Arterial Hypotension

Also known as: Low Blood Pressure / Hypotension / Drop of blood pressure / BP fell / Drop in blood pressure / Blood pressure dropped / Blood pressure decreased / Hypotension, unspecified / Low BP / Fall in blood pressure / BP lowered / Hypotension NOS / Arterial pressure NOS decreased / Blood pressure drop arterial / Pressure arterial decreased / Lowered blood pressure / Arterial blood pressure decreased / Blood pressure low

DrugDrug NameDrug Description
DB11842Angiotensin IIAngiotensin II is under investigation for the treatment of Sepsis, Septic Shock, Diabetes Mellitus, and Acute Renal Failure. Angiotensin II has been investigated for the treatment, basic science, and diagnostic of Hypertension, Renin Angiotensin System, and Idiopathic Membranous Nephropathy. As of December 21, 2017 the FDA approved La Jolla Pharmaceutical's Giapreza (angiotensin II) Injection for Intravenouse Infusion for the indication of acting as a vasoconstrictor to increase blood pressure in adults with septic or other distributive shock. The novelty of the medication lies in the fact that it is the first and only use of synthetic human angiotensin II to help maintain body blood pressure. Shock is the inability to maintain blood flow to vital tissues and the potential resultant organ failure and death within hours, no matter young or o ld. As distributive shock is the most common type of shock in the inpatient setting and affects up to one third of patients in the intensive care unit, the FDA determined that there is a need for treatment options for critically ill hypotensive patients who do not adequately respond to currently available therapies.
DB00668EpinephrineEpinephrine, also known as _adrenaline_, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been available since 1987 in the USA. Many new products/biosimilars and dosage routes have been approved under various names over the last several decades [L4355], [L4356], [L4358]. On August 16, 2018, Teva Pharmaceuticals USA gained approval to market its generic epinephrine auto-injector in 0.3 mg and 0.15 mg strengths [L4353]. Dosage delivery routes for epinephrine include intravenous, inhalation, nebulization, intramuscular injection, and subcutaneous injection. In general, the most common uses of parenteral epinephrine are to relieve respiratory distress due to bronchospasm, to provide rapid relief of hypersensitivity (anaphylactic or anaphylactoid) reactions to drugs, animal serums and other allergens, and to prolong the action of infiltration anesthetics [F2136]. In addition to the above functions, epinephrine is the primary drug administered during cardiopulmonary resuscitation (CPR) to reverse cardiac arrest [A37697], [A37699]. It can be used in severe cases of croup [L4824].
DB00368NorepinephrinePrecursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
DB00388PhenylephrinePhenylephrine is a sympathomimetic amine that acts predominantly on α-adrenergic receptors. It is mainly used to treat nasal congestion, but may also be useful in treating hypotension and shock, hypotension during spinal anaesthesia, prolongation of spinal anaesthesia, paroxysmal supraventricular tachycardia, symptomatic relief of external or internal hemorrhoids, and to increase blood pressure as an aid in the diagnosis of heart murmurs.
DrugDrug NameTargetType
DB11842Angiotensin IIType-1 angiotensin II receptortarget
DB00668EpinephrineAlpha-1A adrenergic receptortarget
DB00668EpinephrineBeta-1 adrenergic receptortarget
DB00668EpinephrineBeta-2 adrenergic receptortarget
DB00668EpinephrineSolute carrier family 22 member 2transporter
DB00668EpinephrineSolute carrier family 22 member 1transporter
DB00668EpinephrineCytochrome P450 2C9enzyme
DB00668EpinephrineCytochrome P450 3A4enzyme
DB00668EpinephrineAlpha-1B adrenergic receptortarget
DB00668EpinephrineAlpha-1D adrenergic receptortarget
DB00668EpinephrineAlpha-2A adrenergic receptortarget
DB00668EpinephrineAlpha-2B adrenergic receptortarget
