Depressive State

Also known as: Depression NOS / Depression / Monopolar depression NOS / Depression psychic / [X]Depression NOS / Depressed state / Depression mental

DrugDrug NameDrug Description
DB00404AlprazolamA triazolobenzodiazepine compound with antianxiety and sedative-hypnotic actions, that is efficacious in the treatment of panic disorders, with or without agoraphobia, and in generalized anxiety disorders. (From AMA Drug Evaluations Annual, 1994, p238)
DB00321AmitriptylineAmitriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, amitriptyline does not affect mood or arousal, but may cause sedation. In depressed individuals, amitriptyline exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Tertiary amine TCAs, such as amitriptyline, are more potent inhibitors of serotonin reuptake than secondary amine TCAs, such as nortriptyline. TCAs also down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine-H1 receptors, α1-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Amitriptyline may be used to treat depression, chronic pain (unlabeled use), irritable bowel syndrome (unlabeled use), diabetic neuropathy (unlabeled use), post-traumatic stress disorder (unlabeled use), and for migraine prophylaxis (unlabeled use).
DB00543AmoxapineAmoxapine, the N-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, amoxapine does not affect mood or arousal, but may cause sedation. In depressed individuals, amoxapine exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. In addition, TCAs down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine H1 receptors, α1-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Amoxapine may be used to treat neurotic and reactive depressive disorders, endogenous and psychotic depression, and mixed symptoms of depression and anxiety or agitation.
DB01242ClomipramineClomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or arousal, but may cause sedation. In depressed individuals, clomipramine exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Tertiary amine TCAs, such as clomipramine, are more potent inhibitors of serotonin reuptake than secondary amine TCAs, such as nortriptyline and desipramine. TCAs also down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine-H1 receptors, α1-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Clomipramine may be used to treat obsessive-compulsive disorder and disorders with an obsessive-compulsive component (e.g. depression, schizophrenia, Tourette’s disorder). Unlabeled indications include panic disorder, chronic pain (e.g. central pain, idiopathic pain disorder, tension headache, diabetic peripheral neuropathy, neuropathic pain), cataplexy and associated narcolepsy, autistic disorder, trichotillomania, onchophagia, stuttering, premature ejaculation, and premenstrual syndrome. Clomipramine is rapidly absorbed from the gastrointestinal tract and demethylated in the liver to its primary active metabolite, desmethylclomipramine.
DB01151DesipramineDesipramine hydrochloride is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, desipramine does not affect mood or arousal, but may cause sedation. In depressed individuals, desipramine exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Secondary amine TCAs, such as desipramine and nortriptyline, are more potent inhibitors of norepinephrine reuptake than tertiary amine TCAs, such as amitriptyline and doxepine. TCAs also down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine-H1 receptors, α1-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Desipramine exerts less anticholinergic and sedative side effects compared to tertiary amine TCAs, such as amitriptyline and clomipramine. Desipramine may be used to treat depression, neuropathic pain (unlabeled use), agitation and insomnia (unlabeled use) and attention-deficit hyperactivity disorder (unlabeled use).
DB01142DoxepinDoxepin hydrochloride is a dibenzoxepin-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, doxepin does not affect mood or arousal, but may cause sedation. In depressed individuals, doxepin exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Tertiary amine TCAs, such as doxepin and amitriptyline, are more potent inhibitors of serotonin reuptake than secondary amine TCAs, such as nortriptyline and desipramine. TCAs also down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine H1 receptors, α1-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. Doxepin has less sedative and anticholinergic effects than amitriptyline. See toxicity section below for a complete listing of side effects. Doxepin may be used to treat depression and insomnia. Unlabeled indications include chronic and neuropathic pain, and anxiety. Doxepin may also be used as a second line agent to treat idiopathic urticaria.
DB01247IsocarboxazidAn MAO inhibitor that is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in the treatment of panic disorder and the phobic disorders. (From AMA, Drug Evaluations Annual, 1994, p311)
DB01356LithiumLithium was used during the 19th century to treat gout. Lithium salts such as lithium carbonate (Li2CO3), lithium citrate, and lithium orotate are mood stabilizers. They are used in the treatment of bipolar disorder, since unlike most other mood altering drugs, they counteract both mania and depression. Lithium can also be used to augment other antidepressant drugs. It is also sometimes prescribed as a preventive treatment for migraine disease and cluster headaches. The active principle in these salts is the lithium ion Li+, which having a smaller diameter, can easily displace K+ and Na+ and even Ca+2, in spite of its greater charge, occupying their sites in several critical neuronal enzymes and neurotransmitter receptors.
DB00934MaprotilineMaprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does not appear to block serotonin reuptake. Maprotiline may be used to treat depressive affective disorders, including dysthymic disorder (depressive neurosis) and major depressive disorder. Maprotiline is effective at reducing symptoms of anxiety associated with depression.
DB01149NefazodoneNefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury, which could lead to the need for a liver transplant, or even death. The incidence of severe liver damage is approximately 1 in 250,000 to 300,000 patient-years. On May 20, 2004, Bristol-Myers Squibb discontinued the sale of Serzone in the United States.
DB00344ProtriptylineProtriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may cause sedation. In depressed individuals, protriptyline exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. In addition, TCAs down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine H1 receptors, α1-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Protriptyline may be used for the treatment of depression.
