Advanced Systemic Mastocytosis

Also known as: Advanced Systemic Mastocytosis (AdvSM)

Drug	Drug Name	Drug Description
DB15233	Avapritinib	A selective tyrosine kinase inhibitor being investigated for the treatment of multidrug resistant gastrointestinal tumors.

Drug	Drug Name	Target	Type
DB15233	Avapritinib	Platelet derived growth factor receptor alpha	target
DB15233	Avapritinib	Mast/stem cell growth factor receptor Kit	target
DB15233	Avapritinib	P-glycoprotein 1	transporter
DB15233	Avapritinib	ATP-binding cassette sub-family G member 2	transporter
DB15233	Avapritinib	Cytochrome P450 3A4	enzyme
DB15233	Avapritinib	Cytochrome P450 2C9	enzyme
DB15233	Avapritinib	Bile salt export pump	transporter
DB15233	Avapritinib	Multidrug and toxin extrusion protein 1	transporter
DB15233	Avapritinib	Multidrug and toxin extrusion protein 2	transporter

Drug	Drug Name	Phase	Status	Count
DB14840	Ripretinib	1	Completed	1
DB00928	Azacitidine	1 / 2	Recruiting	1
DB18489	Elenestinib	1 / 2	Recruiting	1
DB15233	Avapritinib	2	Active Not Recruiting	1
DB18041	Bezuclastinib	2	Recruiting	1