Soft Tissue Sarcoma (STS)

Also known as: Sarcoma, Soft Tissue / Soft Tissue Sarcomas / Soft tissue sarcoma / Sarcoma,Soft Tissue / Malignant neoplasm of soft tissues / Malignant soft tissue neoplasm / Malignant soft tissue neoplasm NOS / Soft tissue cancer / Sarcoma NOS / Sarcoma

DrugDrug NameDrug Description
DB01248DocetaxelDocetaxel is a clinically well established anti-mitotic chemotherapy medication used mainly for the treatment of breast, ovarian, and non-small cell lung cancer. Docetaxel binds to microtubules reversibly with high affinity and has a maximum stoichiometry of one mole docetaxel per mole tubulin in microtubules.
DB00997DoxorubicinDoxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius. Doxorubicin binds to nucleic acids, presumably by specific intercalation of the planar anthracycline nucleus with the DNA double helix.
DB01181IfosfamideIfosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppresive agent.
DB00563MethotrexateAn antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofolate dehydrogenase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
DB06043OlaratumabOlaratumab (IMC-3G3) is a fully human IgG1 monoclonal antibody with antitumor activity that selectively binds the external domain of human platelet-derived growth factor receptor (PDGFR)-α with high affinity and blocks ligand binding. It is composed of two heavy chain molecule fragments and 2 light chain fragments. Studies show that the treatment of olaratumab in combination with doxorubicin resulted in significant reduction of cancer cell proliferation and tumor growth. Olaratumab was granted accelerated approval (as Lartruvo) as initial therapy to treat adults with certain types of soft tissue sarcoma (STS) in October, 2016.
DB01268SunitinibSunitinib is an oral, small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor that was approved by the FDA for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST) on January 26, 2006. Sunitinib inhibits cellular signaling by targeting multiple RTKs. These include all platelet-derived growth factor receptors (PDGF-R) and vascular endothelial growth factor receptors (VEGF-R). Sunitinib also inhibits KIT (CD117), the RTK that drives the majority of GISTs. In addition, sunitinib inhibits other RTKs including RET, CSF-1R, and flt3.
DB00853TemozolomideTemozolomide (Temodar and Temodal) is an oral alkylating agent used for the treatment of refractory anaplastic astrocytoma -- a type of cancerous brain tumor. Temozolomide is not active until it is converted at physiologic pH to the active form, 5-(3-methyltriazen-1-yl)imidazole-4-carboxamide (MTIC).
DB00361VinorelbineVinorelbine (Navelbine®) is an anti-mitotic chemotherapy drug that is given as a treatment for some types of cancer, including breast cancer and non-small cell lung cancer. [Wikipedia]
DrugDrug NameTargetType
DB01248DocetaxelApoptosis regulator Bcl-2target
DB01248DocetaxelTubulin beta-1 chaintarget
DB01248DocetaxelCytochrome P450 3A4enzyme
DB01248DocetaxelCytochrome P450 3A5enzyme
DB01248DocetaxelCytochrome P450 3A7enzyme
DB01248DocetaxelMultidrug resistance protein 1transporter
DB01248DocetaxelMultidrug resistance-associated protein 7transporter
DB01248DocetaxelCytochrome P450 1B1enzyme
DB01248DocetaxelMicrotubule-associated protein 2target
DB01248DocetaxelMicrotubule-associated protein 4target
DB01248DocetaxelMicrotubule-associated protein tautarget
DB01248DocetaxelSolute carrier organic anion transporter family member 1B3transporter
DB01248DocetaxelSolute carrier family 22 member 7transporter
DB01248DocetaxelATP-binding cassette sub-family G member 2transporter
