneezing, runny nose, itchy/watery eyes, itching of nose or throat, pruritus, urticaria, insect bites/stings, and allergic rashes.
DB01142DoxepinA psychotropic agent used for the treatment of depression, anxiety, manic-depressive disorder, and insomnia.
DB00366DoxylamineAn antihistamine used to treat insomnia and allergy symptoms and is used with pyridoxine in the treatment of nausea and vomiting in pregnancy.
DB01215EstazolamA benzodiazepine used for the short-term management of insomnia.
DB00402EszopicloneA sedative-hypnotic used in the treatment of insomnia, improving both the latency phase and the maintenance phase of sleep.
DB00690FlurazepamA long-acting benzodiazepine with a rapid onset of action that is commonly used to treat insomnia.
DB00186LorazepamA long-acting benzodiazepine commonly used to treat panic disorders, severe anxiety, and seizures.
DB01065MelatoninAn endogenous hormone produced by the pineal gland that regulates sleep-wake cycles and when provided exogenously has beneficial effects on sleep-onset latency; available as an over-the-counter supplement.
DB00370MirtazapineA tetracyclic antidepressant used in the treatment of major depression and is used off-label as a drug for insomnia and to increase appetite.
DB01595NitrazepamA long-acting benzodiazepine with intermediate onset commonly used to treat panic disorders, severe anxiety, insomnia, and seizures.
DB00312PentobarbitalA barbiturate drug used to induce sleep, cause sedation, and control certain types of seizures.
DB01174PhenobarbitalA long-lasting barbiturate and anticonvulsant used in the treatment of all types of seizures, except for absent seizures.
DB01589QuazepamA long -acting benzodiazepine used to manage insomnia.
DB00980RamelteonA melatonin receptor agonist used to treat insomnia.
DB00418SecobarbitalA barbiturate used for the short-term treatment of insomnia.
DB01323St. John's WortAn herbal ingredient used in non-prescription therapeutic products for the short-term treatment of minor skin irritations, insomnia, depression, and anxiety.
DB09034SuvorexantA orexin receptor antagonist used to treat insomnia that is characterized by difficulties with sleep onset and/or sleep maintenance.
DB00231TemazepamA short-acting benzodiazepine commonly used to treat panic disorders, severe anxiety, and insomnia.
DB00697TizanidineAn alpha-2 adrenergic agonist used for the short-term treatment of muscle spasticity.
DB00656TrazodoneA serotonin uptake inhibitor used to treat major depressive disorder.
DB00897TriazolamA benzodiazepine used for short term treatment of insomnia.
DB00726TrimipramineA tricyclic antidepressant used to treat depression.
DB00962ZaleplonA sedative used for short term treatment of insomnia in adults.
DB00425ZolpidemA sedative hypnotic used for the short-term treatment of insomnia to improve sleep latency.
DB01198ZopicloneA nonbenzodiazepine hypnotic used for the short-term management of insomnia.
DrugDrug NameTargetType
DB00321AmitriptylineSodium-dependent serotonin transportertarget
DB00321AmitriptylineSodium-dependent noradrenaline transportertarget
DB00321AmitriptylinePotassium voltage-gated channel subfamily KQT member 2target
DB00321AmitriptylineAlpha-2A adrenergic receptortarget
DB00321AmitriptylineCytochrome P450 1A2enzyme
DB00321AmitriptylineCytochrome P450 2C19enzyme
DB00321AmitriptylineCytochrome P450 2D6enzyme
DB00321AmitriptylineSerum albumincarrier
DB00321AmitriptylineAlpha-1-acid glycoprotein 1carrier
DB00321AmitriptylineHistamine H1 receptortarget
DB00321Amitriptyline5-hydroxytryptamine receptor 2Atarget
DB00321Amitriptyline5-hydroxytryptamine receptor 1Atarget
DB00321AmitriptylineAlpha-1A adrenergic receptortarget
DB00321AmitriptylineCytochrome P450 3A4enzyme
DB00321AmitriptylineCytochrome P450 3A5enzyme
DB00321AmitriptylinePotassium voltage-gated channel subfamily A member 1target
DB00321AmitriptylineAlpha-1D adrenergic receptortarget
DB00321AmitriptylineDelta-type opioid receptortarget
DB00321AmitriptylineKappa-type opioid receptortarget
DB00321AmitriptylineHigh affinity nerve growth factor receptortarget