DB00726TrimipramineTricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. [PubChem]
DrugDrug NameTargetType
DB00404AlprazolamCytochrome P450 3A4enzyme
DB00404AlprazolamCytochrome P450 2C9enzyme
DB00404AlprazolamCytochrome P450 3A5enzyme
DB00404AlprazolamCytochrome P450 3A7enzyme
DB00404AlprazolamGABA-A receptor (anion channel)target
DB00321AmitriptylineSodium-dependent serotonin transportertarget
DB00321AmitriptylineSodium-dependent noradrenaline transportertarget
DB00321AmitriptylinePotassium voltage-gated channel subfamily KQT member 2target
DB00321AmitriptylineAlpha-2A adrenergic receptortarget
DB00321AmitriptylineCytochrome P450 1A2enzyme
DB00321AmitriptylineCytochrome P450 2C19enzyme
DB00321AmitriptylineCytochrome P450 2D6enzyme
DB00321AmitriptylineSerum albumincarrier
DB00321AmitriptylineAlpha-1-acid glycoprotein 1carrier
DB00321AmitriptylineMuscarinic acetylcholine receptor M1target
DB00321AmitriptylineMuscarinic acetylcholine receptor M2target
DB00321AmitriptylineMuscarinic acetylcholine receptor M3target
DB00321AmitriptylineMuscarinic acetylcholine receptor M4target
DB00321AmitriptylineMuscarinic acetylcholine receptor M5target
DB00321AmitriptylineHistamine H1 receptortarget
DB00321Amitriptyline5-hydroxytryptamine receptor 2Atarget
DB00321Amitriptyline5-hydroxytryptamine receptor 1Atarget
DB00321AmitriptylineAlpha-1A adrenergic receptortarget
DB00321AmitriptylineCytochrome P450 3A4enzyme
DB00321AmitriptylineCytochrome P450 3A5enzyme
DB00321AmitriptylinePotassium voltage-gated channel subfamily A member 1target
DB00321AmitriptylinePotassium voltage-gated channel subfamily D member 2target
DB00321AmitriptylinePotassium voltage-gated channel subfamily D member 3target
DB00321AmitriptylineAlpha-1D adrenergic receptortarget
DB00321AmitriptylineDelta-type opioid receptortarget
DB00321AmitriptylineKappa-type opioid receptortarget
DB00321AmitriptylineHigh affinity nerve growth factor receptortarget
DB00321AmitriptylineBDNF/NT-3 growth factors receptortarget
DB00321AmitriptylineCytochrome P450 2C9enzyme
DB00321AmitriptylineMultidrug resistance protein 1transporter
DB00321AmitriptylineCytochrome P450 2B6enzyme
DB00321AmitriptylineCytochrome P450 2C8enzyme
DB00321AmitriptylineCytochrome P450 2E1enzyme
DB00321AmitriptylineHistamine H2 receptortarget
DB00321AmitriptylineHistamine H4 receptortarget
DB00321AmitriptylineSigma non-opioid intracellular receptor 1target
DB00321Amitriptyline5-hydroxytryptamine receptor 2Ctarget
DB00321AmitriptylineAlpha-1B adrenergic receptortarget
DB00321Amitriptyline5-hydroxytryptamine receptor 7target
DB00321Amitriptyline5-hydroxytryptamine receptor 1Dtarget
DB00321AmitriptylineMu-type opioid receptortarget
DB00321Amitriptyline5-hydroxytryptamine receptor 1Btarget
DB00321Amitriptyline5-hydroxytryptamine receptor 6target
DB00321AmitriptylinePotassium voltage-gated channel subfamily KQT member 3target
DB00321AmitriptylineBeta adrenergic receptortarget
DB00543AmoxapineSodium-dependent serotonin transportertarget
DB00543AmoxapineSodium-dependent noradrenaline transportertarget
DB00543AmoxapineAlpha-2A adrenergic receptortarget
DB00543AmoxapineD(2) dopamine receptortarget
DB00543AmoxapineAlpha-1A adrenergic receptortarget
DB00543AmoxapineD(1A) dopamine receptortarget
DB00543AmoxapineMuscarinic acetylcholine receptor M1target
DB00543AmoxapineGamma-aminobutyric acid receptor subunit alpha-1target
DB00543AmoxapineAlpha-1-acid glycoprotein 1carrier
DB00543AmoxapineCytochrome P450 2D6enzyme
DB00543Amoxapine5-hydroxytryptamine receptor 2Atarget
DB00543Amoxapine5-hydroxytryptamine receptor 2Ctarget
DB00543Amoxapine5-hydroxytryptamine receptor 6target
DB00543Amoxapine5-hydroxytryptamine receptor 7target
DB00543AmoxapineD(3) dopamine receptortarget
DB00543AmoxapineD(4) dopamine receptortarget
DB00543AmoxapineHistamine H1 receptortarget
DB00543AmoxapineAlpha-1 adrenergic receptorstarget
DB00543AmoxapineMuscarinic acetylcholine receptortarget
DB00543Amoxapine5-hydroxytryptamine receptor 2Btarget
DB00543Amoxapine5-hydroxytryptamine receptor 3Atarget
DB00543Amoxapine5-hydroxytryptamine receptor 1Atarget
DB00543Amoxapine5-hydroxytryptamine receptor 1Btarget
DB00543AmoxapineAlpha-2 adrenergic receptorstarget
