Sickle Cell Disorders

Also known as: Sickle Cell Anaemia / Sickle Cell Anemia / Sickle Cell Disease / Sickle Cells Disease / Anemia, Sickle Cell / Sickle Cell Disorders / Sickle Cell Disorder / Sickle-cell anemia, unspecified / Sickle-cell anaemia, unspecified / Sickle-cell disorders / Sickle cell anemia of unspecified type / Anaemia sickle cell / Sickle-cell anaemia / Sickle cell disease NOS / Sickle-cell anemia / Anemia sickle cell

Drug	Drug Name	Drug Description
DB01005	Hydroxyurea	An antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase. [PubChem]

Drug	Drug Name	Target	Type
DB01005	Hydroxyurea	Ribonucleoside-diphosphate reductase large subunit	target
DB01005	Hydroxyurea	Cytochrome P450 2D6	enzyme

Drug	Drug Name	Phase	Status	Count
DB01005	Hydroxyurea	0	Recruiting	1
DB00678	Losartan	0	Completed	1
DB00331	Metformin	0	Recruiting	1
DB00624	Testosterone	0	Withdrawn	1
DB12298	5-(hydroxymethyl)-2-furaldehyde	1	Completed	1
DB01281	Abatacept	1	Recruiting	2
DB00316	Acetaminophen	1	Recruiting	1
DB03128	Acetylcholine	1	Completed	1
DB00087	Alemtuzumab	1	Recruiting	2
DB06403	Ambrisentan	1	Recruiting	1
DB00098	Antithymocyte immunoglobulin (rabbit)	1	Recruiting	1
DB00207	Azithromycin	1	Recruiting	1
DB01222	Budesonide	1	Completed	1
DB00531	Cyclophosphamide	1	Recruiting	1
DB00091	Cyclosporine	1	Recruiting	1
DB08826	Deferiprone	1	Completed	1
DB01075	Diphenhydramine	1	Recruiting	1
DB00016	Erythropoietin	1	Completed	1
DB01073	Fludarabine	1	Completed	1
DB01073	Fludarabine	1	Recruiting	2
DB01005	Hydroxyurea	1	Completed	4
DB00125	L-Arginine	1	Completed	1
DB00155	L-Citrulline	1	Completed	1
DB00155	L-Citrulline	1	Recruiting	2
DB00155	L-Citrulline	1	Unknown Status	1
DB08932	Macitentan	1	Recruiting	1
DB01042	Melphalan	1	Recruiting	1
DB00563	Methotrexate	1	Recruiting	1
DB00959	Methylprednisolone	1	Recruiting	1
DB00688	Mycophenolate mofetil	1	Recruiting	1
DB00435	Nitric Oxide	1	Completed	1
DB05262	Oxypurinol	1	Completed	1
DB06603	Panobinostat	1	Recruiting	1
DB00454	Pethidine	1	Recruiting	1
DB06809	Plerixafor	1	Recruiting	2
DB08910	Pomalidomide	1	Completed	1
DB06209	Prasugrel	1	Completed	2
DB00571	Propranolol	1	Terminated	1
DB06213	Regadenoson	1	Completed	1
DB01001	Salbutamol	1	Completed	1
DB00203	Sildenafil	1	Completed	1
DB00877	Sirolimus	1	Recruiting	1
DB09153	Sodium Chloride	1	Completed	1
DB09112	Sodium Nitrite	1	Completed	2
DB01390	Sodium bicarbonate	1	Recruiting	1
DB00864	Tacrolimus	1	Recruiting	1
DB12484	Tetrahydrouridine	1	Active Not Recruiting	1
DB04572	Thiotepa	1	Recruiting	1
DB08816	Ticagrelor	1	Active Not Recruiting	1
DB11815	Tilarginine	1	Completed	2
DB09145	Water	1	Active Not Recruiting	1
DB00744	Zileuton	1	Completed	1
DB06151	Acetylcysteine	1 / 2	Enrolling by Invitation	1
DB00945	Acetylsalicylic acid	1 / 2	Completed	1
