Coronary Artery Atherosclerosis

Also known as: Atherosclerosis, Coronary / Arteriosclerosis coronary artery / Coronary Atherosclerosis / Coronary artery sclerosis / Cardiac cirrhosis / Ischemic heart disease / Coronary sclerosis / Arteriosclerotic heart disease / Coronary Arteriosclerosis

DrugDrug NameDrug Description
DB00335AtenololAtenolol is a cardioselective beta-blocker used in a variety of cardiovascular conditions. Sir James Black, a scottish pharmacologist, pioneered the use of beta-blockers for the management of angina pectoris in 1958 for which he received the Nobel Prize.[A178429] Beta-blockers quickly became popular in clinical use and where subsequently investigated for use in myocardial infarction, arrhythmias, and hypertension during the 1960s. Later they continued to be investigated for use in heart failure throughout the 1970-1980s. Atenolol itself was developed early on in this history by Alvogen Malta under the trade name Tenormin and received FDA approval in September, 1981.[label]
DB00175PravastatinPravastatin is the 6-alpha-hydroxy acid form of [mevastatin].[T303] Pravastatin was firstly approved in 1991 becoming the second available statin in the United States. It was the first statin administered as the active form and not as a prodrug.[T274] This drug was developed by Sankyo Co. Ltd.; however, the first approved pravastatin product was developed by Bristol Myers Squibb and FDA approved in 1991.[L6142] Pravastatin is made through a fermentation process in which [mevastatin] is first obtained. The manufacturing process is followed by the hydrolysis of the lactone group and the biological hydroxylation with _Streptomyces carbophilus_ to introduce the allylic 6-alcohol group.[T239]
DrugDrug NamePhaseStatusCount
DB00099Filgrastim1Recruiting1
DB00019Pegfilgrastim1Recruiting1
DB00640Adenosine2 / 3Completed1
DB12091Gadolinium2 / 3Completed1
DB09026Aliskiren3Completed1
DB01076Atorvastatin3Completed1
DB01039Fenofibrate3Terminated1
DB01132Pioglitazone3Unknown Status1
DB06155Rimonabant3Completed1
DB01098Rosuvastatin3Completed1
DB00945Acetylsalicylic acid4Completed1
DB00051Adalimumab4Completed2
DB00381Amlodipine4Completed1
DB09230Azelnidipine4Completed1
DB00612Bisoprolol4Completed1
DB12407Iobitridol4Active Not Recruiting1
DB00883Isosorbide dinitrate4Completed1
DB00275Olmesartan4Unknown Status1
DB01132Pioglitazone4Completed1
DB01132Pioglitazone4Unknown Status1
DB00178Ramipril4Completed1
DB01098Rosuvastatin4Completed1
DB12054BQ-123Not AvailableCompleted1
DB06703GadobutrolNot AvailableNot Yet Recruiting1
DB00264MetoprololNot AvailableNot Yet Recruiting1