Dravet Syndrome

Also known as: Dravet Syndrome (DS) / Dravet syndrome, intractable, without status epilepticus / Severe myoclonic epilepsy of infancy / Epilepsy, Myoclonic, Infantile, Severe / Severe myoclonic epilepsy in infancy (disorder)

DrugDrug NameDrug Description
DB09061CannabidiolAn active cannabinoid used as an adjunctive treatment for the management of seizures associated with Lennox-Gastaut syndrome or Dravet syndrome and symptomatic relief of moderate to severe neuropathic pain or other painful conditions, like cancer.
DB00349ClobazamA benzodiazepine used as adjunct treatment in seizures associated with Lennox-Gastaut syndrome.
DB00574FenfluramineFenfluramine is a phenethylamine that is structurally similar to serotonin. Due to its ability to increase extracellular serotonin levels, modulate serotonergic and other neurologic receptors, and control neurotransmission, it is effective in treating pharmacoresistant seizures.
DB09118StiripentolAn antiepileptic agent used in combination with other anticonvulsants to treat seizures associated with Dravet syndrome.
DrugDrug NameTargetType
DB09061CannabidiolCytochrome P450 2C9enzyme
DB09061CannabidiolCytochrome P450 2C19enzyme
DB09061CannabidiolCytochrome P450 2D6enzyme
DB09061CannabidiolCytochrome P450 3A4enzyme
DB09061CannabidiolCannabinoid receptor 1target
DB09061CannabidiolCannabinoid receptor 2target
DB09061CannabidiolG-protein coupled receptor 12target
DB09061CannabidiolGlycine receptor subunit alpha-1target
DB09061CannabidiolGlycine receptor (alpha-1/beta)target
DB09061CannabidiolGlycine receptor subunit alpha-3target
DB09061CannabidiolN-arachidonyl glycine receptortarget
DB09061CannabidiolG-protein coupled receptor 55target
DB09061Cannabidiol5-hydroxytryptamine receptor 1Atarget
DB09061Cannabidiol5-hydroxytryptamine receptor 2Atarget
DB09061CannabidiolNeuronal acetylcholine receptor subunit alpha-7target
DB09061CannabidiolDelta-type opioid receptortarget
DB09061CannabidiolMu-type opioid receptortarget
DB09061CannabidiolPeroxisome proliferator-activated receptor gammatarget
DB09061CannabidiolCytochrome P450 3A5enzyme
DB09061CannabidiolSerotonin N-acetyltransferaseenzyme
DB09061CannabidiolCytochrome P450 1A1enzyme
DB09061CannabidiolFatty-acid amide hydrolase 1enzyme
DB09061CannabidiolArachidonate 5-lipoxygenaseenzyme
DB09061CannabidiolArachidonate 15-lipoxygenaseenzyme
DB09061CannabidiolQuinone oxidoreductaseenzyme
DB09061CannabidiolMultidrug resistance-associated protein 1transporter
DB09061CannabidiolATP-binding cassette sub-family G member 2transporter
DB09061CannabidiolEquilibrative nucleoside transporter 1transporter
DB09061CannabidiolTransient receptor potential cation channel subfamily V member 1target
DB09061CannabidiolVoltage-dependent T-type calcium channel subunit alpha-1Gtarget
DB09061CannabidiolVoltage-dependent T-type calcium channel subunit alpha-1Htarget
DB09061CannabidiolVoltage-dependent T-type calcium channel subunit alpha-1Itarget
DB09061CannabidiolTransient receptor potential cation channel subfamily A member 1target
DB09061CannabidiolTransient receptor potential cation channel subfamily M member 8target
DB09061CannabidiolTransient receptor potential cation channel subfamily V member 2target
DB09061CannabidiolTransient receptor potential cation channel subfamily V member 3target
DB09061CannabidiolTransient receptor potential cation channel subfamily V member 4target
DB09061CannabidiolVoltage-dependent anion-selective channel protein 1target
DB09061Cannabidiol5-hydroxytryptamine receptor 3Atarget
DB09061CannabidiolAdenosine receptor A1target
DB09061CannabidiolProstaglandin G/H synthase 1target
DB09061CannabidiolProstaglandin G/H synthase 2target
DB09061CannabidiolAcetyl-CoA acetyltransferase, mitochondrialtarget
DB09061CannabidiolSteroid 17-alpha-hydroxylase/17,20 lyasetarget
DB09061Cannabidiol3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
DB09061CannabidiolGlutathione reductase, mitochondrialtarget
DB09061CannabidiolGlutathione peroxidase 1target
DB09061CannabidiolIndoleamine 2,3-dioxygenase 1target
DB09061CannabidiolCytochrome P450 1B1target
DB09061CannabidiolNAD(P)H dehydrogenase [quinone] 1target
DB09061CannabidiolCatalasetarget
DB09061CannabidiolCytochrome P450 3A5target