DB00543AmoxapineHistamine H4 receptortarget
DB00543AmoxapineGABA-A receptor (anion channel)target
DB00543AmoxapineSodium-dependent dopamine transportertarget
DB01242ClomipramineSodium-dependent serotonin transportertarget
DB01242ClomipramineSodium-dependent noradrenaline transportertarget
DB01242ClomipramineGlutathione S-transferase Ptarget
DB01242Clomipramine5-hydroxytryptamine receptor 2Atarget
DB01242ClomipramineCytochrome P450 1A2enzyme
DB01242ClomipramineCytochrome P450 2D6enzyme
DB01242ClomipramineCytochrome P450 2C19enzyme
DB01242ClomipramineMultidrug resistance protein 1transporter
DB01242ClomipramineCytochrome P450 3A4enzyme
DB01242Clomipramine5-hydroxytryptamine receptor 2Btarget
DB01242Clomipramine5-hydroxytryptamine receptor 2Ctarget
DB01242ClomipramineSerum albumincarrier
DB01151DesipramineMuscarinic acetylcholine receptor M1target
DB01151DesipramineSodium-dependent noradrenaline transportertarget
DB01151DesipramineBeta-2 adrenergic receptortarget
DB01151DesipramineMuscarinic acetylcholine receptor M2target
DB01151DesipramineSodium-dependent serotonin transportertarget
DB01151DesipramineHistamine H1 receptortarget
DB01151DesipramineBeta-1 adrenergic receptortarget
DB01151DesipramineCytochrome P450 2D6enzyme
DB01151DesipramineMuscarinic acetylcholine receptor M3target
DB01151DesipramineMuscarinic acetylcholine receptor M4target
DB01151DesipramineMuscarinic acetylcholine receptor M5target
DB01151DesipramineAlpha-1 adrenergic receptorstarget
DB01151Desipramine5-hydroxytryptamine receptor 2Atarget
DB01151DesipramineAlpha-1-acid glycoprotein 1carrier
DB01151DesipramineCytochrome P450 2B6enzyme
DB01151DesipramineCytochrome P450 3A4enzyme
DB01151DesipramineSolute carrier family 22 member 2transporter
DB01151DesipramineSolute carrier family 22 member 1transporter
DB01151DesipramineSolute carrier family 22 member 3transporter
DB01151DesipramineSolute carrier family 22 member 5transporter
DB01151DesipramineMultidrug resistance protein 1transporter
DB01151DesipramineSolute carrier family 22 member 4transporter
DB01151DesipramineCytochrome P450 1A2enzyme
DB01151DesipramineCytochrome P450 2A6enzyme
DB01151DesipramineCytochrome P450 2C18enzyme
DB01151DesipramineCytochrome P450 2C19enzyme
DB01151DesipramineCytochrome P450 2E1enzyme
DB01151DesipramineSphingomyelin phosphodiesterasetarget
DB01151Desipramine5-hydroxytryptamine receptor 1Atarget
DB01151Desipramine5-hydroxytryptamine receptor 2Ctarget
DB01151DesipramineD(2) dopamine receptortarget
DB01151DesipramineAlpha-2 adrenergic receptorstarget
DB01142DoxepinSodium-dependent serotonin transportertarget
DB01142DoxepinSodium-dependent noradrenaline transportertarget
DB01142DoxepinHistamine H1 receptortarget
DB01142DoxepinHistamine H2 receptortarget
DB01142DoxepinCytochrome P450 2D6enzyme
DB01142DoxepinMuscarinic acetylcholine receptor M1target
DB01142DoxepinMuscarinic acetylcholine receptor M2target
DB01142DoxepinMuscarinic acetylcholine receptor M3target
DB01142DoxepinMuscarinic acetylcholine receptor M4target
DB01142DoxepinMuscarinic acetylcholine receptor M5target
DB01142DoxepinAlpha-1A adrenergic receptortarget
DB01142Doxepin5-hydroxytryptamine receptor 1Atarget
DB01142Doxepin5-hydroxytryptamine receptor 2Atarget
DB01142DoxepinD(2) dopamine receptortarget
DB01142DoxepinCytochrome P450 2C19enzyme
DB01142DoxepinCytochrome P450 2C9enzyme
DB01142DoxepinCytochrome P450 1A2enzyme
DB01142DoxepinAlpha-1-acid glycoprotein 1carrier
DB01142DoxepinMultidrug resistance protein 1transporter
DB01142Doxepin5-hydroxytryptamine receptor 2Btarget
DB01142Doxepin5-hydroxytryptamine receptor 2Ctarget
DB01142DoxepinAlpha-1B adrenergic receptortarget
DB01142DoxepinAlpha-1D adrenergic receptortarget
DB01142DoxepinAlpha-2A adrenergic receptortarget
DB01142DoxepinAlpha-2B adrenergic receptortarget
DB01142DoxepinAlpha-2C adrenergic receptortarget
DB01142DoxepinCytochrome P450 3A4enzyme
DB01142Doxepin5-hydroxytryptamine receptor 6target
DB01142DoxepinHistamine H4 receptortarget
DB01142DoxepinPotassium voltage-gated channel subfamily H member 2target
DB01247IsocarboxazidAmine oxidase [flavin-containing] Atarget
DB01247IsocarboxazidAmine oxidase [flavin-containing] Btarget
DB01356LithiumInositol monophosphatase 2target
