Knee Replacement Surgery

Also known as: Total knee replacement / Arthroplasty, Knee / Knee Arthroplasty / Replacement, Total Knee / Knee replacement / Arthroplasty of knee / Arthroplasty, Replacement, Knee / Knee total replacement / Total replacement of knee

DrugDrug NameDrug Description
DB00945Acetylsalicylic acidA salicylate used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events.
DB06605ApixabanAn anticoagulant used for the prophylaxis of stroke and systemic embolism in nonvalvular atrial fibrillation, and deep vein thrombosis(DVT) leading to pulmonary embolism(PE), including in patients after a hip or knee replacement surgery.
DB06695Dabigatran etexilateAn anticoagulant used for the prevention of venous thromboembolic events or stroke in patients with recent elective hip or knee replacement surgery and atrial fibrillation.
DB00569FondaparinuxAn anticoagulant used to prevent venous thromboembolism, to treat deep vein thrombosis, and to improve survival following myocardial infarction.
DB06228RivaroxabanA factor Xa inhibitor used to treat deep vein thrombosis (DVT) and pulmonary embolism (PE). May also be used as thrombosis prophylaxis in specific situations.
DrugDrug NameTargetType
DB00945Acetylsalicylic acidProstaglandin G/H synthase 1target
DB00945Acetylsalicylic acidProstaglandin G/H synthase 2target
DB00945Acetylsalicylic acidAldo-keto reductase family 1 member C1target
DB00945Acetylsalicylic acidSolute carrier family 22 member 6transporter
DB00945Acetylsalicylic acidP-glycoprotein 1transporter
DB00945Acetylsalicylic acidCytochrome P450 2C19enzyme
DB00945Acetylsalicylic acidCytochrome P450 2C9enzyme
DB00945Acetylsalicylic acid5'-AMP-activated protein kinasetarget
DB00945Acetylsalicylic acidEndothelin-1 receptortarget
DB00945Acetylsalicylic acidCellular tumor antigen p53target
DB00945Acetylsalicylic acid78 kDa glucose-regulated proteintarget
DB00945Acetylsalicylic acidRibosomal protein S6 kinase alpha-3target
DB00945Acetylsalicylic acidNF-kappa-B inhibitor alphatarget
DB00945Acetylsalicylic acidTumor necrosis factor-inducible gene 6 proteintarget
DB00945Acetylsalicylic acidCaspase-1target
DB00945Acetylsalicylic acidCaspase-3target
DB00945Acetylsalicylic acidInhibitor of nuclear factor kappa-B kinase subunit betatarget
DB00945Acetylsalicylic acidExtracellular signal-regulated kinase (ERK)target
DB00945Acetylsalicylic acidG1/S-specific cyclin-D1target
DB00945Acetylsalicylic acidMyc proto-oncogene proteintarget
DB00945Acetylsalicylic acidProliferating cell nuclear antigentarget
DB00945Acetylsalicylic acidCyclin Atarget
DB00945Acetylsalicylic acidUDP-glucuronosyltransferase 1-6enzyme
DB00945Acetylsalicylic acidArylamine N-acetyltransferase 2enzyme
DB00945Acetylsalicylic acidSolute carrier family 22 member 8transporter
DB06605ApixabanCoagulation factor Xtarget
DB06605ApixabanCytochrome P450 3A4enzyme
DB06605ApixabanCytochrome P450 1A2enzyme
DB06605ApixabanCytochrome P450 2C8enzyme
DB06605ApixabanCytochrome P450 2C9enzyme
DB06605ApixabanCytochrome P450 2C19enzyme
DB06605ApixabanCytochrome P450 2J2enzyme
DB06605ApixabanP-glycoprotein 1transporter
DB06605ApixabanATP-binding cassette sub-family G member 2transporter
DB06605ApixabanCytochrome P450 3A5enzyme
DB06695Dabigatran etexilateProthrombintarget
DB06695Dabigatran etexilateP-glycoprotein 1transporter
DB06695Dabigatran etexilateLiver carboxylesterase 1enzyme
DB06695Dabigatran etexilateCocaine esteraseenzyme
DB06695Dabigatran etexilateUDP-glucuronosyltransferase 1-9enzyme
DB06695Dabigatran etexilateUDP-glucuronosyltransferase 2B7enzyme
DB06695Dabigatran etexilateUDP-glucuronosyltransferase 2B15enzyme
DB06695Dabigatran etexilateRibosyldihydronicotinamide dehydrogenase [quinone]enzyme
DB00569FondaparinuxAntithrombin-IIItarget
DB00569FondaparinuxCoagulation factor Xtarget
DB06228RivaroxabanCoagulation factor Xtarget
DB06228RivaroxabanCytochrome P450 3A4enzyme
DB06228RivaroxabanCytochrome P450 2J2enzyme
DB06228RivaroxabanP-glycoprotein 1transporter
DB06228RivaroxabanCytochrome P450 3A5enzyme
DB06228RivaroxabanATP-binding cassette sub-family G member 2transporter
DrugDrug NamePhaseStatusCount
DB00296Ropivacaine1 / 2Completed1
DB00297Bupivacaine2Active Not Recruiting1
DB00482Celecoxib2Active Not Recruiting1
DB00482Celecoxib2Recruiting1
DB01189Desflurane2Completed1
DB01225Enoxaparin2Completed2
DB00736Esomeprazole2Recruiting1
DB05713LY-5177172Completed1
DB00818Propofol2Completed1
DB00316Acetaminophen3Unknown Status1
DB00633Dexmedetomidine3Recruiting1
DB00668Epinephrine3Recruiting2
DB00465Ketorolac3Recruiting2
DB01002Levobupivacaine3Recruiting1
DB00295Morphine3Recruiting1
DB01183Naloxone3Unknown Status1
DB00296Ropivacaine3Recruiting1
DB00193Tramadol3Unknown Status1
DB00297Bupivacaine4Completed1
DB00878Chlorhexidine4Terminated1
DB01234Dexamethasone4Recruiting1
DB00633Dexmedetomidine4Recruiting1
DB00569Fondaparinux4Unknown Status1
DB00996Gabapentin4Recruiting1
DB00741Hydrocortisone4Completed1
DB02325Isopropyl alcohol4Terminated1
DB01002Levobupivacaine4Unknown Status1
DB00653Magnesium sulfate4Completed1
DB00295Morphine4Completed1
DB00295Morphine4Unknown Status1
DB06812Povidone-iodine4Terminated1
DB00296Ropivacaine4Completed1
DB00296Ropivacaine4Recruiting1
DB00684Tobramycin4Recruiting1
DB00620Triamcinolone4Recruiting1
DB00512Vancomycin4Recruiting1
DB00297BupivacaineNot AvailableCompleted2
DB00668EpinephrineNot AvailableCompleted1
DB00016ErythropoietinNot AvailableCompleted1
DB00813FentanylNot AvailableCompleted1
DB00813FentanylNot AvailableNot Yet Recruiting1
DB08917Ferric carboxymaltoseNot AvailableCompleted1
DB14501Ferrous glycine sulfateNot AvailableCompleted1
DB13257Ferrous sulfate anhydrousNot AvailableCompleted1
DB09222Fibrinogen humanNot AvailableCompleted1
DB00996GabapentinNot AvailableCompleted1
DB11571Human ThrombinNot AvailableCompleted1
DB00295MorphineNot AvailableNot Yet Recruiting1
DB06228RivaroxabanNot AvailableWithdrawn1
DB00296RopivacaineNot AvailableCompleted2
DB00296RopivacaineNot AvailableNot Yet Recruiting1