Soft Tissue Sarcoma (STS)

Also known as: Sarcoma, Soft Tissue / Soft Tissue Sarcomas / Soft tissue sarcoma / Sarcoma,Soft Tissue / Malignant neoplasm of soft tissues / Malignant soft tissue neoplasm / Malignant soft tissue neoplasm NOS / Soft tissue cancer / Sarcoma NOS / Sarcoma

DrugDrug NameDrug Description
DB01248DocetaxelA taxoid antineoplastic agent used in the treatment of various cancers, such as locally advanced or metastatic breast cancer, metastatic prostate cancer, gastric adenocarcinoma, and head and neck cancer.
DB00997DoxorubicinA medication used to treat various cancers and Kaposi's Sarcoma.
DB01181IfosfamideAn alkylating and immunosuppressive agent used in chemotherapy for the treatment of cancers, including testicular cancer, ovarian cancer, cervical cancer, osteocarcinoma, bladder cancer, small cell lung cancer, and non-Hodgkin's lymphoma.
DB00563MethotrexateAn antineoplastic agent used the treatment of a wide variety of cancers as well as severe psoriasis, severe rheumatoid arthritis, and juvenile rheumatoid arthritis.
DB06043OlaratumabA platelet-derived growth factor receptor alpha blocking antibody used with doxorubicin to treat patients with certain types of soft tissue sarcoma (STS).
DB01268SunitinibA receptor tyrosine kinase inhibitor and chemotherapeutic agent used for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST).
DB11626TasonerminA tumor necrosis factor alpha used along with surgery to remove soft tissue sarcomas of the limbs.
DB00853TemozolomideAn alkylating agent used to treat glioblastoma multiforme and refractory anaplastic astrocytoma.
DB00361VinorelbineA vinca alkaloid used in the treatment of metastatic non-small cell lung carcinoma (NSLC) and in conjunction with other drugs in locally advanced NSCLC.
DrugDrug NameTargetType
DB01248DocetaxelApoptosis regulator Bcl-2target
DB01248DocetaxelTubulin beta-1 chaintarget
DB01248DocetaxelCytochrome P450 3A4enzyme
DB01248DocetaxelCytochrome P450 3A5enzyme
DB01248DocetaxelCytochrome P450 3A7enzyme
DB01248DocetaxelP-glycoprotein 1transporter
DB01248DocetaxelMultidrug resistance-associated protein 7transporter
DB01248DocetaxelCytochrome P450 1B1enzyme
DB01248DocetaxelMicrotubule-associated protein 2target
DB01248DocetaxelMicrotubule-associated protein 4target
DB01248DocetaxelMicrotubule-associated protein tautarget
DB01248DocetaxelSolute carrier organic anion transporter family member 1B3transporter
DB01248DocetaxelSolute carrier family 22 member 7transporter
DB01248DocetaxelATP-binding cassette sub-family G member 2transporter
DB01248DocetaxelCanalicular multispecific organic anion transporter 1transporter
DB01248DocetaxelMultidrug resistance-associated protein 1transporter
DB01248DocetaxelNuclear receptor subfamily 1 group I member 2target
DB00997DoxorubicinDNA topoisomerase 2-alphatarget
DB00997DoxorubicinDNAtarget
DB00997DoxorubicinCytochrome P450 3A4enzyme
DB00997DoxorubicinCytochrome P450 2D6enzyme
DB00997DoxorubicinCytochrome P450 2B6enzyme
DB00997DoxorubicinP-glycoprotein 1transporter
DB00997DoxorubicinCanalicular multispecific organic anion transporter 2transporter
DB00997DoxorubicinMultidrug resistance-associated protein 6transporter
DB00997DoxorubicinMultidrug resistance-associated protein 1transporter
DB00997DoxorubicinMultidrug resistance-associated protein 7transporter