DB01356LithiumInositol monophosphatase 1target
DB01356LithiumGlycogen synthase kinase-3 betatarget
DB01356LithiumGlutamate receptor 3target
DB00934MaprotilineHistamine H1 receptortarget
DB00934MaprotilineSodium-dependent noradrenaline transportertarget
DB00934MaprotilineAlpha-1 adrenergic receptorstarget
DB00934MaprotilineCytochrome P450 2D6enzyme
DB00934MaprotilineAlpha-1-acid glycoprotein 1carrier
DB00934MaprotilineMultidrug resistance protein 1transporter
DB00934MaprotilineMuscarinic acetylcholine receptor M1target
DB00934MaprotilineMuscarinic acetylcholine receptor M2target
DB00934MaprotilineMuscarinic acetylcholine receptor M3target
DB00934MaprotilineMuscarinic acetylcholine receptor M4target
DB00934MaprotilineMuscarinic acetylcholine receptor M5target
DB00934MaprotilineCytochrome P450 1A2enzyme
DB00934Maprotiline5-hydroxytryptamine receptor 2Atarget
DB00934Maprotiline5-hydroxytryptamine receptor 2Ctarget
DB00934Maprotiline5-hydroxytryptamine receptor 7target
DB00934MaprotilineD(2) dopamine receptortarget
DB00934MaprotilineAlpha-2 adrenergic receptorstarget
DB01149Nefazodone5-hydroxytryptamine receptor 2Atarget
DB01149NefazodoneSodium-dependent serotonin transportertarget
DB01149NefazodoneSodium-dependent noradrenaline transportertarget
DB01149NefazodoneAlpha-1A adrenergic receptortarget
DB01149NefazodoneAlpha-1B adrenergic receptortarget
DB01149NefazodoneCytochrome P450 3A4enzyme
DB01149NefazodoneCytochrome P450 2D6enzyme
DB01149NefazodoneSodium-dependent dopamine transportertarget
DB01149NefazodoneAlpha-2A adrenergic receptortarget
DB01149Nefazodone5-hydroxytryptamine receptor 1Atarget
DB01149NefazodoneCYP2B proteinenzyme
DB01149NefazodoneCytochrome P450 3A5enzyme
DB01149NefazodoneCytochrome P450 3A7enzyme
DB01149NefazodoneMultidrug resistance protein 1transporter
DB01149Nefazodone5-hydroxytryptamine receptor 2Ctarget
DB01149NefazodoneCytochrome P450 1A2enzyme
DB01149NefazodonePotassium voltage-gated channel subfamily H member 2target
DB00344ProtriptylineSodium-dependent noradrenaline transportertarget
DB00344ProtriptylineSodium-dependent serotonin transportertarget
DB00344ProtriptylineCytochrome P450 2D6enzyme
DB00344ProtriptylineMultidrug resistance protein 1transporter
DB00726TrimipramineSodium-dependent serotonin transportertarget
DB00726TrimipramineSodium-dependent noradrenaline transportertarget
DB00726TrimipramineCytochrome P450 2D6enzyme
DB00726TrimipramineSodium-dependent dopamine transportertarget
DB00726Trimipramine5-hydroxytryptamine receptor 2Atarget
DB00726Trimipramine5-hydroxytryptamine receptor 1Atarget
DB00726TrimipramineAlpha-1A adrenergic receptortarget
DB00726TrimipramineAlpha-1B adrenergic receptortarget
DB00726TrimipramineD(2) dopamine receptortarget
DB00726TrimipramineAlpha-2B adrenergic receptortarget
DB00726TrimipramineHistamine H1 receptortarget
DB00726TrimipramineCytochrome P450 2C19enzyme
DB00726TrimipramineCytochrome P450 3A4enzyme
DB00726TrimipramineMultidrug resistance protein 1transporter
DB00726TrimipramineCytochrome P450 2C9enzyme
DB00726Trimipramine5-hydroxytryptamine receptor 2Ctarget
DB00726Trimipramine5-hydroxytryptamine receptor 3Atarget
DB00726Trimipramine5-hydroxytryptamine receptor 1Dtarget
DB00726TrimipramineAlpha-2A adrenergic receptortarget
DB00726TrimipramineD(1) dopamine receptortarget
DB00726TrimipramineBeta adrenergic receptortarget
DB00726TrimipramineMuscarinic acetylcholine receptortarget
DB00726Trimipramine5-hydroxytryptamine receptor 1Ctarget
DrugDrug NamePhaseStatusCount
DB00741Hydrocortisone0Recruiting1
DB01221Ketamine0Completed1
DB01221Ketamine0Recruiting2
DB00683Midazolam0Completed1
DB00425Zolpidem0Completed1
DB00321Amitriptyline1Not Yet Recruiting1
DB00083Botulinum Toxin Type A1Recruiting1
DB00921Buprenorphine1Unknown Status1
DB01156Bupropion1Completed1
DB11121Chloroxylenol1Recruiting1
DB00215Citalopram1Completed2
DB01242Clomipramine1Completed1
DB01151Desipramine1Completed2
DB00390Digoxin1Completed1
DB01126Dutasteride1Completed1
DB01175Escitalopram1Completed1
DB00687Fludrocortisone1Completed1
DB00472Fluoxetine1Completed2
DB00176Fluvoxamine1Completed1
DB01381Ginkgo biloba1Completed1
DB00986Glycopyrronium1Terminated1
DB00458Imipramine1Completed1
DB00065Infliximab1Recruiting1
DB01221Ketamine1Completed3