DB00321AmitriptylineBDNF/NT-3 growth factors receptortarget
DB00321AmitriptylineCytochrome P450 2C9enzyme
DB00321AmitriptylineCytochrome P450 2B6enzyme
DB00321AmitriptylineCytochrome P450 2C8enzyme
DB00321AmitriptylineHistamine H2 receptortarget
DB00321AmitriptylineHistamine H4 receptortarget
DB00321AmitriptylineSigma non-opioid intracellular receptor 1target
DB00321Amitriptyline5-hydroxytryptamine receptor 2Ctarget
DB00321AmitriptylineAlpha-1B adrenergic receptortarget
DB00321Amitriptyline5-hydroxytryptamine receptor 7target
DB00321Amitriptyline5-hydroxytryptamine receptor 1Dtarget
DB00321AmitriptylineMu-type opioid receptortarget
DB00321Amitriptyline5-hydroxytryptamine receptor 1Btarget
DB00321Amitriptyline5-hydroxytryptamine receptor 6target
DB00321AmitriptylinePotassium voltage-gated channel subfamily KQT member 3target
DB00321AmitriptylineUDP-glucuronosyltransferase 2B10enzyme
DB00321Amitriptyline5-hydroxytryptamine receptor 1Ctarget
DB00321AmitriptylineMuscarinic acetylcholine receptortarget
DB00321AmitriptylineHERG human cardiac K+ channeltarget
DB00321AmitriptylineP-glycoprotein 1transporter
DB00321AmitriptylineUDP-glucuronosyltransferase 1-4enzyme
DB00237ButabarbitalNeuronal acetylcholine receptor subunit alpha-4target
DB00237ButabarbitalNeuronal acetylcholine receptor subunit alpha-7target
DB00237ButabarbitalGlutamate receptor 2target
DB00237ButabarbitalGlutamate receptor ionotropic, kainate 2target
DB00237ButabarbitalGABA-A receptor (anion channel)target
DB01151DesipramineMuscarinic acetylcholine receptor M1target
DB01151DesipramineSodium-dependent noradrenaline transportertarget
DB01151DesipramineBeta-2 adrenergic receptortarget
DB01151DesipramineMuscarinic acetylcholine receptor M2target
DB01151DesipramineSodium-dependent serotonin transportertarget
DB01151DesipramineHistamine H1 receptortarget
DB01151DesipramineBeta-1 adrenergic receptortarget
DB01151DesipramineCytochrome P450 2D6enzyme
DB01151DesipramineMuscarinic acetylcholine receptor M3target
DB01151DesipramineMuscarinic acetylcholine receptor M4target
DB01151DesipramineMuscarinic acetylcholine receptor M5target
DB01151DesipramineAlpha-1 adrenergic receptorstarget
DB01151Desipramine5-hydroxytryptamine receptor 2Atarget
DB01151DesipramineAlpha-1-acid glycoprotein 1carrier
DB01151DesipramineCytochrome P450 2B6enzyme
DB01151DesipramineCytochrome P450 3A4enzyme
DB01151DesipramineSolute carrier family 22 member 2transporter
DB01151DesipramineSolute carrier family 22 member 1transporter
DB01151DesipramineSolute carrier family 22 member 3transporter
DB01151DesipramineSolute carrier family 22 member 5transporter
DB01151DesipramineP-glycoprotein 1transporter
DB01151DesipramineSolute carrier family 22 member 4transporter
DB01151DesipramineCytochrome P450 1A2enzyme
DB01151DesipramineCytochrome P450 2E1enzyme
DB01151DesipramineSphingomyelin phosphodiesterasetarget
DB01151Desipramine5-hydroxytryptamine receptor 1Atarget
DB01151Desipramine5-hydroxytryptamine receptor 2Ctarget
DB01151DesipramineDopamine D2 receptortarget
DB01151DesipramineAlpha-2 adrenergic receptorstarget
DB01075DiphenhydramineHistamine H1 receptortarget
DB01075DiphenhydramineCytochrome P450 2D6enzyme
DB01075DiphenhydramineCytochrome P450 2C9enzyme
DB01075DiphenhydramineCytochrome P450 2C19enzyme
DB01075DiphenhydramineSolute carrier family 22 member 2transporter
DB01075DiphenhydramineSolute carrier family 22 member 5transporter
DB01075DiphenhydramineProstaglandin G/H synthase 1enzyme
DB01075DiphenhydramineMuscarinic acetylcholine receptor M2target
DB01142DoxepinSodium-dependent serotonin transportertarget
DB01142DoxepinSodium-dependent noradrenaline transportertarget
DB01142DoxepinHistamine H1 receptortarget
DB01142DoxepinHistamine H2 receptortarget
DB01142DoxepinCytochrome P450 2D6enzyme
DB01142DoxepinMuscarinic acetylcholine receptor M1target
DB01142DoxepinMuscarinic acetylcholine receptor M2target
DB01142DoxepinMuscarinic acetylcholine receptor M3target
DB01142DoxepinMuscarinic acetylcholine receptor M4target
DB01142DoxepinMuscarinic acetylcholine receptor M5target
DB01142DoxepinAlpha-1A adrenergic receptortarget
