Congenital Hypoplastic Anemia

Also known as: Diamond-Blackfan Anemia / Fanconi's Anemia / Hypoplastic anaemia / Fanconi Anemia / Anemia, Hypoplastic / Congenital hypoplastic anemia / Anemia, Diamond-Blackfan / Hypoplastic anemia / Fanconi Anemias / Hypoplastic Anemias, Congenital / Diamond Blackfan Anemia / Anemia, Diamond Blackfan / Anemia, Hypoplastic, Congenital / Blackfan-Diamond syndrome / Congenital aplastic anaemia / Congenital aplastic anemia / Constitutional aplastic anaemia / Constitutional aplastic anemia / Anaemia hypoplastic / Anemia hypoplastic / Diamond-Blackfan anaemia / Fanconi's anaemia

DrugDrug NameDrug Description
DB00443BetamethasoneA glucocorticoid given orally, parenterally, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. Its lack of mineralocorticoid properties makes betamethasone particularly suitable for treating cerebral edema and congenital adrenal hyperplasia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p724)
DB00297BupivacaineA widely used local anesthetic agent. [PubChem]
DB01380Cortisone acetateCortisone acetate is a steroid hormone that has both glucocoriticoid and mineral corticoid activities. Corticosteroids are used to provide relief for inflamed areas of the body. They lessen swelling, redness, itching, and allergic reactions. They are often used as part of the treatment for a number of different diseases, such as severe allergies or skin problems, asthma, or arthritis. Endogenous glucocorticoids and some synthetic corticoids have high affinity to the protein transcortin (also called CBG, corticosteroid-binding protein), whereas all of them bind albumin. Glucocorticoids also bind to the cytosolic glucocorticoid receptor.
DB01234DexamethasoneAn anti-inflammatory 9-fluoro-glucocorticoid.
DB00959MethylprednisoloneA prednisolone derivative with similar anti-inflammatory action.
DB06412OxymetholoneOxymetholone is a synthetic anabolic steroid marketed under the brand name Anapolon by Hoffmann La Roche Limitedand used in the treatment of osteoporosis, anaemia, and as an agent to stimulate muscle growth in malnourished or underdeveloped patients. Anabolic-androgenic steroids (AAS), such as oxymetholone, have been abused by bodybuilders and athletes. The uncontrolled misuse of oxymetholone can lead to a large variety of detrimental effects, the most often reported of which are cardiovascular events. In 2009, no producers of oxymetholone were identified worldwide (SRI 2009), but it was available from 14 suppliers, including 8 U.S. suppliers (ChemSources 2009).
DB00860PrednisoloneA glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
DB00635PrednisoneA synthetic anti-inflammatory glucocorticoid derived from cortisone. It is biologically inert and converted to prednisolone in the liver.
DB00620TriamcinoloneA glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. (From Martindale, The Extra Pharmacopoeia, 30th ed, p739)
DrugDrug NameTargetType
DB00443BetamethasoneGlucocorticoid receptortarget
DB00443BetamethasoneCytochrome P450 3A4enzyme
DB00443BetamethasoneMultidrug resistance protein 1transporter
DB00443BetamethasoneCytochrome P450 19A1enzyme
DB00297BupivacaineSodium channel protein type 10 subunit alphatarget
DB00297BupivacaineProstaglandin E2 receptor EP1 subtypetarget
DB00297BupivacaineCytochrome P450 3A4enzyme
DB00297BupivacaineCytochrome P450 2C19enzyme
DB00297BupivacaineCytochrome P450 2D6enzyme
DB01380Cortisone acetateGlucocorticoid receptortarget
DB01380Cortisone acetateCytochrome P450 3A4enzyme
DB01234DexamethasoneGlucocorticoid receptortarget
DB01234DexamethasoneAnnexin A1target