DB01221Ketamine1Recruiting2
DB11889Lanicemine1Completed1
DB11889Lanicemine1Not Yet Recruiting1
DB00279Liothyronine1Completed1
DB01356Lithium1Completed1
DB00331Metformin1Completed1
DB00683Midazolam1Recruiting1
DB05805NS-23591Completed1
DB00704Naltrexone1Recruiting1
DB00107Oxytocin1Unknown Status1
DB11664Psilocybine1Not Yet Recruiting1
DB01224Quetiapine1Completed1
DB06817Raltegravir1Completed2
DB01270Ranibizumab1Unknown Status1
DB01104Sertraline1Terminated1
DB00641Simvastatin1Terminated1
DB09070Tibolone1Unknown Status1
DB00656Trazodone1Not Yet Recruiting1
DB05700Vortioxetine1Completed1
DB09068Vortioxetine1Completed1
DB00921Buprenorphine1 / 2Active Not Recruiting1
DB00921Buprenorphine1 / 2Recruiting1
DB13006Cibinetide1 / 2Completed1
DB01119Diazoxide1 / 2Terminated1
DB01221Ketamine1 / 2Completed1
DB01221Ketamine1 / 2Recruiting1
DB01183Naloxone1 / 2Active Not Recruiting1
DB01183Naloxone1 / 2Recruiting1
DB00740Riluzole1 / 2Completed1
DB01104Sertraline1 / 2Active Not Recruiting1
DB00285Venlafaxine1 / 2Active Not Recruiting1
DB00285Venlafaxine1 / 2Recruiting1
DB00118Ademetionine2Completed1
DB01217Anastrozole2Completed1
DB01238Aripiprazole2Completed1
DB11833Basimglurant2Completed1
DB00083Botulinum Toxin Type A2Completed2
DB00921Buprenorphine2Completed1
DB00490Buspirone2Terminated1
DB00169Cholecalciferol2Recruiting1
DB00515Cisplatin2Completed1
DB00215Citalopram2Completed4
DB00215Citalopram2Withdrawn1
DB00115Cyanocobalamin2Completed1
DB00531Cyclophosphamide2Completed1
DB11923Decoglurant2Withdrawn1
DB11807Dexmecamylamine2Completed1
DB01075Diphenhydramine2Completed1
DB00843Donepezil2Completed1
DB00997Doxorubicin2Completed1
DB01395Drospirenone2Terminated1
DB00476Duloxetine2Completed2
DB00476Duloxetine2Terminated1
DB01175Escitalopram2Completed2
DB11823Esketamine2Recruiting1
DB00977Ethinyl Estradiol2Terminated1
DB04953Ezogabine2Completed1
DB00472Fluoxetine2Completed4
DB00158Folic Acid2Completed1
DB05087Ganaxolone2Recruiting1
DB00441Gemcitabine2Completed1
DB01645Genistein2Completed1
DB10989Hepatitis A Vaccine2Completed1
DB00458Imipramine2Completed1
DB11867JNJ-393934062Recruiting1
DB01221Ketamine2Completed3
DB01221Ketamine2Recruiting3
DB01221Ketamine2Terminated1
DB01221Ketamine2Unknown Status1
DB04465Lactose2Terminated1
DB11889Lanicemine2Completed1
DB01356Lithium2Completed1
DB00657Mecamylamine2Completed1
DB01065Melatonin2Completed1
DB00422Methylphenidate2Terminated1
DB00683Midazolam2Unknown Status1
DB00370Mirtazapine2Active Not Recruiting1
DB00370Mirtazapine2Completed3
DB00745Modafinil2Withdrawn1
DB00325Nitroprusside2Recruiting1
DB06690Nitrous oxide2Active Not Recruiting1
DB00540Nortriptyline2Completed1
DB05423ORG-345172Completed2
DB11133Omega-3 fatty acids2Completed1
DB09539Omega-3-acid ethyl esters2Unknown Status1
DB09539Omega-3-acid ethyl esters2Withdrawn1
DB00715Paroxetine2Completed1
DB00715Paroxetine2Terminated1
DB00806Pentoxifylline2Completed1
DB09286Pipamperone2Completed1
DB00740Riluzole2Completed1
DB00740Riluzole2Unknown Status1
DB01098Rosuvastatin2Unknown Status1
DB12519Sarcosine2Completed1
DB01104Sertraline2Completed4
DB00877Sirolimus2Recruiting1
DB05521Telaprevir2Terminated1
DB00624Testosterone2Completed2
DB09270Ubidecarenone2Withdrawn1
DB08867Ulipristal2Terminated1
DB00285Venlafaxine2Completed1
DB00285Venlafaxine2Terminated1
DB00126Vitamin C2Recruiting1
DB00163Vitamin E2Recruiting1
DB01593Zinc2Completed1
DB00246Ziprasidone2Completed1
DB00118Ademetionine2 / 3Completed1
DB01156Bupropion2 / 3Completed1
DB11121Chloroxylenol2 / 3Completed1
DB00215Citalopram2 / 3Completed2
DB01175Escitalopram2 / 3Completed3
DB01175Escitalopram2 / 3Not Yet Recruiting2
DB00783Estradiol2 / 3Completed1
DB00472Fluoxetine2 / 3Completed2
DB01221Ketamine2 / 3Recruiting3
DB01356Lithium2 / 3Completed1
DB09407Magnesium chloride2 / 3Active Not Recruiting1
DB12751Malic Acid2 / 3Completed1
DB01065Melatonin2 / 3Active Not Recruiting1
DB01065Melatonin2 / 3Terminated1
DB04896Milnacipran2 / 3Recruiting1
DB00370Mirtazapine2 / 3Completed1
DB01104Sertraline2 / 3Completed4
DB00656Trazodone2 / 3Completed1
DB00285Venlafaxine2 / 3Completed2
DB00659Acamprosate3Terminated1
DB06594Agomelatine3Terminated1
DB00404Alprazolam3Terminated1
DB06288Amisulpride3Terminated1
DB00321Amitriptyline3Terminated1
