Infections, Cytomegalovirus

Also known as: Cytomegalovirus infection / Cytomegalovirus Infections / Cytomegalovirus disease / Cytomegalic inclusion disease / Cytomegaloviral disease / CMV infection / Cytomegalus virus infection / Cytomegaloviral infections

DrugDrug NameDrug Description
DB00787AcyclovirAciclovir is a guanosine analog antiviral drug and an antimetabolite used in the treatment of herpes simplex virus infections, varicella zoster (chickenpox) and herpes zoster (shingles). Aciclovir has also been investigated for the treatment of herpes labialis applied using an iontophoretic device. Currently approved drugs for the treatment of herpes labialis (cold sores) exhibit low levels of efficacy due to the limited ability of the drugs to penetrate the skin to the site where the herpes virus is replicating. Iontophoresis uses electric current to enhance the delivery of drugs through the skin.
DB12070LetermovirLetermovir recieved approval from the FDA on November 8th, 2017 for use in prophylaxis of cytomegalovirus (CMV) infection in allogeneic hematopoietic stem cell transplant patients [L1021]. It represents the first entry into a new class of CMV anti-infectives, DNA terminase complex inhibitors [A31290]. Letermovir has recieved both priority and orphan drug status from the FDA. It is currently marketed under the brand name Prevymis [L1021].
DrugDrug NameTargetType
DB00787AcyclovirDNA polymerase catalytic subunittarget
DB00787AcyclovirDNA polymerase catalytic subunittarget
DB00787AcyclovirThymidine kinasetarget
DB00787AcyclovirSolute carrier family 22 member 1transporter
DB00787AcyclovirSolute carrier family 22 member 6transporter
DB00787AcyclovirSolute carrier family 22 member 8transporter
DB00787AcyclovirIleal sodium/bile acid cotransportertransporter
DB00787AcyclovirMultidrug and toxin extrusion protein 1transporter
DB00787AcyclovirMultidrug and toxin extrusion protein 2transporter
DB12070LetermovirUDP-glucuronosyltransferase 1-1enzyme
DB12070LetermovirUDP-glucuronosyltransferase 1-3enzyme
DB12070LetermovirSolute carrier organic anion transporter family member 1B1transporter
DB12070LetermovirSolute carrier organic anion transporter family member 1B3transporter
DB12070LetermovirTripartite terminase subunit 1target
DB12070LetermovirTripartite terminase subunit 2target
DB12070LetermovirTripartite terminase subunit 3target
DB12070LetermovirCytochrome P450 2D6enzyme
DB12070LetermovirCytochrome P450 2C8enzyme
DB12070LetermovirCytochrome P450 2C19enzyme
DB12070LetermovirCytochrome P450 2C9enzyme
DB12070LetermovirCytochrome P450 2B6enzyme
DB12070LetermovirMultidrug resistance protein 1transporter
DB12070LetermovirATP-binding cassette sub-family G member 2transporter
DB12070LetermovirBile salt export pumptransporter
DB12070LetermovirSolute carrier family 22 member 8transporter
DB12070LetermovirCanalicular multispecific organic anion transporter 1transporter
DB12070LetermovirCytochrome P450 3A4enzyme
DB12070LetermovirCytochrome P450 3A5enzyme
DB12070LetermovirCytochrome P450 3A7enzyme
DB12070LetermovirCytochrome P450 3A43enzyme
DrugDrug NamePhaseStatusCount
DB00369Cidofovir1Withdrawn1
DB00900Didanosine1Completed1
DB01004Ganciclovir1Completed2
DB06234Maribavir1Completed1
DB01032Probenecid1Withdrawn1
DB01610Valganciclovir1Completed1
DB00495Zidovudine1Completed1
DB01004Ganciclovir1 / 2Completed1
DB01610Valganciclovir1 / 2Completed1
DB05176Brincidofovir2Completed1
DB00783Estradiol2Completed1
DB12901Fiacitabine2Completed1
DB12070Letermovir2Recruiting1
DB06234Maribavir2Completed2
DB00577Valaciclovir2Recruiting1
DB01610Valganciclovir2Completed1
DB01610Valganciclovir2Recruiting2
DB06361rsPSMA Vaccine2Unknown Status1
DB10989Hepatitis A Vaccine2 / 3Terminated1
DB01610Valganciclovir2 / 3Completed1
DB01610Valganciclovir2 / 3Not Yet Recruiting1
DB00787Acyclovir3Completed1
DB00718Adefovir dipivoxil3Completed1
DB09274Artesunate3Completed1
DB01004Ganciclovir3Completed3
DB01004Ganciclovir3Not Yet Recruiting1
DB01004Ganciclovir3Terminated1
DB12070Letermovir3Completed1
DB12070Letermovir3Recruiting1
DB00583Levocarnitine3Completed1
DB06234Maribavir3Completed2
DB00577Valaciclovir3Completed1
DB01610Valganciclovir3Completed5
DB01610Valganciclovir3Not Yet Recruiting1
DB01610Valganciclovir3Terminated2
DB00098Antithymocyte immunoglobulin (rabbit)4Completed3
DB00074Basiliximab4Completed1
DB01590Everolimus4Completed3
DB01590Everolimus4Unknown Status1
DB00529Foscarnet4Completed1
DB00529Foscarnet4Recruiting1
DB01004Ganciclovir4Completed3
DB01004Ganciclovir4Recruiting1
DB00653Magnesium sulfate4Completed1
DB00959Methylprednisolone4Completed1
DB01024Mycophenolic acid4Completed4
DB01024Mycophenolic acid4Recruiting1
DB01024Mycophenolic acid4Unknown Status1
DB00635Prednisone4Completed2
DB00635Prednisone4Unknown Status1
DB00877Sirolimus4Completed1
DB00877Sirolimus4Recruiting1
DB00864Tacrolimus4Completed2
DB00864Tacrolimus4Unknown Status1
DB00577Valaciclovir4Terminated1
DB01610Valganciclovir4Completed5
DB00529FoscarnetNot AvailableCompleted1
DB01004GanciclovirNot AvailableCompleted6
DB01004GanciclovirNot AvailableRecruiting1
DB01004GanciclovirNot AvailableUnknown Status1
DB12531LobucavirNot AvailableCompleted1
DB01610ValganciclovirNot AvailableCompleted3
DB01610ValganciclovirNot AvailableRecruiting1
DB01610ValganciclovirNot AvailableUnknown Status1
DB00495ZidovudineNot AvailableCompleted1