DB01142Doxepin5-hydroxytryptamine receptor 1Atarget
DB01142Doxepin5-hydroxytryptamine receptor 2Atarget
DB01142DoxepinCytochrome P450 2C19enzyme
DB01142DoxepinCytochrome P450 2C9enzyme
DB01142DoxepinCytochrome P450 1A2enzyme
DB01142DoxepinP-glycoprotein 1transporter
DB01142Doxepin5-hydroxytryptamine receptor 2Btarget
DB01142Doxepin5-hydroxytryptamine receptor 2Ctarget
DB01142DoxepinAlpha-1B adrenergic receptortarget
DB01142DoxepinAlpha-1D adrenergic receptortarget
DB01142DoxepinCytochrome P450 3A4enzyme
DB01142Doxepin5-hydroxytryptamine receptor 6target
DB01142DoxepinHistamine H4 receptortarget
DB01142DoxepinPotassium voltage-gated channel subfamily H member 2target
DB01142DoxepinSerum albumincarrier
DB01142DoxepinAlpha-1-acid glycoprotein 1carrier
DB00366DoxylamineHistamine H1 receptortarget
DB00366DoxylamineMuscarinic acetylcholine receptor M1target
DB00366DoxylamineCYP2B proteinenzyme
DB00366DoxylamineNuclear receptor subfamily 1 group I member 3target
DB01215EstazolamCytochrome P450 3A4enzyme
DB01215EstazolamGamma-aminobutyric acid receptor subunit alpha-1target
DB01215EstazolamGamma-aminobutyric acid receptor subunit alpha-2target
DB01215EstazolamGamma-aminobutyric acid receptor subunit alpha-3target
DB01215EstazolamGamma-aminobutyric acid receptor subunit alpha-5target
DB01215EstazolamGamma-aminobutyric acid receptor subunit gamma-1target
DB01215EstazolamGamma-aminobutyric acid receptor subunit gamma-2target
DB01215EstazolamGamma-aminobutyric acid receptor subunit gamma-3target
DB01215EstazolamGamma-aminobutyric acid receptor subunit beta-1target
DB01215EstazolamGamma-aminobutyric acid receptor subunit beta-2target
DB01215EstazolamGamma-aminobutyric acid receptor subunit beta-3target
DB01215EstazolamGamma-aminobutyric acid receptor subunit deltatarget
DB01215EstazolamGamma-aminobutyric acid receptor subunit epsilontarget
DB01215EstazolamGamma-aminobutyric acid receptor subunit pitarget
DB01215EstazolamGamma-aminobutyric acid receptor subunit rho-1target
DB01215EstazolamGamma-aminobutyric acid receptor subunit rho-2target
DB01215EstazolamGamma-aminobutyric acid receptor subunit rho-3target
DB01215EstazolamGABA-A receptor (anion channel)target
DB00402EszopicloneCytochrome P450 3A4enzyme
DB00402EszopicloneGamma-aminobutyric acid receptor subunit alpha-1target
DB00402EszopicloneGamma-aminobutyric acid receptor subunit alpha-2target
DB00402EszopicloneGamma-aminobutyric acid receptor subunit alpha-3target
DB00402EszopicloneGamma-aminobutyric acid receptor subunit alpha-5target
DB00402EszopicloneCytochrome P450 2C8enzyme
DB00402EszopicloneGABA-A receptor (anion channel)target
DB00690FlurazepamGamma-aminobutyric acid receptor subunit alpha-1target
DB00690FlurazepamGamma-aminobutyric acid receptor subunit beta-1target
DB00690FlurazepamGamma-aminobutyric acid receptor subunit beta-3target
DB00690FlurazepamGamma-aminobutyric acid receptor subunit alpha-5target
DB00690FlurazepamGamma-aminobutyric acid receptor subunit alpha-3target
DB00690FlurazepamGamma-aminobutyric acid receptor subunit alpha-2target
DB00690FlurazepamGamma-aminobutyric acid receptor subunit beta-2target
DB00690FlurazepamGamma-aminobutyric acid receptor subunit alpha-4target
DB00690FlurazepamGamma-aminobutyric acid receptor subunit alpha-6target
DB00690FlurazepamGamma-aminobutyric acid receptor subunit gamma-1target
DB00690FlurazepamGamma-aminobutyric acid receptor subunit gamma-2target
DB00690FlurazepamGamma-aminobutyric acid receptor subunit gamma-3target
DB00690FlurazepamGamma-aminobutyric acid receptor subunit deltatarget
DB00690FlurazepamGamma-aminobutyric acid receptor subunit epsilontarget
DB00690FlurazepamGamma-aminobutyric acid receptor subunit pitarget
DB00690FlurazepamGamma-aminobutyric acid receptor subunit rho-2target
DB00690FlurazepamGamma-aminobutyric acid receptor subunit thetatarget
DB00690FlurazepamGamma-aminobutyric acid receptor subunit rho-1target
DB00690FlurazepamCytochrome P450 3A4enzyme
DB00690FlurazepamGamma-aminobutyric acid receptor subunit rho-3target
DB00690FlurazepamP-glycoprotein 1transporter