DB01248DocetaxelCanalicular multispecific organic anion transporter 1transporter
DB01248DocetaxelMultidrug resistance-associated protein 1transporter
DB01248DocetaxelNuclear receptor subfamily 1 group I member 2target
DB00997DoxorubicinDNA topoisomerase 2-alphatarget
DB00997DoxorubicinDNAtarget
DB00997DoxorubicinCytochrome P450 3A4enzyme
DB00997DoxorubicinCytochrome P450 2D6enzyme
DB00997DoxorubicinCytochrome P450 2B6enzyme
DB00997DoxorubicinMultidrug resistance protein 1transporter
DB00997DoxorubicinCanalicular multispecific organic anion transporter 2transporter
DB00997DoxorubicinMultidrug resistance-associated protein 6transporter
DB00997DoxorubicinMultidrug resistance-associated protein 1transporter
DB00997DoxorubicinMultidrug resistance-associated protein 7transporter
DB00997DoxorubicinATP-binding cassette sub-family G member 2transporter
DB00997DoxorubicinBile salt export pumptransporter
DB00997DoxorubicinSolute carrier family 22 member 16transporter
DB00997DoxorubicinATP-binding cassette sub-family B member 8, mitochondrialtransporter
DB00997DoxorubicinCytochrome P450 1B1enzyme
DB00997DoxorubicinCarbonyl reductase [NADPH] 1enzyme
DB00997DoxorubicinCarbonyl reductase [NADPH] 3enzyme
DB00997DoxorubicinAlcohol dehydrogenase [NADP(+)]enzyme
DB00997DoxorubicinAldo-keto reductase family 1 member C3enzyme
DB00997DoxorubicinNAD(P)H dehydrogenase [quinone] 1enzyme
DB00997DoxorubicinXanthine dehydrogenase/oxidaseenzyme
DB00997DoxorubicinNitric oxide synthase, endothelialenzyme
DB00997DoxorubicinNitric oxide synthase, inducibleenzyme
DB00997DoxorubicinNitric oxide synthase, brainenzyme
DB00997DoxorubicinNADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrialenzyme
DB00997DoxorubicinNADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrialenzyme
DB00997DoxorubicinNADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrialenzyme
DB00997DoxorubicinNADPH--cytochrome P450 reductaseenzyme
DB00997DoxorubicinRalA-binding protein 1transporter
DB00997DoxorubicinCanalicular multispecific organic anion transporter 1transporter
DB00997DoxorubicinSerum albumincarrier
DB00997DoxorubicinNucleolar and coiled-body phosphoprotein 1target
DB01181IfosfamideCytochrome P450 2B6enzyme
DB01181IfosfamideDNAtarget
DB01181IfosfamideCytochrome P450 3A4enzyme
DB01181IfosfamideCytochrome P450 3A5enzyme
DB01181IfosfamideCytochrome P450 2C9enzyme
DB01181IfosfamideCytochrome P450 2C8enzyme
DB01181IfosfamideCytochrome P450 2A6enzyme
DB01181IfosfamideCytochrome P450 2C19enzyme
DB01181IfosfamideCytochrome P450 2C18enzyme
DB01181IfosfamideProstaglandin G/H synthase 1enzyme
DB01181IfosfamideCytochrome P450 3A7enzyme
DB01181IfosfamideNuclear receptor subfamily 1 group I member 2target
DB00563MethotrexateDihydrofolate reductasetarget
DB00563MethotrexateAldehyde oxidaseenzyme
DB00563MethotrexateMethylenetetrahydrofolate reductaseenzyme
DB00563MethotrexateSerum albumincarrier
DB00563MethotrexateCanalicular multispecific organic anion transporter 2transporter
DB00563MethotrexateMultidrug resistance-associated protein 4transporter
DB00563MethotrexateMultidrug resistance-associated protein 1transporter
DB00563MethotrexateSolute carrier family 22 member 6transporter
DB00563MethotrexateMultidrug resistance-associated protein 7transporter
DB00563MethotrexateSolute carrier family 22 member 8transporter
DB00563MethotrexateCanalicular multispecific organic anion transporter 1transporter
DB00563MethotrexateMultidrug resistance protein 1transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 1A2transporter
DB00563MethotrexateMonocarboxylate transporter 1transporter