DB00997DoxorubicinATP-binding cassette sub-family G member 2transporter
DB00997DoxorubicinBile salt export pumptransporter
DB00997DoxorubicinSolute carrier family 22 member 16transporter
DB00997DoxorubicinATP-binding cassette sub-family B member 8, mitochondrialtransporter
DB00997DoxorubicinCytochrome P450 1B1enzyme
DB00997DoxorubicinCarbonyl reductase [NADPH] 1enzyme
DB00997DoxorubicinCarbonyl reductase [NADPH] 3enzyme
DB00997DoxorubicinAlcohol dehydrogenase [NADP(+)]enzyme
DB00997DoxorubicinAldo-keto reductase family 1 member C3enzyme
DB00997DoxorubicinNAD(P)H dehydrogenase [quinone] 1enzyme
DB00997DoxorubicinXanthine dehydrogenase/oxidaseenzyme
DB00997DoxorubicinNitric oxide synthase, endothelialenzyme
DB00997DoxorubicinNitric oxide synthase, inducibleenzyme
DB00997DoxorubicinNitric oxide synthase, brainenzyme
DB00997DoxorubicinNADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrialenzyme
DB00997DoxorubicinNADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrialenzyme
DB00997DoxorubicinNADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrialenzyme
DB00997DoxorubicinNADPH--cytochrome P450 reductaseenzyme
DB00997DoxorubicinRalA-binding protein 1transporter
DB00997DoxorubicinCanalicular multispecific organic anion transporter 1transporter
DB00997DoxorubicinSerum albumincarrier
DB00997DoxorubicinNucleolar and coiled-body phosphoprotein 1target
DB01181IfosfamideCytochrome P450 2B6enzyme
DB01181IfosfamideDNAtarget
DB01181IfosfamideCytochrome P450 3A4enzyme
DB01181IfosfamideCytochrome P450 3A5enzyme
DB01181IfosfamideCytochrome P450 2C9enzyme
DB01181IfosfamideCytochrome P450 2C8enzyme
DB01181IfosfamideCytochrome P450 2A6enzyme
DB01181IfosfamideCytochrome P450 2C19enzyme
DB01181IfosfamideCytochrome P450 2C18enzyme
DB01181IfosfamideProstaglandin G/H synthase 1enzyme
DB01181IfosfamideNuclear receptor subfamily 1 group I member 2target
DB00563MethotrexateDihydrofolate reductasetarget
DB00563MethotrexateAldehyde oxidaseenzyme
DB00563MethotrexateMethylenetetrahydrofolate reductaseenzyme
DB00563MethotrexateSerum albumincarrier
DB00563MethotrexateCanalicular multispecific organic anion transporter 2transporter
DB00563MethotrexateMultidrug resistance-associated protein 4transporter
DB00563MethotrexateMultidrug resistance-associated protein 1transporter
DB00563MethotrexateSolute carrier family 22 member 6transporter
DB00563MethotrexateMultidrug resistance-associated protein 7transporter
DB00563MethotrexateSolute carrier family 22 member 8transporter
DB00563MethotrexateCanalicular multispecific organic anion transporter 1transporter
DB00563MethotrexateP-glycoprotein 1transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 1A2transporter
DB00563MethotrexateMonocarboxylate transporter 1transporter
DB00563MethotrexateATP-binding cassette sub-family C member 11transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 1B3transporter
DB00563MethotrexateSolute carrier family 22 member 11transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 1C1transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 3A1transporter
DB00563MethotrexateATP-binding cassette sub-family G member 2transporter
DB00563MethotrexateSolute carrier family 22 member 7transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 1B1transporter
DB00563Methotrexate6-phosphogluconate dehydrogenase, decarboxylatingenzyme