DB00668EpinephrineTumor necrosis factortarget
DB00668EpinephrineCatechol O-methyltransferaseenzyme
DB00668EpinephrineMonoamine oxidaseenzyme
DB00368NorepinephrinePhenylalanine-4-hydroxylasetarget
DB00368NorepinephrineAlpha-1A adrenergic receptortarget
DB00368NorepinephrineAlpha-1B adrenergic receptortarget
DB00368NorepinephrineAlpha-1D adrenergic receptortarget
DB00368NorepinephrineAlpha-2A adrenergic receptortarget
DB00368NorepinephrineAlpha-2B adrenergic receptortarget
DB00368NorepinephrineAlpha-2C adrenergic receptortarget
DB00368NorepinephrineBeta-1 adrenergic receptortarget
DB00368NorepinephrineBeta-2 adrenergic receptortarget
DB00368NorepinephrineBeta-3 adrenergic receptortarget
DB00368NorepinephrineSolute carrier family 22 member 2transporter
DB00368NorepinephrineSolute carrier family 22 member 3transporter
DB00368NorepinephrineSolute carrier family 22 member 5transporter
DB00368NorepinephrineSolute carrier family 22 member 1transporter
DB00368NorepinephrinePOU domain, class 5, transcription factor 1transporter
DB00368NorepinephrineSodium-dependent noradrenaline transportertransporter
DB00368NorepinephrineSynaptic vesicular amine transportertarget
DB00368NorepinephrineChromaffin granule amine transportertarget
DB00388PhenylephrineAlpha-1A adrenergic receptortarget
DB00388PhenylephrineAlpha-1B adrenergic receptortarget
DB00388PhenylephrineAmine oxidase [flavin-containing] Aenzyme
DB00388PhenylephrineAlpha-1D adrenergic receptortarget
DB00388PhenylephrineCytochrome P450 1A2enzyme
DrugDrug NamePhaseStatusCount
DB00988Dopamine1Completed1
DB00988Dopamine1Unknown Status1
DB06262Droxidopa1Completed1
DB00741Hydrocortisone1Completed1
DB00388Phenylephrine1Unknown Status1
DB00126Ascorbic acid1 / 2Completed1
DB01164Calcium Chloride1 / 2Completed1
DB04398Lactic Acid1 / 2Completed1
DB05313MP41 / 2Completed1
DB00761Potassium chloride1 / 2Completed1
DB09153Sodium chloride1 / 2Completed1
DB06151Acetylcysteine2Completed1
DB00297Bupivacaine2Completed1
DB00746Deferoxamine2Completed1
DB01364Ephedrine2Completed1
DB00668Epinephrine2Active Not Recruiting1
DB00187Esmolol2Recruiting1
DB00200Hydroxocobalamin2Not Yet Recruiting1
DB00610Metaraminol2Completed1
DB09241Methylene blue2Not Yet Recruiting1
DB05799NOX-1002Completed1
DB00325Nitroprusside2Completed1
DB00368Norepinephrine2Recruiting1
DB00043Omalizumab2Active Not Recruiting1
DB00388Phenylephrine2Completed1
DB00388Phenylephrine2Recruiting1
DB00818Propofol2Completed1
DB00302Tranexamic acid2Terminated1
DB01364Ephedrine2 / 3Completed1
DB00813Fentanyl2 / 3Recruiting1
DB00211Midodrine2 / 3Recruiting1
DB12750N-omega-nitro-L-arginine methyl ester2 / 3Completed1
DB00904Ondansetron2 / 3Unknown Status1
DB00388Phenylephrine2 / 3Completed1
DB09153Sodium chloride2 / 3Recruiting1
DB00297Bupivacaine3Completed1
DB11121Chloroxylenol3Completed2
DB09341Dextrose, unspecified form3Recruiting1
DB00988Dopamine3Recruiting1
DB00055Drotrecogin alfa3Completed1
DB09106Hydroxyethyl Starch3Completed2
DB05313MP43Completed2
DB00211Midodrine3Recruiting1
DB00368Norepinephrine3Completed1
DB00388Phenylephrine3Completed1
DB00750Prilocaine3Completed1
DB00899Remifentanil3Completed1
DB00572Atropine4Completed1
DB00297Bupivacaine4Completed3
DB00429Carboprost tromethamine4Completed1
DB11121Chloroxylenol4Recruiting1
DB01234Dexamethasone4Completed1
DB00841Dobutamine4Active Not Recruiting1
DB00841Dobutamine4Completed1
DB00988Dopamine4Active Not Recruiting1
DB12313Dopexamine4Completed1
DB06262Droxidopa4Recruiting1
DB01364Ephedrine4Completed3
DB00668Epinephrine4Completed2
DB00695Furosemide4Completed1
DB09106Hydroxyethyl Starch4Completed1
DB09106Hydroxyethyl Starch4Unknown Status1
DB00753Isoflurane4Terminated1
DB01002Levobupivacaine4Active Not Recruiting1
DB01002Levobupivacaine4Completed1
DB00583Levocarnitine4Unknown Status1
DB00353Methylergometrine4Completed1
DB00211Midodrine4Withdrawn1
DB00295Morphine4Completed1
DB00368Norepinephrine4Completed4
DB00368Norepinephrine4Not Yet Recruiting1
DB00368Norepinephrine4Recruiting1
DB00904Ondansetron4Recruiting1