DB00563MethotrexateATP-binding cassette sub-family C member 11transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 1B3transporter
DB00563MethotrexateSolute carrier family 22 member 11transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 1C1transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 3A1transporter
DB00563MethotrexateATP-binding cassette sub-family G member 2transporter
DB00563MethotrexateSolute carrier family 22 member 7transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 1B1transporter
DB00563Methotrexate6-phosphogluconate dehydrogenase, decarboxylatingenzyme
DB00563MethotrexateProton-coupled folate transportertransporter
DB00563MethotrexateFolylpolyglutamate synthase, mitochondrialenzyme
DB00563MethotrexateGamma-glutamyl hydrolaseenzyme
DB00563MethotrexateDihydrofolate reductaseenzyme
DB00563MethotrexateThymidylate synthaseenzyme
DB00563MethotrexateBifunctional purine biosynthesis protein PURHenzyme
DB00563MethotrexateSolute carrier organic anion transporter family member 4C1transporter
DB00563MethotrexateFolate transporter 1transporter
DB00563MethotrexateFolate receptor alphatransporter
DB06043OlaratumabPlatelet-derived growth factor receptor alphatarget
DB01268SunitinibPlatelet-derived growth factor receptor betatarget
DB01268SunitinibVascular endothelial growth factor receptor 1target
DB01268SunitinibVascular endothelial growth factor receptor 2target
DB01268SunitinibVascular endothelial growth factor receptor 3target
DB01268SunitinibMast/stem cell growth factor receptor Kittarget
DB01268SunitinibReceptor-type tyrosine-protein kinase FLT3target
DB01268SunitinibMacrophage colony-stimulating factor 1 receptortarget
DB01268SunitinibPlatelet-derived growth factor receptor alphatarget
DB01268SunitinibCytochrome P450 3A4enzyme
DB01268SunitinibCytochrome P450 3A5enzyme
DB01268SunitinibCytochrome P450 3A7enzyme
DB01268SunitinibMultidrug resistance-associated protein 4transporter
DB01268SunitinibMultidrug resistance protein 1transporter
DB01268SunitinibCanalicular multispecific organic anion transporter 1transporter
DB01268SunitinibATP-binding cassette sub-family G member 2transporter
DB00853TemozolomideDNAtarget
DB00853TemozolomideCytochrome P450 3A4enzyme
DB00361VinorelbineTubulin beta chaintarget
DB00361VinorelbineCytochrome P450 3A4enzyme
DB00361VinorelbineMultidrug resistance protein 1transporter
DB00361VinorelbineCytochrome P450 2D6enzyme
DrugDrug NamePhaseStatusCount
DB12707AR-421Suspended1
DB00188Bortezomib1Completed1
DB00958Carboplatin1Recruiting1
DB00515Cisplatin1Recruiting1
DB09110Coenzyme M1Recruiting1
DB00531Cyclophosphamide1Recruiting1
DB00851Dacarbazine1Completed1
DB01234Dexamethasone1Completed1
DB01248Docetaxel1Terminated1
DB00997Doxorubicin1Active Not Recruiting1
DB00997Doxorubicin1Completed2
DB00997Doxorubicin1Recruiting4
DB05847Doxorubicin1Recruiting1
DB06210Eltrombopag1Terminated1
DB01590Everolimus1Completed1
DB00441Gemcitabine1Recruiting2
DB01181Ifosfamide1Recruiting2
DB00724Imiquimod1Recruiting1
DB12167LY-30234141Recruiting1
DB05940Olaparib1Active Not Recruiting1
DB09074Olaparib1Active Not Recruiting1
DB06043Olaratumab1Active Not Recruiting1
DB06043Olaratumab1Recruiting3
DB06589Pazopanib1Completed1
DB06589Pazopanib1Suspended1
DB09037Pembrolizumab1Recruiting3
DB11942Selinexor1Recruiting1
DB01268Sunitinib1Completed1
DB05109Trabectedin1Active Not Recruiting1
DB05109Trabectedin1Completed1
DB00112Bevacizumab1 / 2Completed1
DB11646Conatumumab1 / 2Completed1
DB00380Dexrazoxane1 / 2Unknown Status1
DB01248Docetaxel1 / 2Completed1
DB01248Docetaxel1 / 2Recruiting1
DB00997Doxorubicin1 / 2Completed1