DB00563MethotrexateProton-coupled folate transportertransporter
DB00563MethotrexateFolylpolyglutamate synthase, mitochondrialenzyme
DB00563MethotrexateGamma-glutamyl hydrolaseenzyme
DB00563MethotrexateDihydrofolate reductaseenzyme
DB00563MethotrexateThymidylate synthaseenzyme
DB00563MethotrexateBifunctional purine biosynthesis protein PURHenzyme
DB00563MethotrexateSolute carrier organic anion transporter family member 4C1transporter
DB00563MethotrexateFolate transporter 1transporter
DB00563MethotrexateFolate receptor alphatransporter
DB00563MethotrexateCytochrome P450 3A4enzyme
DB00563MethotrexateThymidylate synthasetarget
DB00563MethotrexateBifunctional purine biosynthesis protein PURHtarget
DB00563MethotrexateFolate receptor betatransporter
DB00563MethotrexateSolute carrier family 15 member 1transporter
DB00563MethotrexateProton-coupled amino acid transporter 1transporter
DB06043OlaratumabPlatelet-derived growth factor receptor alphatarget
DB01268SunitinibPlatelet-derived growth factor receptor betatarget
DB01268SunitinibVascular endothelial growth factor receptor 1target
DB01268SunitinibVascular endothelial growth factor receptor 2target
DB01268SunitinibVascular endothelial growth factor receptor 3target
DB01268SunitinibMast/stem cell growth factor receptor Kittarget
DB01268SunitinibReceptor-type tyrosine-protein kinase FLT3target
DB01268SunitinibMacrophage colony-stimulating factor 1 receptortarget
DB01268SunitinibPlatelet-derived growth factor receptor alphatarget
DB01268SunitinibCytochrome P450 3A4enzyme
DB01268SunitinibCytochrome P450 3A5enzyme
DB01268SunitinibCytochrome P450 3A7enzyme
DB01268SunitinibMultidrug resistance-associated protein 4transporter
DB01268SunitinibP-glycoprotein 1transporter
DB01268SunitinibCanalicular multispecific organic anion transporter 1transporter
DB01268SunitinibATP-binding cassette sub-family G member 2transporter
DB11626TasonerminTumor necrosis factor receptor superfamily member 1Atarget
DB11626TasonerminTumor necrosis factor receptor superfamily member 1Btarget
DB00853TemozolomideDNAtarget
DB00361VinorelbineTubulin beta chaintarget
DB00361VinorelbineCytochrome P450 3A4enzyme
DB00361VinorelbineP-glycoprotein 1transporter
DB00361VinorelbineCytochrome P450 2D6enzyme
DrugDrug NamePhaseStatusCount
DB00297Bupivacaine0Recruiting1
DB12091Gadolinium0Not Yet Recruiting1
DB15299AMG-2321Recruiting1
DB12707AR-421Terminated1
DB12001Abemaciclib1Active Not Recruiting1
DB00928Azacitidine1Unknown Status1
DB00112Bevacizumab1Completed1
DB00188Bortezomib1Completed1
DB00958Carboplatin1Active Not Recruiting1
DB00515Cisplatin1Active Not Recruiting1
DB09110Coenzyme M1Completed1
DB00851Dacarbazine1Completed1
DB01234Dexamethasone1Completed1
DB01248Docetaxel1Completed1
DB01248Docetaxel1Not Yet Recruiting1
DB01248Docetaxel1Terminated1
DB00997Doxorubicin1Active Not Recruiting1
DB00997Doxorubicin1Completed5
DB00997Doxorubicin1Not Yet Recruiting1
DB00997Doxorubicin1Recruiting1
DB05847Doxorubicin1Recruiting1
DB11714Durvalumab1Recruiting1
DB06210Eltrombopag1Terminated1
DB15017Enoblituzumab1Completed1
DB15017Enoblituzumab1Recruiting1
DB01590Everolimus1Completed1
DB00441Gemcitabine1Active Not Recruiting2
DB00441Gemcitabine1Completed1
DB00441Gemcitabine1Not Yet Recruiting1
DB01181Ifosfamide1Completed1
DB01181Ifosfamide1Recruiting1
DB00724Imiquimod1Active Not Recruiting1
DB06186Ipilimumab1Completed1