DB00690FlurazepamCytochrome P450 2E1enzyme
DB00690FlurazepamCytochrome P450 2A6enzyme
DB00690FlurazepamSolute carrier family 22 member 2transporter
DB00186LorazepamTranslocator proteintarget
DB00186LorazepamUDP-glucuronosyltransferase 2B15enzyme
DB00186LorazepamGABA-A receptor (anion channel)target
DB00186LorazepamCytochrome P450 3A4enzyme
DB01065MelatoninAcetylserotonin O-methyltransferasetarget
DB01065MelatoninMelatonin receptor type 1Atarget
DB01065MelatoninMelatonin receptor type 1Btarget
DB01065MelatoninNuclear receptor ROR-betatarget
DB01065MelatoninCalmodulintarget
DB01065MelatoninCalreticulintarget
DB01065MelatoninRibosyldihydronicotinamide dehydrogenase [quinone]target
DB01065MelatoninMyeloperoxidasetarget
DB01065MelatoninEstrogen receptor alphatarget
DB01065MelatoninEosinophil peroxidasetarget
DB01065MelatoninCytochrome P450 1A1enzyme
DB01065MelatoninCytochrome P450 1A2enzyme
DB01065MelatoninCytochrome P450 2C19enzyme
DB01065MelatoninCytochrome P450 2C9enzyme
DB01065MelatoninAcetylserotonin O-methyltransferaseenzyme
DB01065MelatoninIndoleamine 2,3-dioxygenase 1enzyme
DB01065MelatoninMyeloperoxidaseenzyme
DB01065MelatoninCytochrome P450 1B1enzyme
DB01065MelatoninSolute carrier family 22 member 8transporter
DB01065MelatoninCytochrome P450 19A1enzyme
DB00370Mirtazapine5-hydroxytryptamine receptor 2Atarget
DB00370Mirtazapine5HT3 serotonin receptortarget
DB00370MirtazapineAlpha-2A adrenergic receptortarget
DB00370Mirtazapine5-hydroxytryptamine receptor 2Ctarget
DB00370MirtazapineKappa-type opioid receptortarget
DB00370MirtazapineHistamine H1 receptortarget
DB00370MirtazapineCytochrome P450 1A2enzyme
DB00370MirtazapineCytochrome P450 3A4enzyme
DB00370MirtazapineCytochrome P450 2D6enzyme
DB00370MirtazapineAlpha-1 adrenergic receptorstarget
DB00370MirtazapineSodium-dependent serotonin transportertransporter
DB01595NitrazepamGamma-aminobutyric acid receptor subunit alpha-1target
DB01595NitrazepamSodium channel protein type 1 subunit alphatarget
DB01595NitrazepamGamma-aminobutyric acid receptor subunit alpha-2target
DB01595NitrazepamGamma-aminobutyric acid receptor subunit alpha-3target
DB01595NitrazepamGamma-aminobutyric acid receptor subunit alpha-4target
DB01595NitrazepamGamma-aminobutyric acid receptor subunit alpha-5target
DB01595NitrazepamGamma-aminobutyric acid receptor subunit alpha-6target
DB01595NitrazepamGamma-aminobutyric acid receptor subunit beta-1target
DB01595NitrazepamGamma-aminobutyric acid receptor subunit beta-2target
DB01595NitrazepamGamma-aminobutyric acid receptor subunit beta-3target
DB01595NitrazepamGamma-aminobutyric acid receptor subunit gamma-1target
DB01595NitrazepamGamma-aminobutyric acid receptor subunit gamma-2target
DB01595NitrazepamGamma-aminobutyric acid receptor subunit gamma-3target
DB01595NitrazepamGamma-aminobutyric acid receptor subunit deltatarget
DB01595NitrazepamGamma-aminobutyric acid receptor subunit epsilontarget
DB01595NitrazepamGamma-aminobutyric acid receptor subunit pitarget
DB01595NitrazepamGamma-aminobutyric acid receptor subunit rho-1target
DB01595NitrazepamGamma-aminobutyric acid receptor subunit rho-2target
DB01595NitrazepamGamma-aminobutyric acid receptor subunit rho-3target
DB01595NitrazepamGamma-aminobutyric acid receptor subunit thetatarget
DB01595NitrazepamCytochrome P450 3A4enzyme
DB01595NitrazepamCytochrome P450 2E1enzyme
DB00312PentobarbitalGamma-aminobutyric acid receptor subunit alpha-1target
DB00312PentobarbitalCytochrome P450 3A4enzyme
DB00312PentobarbitalGamma-aminobutyric acid receptor subunit alpha-4target
DB00312PentobarbitalGamma-aminobutyric acid receptor subunit alpha-6target
DB00312PentobarbitalGamma-aminobutyric acid receptor subunit alpha-2target
DB00312PentobarbitalGamma-aminobutyric acid receptor subunit alpha-3target
DB00312PentobarbitalGamma-aminobutyric acid receptor subunit alpha-5target
DB00312PentobarbitalNeuronal acetylcholine receptor subunit alpha-4target
DB00312PentobarbitalNeuronal acetylcholine receptor subunit alpha-7target
DB00312PentobarbitalGlutamate receptor 2target
DB00312PentobarbitalGlutamate receptor ionotropic, kainate 2target