DB00997Doxorubicin1 / 2Unknown Status1
DB00441Gemcitabine1 / 2Completed1
DB00441Gemcitabine1 / 2Recruiting1
DB01181Ifosfamide1 / 2Completed1
DB09035Nivolumab1 / 2Recruiting1
DB06043Olaratumab1 / 2Recruiting1
DB06043Olaratumab1 / 2Unknown Status1
DB01229Paclitaxel1 / 2Active Not Recruiting1
DB09037Pembrolizumab1 / 2Not Yet Recruiting1
DB00398Sorafenib1 / 2Completed1
DB00398Sorafenib1 / 2Unknown Status1
DB01268Sunitinib1 / 2Recruiting1
DB01268Sunitinib1 / 2Unknown Status1
DB05109Trabectedin1 / 2Recruiting1
DB00313Valproic Acid1 / 2Completed1
DB13896talimogene laherparepvec1 / 2Recruiting1
DB06263Amrubicin2Completed1
DB06626Axitinib2Active Not Recruiting1
DB06626Axitinib2Recruiting1
DB00112Bevacizumab2Terminated1
DB00112Bevacizumab2Unknown Status2
DB11958Brivanib2Completed1
DB00958Carboplatin2Completed2
DB04849Cediranib2Completed1
DB12033Cediranib2Completed1
DB00380Dexrazoxane2Recruiting1
DB01248Docetaxel2Completed1
DB01248Docetaxel2Unknown Status1
DB00997Doxorubicin2Active Not Recruiting1
DB00997Doxorubicin2Completed2
DB00997Doxorubicin2Recruiting3
DB00997Doxorubicin2Terminated2
DB00997Doxorubicin2Unknown Status2
DB05719Elesclomol2Completed1
DB11727Endostar2Unknown Status1
DB04940Eribulin2Completed2
DB08871Eribulin2Completed2
DB00773Etoposide2Completed1
DB01590Everolimus2Completed1
DB01590Everolimus2Recruiting1
DB13103GPX-1502Completed1
DB00441Gemcitabine2Completed2
DB00441Gemcitabine2Recruiting1
DB00441Gemcitabine2Unknown Status1
DB01645Genistein2Recruiting1
DB01181Ifosfamide2Completed3
DB01181Ifosfamide2Recruiting3
DB06186Ipilimumab2Not Yet Recruiting1
DB09079Nintedanib2Recruiting1
DB09035Nivolumab2Not Yet Recruiting2
DB06043Olaratumab2Recruiting1
DB01229Paclitaxel2Recruiting1
DB06603Panobinostat2Completed1
DB06589Pazopanib2Active Not Recruiting1
DB06589Pazopanib2Completed1
DB06589Pazopanib2Not Yet Recruiting1
DB06589Pazopanib2Recruiting2
DB06589Pazopanib2Terminated1
DB06589Pazopanib2Withdrawn1
DB12842Pegamotecan2Suspended1
DB09037Pembrolizumab2Recruiting2
DB00642Pemetrexed2Completed1
DB08910Pomalidomide2Terminated1
DB11730Ribociclib2Active Not Recruiting1
DB11730Ribociclib2Recruiting1
DB00398Sorafenib2Completed1
DB01268Sunitinib2Unknown Status1
DB11941Tasisulam2Completed1
DB00853Temozolomide2Completed1
DB00853Temozolomide2Withdrawn1
DB01030Topotecan2Completed1
DB05109Trabectedin2Active Not Recruiting1
DB12902Trofosfamide2Unknown Status1
DB08881Vemurafenib2Recruiting1
DB00361Vinorelbine2Completed1
DB02546Vorinostat2Completed1
DB11885Anlotinib2 / 3Active Not Recruiting1
DB01234Dexamethasone3Recruiting1
DB01248Docetaxel3Completed1
DB00997Doxorubicin3Active Not Recruiting1
DB00997Doxorubicin3Completed1
DB00773Etoposide3Recruiting1
DB00441Gemcitabine3Completed1
DB01177Idarubicin3Recruiting1
DB06043Olaratumab3Active Not Recruiting1
DB06589Pazopanib3Completed1
DB05109Trabectedin3Recruiting2
DB12902Trofosfamide3Recruiting1
DB00945Acetylsalicylic acidNot AvailableCompleted1
DB01008BusulfanNot AvailableRecruiting1
DB00958CarboplatinNot AvailableRecruiting1
DB09110Coenzyme MNot AvailableRecruiting1
DB01142DoxepinNot AvailableActive Not Recruiting1
DB01225EnoxaparinNot AvailableCompleted1
DB04940EribulinNot AvailableRecruiting1
DB08871EribulinNot AvailableRecruiting1
DB00773EtoposideNot AvailableRecruiting1
DB06215FerumoxytolNot AvailableWithdrawn1
DB01181IfosfamideNot AvailableRecruiting1
DB01042MelphalanNot AvailableRecruiting1
DB01229PaclitaxelNot AvailableRecruiting1
DB06589PazopanibNot AvailableRecruiting1
DB04572ThiotepaNot AvailableRecruiting1
DB05109TrabectedinNot AvailableNo Longer Available1
DB05109TrabectedinNot AvailableRecruiting2