DB12167LY-30234141Active Not Recruiting1
DB12050LY-30394781Active Not Recruiting1
DB06448Lonafarnib1Terminated1
DB05940Olaparib1Active Not Recruiting1
DB09074Olaparib1Active Not Recruiting1
DB06043Olaratumab1Active Not Recruiting1
DB06043Olaratumab1Completed3
DB06043Olaratumab1Recruiting1
DB06603Panobinostat1Completed1
DB06589Pazopanib1Completed1
DB06589Pazopanib1Terminated1
DB09037Pembrolizumab1Active Not Recruiting2
DB09037Pembrolizumab1Recruiting1
DB05626Retaspimycin1Completed1
DB06233Ridaforolimus1Withdrawn1
DB11942Selinexor1Active Not Recruiting1
DB00398Sorafenib1Completed1
DB01268Sunitinib1Completed1
DB12550Taladegib1Active Not Recruiting1
DB00853Temozolomide1Unknown Status1
DB15375Tozuleristide1Withdrawn1
DB05109Trabectedin1Active Not Recruiting1
DB05109Trabectedin1Completed1
DB05109Trabectedin1Recruiting2
DB00313Valproic acid1Completed1
DB00126Ascorbic acid1 / 2Recruiting1
DB00112Bevacizumab1 / 2Recruiting1
DB11646Conatumumab1 / 2Completed1
DB00531Cyclophosphamide1 / 2Unknown Status1
DB00380Dexrazoxane1 / 2Unknown Status1
DB01248Docetaxel1 / 2Active Not Recruiting1
DB00997Doxorubicin1 / 2Completed1
DB00997Doxorubicin1 / 2Unknown Status1
DB06091Evofosfamide1 / 2Completed1
DB00441Gemcitabine1 / 2Active Not Recruiting1
DB00441Gemcitabine1 / 2Recruiting2
DB01181Ifosfamide1 / 2Completed1
DB09035Nivolumab1 / 2Active Not Recruiting1
DB06043Olaratumab1 / 2Active Not Recruiting1
DB06043Olaratumab1 / 2Unknown Status1
DB01229Paclitaxel1 / 2Completed1
DB01229Paclitaxel1 / 2Recruiting1
DB06589Pazopanib1 / 2Suspended1
DB09037Pembrolizumab1 / 2Suspended1
DB00877Sirolimus1 / 2Suspended1
DB00398Sorafenib1 / 2Completed1
DB00398Sorafenib1 / 2Unknown Status1
DB01268Sunitinib1 / 2Active Not Recruiting1
DB01268Sunitinib1 / 2Unknown Status1
DB13896Talimogene laherparepvec1 / 2Active Not Recruiting1
DB15147Tinostamustine1 / 2Active Not Recruiting1
DB05109Trabectedin1 / 2Recruiting1
DB05434ABT-5102Completed1
DB12001Abemaciclib2Recruiting1
DB00041Aldesleukin2Recruiting1
DB06263Amrubicin2Completed1
DB11885Anlotinib2Not Yet Recruiting2
DB11885Anlotinib2Recruiting2
DB00126Ascorbic acid2Suspended1
DB11595Atezolizumab2Recruiting1
DB06626Axitinib2Active Not Recruiting2
DB00112Bevacizumab2Terminated1
DB00112Bevacizumab2Unknown Status2
DB11958Brivanib2Completed1
DB11865Brivanib alaninate2Completed1
DB00958Carboplatin2Completed2
DB04849Cediranib2Completed1
DB12033Cediranib2Completed1
DB00531Cyclophosphamide2Recruiting1
DB00380Dexrazoxane2Recruiting1
DB01248Docetaxel2Completed1
DB01248Docetaxel2Recruiting1
DB01248Docetaxel2Unknown Status1
DB01142Doxepin2Terminated1
DB00997Doxorubicin2Active Not Recruiting1
DB00997Doxorubicin2Completed3
DB00997Doxorubicin2Recruiting5
DB00997Doxorubicin2Terminated2
DB00997Doxorubicin2Unknown Status2
DB05719Elesclomol2Completed1
DB06423Endostatin2Unknown Status1
DB00445Epirubicin2Recruiting1
DB04940Eribulin2Completed2
DB08871Eribulin2Completed2
DB00773Etoposide2Completed1
DB01590Everolimus2Completed1
DB01590Everolimus2Recruiting1
DB06091Evofosfamide2Terminated1
DB01073Fludarabine2Recruiting1
DB13103GPX-1502Completed1
DB00441Gemcitabine2Completed3
DB00441Gemcitabine2Recruiting2
DB00441Gemcitabine2Suspended1
DB00441Gemcitabine2Unknown Status1
DB01645Genistein2Recruiting1
DB06177Glufosfamide2Completed1
DB14865Human interleukin-22Recruiting1
DB01181Ifosfamide2Completed3
