HIV-1-infection

DrugDrug NameDrug Description
DB00879EmtricitabineEmtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) for the treatment of HIV infection in adults. Emtricitabine is a cytidine analogue. The drug works by inhibiting HIV reverse transcriptase, preventing transcription of HIV RNA to DNA.
DB09299Tenofovir alafenamideTenofovir alafenamide is a novel [tenofovir] prodrug developed in order to improve renal safety when compared to the counterpart [tenofovir disoproxil].[A178060] Both of these prodrugs were first created to cover the polar phosphonic acid group on tenofovir by using a novel oxycarbonyloxymethyl linkers to improve the oral bioavailability and intestinal diffusion.[T239] Tenofovir alafenamide is an alanine ester form characterized for presenting low systemic levels but high intracellular concentration.[A178219] It has been reported to produce a large antiviral efficacy at doses ten times lower than tenofovir disoproxil.[A178327] The first approved product including tenofovir alafenamide was developed by Gilead Sciences Inc and FDA approved on 2015.[L6271]
DB00300Tenofovir disoproxilTenofovir disoproxil fumarate (a prodrug of tenofovir), marketed by Gilead Sciences under the trade name _Viread_, belongs to a class of antiretroviral drugs known as nucleotide analogue reverse transcriptase inhibitors (nRTIs). This drug is prescribed in combination with other drugs in the management of HIV infection as well as in Hepatitis B therapy. Tenofovir disoproxil was initially approved in 2001 [FDA label].
DrugDrug NameTargetType
DB00879EmtricitabineReverse transcriptase/RNaseHtarget
DB00879EmtricitabineDeoxycytidine kinaseenzyme
DB00879EmtricitabineSerum albumincarrier
DB09299Tenofovir alafenamideReverse transcriptase/RNaseHtarget
DB09299Tenofovir alafenamideMultidrug resistance protein 1transporter
DB09299Tenofovir alafenamideMultidrug resistance-associated protein 4transporter
DB09299Tenofovir alafenamideSolute carrier family 22 member 6transporter
DB09299Tenofovir alafenamideSolute carrier family 22 member 8transporter
DB09299Tenofovir alafenamideLysosomal protective proteinenzyme
DB09299Tenofovir alafenamideLiver carboxylesterase 1enzyme
DB09299Tenofovir alafenamideATP-binding cassette sub-family G member 2transporter
DB09299Tenofovir alafenamideSolute carrier organic anion transporter family member 1B1transporter
DB09299Tenofovir alafenamideSolute carrier organic anion transporter family member 1B3transporter
DB09299Tenofovir alafenamideReverse transcriptasetarget
DB09299Tenofovir alafenamideDNA polymerasetarget
DB09299Tenofovir alafenamideSerum albumincarrier
DB09299Tenofovir alafenamideCytochrome P450 3A4enzyme
DB09299Tenofovir alafenamideAdenylate kinase isoenzyme 1enzyme
DB09299Tenofovir alafenamideAdenylate kinase 2, mitochondrialenzyme
DB09299Tenofovir alafenamideNucleoside diphosphate kinase Aenzyme
DB09299Tenofovir alafenamideNucleoside diphosphate kinase Benzyme
DB00300Tenofovir disoproxilReverse transcriptase/RNaseHtarget
DB00300Tenofovir disoproxilSolute carrier family 22 member 6transporter
DB00300Tenofovir disoproxilSolute carrier family 22 member 8transporter
DB00300Tenofovir disoproxilMultidrug resistance-associated protein 7transporter