DB00312PentobarbitalCytochrome P450 2C19enzyme
DB00312PentobarbitalCytochrome P450 2A6enzyme
DB00312PentobarbitalGABA-A receptor (anion channel)target
DB00312PentobarbitalNMDA receptortarget
DB00312PentobarbitalNuclear receptor subfamily 1 group I member 2target
DB01174PhenobarbitalGamma-aminobutyric acid receptor subunit alpha-1target
DB01174PhenobarbitalCytochrome P450 2C19enzyme
DB01174PhenobarbitalCytochrome P450 2C9enzyme
DB01174PhenobarbitalCytochrome P450 2B6enzyme
DB01174PhenobarbitalCytochrome P450 2C8enzyme
DB01174PhenobarbitalCytochrome P450 1A2enzyme
DB01174PhenobarbitalCytochrome P450 3A4enzyme
DB01174PhenobarbitalCanalicular multispecific organic anion transporter 2transporter
DB01174PhenobarbitalBile salt export pumptransporter
DB01174PhenobarbitalP-glycoprotein 1transporter
DB01174PhenobarbitalMultidrug resistance-associated protein 1transporter
DB01174PhenobarbitalSolute carrier organic anion transporter family member 2A1transporter
DB01174PhenobarbitalCanalicular multispecific organic anion transporter 1transporter
DB01174PhenobarbitalNeuronal acetylcholine receptor subunit alpha-4target
DB01174PhenobarbitalNeuronal acetylcholine receptor subunit alpha-7target
DB01174PhenobarbitalGlutamate receptor 2target
DB01174PhenobarbitalGlutamate receptor ionotropic, kainate 2target
DB01174PhenobarbitalCytochrome P450 2A6enzyme
DB01174PhenobarbitalCytochrome P450 2E1enzyme
DB01174PhenobarbitalCytochrome P450 3A5enzyme
DB01174PhenobarbitalCytochrome P450 1A1enzyme
DB01174PhenobarbitalCytochrome P450 2C18enzyme
DB01174PhenobarbitalCytochrome P450 3A7enzyme
DB01174PhenobarbitalCytochrome P450 4B1enzyme
DB01174PhenobarbitalNMDA receptortarget
DB01174PhenobarbitalNuclear receptor subfamily 1 group I member 2target
DB01174PhenobarbitalUDP-glucuronosyltransferase 1-1enzyme
DB01174PhenobarbitalUDP-glucuronosyltransferase 2B7enzyme
DB01589QuazepamGamma-aminobutyric acid receptor subunit alpha-1target
DB01589QuazepamGamma-aminobutyric acid receptor subunit alpha-2target
DB01589QuazepamGamma-aminobutyric acid receptor subunit alpha-3target
DB01589QuazepamGamma-aminobutyric acid receptor subunit alpha-5target
DB01589QuazepamGamma-aminobutyric acid receptor subunit gamma-1target
DB01589QuazepamGamma-aminobutyric acid receptor subunit gamma-2target
DB01589QuazepamGamma-aminobutyric acid receptor subunit gamma-3target
DB01589QuazepamGamma-aminobutyric acid receptor subunit beta-1target
DB01589QuazepamGamma-aminobutyric acid receptor subunit beta-3target
DB01589QuazepamGamma-aminobutyric acid receptor subunit deltatarget
DB01589QuazepamGamma-aminobutyric acid receptor subunit epsilontarget
DB01589QuazepamGamma-aminobutyric acid receptor subunit pitarget
DB01589QuazepamGamma-aminobutyric acid receptor subunit rho-1target
DB01589QuazepamGamma-aminobutyric acid receptor subunit rho-2target
DB01589QuazepamGamma-aminobutyric acid receptor subunit rho-3target
DB01589QuazepamCytochrome P450 2C19enzyme
DB01589QuazepamCytochrome P450 2C9enzyme
DB01589QuazepamCytochrome P450 3A4enzyme
DB01589QuazepamGABA-A receptor (anion channel)target
DB01589QuazepamCytochrome P450 2B6enzyme
DB00980RamelteonMelatonin receptor type 1Btarget
DB00980RamelteonMelatonin receptor type 1Atarget
DB00980RamelteonCytochrome P450 1A2enzyme
DB00980RamelteonCytochrome P450 2C19enzyme
DB00980RamelteonCytochrome P450 3A4enzyme
DB00980RamelteonCytochrome P450 2C9enzyme
DB00418SecobarbitalGamma-aminobutyric acid receptor subunit alpha-1target
DB00418SecobarbitalCytochrome P450 2C8enzyme
DB00418SecobarbitalCytochrome P450 2C9enzyme
DB00418SecobarbitalGamma-aminobutyric acid receptor subunit alpha-2target
DB00418SecobarbitalGamma-aminobutyric acid receptor subunit alpha-3target
DB00418SecobarbitalGamma-aminobutyric acid receptor subunit alpha-4target
DB00418SecobarbitalGamma-aminobutyric acid receptor subunit alpha-5target
DB00418SecobarbitalGamma-aminobutyric acid receptor subunit alpha-6target
DB00418SecobarbitalNeuronal acetylcholine receptor subunit alpha-4target
DB00418SecobarbitalNeuronal acetylcholine receptor subunit alpha-7target