DB00381Amlodipine3Unknown Status1
DB01238Aripiprazole3Terminated1
DB06413Armodafinil3Completed4
DB12867Benperidol3Terminated1
DB00810Biperiden3Terminated1
DB09128Brexpiprazole3Active Not Recruiting1
DB09128Brexpiprazole3Completed4
DB01558Bromazepam3Terminated1
DB09017Brotizolam3Terminated1
DB00921Buprenorphine3Active Not Recruiting1
DB00921Buprenorphine3Completed1
DB00921Buprenorphine3Unknown Status1
DB01156Bupropion3Completed1
DB01156Bupropion3Terminated1
DB00490Buspirone3Terminated1
DB00564Carbamazepine3Terminated1
DB06016Cariprazine3Active Not Recruiting1
DB06016Cariprazine3Recruiting1
DB00482Celecoxib3Recruiting1
DB01563Chloral hydrate3Terminated1
DB01239Chlorprothixene3Terminated1
DB00215Citalopram3Completed2
DB00215Citalopram3Terminated1
DB00349Clobazam3Terminated1
DB01242Clomipramine3Terminated1
DB01068Clonazepam3Terminated1
DB00363Clozapine3Terminated1
DB01151Desipramine3Completed3
DB06700Desvenlafaxine3Completed1
DB11807Dexmecamylamine3Completed4
DB00829Diazepam3Terminated1
DB01075Diphenhydramine3Terminated1
DB00843Donepezil3Completed1
DB00843Donepezil3Terminated1
DB01142Doxepin3Terminated1
DB00476Duloxetine3Completed4
DB00476Duloxetine3Terminated2
DB01175Escitalopram3Completed5
DB01175Escitalopram3Recruiting2
DB01175Escitalopram3Terminated2
DB01175Escitalopram3Unknown Status1
DB00472Fluoxetine3Completed4
DB00472Fluoxetine3Terminated2
DB00875Flupentixol3Terminated1
DB00623Fluphenazine3Terminated1
DB00690Flurazepam3Terminated1
DB04842Fluspirilene3Terminated1
DB00176Fluvoxamine3Terminated1
DB00996Gabapentin3Terminated1
DB00674Galantamine3Terminated1
DB09341Glucose3Completed1
DB00502Haloperidol3Terminated1
DB00557Hydroxyzine3Terminated1
DB08887Icosapent ethyl3Completed1
DB00458Imipramine3Terminated1
DB12590Indiplon3Terminated1
DB01221Ketamine3Not Yet Recruiting1
DB06218Lacosamide3Terminated1
DB00555Lamotrigine3Completed1
DB00555Lamotrigine3Terminated1
DB01202Levetiracetam3Terminated1
DB00279Liothyronine3Completed1
DB01255Lisdexamfetamine3Terminated1
DB01356Lithium3Completed1
DB01356Lithium3Terminated1
DB00186Lorazepam3Terminated1
DB00934Maprotiline3Terminated1
DB00657Mecamylamine3Completed1
DB01065Melatonin3Terminated1
DB09224Melperone3Terminated1
DB01043Memantine3Completed1
DB01043Memantine3Recruiting1
DB01043Memantine3Terminated1
DB01403Methotrimeprazine3Terminated1
DB00422Methylphenidate3Terminated1
DB00422Methylphenidate3Unknown Status1
DB01011Metyrapone3Completed1
DB06148Mianserin3Terminated1
DB00683Midazolam3Terminated1
DB00834Mifepristone3Unknown Status1
DB04896Milnacipran3Completed1
DB01017Minocycline3Recruiting1
DB00370Mirtazapine3Terminated1
DB01171Moclobemide3Terminated1
DB01183Naloxone3Active Not Recruiting1
DB01183Naloxone3Completed1
DB00704Naltrexone3Completed1
DB00699Nicergoline3Terminated1
DB01595Nitrazepam3Terminated1
DB00540Nortriptyline3Terminated1
DB00334Olanzapine3Terminated1
DB11133Omega-3 fatty acids3Completed1
DB00842Oxazepam3Terminated1
DB00776Oxcarbazepine3Terminated1
DB01267Paliperidone3Terminated1
DB00715Paroxetine3Completed4
DB00715Paroxetine3Terminated1
DB00008Peginterferon alfa-2a3Completed1
DB00850Perphenazine3Terminated1
DB01174Phenobarbital3Terminated1
DB00252Phenytoin3Terminated1
DB01100Pimozide3Terminated1
DB09286Pipamperone3Terminated1
DB09210Piracetam3Terminated1
DB00230Pregabalin3Terminated1
DB01069Promethazine3Terminated1
DB01224Quetiapine3Completed3
DB01224Quetiapine3Terminated1
DB00234Reboxetine3Terminated1
DB00811Ribavirin3Completed1
DB00734Risperidone3Completed3
DB00734Risperidone3Terminated1
DB00989Rivastigmine3Terminated1
DB06144Sertindole3Terminated1
DB01104Sertraline3Active Not Recruiting1
DB01104Sertraline3Completed10
DB01104Sertraline3Terminated2
DB00391Sulpiride3Terminated1
DB00231Temazepam3Terminated1
DB00679Thioridazine3Terminated1
DB00273Topiramate3Terminated1
DB00752Tranylcypromine3Terminated1
DB00656Trazodone3Terminated1
DB00897Triazolam3Terminated1
DB00726Trimipramine3Terminated1
DB00313Valproic Acid3Terminated1
DB00862Vardenafil3Completed1
DB00285Venlafaxine3Completed5
DB00285Venlafaxine3Terminated1
DB00962Zaleplon3Terminated1
DB01593Zinc3Terminated1
DB00246Ziprasidone3Completed1
DB00246Ziprasidone3Terminated1
DB00425Zolpidem3Terminated1
DB01198Zopiclone3Terminated1