DB01234DexamethasoneNitric oxide synthase, inducibletarget
DB01234DexamethasoneNuclear receptor subfamily 0 group B member 1target
DB01234DexamethasoneCytochrome P450 3A4enzyme
DB01234DexamethasoneCytochrome P450 3A5enzyme
DB01234DexamethasoneCytochrome P450 3A7enzyme
DB01234DexamethasoneBile salt export pumptransporter
DB01234DexamethasoneMultidrug resistance protein 1transporter
DB01234DexamethasoneCanalicular multispecific organic anion transporter 1transporter
DB01234DexamethasoneSolute carrier organic anion transporter family member 1A2transporter
DB01234DexamethasoneATP-binding cassette sub-family G member 2transporter
DB01234DexamethasoneCholesterol side-chain cleavage enzyme, mitochondrialenzyme
DB01234DexamethasoneSteroid 17-alpha-hydroxylase/17,20 lyaseenzyme
DB01234DexamethasoneCytochrome P450 19A1enzyme
DB01234DexamethasoneCytochrome P450 1A1enzyme
DB01234DexamethasoneCytochrome P450 1B1enzyme
DB01234DexamethasoneCytochrome P450 2A6enzyme
DB01234DexamethasoneCytochrome P450 2B6enzyme
DB01234DexamethasoneCytochrome P450 2C19enzyme
DB01234DexamethasoneCytochrome P450 2C8enzyme
DB01234DexamethasoneCytochrome P450 2D6enzyme
DB01234DexamethasoneCytochrome P450 2E1enzyme
DB01234DexamethasoneCytochrome P450 3A43enzyme
DB01234DexamethasoneCytochrome P450 4A11enzyme
DB01234DexamethasoneNuclear receptor subfamily 1 group I member 2target
DB00959MethylprednisoloneGlucocorticoid receptortarget
DB00959MethylprednisoloneCytochrome P450 3A4enzyme
DB00959MethylprednisoloneMultidrug resistance protein 1transporter
DB06412OxymetholoneAndrogen receptortarget
DB06412OxymetholoneSerum albumincarrier
DB06412OxymetholoneSex hormone-binding globulincarrier
DB06412OxymetholoneNatriuretic peptides Btarget
DB06412OxymetholoneAmine oxidase [flavin-containing] Aenzyme
DB06412OxymetholoneCytochrome P450 2D6enzyme
DB06412Oxymetholone3-oxo-5-alpha-steroid 4-dehydrogenase 1enzyme
DB06412OxymetholoneCytochrome P450 3A4enzyme
DB06412OxymetholoneCytochrome P450 3A5enzyme
DB06412OxymetholoneCytochrome P450 3A7enzyme
DB06412OxymetholoneCytochrome P450 3A43enzyme
DB00860PrednisoloneCorticosteroid-binding globulincarrier
DB00860PrednisoloneCytochrome P450 3A4enzyme
DB00860PrednisoloneGlucocorticoid receptortarget
DB00860PrednisoloneSolute carrier organic anion transporter family member 1A2transporter
DB00860PrednisoloneMultidrug resistance protein 1transporter
DB00635PrednisoneGlucocorticoid receptortarget
DB00635PrednisoneCytochrome P450 3A4enzyme
DB00635PrednisoneMultidrug resistance protein 1transporter
DB00635PrednisoneSolute carrier organic anion transporter family member 1A2transporter
DB00635PrednisoneCytochrome P450 2C19enzyme
DB00635PrednisoneSerum albumincarrier
DB00635PrednisoneCorticosteroid 11-beta-dehydrogenase isozyme 1target
DB00620TriamcinoloneCorticosteroid-binding globulincarrier
DB00620TriamcinoloneGlucocorticoid receptortarget
DB00620TriamcinoloneCytochrome P450 3A4enzyme
DB00620TriamcinoloneProstaglandin G/H synthase 2enzyme
DB00620TriamcinoloneCholinesteraseenzyme
DrugDrug NamePhaseStatusCount
DB01281Abatacept1Recruiting1
DB01143Amifostine1Unknown Status1
DB00091Ciclosporin1Completed2
DB00531Cyclophosphamide1Completed1
DB00099Filgrastim1Active Not Recruiting1
DB00099Filgrastim1Unknown Status1
DB01073Fludarabine1Completed1
DB01073Fludarabine1Terminated1
DB00563Methotrexate1Completed1
DB00959Methylprednisolone1Active Not Recruiting1
DB00688Mycophenolate mofetil1Completed1
DB00621Oxandrolone1Completed1
DB06809Plerixafor1Active Not Recruiting1
DB00635Prednisone1Active Not Recruiting1
DB04216Quercetin1Recruiting1
DB04974AP19031 / 2Active Not Recruiting1