DB00418SecobarbitalGlutamate receptor 2target
DB00418SecobarbitalGlutamate receptor ionotropic, kainate 2target
DB00418SecobarbitalCytochrome P450 1A2enzyme
DB00418SecobarbitalNMDA receptortarget
DB00418SecobarbitalCytochrome P450 2C19enzyme
DB01323St. John's WortP-glycoprotein 1transporter
DB01323St. John's WortCytochrome P450 3A4enzyme
DB01323St. John's WortCytochrome P450 2D6enzyme
DB01323St. John's WortCytochrome P450 2C19enzyme
DB09034SuvorexantOrexin receptor type 1target
DB09034SuvorexantOrexin receptor type 2target
DB09034SuvorexantCytochrome P450 3A4enzyme
DB00231TemazepamTranslocator proteintarget
DB00231TemazepamGamma-aminobutyric acid receptor subunit alpha-1target
DB00231TemazepamGamma-aminobutyric acid receptor subunit alpha-2target
DB00231TemazepamGamma-aminobutyric acid receptor subunit alpha-3target
DB00231TemazepamGamma-aminobutyric acid receptor subunit alpha-4target
DB00231TemazepamGamma-aminobutyric acid receptor subunit alpha-5target
DB00231TemazepamGamma-aminobutyric acid receptor subunit alpha-6target
DB00231TemazepamGamma-aminobutyric acid receptor subunit beta-1target
DB00231TemazepamGamma-aminobutyric acid receptor subunit beta-2target
DB00231TemazepamGamma-aminobutyric acid receptor subunit beta-3target
DB00231TemazepamGamma-aminobutyric acid receptor subunit gamma-1target
DB00231TemazepamGamma-aminobutyric acid receptor subunit gamma-2target
DB00231TemazepamGamma-aminobutyric acid receptor subunit gamma-3target
DB00231TemazepamGamma-aminobutyric acid receptor subunit deltatarget
DB00231TemazepamGamma-aminobutyric acid receptor subunit epsilontarget
DB00231TemazepamGamma-aminobutyric acid receptor subunit pitarget
DB00231TemazepamGamma-aminobutyric acid receptor subunit rho-1target
DB00231TemazepamGamma-aminobutyric acid receptor subunit rho-2target
DB00231TemazepamGamma-aminobutyric acid receptor subunit thetatarget
DB00231TemazepamGamma-aminobutyric acid receptor subunit rho-3target
DB00231TemazepamCytochrome P450 3A4enzyme
DB00231TemazepamCytochrome P450 2B6enzyme
DB00231TemazepamCytochrome P450 2C9enzyme
DB00231TemazepamGABA-A receptor (anion channel)target
DB00697TizanidineAlpha-2 adrenergic receptorstarget
DB00697TizanidineCytochrome P450 1A2enzyme
DB00697TizanidineNischarintarget
DB00697TizanidineAlpha-1 adrenergic receptorstarget
DB00656Trazodone5-hydroxytryptamine receptor 2Atarget
DB00656TrazodoneSodium-dependent serotonin transportertarget
DB00656TrazodoneAlpha-1A adrenergic receptortarget
DB00656TrazodoneAlpha-2A adrenergic receptortarget
DB00656TrazodoneHistamine H1 receptortarget
DB00656Trazodone5-hydroxytryptamine receptor 1Atarget
DB00656TrazodoneCytochrome P450 2D6enzyme
DB00656TrazodoneCytochrome P450 3A4enzyme
DB00656Trazodone5-hydroxytryptamine receptor 2Ctarget
DB00656TrazodoneCytochrome P450 3A5enzyme
DB00656TrazodoneCytochrome P450 3A7enzyme
DB00656TrazodoneP-glycoprotein 1transporter
DB00656Trazodone5-hydroxytryptamine receptor 1Ctarget
DB00897TriazolamTranslocator proteintarget
DB00897TriazolamCytochrome P450 3A4enzyme
DB00897TriazolamCytochrome P450 3A5enzyme
DB00897TriazolamCytochrome P450 3A7enzyme
DB00897TriazolamGamma-aminobutyric acid receptor subunit alpha-1target
DB00897TriazolamGamma-aminobutyric acid receptor subunit alpha-2target
DB00897TriazolamGamma-aminobutyric acid receptor subunit alpha-3target
DB00897TriazolamGamma-aminobutyric acid receptor subunit alpha-4target
DB00897TriazolamGamma-aminobutyric acid receptor subunit alpha-5target
DB00897TriazolamGamma-aminobutyric acid receptor subunit alpha-6target
DB00897TriazolamGamma-aminobutyric acid receptor subunit beta-1target
DB00897TriazolamGamma-aminobutyric acid receptor subunit beta-2target
DB00897TriazolamGamma-aminobutyric acid receptor subunit beta-3target
DB00897TriazolamGamma-aminobutyric acid receptor subunit gamma-1target
DB00897TriazolamGamma-aminobutyric acid receptor subunit gamma-2target
DB00897TriazolamGamma-aminobutyric acid receptor subunit gamma-3target
DB00897TriazolamGamma-aminobutyric acid receptor subunit deltatarget
DB00897TriazolamGamma-aminobutyric acid receptor subunit epsilontarget