DB09061CannabidiolCytochrome P450 2D6target
DB09061CannabidiolSuperoxide dismutase [Cu-Zn]target
DB09061CannabidiolCytochrome P450 1A2target
DB09061CannabidiolCytochrome P450 3A7target
DB09061CannabidiolSerotonin N-acetyltransferasetarget
DB09061CannabidiolN-acylethanolamine-hydrolyzing acid amidasetarget
DB09061CannabidiolCytochrome P450 1A2enzyme
DB09061CannabidiolCytochrome P450 1B1enzyme
DB09061CannabidiolCytochrome P450 2A6enzyme
DB09061CannabidiolCytochrome P450 2B6enzyme
DB09061CannabidiolCytochrome P450 2C8enzyme
DB09061CannabidiolCytochrome P450 2E1enzyme
DB09061CannabidiolCytochrome P450 3A7enzyme
DB09061CannabidiolUDP-glucuronosyltransferase 1-7enzyme
DB09061CannabidiolUDP-glucuronosyltransferase 1-9enzyme
DB09061CannabidiolUDP-glucuronosyltransferase 2B7enzyme
DB09061CannabidiolUDP-glucuronosyltransferase 2B17enzyme
DB09061CannabidiolP-glycoprotein 1transporter
DB09061CannabidiolCytochrome P450 2J2enzyme
DB09061CannabidiolLiver carboxylesterase 1enzyme
DB00349ClobazamCytochrome P450 2C19enzyme
DB00349ClobazamCytochrome P450 3A4enzyme
DB00349ClobazamCytochrome P450 2B6enzyme
DB00349ClobazamCytochrome P450 2C18enzyme
DB00349ClobazamP-glycoprotein 1transporter
DB00349ClobazamGABA(A) Receptortarget
DB00349ClobazamCytochrome P450 2D6enzyme
DB00349ClobazamGABA(A) Receptor Benzodiazepine Binding Sitetarget
DB00349ClobazamSerum albumincarrier
DB00349ClobazamAlpha-1-acid glycoprotein 1carrier
DB00349ClobazamCytochrome P450 2C9enzyme
DB00349ClobazamUDP-glucuronosyltransferase 1-4enzyme
DB00349ClobazamUDP-glucuronosyltransferase 1-6enzyme
DB00349ClobazamUDP-glucuronosyltransferase 2B4enzyme
DB00349ClobazamUDP-glucuronosyltransferase 1-1enzyme
DB00349ClobazamCytochrome P450 1A2enzyme
DB00349ClobazamCytochrome P450 2C8enzyme
DB00349ClobazamCytochrome P450 3A5enzyme
DB00349ClobazamCytochrome P450 3A7enzyme
DB00574Fenfluramine5-hydroxytryptamine receptor 2Ctarget
DB00574Fenfluramine5-hydroxytryptamine receptor 2Btarget
DB00574FenfluramineCytochrome P450 2D6enzyme
DB00574FenfluramineSodium-dependent serotonin transportertarget
DB00574Fenfluramine5-hydroxytryptamine receptor 2Atarget
DB00574Fenfluramine5-hydroxytryptamine receptor 1Dtarget
DB00574FenfluramineSigma non-opioid intracellular receptor 1target
DB00574Fenfluramine5-hydroxytryptamine receptor 1Atarget
DB00574FenfluramineCytochrome P450 1A2enzyme
DB00574FenfluramineCytochrome P450 2B6enzyme
DB00574FenfluramineCytochrome P450 2C9enzyme
DB00574FenfluramineCytochrome P450 2C19enzyme
DB00574FenfluramineCytochrome P450 3A4enzyme
DB00574FenfluramineCytochrome P450 3A5enzyme
DB09118StiripentolCytochrome P450 2C19enzyme
DB09118StiripentolCytochrome P450 2D6enzyme
DB09118StiripentolCytochrome P450 3A4enzyme
DB09118StiripentolCytochrome P450 1A2enzyme
DB09118StiripentolCytochrome P450 2C9enzyme
DB09118StiripentolGABA(A) Receptortarget
DB09118StiripentolL-lactate dehydrogenase A chaintarget
DB09118StiripentolL-lactate dehydrogenase B chaintarget
DB09118StiripentolCytochrome P450 2B6enzyme
DB09118StiripentolCytochrome P450 2C8enzyme
DB09118StiripentolP-glycoprotein 1transporter
DB09118StiripentolATP-binding cassette sub-family G member 2transporter
DrugDrug NamePhaseStatusCount
DB09061Cannabidiol1Completed1
DB15932Clemizole1Completed1
DB00574Fenfluramine1Completed1
DB09061Cannabidiol1 / 2Terminated1
DB18579ETX1011 / 2Recruiting3
DB16912Zorevunersen1 / 2Completed1
DB09061Cannabidiol2Completed1
DB15932Clemizole2Recruiting1
DB16987Soticlestat2Active Not Recruiting1
DB16987Soticlestat2Completed1
DB00661Verapamil2Completed1
DB16912Zorevunersen2Enrolling by Invitation1
DB09061Cannabidiol3Completed3
DB09061Cannabidiol3Unknown Status1
DB09061Cannabidiol3Withdrawn1
DB00349Clobazam3Terminated1
DB00349Clobazam3Withdrawn1
DB00574Fenfluramine3Active Not Recruiting1
DB00574Fenfluramine3Completed3
DB00574Fenfluramine3Not Yet Recruiting1
DB00574Fenfluramine3Recruiting2
DB00574Fenfluramine3Terminated1
DB16987Soticlestat3Active Not Recruiting1
DB16987Soticlestat3Recruiting1
DB09061Cannabidiol4Recruiting1
DB09061CannabidiolNot AvailableNot Yet Recruiting1
DB00574FenfluramineNot AvailableApproved for Marketing1
DB00574FenfluramineNot AvailableAvailable1
DB09118StiripentolNot AvailableApproved for Marketing1
DB09118StiripentolNot AvailableNo Longer Available3