DB00087	Alemtuzumab	1 / 2	Active Not Recruiting	1
DB00087	Alemtuzumab	1 / 2	Recruiting	4
DB00207	Azithromycin	1 / 2	Recruiting	1
DB00169	Cholecalciferol	1 / 2	Completed	1
DB00257	Clotrimazole	1 / 2	Completed	1
DB00318	Codeine	1 / 2	Completed	1
DB00531	Cyclophosphamide	1 / 2	Active Not Recruiting	1
DB00531	Cyclophosphamide	1 / 2	Recruiting	2
DB00091	Cyclosporine	1 / 2	Completed	1
DB00091	Cyclosporine	1 / 2	Recruiting	1
DB00063	Eptifibatide	1 / 2	Terminated	1
DB00153	Ergocalciferol	1 / 2	Completed	1
DB01073	Fludarabine	1 / 2	Completed	1
DB01073	Fludarabine	1 / 2	Recruiting	2
DB01005	Hydroxyurea	1 / 2	Active Not Recruiting	1
DB01005	Hydroxyurea	1 / 2	Completed	1
DB01005	Hydroxyurea	1 / 2	Terminated	1
DB00028	Immune Globulin Human	1 / 2	Recruiting	1
DB00125	L-Arginine	1 / 2	Enrolling by Invitation	1
DB01042	Melphalan	1 / 2	Recruiting	1
DB00688	Mycophenolate mofetil	1 / 2	Completed	1
DB00688	Mycophenolate mofetil	1 / 2	Recruiting	1
DB00552	Pentostatin	1 / 2	Recruiting	2
DB12544	Rivipansel	1 / 2	Completed	1
DB00641	Simvastatin	1 / 2	Completed	2
DB00877	Sirolimus	1 / 2	Active Not Recruiting	1
DB00877	Sirolimus	1 / 2	Recruiting	3
DB09112	Sodium Nitrite	1 / 2	Terminated	1
DB00864	Tacrolimus	1 / 2	Recruiting	1
DB00399	Zoledronic acid	1 / 2	Withdrawn	1
DB12298	5-(hydroxymethyl)-2-furaldehyde	2	Terminated	1
DB00054	Abciximab	2	Withdrawn	1
DB03128	Acetylcholine	2	Completed	2
DB00087	Alemtuzumab	2	Active Not Recruiting	1
DB00087	Alemtuzumab	2	Completed	2
DB00087	Alemtuzumab	2	Recruiting	2
DB09312	Antilymphocyte immunoglobulin (horse)	2	Recruiting	1
DB00098	Antithymocyte immunoglobulin (rabbit)	2	Recruiting	2
DB00098	Antithymocyte immunoglobulin (rabbit)	2	Terminated	1
DB01076	Atorvastatin	2	Enrolling by Invitation	1
DB01008	Busulfan	2	Completed	2
DB01008	Busulfan	2	Recruiting	3
DB01008	Busulfan	2	Terminated	3
DB06168	Canakinumab	2	Not Yet Recruiting	1
DB00169	Cholecalciferol	2	Active Not Recruiting	1
DB00169	Cholecalciferol	2	Unknown Status	1
DB00531	Cyclophosphamide	2	Active Not Recruiting	2
DB00531	Cyclophosphamide	2	Completed	1
DB00531	Cyclophosphamide	2	Recruiting	3
DB00531	Cyclophosphamide	2	Terminated	2
DB00091	Cyclosporine	2	Completed	1
DB06779	Dalteparin	2	Completed	1
DB01262	Decitabine	2	Completed	1
DB01609	Deferasirox	2	Completed	3
DB00746	Deferoxamine	2	Completed	2
DB04932	Defibrotide	2	Not Yet Recruiting	1
DB00153	Ergocalciferol	2	Unknown Status	1
DB00813	Fentanyl	2	Completed	1
DB00813	Fentanyl	2	Withdrawn	1
DB01073	Fludarabine	2	Active Not Recruiting	1
DB01073	Fludarabine	2	Completed	1
DB01073	Fludarabine	2	Recruiting	6
DB01073	Fludarabine	2	Terminated	3
DB00996	Gabapentin	2	Recruiting	1
DB01109	Heparin	2	Recruiting	1
DB00327	Hydromorphone	2	Withdrawn	1
DB01005	Hydroxyurea	2	Completed	2
DB01005	Hydroxyurea	2	Recruiting	5