DB00107Oxytocin4Completed2
DB00388Phenylephrine4Completed6
DB00388Phenylephrine4Not Yet Recruiting1
DB00388Phenylephrine4Recruiting2
DB01236Sevoflurane4Recruiting1
DB01236Sevoflurane4Terminated1
DB00820Tadalafil4Completed1
DB00802AlfentanilNot AvailableRecruiting1
DB00479AmikacinNot AvailableRecruiting1
DB00513Aminocaproic AcidNot AvailableRecruiting1
DB09009ArticaineNot AvailableActive Not Recruiting1
DB00572AtropineNot AvailableActive Not Recruiting1
DB01086BenzocaineNot AvailableActive Not Recruiting1
DB00559BosentanNot AvailableRecruiting1
DB00297BupivacaineNot AvailableActive Not Recruiting1
DB12926CafedrineNot AvailableCompleted1
DB01413CefepimeNot AvailableRecruiting1
DB01161ChloroprocaineNot AvailableActive Not Recruiting1
DB11121ChloroxylenolNot AvailableCompleted1
DB00369CidofovirNot AvailableRecruiting1
DB00537CiprofloxacinNot AvailableRecruiting1
DB00363ClozapineNot AvailableRecruiting1
DB01189DesfluraneNot AvailableActive Not Recruiting1
DB00633DexmedetomidineNot AvailableCompleted1
DB00841DobutamineNot AvailableActive Not Recruiting1
DB00988DopamineNot AvailableActive Not Recruiting1
DB00988DopamineNot AvailableCompleted2
DB01364EphedrineNot AvailableActive Not Recruiting1
DB01364EphedrineNot AvailableCompleted3
DB01364EphedrineNot AvailableNot Yet Recruiting1
DB01364EphedrineNot AvailableRecruiting2
DB00668EpinephrineNot AvailableActive Not Recruiting1
DB00668EpinephrineNot AvailableCompleted2
DB00668EpinephrineNot AvailableUnknown Status1
DB00828FosfomycinNot AvailableRecruiting1
DB00986GlycopyrroniumNot AvailableActive Not Recruiting1
DB00889GranisetronNot AvailableCompleted1
DB00502HaloperidolNot AvailableRecruiting1
DB00753IsofluraneNot AvailableActive Not Recruiting1
DB01064IsoprenalineNot AvailableActive Not Recruiting1
DB00598LabetalolNot AvailableRecruiting1
DB01002LevobupivacaineNot AvailableActive Not Recruiting1
DB00281LidocaineNot AvailableActive Not Recruiting1
DB08815LurasidoneNot AvailableRecruiting1
DB00961MepivacaineNot AvailableActive Not Recruiting1
DB00474MethohexitalNot AvailableCompleted1
DB00959MethylprednisoloneNot AvailableRecruiting1
DB00211MidodrineNot AvailableWithdrawn1
DB00235MilrinoneNot AvailableActive Not Recruiting1
DB01618MolindoneNot AvailableRecruiting1
DB00607NafcillinNot AvailableRecruiting1
DB01115NifedipineNot AvailableRecruiting1
DB00727NitroglycerinNot AvailableCompleted1
DB00368NorepinephrineNot AvailableActive Not Recruiting1
DB00368NorepinephrineNot AvailableCompleted4
DB00904OndansetronNot AvailableTerminated1
DB00904OndansetronNot AvailableUnknown Status1
DB00497OxycodoneNot AvailableRecruiting1
DB00312PentobarbitalNot AvailableRecruiting1
DB00388PhenylephrineNot AvailableActive Not Recruiting1
DB00388PhenylephrineNot AvailableCompleted4
DB00388PhenylephrineNot AvailableRecruiting3
DB00750PrilocaineNot AvailableActive Not Recruiting1
DB00721ProcaineNot AvailableActive Not Recruiting1
DB00818PropofolNot AvailableActive Not Recruiting1
DB00818PropofolNot AvailableCompleted2
DB09290RamosetronNot AvailableCompleted1
DB09290RamosetronNot AvailableUnknown Status1
DB00728RocuroniumNot AvailableRecruiting1
DB00296RopivacaineNot AvailableActive Not Recruiting1
DB00296RopivacaineNot AvailableCompleted1
DB00658SevelamerNot AvailableRecruiting1
DB01236SevofluraneNot AvailableActive Not Recruiting1
DB09153Sodium chlorideNot AvailableActive Not Recruiting1
DB09153Sodium chlorideNot AvailableCompleted1
DB00421SpironolactoneNot AvailableRecruiting1
DB02638TerlipressinNot AvailableActive Not Recruiting1
DB09085TetracaineNot AvailableActive Not Recruiting1
DB12927TheodrenalineNot AvailableCompleted1
DB00684TobramycinNot AvailableRecruiting1
DB00302Tranexamic acidNot AvailableRecruiting1
DB00512VancomycinNot AvailableRecruiting1
DB00067VasopressinNot AvailableActive Not Recruiting1
DB00067VasopressinNot AvailableCompleted2
DB01339VecuroniumNot AvailableRecruiting1
DB00682WarfarinNot AvailableRecruiting1
DB00246ZiprasidoneNot AvailableRecruiting1
DB00425ZolpidemNot AvailableRecruiting1