DB00897TriazolamGamma-aminobutyric acid receptor subunit pitarget
DB00897TriazolamGamma-aminobutyric acid receptor subunit rho-1target
DB00897TriazolamGamma-aminobutyric acid receptor subunit rho-2target
DB00897TriazolamGamma-aminobutyric acid receptor subunit rho-3target
DB00897TriazolamGamma-aminobutyric acid receptor subunit thetatarget
DB00897TriazolamCytochrome P450 2C8enzyme
DB00897TriazolamGABA-A receptor (anion channel)target
DB00726TrimipramineSodium-dependent serotonin transportertarget
DB00726TrimipramineSodium-dependent noradrenaline transportertarget
DB00726TrimipramineCytochrome P450 2D6enzyme
DB00726TrimipramineSodium-dependent dopamine transportertarget
DB00726Trimipramine5-hydroxytryptamine receptor 2Atarget
DB00726Trimipramine5-hydroxytryptamine receptor 1Atarget
DB00726TrimipramineAlpha-1A adrenergic receptortarget
DB00726TrimipramineAlpha-1B adrenergic receptortarget
DB00726TrimipramineDopamine D2 receptortarget
DB00726TrimipramineAlpha-2B adrenergic receptortarget
DB00726TrimipramineHistamine H1 receptortarget
DB00726TrimipramineCytochrome P450 2C19enzyme
DB00726TrimipramineP-glycoprotein 1transporter
DB00726TrimipramineCytochrome P450 2C9enzyme
DB00726Trimipramine5-hydroxytryptamine receptor 2Ctarget
DB00726Trimipramine5-hydroxytryptamine receptor 3Atarget
DB00726Trimipramine5-hydroxytryptamine receptor 1Dtarget
DB00726TrimipramineAlpha-2A adrenergic receptortarget
DB00726TrimipramineD(1) dopamine receptortarget
DB00726TrimipramineBeta adrenergic receptortarget
DB00726TrimipramineMuscarinic acetylcholine receptortarget
DB00726Trimipramine5-hydroxytryptamine receptor 1Ctarget
DB00962ZaleplonTranslocator proteintarget
DB00962ZaleplonGamma-aminobutyric acid receptor subunit alpha-1target
DB00962ZaleplonCytochrome P450 3A4enzyme
DB00962ZaleplonAldehyde oxidaseenzyme
DB00962ZaleplonCytochrome P450 3A5enzyme
DB00962ZaleplonCytochrome P450 3A7enzyme
DB00425ZolpidemGamma-aminobutyric acid receptor subunit alpha-1target
DB00425ZolpidemCytochrome P450 3A4enzyme
DB00425ZolpidemCytochrome P450 1A2enzyme
DB00425ZolpidemGamma-aminobutyric acid receptor subunit alpha-2target
DB00425ZolpidemGamma-aminobutyric acid receptor subunit alpha-3target
DB00425ZolpidemCytochrome P450 2C9enzyme
DB00425ZolpidemCytochrome P450 2C19enzyme
DB00425ZolpidemCytochrome P450 2D6enzyme
DB00425ZolpidemGamma-aminobutyric acid receptor subunit gamma-2target
DB01198ZopicloneTranslocator proteintarget
DB01198ZopicloneCytochrome P450 2C8enzyme
DB01198ZopicloneCytochrome P450 2C9enzyme
DB01198ZopicloneCytochrome P450 3A4enzyme
DB01198ZopicloneProstaglandin G/H synthase 1enzyme
DB01198ZopicloneGamma-aminobutyric acid receptor subunit alpha-1target
DB01198ZopicloneGamma-aminobutyric acid receptor subunit alpha-2target
DB01198ZopicloneGamma-aminobutyric acid receptor subunit alpha-3target
DB01198ZopicloneGamma-aminobutyric acid receptor subunit alpha-5target
DB01198ZopicloneCytochrome P450 2E1enzyme
DrugDrug NamePhaseStatusCount
DB00945Acetylsalicylic acid0Completed1
DB01142Doxepin0Completed1
DB01198Zopiclone0Completed1
DB06673Almorexant1Completed1
DB12032Atagabalin1Completed1
DB12537Benzodiazepine1Completed1
DB00402Eszopiclone1Completed2
DB01205Flumazenil1Completed1
DB00996Gabapentin1Completed1
DB15092LY-26248031Completed1
DB15092LY-26248031Terminated1
DB11951Lemborexant1Completed2
DB01065Melatonin1Completed2
DB12288Piromelatine1Completed1
DB00818Propofol1Completed1
DB00980Ramelteon1Completed2
DB14822SB-6498681Completed4
DB14822SB-6498681Withdrawn1
DB09034Suvorexant1Completed4
DB00231Temazepam1Completed1
DB00425Zolpidem1Completed4
DB01198Zopiclone1Completed4
DB00633Dexmedetomidine1 / 2Completed1
DB00425Zolpidem1 / 2Completed1
DB06413Armodafinil2Completed2
DB12032Atagabalin2Completed1
DB12032Atagabalin2Withdrawn1
DB06634Casopitant2Completed4
DB01175Escitalopram2Completed1
DB13257Ferrous sulfate anhydrous2Completed1
DB00996Gabapentin2Terminated1
DB08872Gabapentin enacarbil2Terminated1
DB01592Iron2Completed1
DB14009Medical Cannabis2Recruiting1
DB01065Melatonin2Completed1
DB00370Mirtazapine2Active Not Recruiting1
DB00486Nabilone2Unknown Status1