DB01005	Hydroxyurea	2	Terminated	1
DB01050	Ibuprofen	2	Withdrawn	1
DB01221	Ketamine	2	Terminated	1
DB00125	L-Arginine	2	Completed	2
DB00125	L-Arginine	2	Recruiting	2
DB00130	L-Glutamine	2	Completed	3
DB00130	L-Glutamine	2	Terminated	1
DB01202	Levetiracetam	2	Active Not Recruiting	1
DB00678	Losartan	2	Completed	1
DB00678	Losartan	2	Recruiting	1
DB12583	Maltodextrin	2	Completed	1
DB01042	Melphalan	2	Recruiting	2
DB00563	Methotrexate	2	Recruiting	1
DB00764	Mometasone	2	Recruiting	1
DB00295	Morphine	2	Withdrawn	1
DB00688	Mycophenolate mofetil	2	Active Not Recruiting	1
DB00688	Mycophenolate mofetil	2	Completed	1
DB00688	Mycophenolate mofetil	2	Recruiting	2
DB00688	Mycophenolate mofetil	2	Terminated	1
DB00435	Nitric Oxide	2	Completed	3
DB00435	Nitric Oxide	2	Terminated	2
DB00727	Nitroglycerin	2	Completed	1
DB06690	Nitrous oxide	2	Recruiting	1
DB09140	Oxygen	2	Terminated	1
DB00252	Phenytoin	2	Terminated	1
DB06209	Prasugrel	2	Completed	2
DB00635	Prednisone	2	Terminated	1
DB00571	Propranolol	2	Completed	1
DB06213	Regadenoson	2	Recruiting	1
DB08931	Riociguat	2	Recruiting	1
DB00073	Rituximab	2	Terminated	1
DB06228	Rivaroxaban	2	Enrolling by Invitation	1
DB12544	Rivipansel	2	Completed	1
DB00360	Sapropterin	2	Completed	1
DB00203	Sildenafil	2	Terminated	2
DB00877	Sirolimus	2	Active Not Recruiting	2
DB00877	Sirolimus	2	Recruiting	2
DB09153	Sodium Chloride	2	Withdrawn	1
DB09112	Sodium Nitrite	2	Not Yet Recruiting	1
DB00864	Tacrolimus	2	Recruiting	1
DB00864	Tacrolimus	2	Terminated	2
DB00820	Tadalafil	2	Withdrawn	1
DB04572	Thiotepa	2	Recruiting	2
DB08816	Ticagrelor	2	Completed	1
DB11815	Tilarginine	2	Completed	2
DB11909	Varespladib	2	Terminated	1
DB02546	Vorinostat	2	Completed	1
DB00087	Alemtuzumab	2 / 3	Active Not Recruiting	1
DB01008	Busulfan	2 / 3	Active Not Recruiting	1
DB00608	Chloroquine	2 / 3	Active Not Recruiting	1
DB00531	Cyclophosphamide	2 / 3	Active Not Recruiting	1
DB01609	Deferasirox	2 / 3	Unknown Status	1
DB08826	Deferiprone	2 / 3	Unknown Status	1
DB00746	Deferoxamine	2 / 3	Unknown Status	1
DB01073	Fludarabine	2 / 3	Active Not Recruiting	1
DB00677	Isoflurophate	2 / 3	Unknown Status	1
DB00653	Magnesium Sulfate	2 / 3	Completed	1
DB00435	Nitric Oxide	2 / 3	Completed	1
DB06151	Acetylcysteine	3	Completed	1
DB00087	Alemtuzumab	3	Recruiting	1
DB06605	Apixaban	3	Active Not Recruiting	1
DB00559	Bosentan	3	Terminated	1
DB01609	Deferasirox	3	Completed	1
DB01609	Deferasirox	3	Terminated	1
DB00035	Desmopressin	3	Recruiting	1
DB01234	Dexamethasone	3	Terminated	1
DB01073	Fludarabine	3	Recruiting	1
DB01005	Hydroxyurea	3	Active Not Recruiting	1
DB01005	Hydroxyurea	3	Completed	2
DB01005	Hydroxyurea	3	Not Yet Recruiting	1
DB01005	Hydroxyurea	3	Recruiting	2
DB01005	Hydroxyurea	3	Terminated	3
DB01221	Ketamine	3	Not Yet Recruiting	1
DB00125	L-Arginine	3	Completed	1