DB01181Ifosfamide2Recruiting6
DB06186Ipilimumab2Not Yet Recruiting1
DB06186Ipilimumab2Recruiting1
DB12748LTX-3152Recruiting1
DB05608MKC-12Completed1
DB09079Nintedanib2Recruiting1
DB09035Nivolumab2Not Yet Recruiting2
DB09035Nivolumab2Recruiting1
DB01229Paclitaxel2Recruiting1
DB01229Paclitaxel2Unknown Status1
DB05668Palifosfamide2Unknown Status1
DB06603Panobinostat2Completed1
DB06589Pazopanib2Active Not Recruiting2
DB06589Pazopanib2Completed1
DB06589Pazopanib2Not Yet Recruiting1
DB06589Pazopanib2Terminated2
DB06589Pazopanib2Withdrawn1
DB12842Pegamotecan2Suspended1
DB06592Pegargiminase2Recruiting1
DB09037Pembrolizumab2Active Not Recruiting2
DB00642Pemetrexed2Completed1
DB11616Pirarubicin2Recruiting1
DB08910Pomalidomide2Terminated1
DB11730Ribociclib2Active Not Recruiting1
DB11730Ribociclib2Recruiting1
DB06233Ridaforolimus2Completed1
DB14765Rivoceranib2Not Yet Recruiting1
DB14765Rivoceranib2Recruiting2
DB00398Sorafenib2Completed1
DB14892Spartalizumab2Active Not Recruiting1
DB01268Sunitinib2Terminated1
DB11941Tasisulam2Completed1
DB00853Temozolomide2Completed1
DB00853Temozolomide2Withdrawn1
DB01030Topotecan2Completed1
DB15043Toripalimab2Not Yet Recruiting1
DB05109Trabectedin2Completed1
DB12902Trofosfamide2Unknown Status1
DB03754Tromethamine2Unknown Status1
DB08881Vemurafenib2Recruiting1
DB00541Vincristine2Completed1
DB00361Vinorelbine2Completed1
DB02546Vorinostat2Completed1
DB11885Anlotinib2 / 3Active Not Recruiting1
DB11791Capmatinib3Recruiting1
DB09063Ceritinib3Recruiting1
DB08912Dabrafenib3Recruiting1
DB00851Dacarbazine3Completed1
DB01234Dexamethasone3Completed1
DB01248Docetaxel3Completed1
DB00997Doxorubicin3Active Not Recruiting1
DB00997Doxorubicin3Completed2
DB11714Durvalumab3Recruiting1
DB08871Eribulin3Completed1
DB00773Etoposide3Active Not Recruiting1
DB06091Evofosfamide3Completed1
DB15149Futibatinib3Recruiting1
DB00441Gemcitabine3Completed1
DB11978Glasdegib3Recruiting1
DB01177Idarubicin3Active Not Recruiting1
DB01259Lapatinib3Recruiting1
DB04868Nilotinib3Recruiting1
DB09074Olaparib3Recruiting1
DB06043Olaratumab3Active Not Recruiting1
DB09073Palbociclib3Recruiting1
DB06589Pazopanib3Completed1
DB05109Trabectedin3Active Not Recruiting1
DB05109Trabectedin3Completed1
DB08911Trametinib3Recruiting1
DB12902Trofosfamide3Active Not Recruiting1
DB00997Doxorubicin4Recruiting1
DB01181Ifosfamide4Recruiting1
DB00945Acetylsalicylic acidNot AvailableCompleted1
DB01008BusulfanNot AvailableRecruiting1
DB00958CarboplatinNot AvailableRecruiting1
DB09110Coenzyme MNot AvailableRecruiting1
DB06779DalteparinNot AvailableActive Not Recruiting1
DB00997DoxorubicinNot AvailableRecruiting1
DB01225EnoxaparinNot AvailableCompleted1
DB04940EribulinNot AvailableCompleted1
DB08871EribulinNot AvailableCompleted1
DB00773EtoposideNot AvailableRecruiting1
DB06091EvofosfamideNot AvailableNo Longer Available1
DB06215FerumoxytolNot AvailableWithdrawn1
DB00099FilgrastimNot AvailableRecruiting1
DB01181IfosfamideNot AvailableRecruiting1
DB01042MelphalanNot AvailableRecruiting1
DB06043OlaratumabNot AvailableAvailable1
DB01229PaclitaxelNot AvailableRecruiting1
DB06589PazopanibNot AvailableCompleted1
DB04572ThiotepaNot AvailableRecruiting1
DB05109TrabectedinNot AvailableCompleted1
DB05109TrabectedinNot AvailableNo Longer Available1
DB05109TrabectedinNot AvailableRecruiting1
DB01586Ursodeoxycholic acidNot AvailableRecruiting1