DB00087Alemtuzumab1 / 2Recruiting2
DB00087Alemtuzumab1 / 2Terminated1
DB01008Busulfan1 / 2Completed1
DB00091Ciclosporin1 / 2Completed1
DB00091Ciclosporin1 / 2Recruiting1
DB00531Cyclophosphamide1 / 2Completed1
DB00531Cyclophosphamide1 / 2Recruiting1
DB00531Cyclophosphamide1 / 2Terminated1
DB01406Danazol1 / 2Terminated1
DB00099Filgrastim1 / 2Completed1
DB00099Filgrastim1 / 2Recruiting2
DB01073Fludarabine1 / 2Completed2
DB01073Fludarabine1 / 2Recruiting2
DB01073Fludarabine1 / 2Terminated2
DB01005Hydroxyurea1 / 2Recruiting1
DB00149L-Leucine1 / 2Active Not Recruiting1
DB00959Methylprednisolone1 / 2Completed1
DB00959Methylprednisolone1 / 2Recruiting1
DB00688Mycophenolate mofetil1 / 2Recruiting1
DB06809Plerixafor1 / 2Completed1
DB06809Plerixafor1 / 2Recruiting2
DB00073Rituximab1 / 2Recruiting1
DB00877Sirolimus1 / 2Recruiting1
DB04572Thiotepa1 / 2Recruiting1
DB00316Acetaminophen2Active Not Recruiting1
DB00087Alemtuzumab2Completed1
DB09312Antilymphocyte immunoglobulin (horse)2Completed1
DB00098Antithymocyte immunoglobulin (rabbit)2Recruiting2
DB01008Busulfan2Completed2
DB01008Busulfan2Recruiting3
DB01008Busulfan2Unknown Status1
DB00493Cefotaxime2Active Not Recruiting1
DB00091Ciclosporin2Active Not Recruiting1
DB00091Ciclosporin2Completed3
DB00531Cyclophosphamide2Active Not Recruiting1
DB00531Cyclophosphamide2Completed1
DB00531Cyclophosphamide2Recruiting3
DB00531Cyclophosphamide2Terminated1
DB00531Cyclophosphamide2Unknown Status1
DB01609Deferasirox2Completed1
DB06210Eltrombopag2Active Not Recruiting1
DB06210Eltrombopag2Recruiting1
DB00099Filgrastim2Completed1
DB00099Filgrastim2Recruiting3
DB01073Fludarabine2Active Not Recruiting2
DB01073Fludarabine2Completed2
DB01073Fludarabine2Recruiting4
DB01073Fludarabine2Unknown Status1
DB01042Melphalan2Active Not Recruiting1
DB01042Melphalan2Unknown Status1
DB00331Metformin2Recruiting1
DB00563Methotrexate2Active Not Recruiting1
DB00563Methotrexate2Completed1
DB00959Methylprednisolone2Completed1
DB00959Methylprednisolone2Recruiting2
DB00959Methylprednisolone2Unknown Status1
DB00688Mycophenolate mofetil2Active Not Recruiting2
DB06809Plerixafor2Recruiting1
DB04216Quercetin2Recruiting1
DB10415Rabbit2Recruiting1
DB00073Rituximab2Completed1
DB00073Rituximab2Recruiting1
DB00864Tacrolimus2Active Not Recruiting1
DB00087Alemtuzumab2 / 3Active Not Recruiting1
DB01008Busulfan2 / 3Active Not Recruiting1
DB01008Busulfan2 / 3Completed1
DB00531Cyclophosphamide2 / 3Active Not Recruiting1
DB00531Cyclophosphamide2 / 3Recruiting1
DB00531Cyclophosphamide2 / 3Unknown Status1
DB01073Fludarabine2 / 3Active Not Recruiting1
DB01073Fludarabine2 / 3Completed1
DB01073Fludarabine2 / 3Recruiting1
DB01073Fludarabine2 / 3Unknown Status1
DB00688Mycophenolate mofetil2 / 3Recruiting1
DB00877Sirolimus2 / 3Recruiting1
DB01609Deferasirox4Completed1
DB00092AlefaceptNot AvailableTerminated1
DB09312Antilymphocyte immunoglobulin (horse)Not AvailableActive Not Recruiting1
DB00098Antithymocyte immunoglobulin (rabbit)Not AvailableActive Not Recruiting1
DB01008BusulfanNot AvailableTerminated1
DB00091CiclosporinNot AvailableTerminated1
DB00531CyclophosphamideNot AvailableCompleted3
DB00531CyclophosphamideNot AvailableTerminated1
DB00005EtanerceptNot AvailableCompleted1
DB00099FilgrastimNot AvailableTerminated1
DB01073FludarabineNot AvailableActive Not Recruiting1
DB01073FludarabineNot AvailableCompleted1
DB01042MelphalanNot AvailableActive Not Recruiting1
DB01042MelphalanNot AvailableTerminated1
DB00959MethylprednisoloneNot AvailableTerminated1
DB00688Mycophenolate mofetilNot AvailableTerminated1
DB09145WaterNot AvailableCompleted1