DB00130	L-Glutamine	3	Completed	1
DB00653	Magnesium Sulfate	3	Completed	1
DB12583	Maltodextrin	3	Completed	1
DB01042	Melphalan	3	Recruiting	1
DB00422	Methylphenidate	3	Completed	1
DB00295	Morphine	3	Active Not Recruiting	1
DB00844	Nalbuphine	3	Active Not Recruiting	1
DB06209	Prasugrel	3	Terminated	1
DB12544	Rivipansel	3	Recruiting	2
DB09422	Soybean oil	3	Not Yet Recruiting	1
DB00173	Adenine	4	Not Yet Recruiting	1
DB00318	Codeine	4	Withdrawn	1
DB01609	Deferasirox	4	Completed	1
DB08826	Deferiprone	4	Enrolling by Invitation	1
DB08826	Deferiprone	4	Recruiting	1
DB00746	Deferoxamine	4	Completed	1
DB00746	Deferoxamine	4	Recruiting	1
DB00514	Dextromethorphan	4	Withdrawn	1
DB00294	Etonogestrel	4	Active Not Recruiting	1
DB00813	Fentanyl	4	Completed	1
DB00327	Hydromorphone	4	Completed	1
DB01005	Hydroxyurea	4	Active Not Recruiting	1
DB01005	Hydroxyurea	4	Completed	1
DB01005	Hydroxyurea	4	Enrolling by Invitation	1
DB01050	Ibuprofen	4	Terminated	2
DB04335	Inosine	4	Not Yet Recruiting	1
DB01221	Ketamine	4	Terminated	1
DB00465	Ketorolac	4	Terminated	1
DB00295	Morphine	4	Completed	1
DB00295	Morphine	4	Withdrawn	1
DB11194	Pyruvic acid	4	Not Yet Recruiting	1
DB00203	Sildenafil	4	Withdrawn	1
DB09449	Sodium phosphate	4	Not Yet Recruiting	1
DB09525	Sodium phosphate	4	Not Yet Recruiting	1
DB00819	Acetazolamide	Not Available	Recruiting	1
DB00092	Alefacept	Not Available	Suspended	1
DB00098	Antithymocyte immunoglobulin (rabbit)	Not Available	Recruiting	1
DB00188	Bortezomib	Not Available	Terminated	1
DB01008	Busulfan	Not Available	Completed	1
DB01008	Busulfan	Not Available	Terminated	1
DB00493	Cefotaxime	Not Available	Recruiting	1
DB00493	Cefotaxime	Not Available	Terminated	1
DB00257	Clotrimazole	Not Available	Completed	1
DB09110	Coenzyme M	Not Available	Recruiting	1
DB09110	Coenzyme M	Not Available	Terminated	1
DB00531	Cyclophosphamide	Not Available	Completed	1
DB00531	Cyclophosphamide	Not Available	Recruiting	1
DB00531	Cyclophosphamide	Not Available	Terminated	2
DB00987	Cytarabine	Not Available	Terminated	1
DB00584	Enalapril	Not Available	Terminated	1
DB01073	Fludarabine	Not Available	Recruiting	1
DB01073	Fludarabine	Not Available	Terminated	1
DB04173	Fructose	Not Available	Completed	1
DB09341	Glucose	Not Available	Terminated	1
DB01005	Hydroxyurea	Not Available	Active Not Recruiting	2
DB01005	Hydroxyurea	Not Available	Completed	3
DB01005	Hydroxyurea	Not Available	Recruiting	4
DB01221	Ketamine	Not Available	Recruiting	2
DB00333	Methadone	Not Available	Recruiting	1
DB00295	Morphine	Not Available	Recruiting	1
DB00688	Mycophenolate mofetil	Not Available	Recruiting	1
DB01270	Ranibizumab	Not Available	Withdrawn	1
DB06213	Regadenoson	Not Available	Recruiting	1
DB00073	Rituximab	Not Available	Terminated	1
DB00877	Sirolimus	Not Available	Recruiting	1