DB00300Tenofovir disoproxilMultidrug resistance-associated protein 4transporter
DB00300Tenofovir disoproxilCanalicular multispecific organic anion transporter 1transporter
DB00300Tenofovir disoproxilAdenylate kinase 2, mitochondrialenzyme
DB00300Tenofovir disoproxilAdenylate kinase 4, mitochondrialenzyme
DB00300Tenofovir disoproxilMultidrug resistance protein 1transporter
DB00300Tenofovir disoproxilNucleoside diphosphokinaseenzyme
DB00300Tenofovir disoproxilCreatine kinaseenzyme
DB00300Tenofovir disoproxilDNA polymerase/reverse transcriptasetarget
DrugDrug NamePhaseStatusCount
DB01076Atorvastatin1Not Yet Recruiting1
DB01211Clarithromycin1Not Yet Recruiting1
DB09102Daclatasvir1Recruiting1
DB08930Dolutegravir1Not Yet Recruiting1
DB08930Dolutegravir1Recruiting1
DB14929Elsulfavirine1Completed1
DB14929Elsulfavirine1Not Yet Recruiting1
DB14929Elsulfavirine1Recruiting1
DB00879Emtricitabine1Completed1
DB00977Ethinylestradiol1Not Yet Recruiting1
DB00367Levonorgestrel1Not Yet Recruiting1
DB00338Omeprazole1Not Yet Recruiting1
DB00615Rifabutin1Not Yet Recruiting1
DB01045Rifampicin1Not Yet Recruiting2
DB08934Sofosbuvir1Recruiting1
DB09299Tenofovir alafenamide1Not Yet Recruiting1
DB00300Tenofovir disoproxil1Completed1
DB00205Pyrimethamine1 / 2Recruiting1
DB00313Valproic Acid1 / 2Recruiting1
DB09033Vedolizumab1 / 2Not Yet Recruiting1
DB15166Albuvirtide2Recruiting1
DB11908Dapivirine2Withdrawn1
DB01264Darunavir2Active Not Recruiting1
DB01264Darunavir2Recruiting1
DB08930Dolutegravir2Recruiting1
DB00879Emtricitabine2Withdrawn1
DB00709Lamivudine2Recruiting1
DB15061Lefitolimod2Recruiting1
DB00367Levonorgestrel2Recruiting1
DB00331Metformin2Recruiting1
DB00545Pyridostigmine2Active Not Recruiting1
DB08864Rilpivirine2Recruiting1
DB00503Ritonavir2Active Not Recruiting1
DB00503Ritonavir2Recruiting1
DB14903Rovafovir etalafenamide2Active Not Recruiting1
DB09153Sodium chloride2Recruiting1
DB09299Tenofovir alafenamide2Active Not Recruiting1
DB00300Tenofovir disoproxil2Withdrawn1
DB06825Triptorelin2Recruiting1
DB00625Efavirenz2 / 3Completed1
DB14929Elsulfavirine2 / 3Completed1
DB00879Emtricitabine2 / 3Recruiting1
DB05941Leronlimab2 / 3Recruiting1
DB04835Maraviroc2 / 3Recruiting1
DB00331Metformin2 / 3Recruiting1
DB00300Tenofovir disoproxil2 / 3Recruiting1
DB11799Bictegravir3Active Not Recruiting1
DB08930Dolutegravir3Active Not Recruiting2
DB00879Emtricitabine3Active Not Recruiting1
DB12698Ibalizumab3Recruiting1
DB00709Lamivudine3Recruiting2
DB06817Raltegravir3Recruiting2
DB09299Tenofovir alafenamide3Active Not Recruiting2
DB01048Abacavir4Recruiting1
DB11799Bictegravir4Recruiting1
DB09065Cobicistat4Recruiting1
DB08930Dolutegravir4Recruiting2
DB00625Efavirenz4Recruiting1
DB09101Elvitegravir4Recruiting1
DB00879Emtricitabine4Recruiting3
DB00709Lamivudine4Recruiting1
DB01577Metamfetamine4Not Yet Recruiting1
DB00331Metformin4Recruiting1
DB08864Rilpivirine4Recruiting1
DB08934Sofosbuvir4Recruiting2
DB09299Tenofovir alafenamide4Recruiting3
DB00300Tenofovir disoproxil4Recruiting2
DB11613Velpatasvir4Recruiting2
DB11799BictegravirNot AvailableRecruiting1
DB00625EfavirenzNot AvailableCompleted1
DB00879EmtricitabineNot AvailableCompleted1
DB00879EmtricitabineNot AvailableRecruiting1
DB08864RilpivirineNot AvailableCompleted1
DB09299Tenofovir alafenamideNot AvailableRecruiting2