DB01624Zuclopenthixol3Terminated1
DB06470clomethiazole3Terminated1
DB00316Acetaminophen4Unknown Status1
DB00945Acetylsalicylic acid4Active Not Recruiting1
DB00630Alendronic acid4Completed1
DB09128Brexpiprazole4Not Yet Recruiting1
DB00921Buprenorphine4Unknown Status1
DB01156Bupropion4Completed6
DB01156Bupropion4Terminated2
DB01156Bupropion4Unknown Status3
DB00490Buspirone4Completed1
DB01164Calcium Chloride4Terminated1
DB00796Candesartan cilexetil4Terminated1
DB00190Carbidopa4Recruiting1
DB00215Citalopram4Completed8
DB00215Citalopram4Terminated1
DB00215Citalopram4Unknown Status1
DB01151Desipramine4Completed1
DB06700Desvenlafaxine4Completed1
DB06700Desvenlafaxine4Recruiting1
DB00843Donepezil4Completed2
DB00476Duloxetine4Active Not Recruiting1
DB00476Duloxetine4Completed8
DB00476Duloxetine4Recruiting2
DB00476Duloxetine4Suspended1
DB00476Duloxetine4Terminated1
DB00476Duloxetine4Unknown Status1
DB01175Escitalopram4Completed18
DB01175Escitalopram4Recruiting4
DB01175Escitalopram4Suspended1
DB01175Escitalopram4Terminated4
DB01175Escitalopram4Unknown Status5
DB01175Escitalopram4Withdrawn1
DB00783Estradiol4Completed3
DB00402Eszopiclone4Completed1
DB00402Eszopiclone4Unknown Status1
DB00292Etomidate4Recruiting1
DB08868Fingolimod4Terminated1
DB00472Fluoxetine4Completed4
DB00472Fluoxetine4Terminated3
DB00472Fluoxetine4Unknown Status2
DB00472Fluoxetine4Withdrawn1
DB00875Flupentixol4Completed1
DB00588Fluticasone propionate4Completed1
DB00158Folic Acid4Completed1
DB00674Galantamine4Terminated1
DB00502Haloperidol4Completed1
DB01050Ibuprofen4Terminated1
DB00458Imipramine4Completed1
DB00065Infliximab4Completed1
DB00065Infliximab4Not Yet Recruiting1
DB01221Ketamine4Completed1
DB01221Ketamine4Not Yet Recruiting1
DB01221Ketamine4Recruiting2
DB01221Ketamine4Withdrawn1
DB04398Lactic Acid4Terminated1
DB00555Lamotrigine4Active Not Recruiting1
DB00555Lamotrigine4Completed1
DB00555Lamotrigine4Unknown Status1
DB01235Levodopa4Recruiting1
DB00451Levothyroxine4Recruiting1
DB00279Liothyronine4Completed2
DB01356Lithium4Completed7
DB01356Lithium4Unknown Status1
DB01043Memantine4Completed2
DB00331Metformin4Active Not Recruiting1
DB00331Metformin4Completed1
DB00474Methohexital4Completed1
DB00422Methylphenidate4Completed1
DB06148Mianserin4Recruiting1
DB00683Midazolam4Completed1
DB00370Mirtazapine4Completed2
DB00370Mirtazapine4Terminated1
DB00295Morphine4Completed1
DB00704Naltrexone4Completed3
DB00393Nimodipine4Terminated1
DB00540Nortriptyline4Completed4
DB00334Olanzapine4Completed2
DB00338Omeprazole4Completed1
DB00497Oxycodone4Completed1
DB00715Paroxetine4Completed6
DB00715Paroxetine4Terminated1
DB00715Paroxetine4Unknown Status1
DB00252Phenytoin4Completed1
DB00761Potassium Chloride4Terminated1
DB00413Pramipexole4Completed5
DB00818Propofol4Completed1
DB01224Quetiapine4Completed3
DB00481Raloxifene4Completed1
DB00234Reboxetine4Unknown Status1
DB00938Salmeterol4Completed1
DB01104Sertraline4Completed17
DB01104Sertraline4Terminated3
DB01104Sertraline4Unknown Status4
DB00203Sildenafil4Completed2
DB09153Sodium Chloride4Completed1
DB09153Sodium Chloride4Terminated1
DB00202Succinylcholine4Completed1
DB09034Suvorexant4Not Yet Recruiting1
DB00193Tramadol4Unknown Status1
DB00752Tranylcypromine4Completed1
DB00313Valproic Acid4Completed1
DB01273Varenicline4Completed1
DB00285Venlafaxine4Completed15
DB00285Venlafaxine4Suspended1
DB00285Venlafaxine4Terminated1
DB06684Vilazodone4Completed1
DB09068Vortioxetine4Completed1
DB09068Vortioxetine4Recruiting1
DB00246Ziprasidone4Completed2
DB00425Zolpidem4Completed2
DB00425Zolpidem4Recruiting1
DB06151AcetylcysteineNot AvailableRecruiting1
DB00118AdemetionineNot AvailableCompleted2
DB01238AripiprazoleNot AvailableCompleted1
DB01238AripiprazoleNot AvailableRecruiting1
DB00289AtomoxetineNot AvailableRecruiting1
DB01086BenzocaineNot AvailableCompleted1
DB00921BuprenorphineNot AvailableCompleted1
DB00921BuprenorphineNot AvailableRecruiting1
DB01156BupropionNot AvailableCompleted3
DB01156BupropionNot AvailableRecruiting3
DB00201CaffeineNot AvailableRecruiting1
DB00482CelecoxibNot AvailableRecruiting1
DB11121ChloroxylenolNot AvailableCompleted1
DB00356ChlorzoxazoneNot AvailableCompleted1
DB00215CitalopramNot AvailableActive Not Recruiting1
DB00215CitalopramNot AvailableCompleted6