DB05026Nelotanserin2Completed1
DB01267Paliperidone2Completed1
DB14961Seltorexant2Completed1
DB09034Suvorexant2Recruiting1
DB00962Zaleplon2Completed1
DB01224Quetiapine2 / 3Completed1
DB00321Amitriptyline3Terminated1
DB12537Benzodiazepine3Not Yet Recruiting1
DB09017Brotizolam3Not Yet Recruiting1
DB01075Diphenhydramine3Unknown Status1
DB12177Eplivanserin3Completed3
DB01175Escitalopram3Terminated1
DB06678Esmirtazapine3Completed4
DB00402Eszopiclone3Completed9
DB00402Eszopiclone3Not Yet Recruiting1
DB00996Gabapentin3Not Yet Recruiting1
DB06554Gaboxadol3Completed4
DB06554Gaboxadol3Withdrawn1
DB12590Indiplon3Terminated1
DB12590Indiplon3Withdrawn1
DB11951Lemborexant3Completed1
DB11951Lemborexant3Recruiting1
DB01065Melatonin3Completed1
DB00980Ramelteon3Completed2
DB00980Ramelteon3Terminated3
DB01104Sertraline3Terminated1
DB09034Suvorexant3Completed2
DB05359Tasimelteon3Completed1
DB00656Trazodone3Completed1
DB00656Trazodone3Not Yet Recruiting1
DB00656Trazodone3Recruiting1
DB00285Venlafaxine3Completed1
DB00425Zolpidem3Completed3
DB00425Zolpidem3Recruiting1
DB00425Zolpidem3Terminated1
DB01198Zopiclone3Completed3
DB15490Zuranolone3Recruiting1
DB00289Atomoxetine4Completed1
DB00289Atomoxetine4Unknown Status1
DB01156Bupropion4Terminated1
DB01142Doxepin4Completed1
DB01175Escitalopram4Completed1
DB01175Escitalopram4Unknown Status1
DB00402Eszopiclone4Completed8
DB00402Eszopiclone4Terminated1
DB00402Eszopiclone4Unknown Status1
DB00898Ethanol4Completed1
DB00996Gabapentin4Completed1
DB01018Guanfacine4Terminated1
DB00745Modafinil4Terminated1
DB01224Quetiapine4Completed1
DB01224Quetiapine4Terminated1
DB01129Rabeprazole4Completed1
DB00980Ramelteon4Completed4
DB00980Ramelteon4Recruiting1
DB00980Ramelteon4Unknown Status2
DB09034Suvorexant4Completed2
DB09034Suvorexant4Not Yet Recruiting2
DB09034Suvorexant4Recruiting7
DB09034Suvorexant4Terminated1
DB00231Temazepam4Completed2
DB00656Trazodone4Terminated1
DB00425Zolpidem4Completed9
DB00425Zolpidem4Recruiting1
DB01198Zopiclone4Completed1
DB01198Zopiclone4Recruiting1
DB00802AlfentanilNot AvailableRecruiting1
DB00479AmikacinNot AvailableRecruiting1
DB00513Aminocaproic acidNot AvailableRecruiting1
DB06413ArmodafinilNot AvailableActive Not Recruiting1
DB00559BosentanNot AvailableRecruiting1
DB01413CefepimeNot AvailableRecruiting1
DB00369CidofovirNot AvailableRecruiting1
DB00537CiprofloxacinNot AvailableRecruiting1
DB00363ClozapineNot AvailableRecruiting1
DB00633DexmedetomidineNot AvailableCompleted1
DB01175EscitalopramNot AvailableTerminated1
DB01175EscitalopramNot AvailableUnknown Status1
DB00402EszopicloneNot AvailableCompleted5
DB00828FosfomycinNot AvailableRecruiting1
DB00996GabapentinNot AvailableCompleted1
DB00502HaloperidolNot AvailableRecruiting1
DB00598LabetalolNot AvailableRecruiting1
DB08815LurasidoneNot AvailableRecruiting1
DB14009Medical CannabisNot AvailableRecruiting1
DB01065MelatoninNot AvailableEnrolling by Invitation1
DB01065MelatoninNot AvailableUnknown Status1
DB00422MethylphenidateNot AvailableCompleted1
DB00959MethylprednisoloneNot AvailableRecruiting1
DB00683MidazolamNot AvailableUnknown Status1
DB01618MolindoneNot AvailableRecruiting1
DB00607NafcillinNot AvailableRecruiting1
DB01115NifedipineNot AvailableRecruiting1
DB00497OxycodoneNot AvailableRecruiting1
DB00312PentobarbitalNot AvailableRecruiting1
DB00319PiperacillinNot AvailableRecruiting1
DB00457PrazosinNot AvailableCompleted1
DB01224QuetiapineNot AvailableUnknown Status1
DB00980RamelteonNot AvailableCompleted2
DB00980RamelteonNot AvailableTerminated1
DB00734RisperidoneNot AvailableCompleted1
DB00728RocuroniumNot AvailableRecruiting1
DB00658SevelamerNot AvailableRecruiting1
DB00421SpironolactoneNot AvailableRecruiting1
DB01606TazobactamNot AvailableRecruiting1
DB00684TobramycinNot AvailableRecruiting1
DB00302Tranexamic acidNot AvailableRecruiting1
DB00656TrazodoneNot AvailableCompleted1
DB00512VancomycinNot AvailableRecruiting1
DB01339VecuroniumNot AvailableRecruiting1
DB00682WarfarinNot AvailableRecruiting1
DB00246ZiprasidoneNot AvailableRecruiting1
DB00425ZolpidemNot AvailableCompleted3
DB00425ZolpidemNot AvailableRecruiting1