DB00215CitalopramNot AvailableRecruiting1
DB00215CitalopramNot AvailableTerminated1
DB01242ClomipramineNot AvailableCompleted1
DB01151DesipramineNot AvailableCompleted3
DB06700DesvenlafaxineNot AvailableCompleted1
DB00514DextromethorphanNot AvailableRecruiting1
DB01075DiphenhydramineNot AvailableRecruiting1
DB01395DrospirenoneNot AvailableCompleted1
DB00476DuloxetineNot AvailableCompleted2
DB00476DuloxetineNot AvailableRecruiting3
DB01175EscitalopramNot AvailableActive Not Recruiting3
DB01175EscitalopramNot AvailableCompleted9
DB01175EscitalopramNot AvailableRecruiting3
DB01175EscitalopramNot AvailableUnknown Status4
DB00898EthanolNot AvailableCompleted1
DB00977Ethinyl EstradiolNot AvailableCompleted1
DB00292EtomidateNot AvailableCompleted1
DB00950FexofenadineNot AvailableRecruiting1
DB00472FluoxetineNot AvailableActive Not Recruiting1
DB00472FluoxetineNot AvailableCompleted8
DB00472FluoxetineNot AvailableRecruiting1
DB00472FluoxetineNot AvailableUnknown Status1
DB00472FluoxetineNot AvailableWithdrawn1
DB00712FlurbiprofenNot AvailableRecruiting1
DB00176FluvoxamineNot AvailableCompleted1
DB00176FluvoxamineNot AvailableRecruiting1
DB00176FluvoxamineNot AvailableUnknown Status1
DB00158Folic AcidNot AvailableCompleted1
DB00996GabapentinNot AvailableActive Not Recruiting1
DB00996GabapentinNot AvailableCompleted1
DB01404GinsengNot AvailableCompleted1
DB00458ImipramineNot AvailableCompleted1
DB01221KetamineNot AvailableCompleted3
DB01221KetamineNot AvailableRecruiting2
DB01221KetamineNot AvailableTerminated2
DB01221KetamineNot AvailableWithdrawn1
DB00555LamotrigineNot AvailableCompleted1
DB00555LamotrigineNot AvailableRecruiting1
DB00007LeuprolideNot AvailableUnknown Status1
DB11256Levomefolic acidNot AvailableTerminated1
DB00451LevothyroxineNot AvailableRecruiting1
DB00281LidocaineNot AvailableCompleted1
DB01356LithiumNot AvailableNot Yet Recruiting2
DB00186LorazepamNot AvailableCompleted1
DB00331MetforminNot AvailableActive Not Recruiting1
DB00474MethohexitalNot AvailableCompleted1
DB00422MethylphenidateNot AvailableCompleted1
DB00683MidazolamNot AvailableRecruiting1
DB00834MifepristoneNot AvailableCompleted2
DB04896MilnacipranNot AvailableActive Not Recruiting2
DB04896MilnacipranNot AvailableRecruiting2
DB04896MilnacipranNot AvailableUnknown Status1
DB01017MinocyclineNot AvailableRecruiting2
DB01017MinocyclineNot AvailableUnknown Status1
DB00370MirtazapineNot AvailableActive Not Recruiting2
DB00370MirtazapineNot AvailableCompleted1
DB00370MirtazapineNot AvailableRecruiting5
DB00745ModafinilNot AvailableUnknown Status1
DB00540NortriptylineNot AvailableActive Not Recruiting2
DB00540NortriptylineNot AvailableCompleted1
DB00540NortriptylineNot AvailableRecruiting3
DB00334OlanzapineNot AvailableRecruiting1
DB11133Omega-3 fatty acidsNot AvailableActive Not Recruiting1
DB11133Omega-3 fatty acidsNot AvailableCompleted1
DB09539Omega-3-acid ethyl estersNot AvailableCompleted1
DB00338OmeprazoleNot AvailableRecruiting1
DB00715ParoxetineNot AvailableActive Not Recruiting3
DB00715ParoxetineNot AvailableCompleted3
DB00715ParoxetineNot AvailableRecruiting4
DB00457PrazosinNot AvailableRecruiting1
DB00344ProtriptylineNot AvailableCompleted1
DB01224QuetiapineNot AvailableNot Yet Recruiting1
DB00734RisperidoneNot AvailableWithdrawn1
DB00412RosiglitazoneNot AvailableCompleted1
DB00747ScopolamineNot AvailableUnknown Status1
DB01104SertralineNot AvailableActive Not Recruiting2
DB01104SertralineNot AvailableCompleted11
DB01104SertralineNot AvailableRecruiting2
DB01104SertralineNot AvailableTerminated1
DB01104SertralineNot AvailableUnknown Status1
DB01104SertralineNot AvailableWithdrawn1
DB01323St. John's WortNot AvailableCompleted1
DB00202SuccinylcholineNot AvailableCompleted1
DB00675TamoxifenNot AvailableActive Not Recruiting1
DB00853TemozolomideNot AvailableCompleted1
DB00624TestosteroneNot AvailableCompleted2
DB00656TrazodoneNot AvailableRecruiting2
DB01273VareniclineNot AvailableActive Not Recruiting1
DB01273VareniclineNot AvailableCompleted1
DB00285VenlafaxineNot AvailableActive Not Recruiting2
DB00285VenlafaxineNot AvailableCompleted4
DB00285VenlafaxineNot AvailableRecruiting2
DB02546VorinostatNot AvailableCompleted1
DB01593ZincNot AvailableRecruiting1