SMF

Also known as: Secondary Myelofibrosis / Myelofibrosis / Myelofibrosis due to another disorder (disorder)

Drug	Drug Name	Drug Description
DB12500	Fedratinib	Fedratinib is indicated for the treatment of adult patients with intermediate-2 or high-risk primary or secondary (post-polycythemia vera or post-essential thrombocythemia) myelofibrosis.[L8090,L47016]

Drug	Drug Name	Target	Type
DB12500	Fedratinib	P-glycoprotein 1	transporter
DB12500	Fedratinib	ATP-binding cassette sub-family G member 2	transporter
DB12500	Fedratinib	Solute carrier organic anion transporter family member 1B1	transporter
DB12500	Fedratinib	Solute carrier organic anion transporter family member 1B3	transporter
DB12500	Fedratinib	POU domain, class 2, transcription factor 2	transporter
DB12500	Fedratinib	Multidrug and toxin extrusion protein 1	transporter
DB12500	Fedratinib	Multidrug and toxin extrusion protein 2	transporter
DB12500	Fedratinib	Cytochrome P450 3A4	enzyme
DB12500	Fedratinib	Cytochrome P450 2C19	enzyme
DB12500	Fedratinib	Dimethylaniline monooxygenase [N-oxide-forming] 3	enzyme
DB12500	Fedratinib	Tyrosine-protein kinase JAK2	target
DB12500	Fedratinib	Receptor-type tyrosine-protein kinase FLT3	target
DB12500	Fedratinib	Tyrosine-protein kinase JAK1	target
DB12500	Fedratinib	Cytochrome P450 2D6	enzyme

Drug	Drug Name	Phase	Status	Count
DB00531	Cyclophosphamide	0	Completed	1
DB00099	Filgrastim	0	Completed	1
DB01073	Fludarabine	0	Completed	1
DB00888	Mechlorethamine	0	Completed	1
DB00688	Mycophenolate mofetil	0	Completed	1
DB00642	Pemetrexed	0	Completed	1
DB00864	Tacrolimus	0	Completed	1
DB17086	AVI-014	1	Recruiting	1
DB00531	Cyclophosphamide	1	Recruiting	1
DB00531	Cyclophosphamide	1	Terminated	1
DB00091	Cyclosporine	1	Terminated	1
DB00099	Filgrastim	1	Recruiting	1
DB01073	Fludarabine	1	Completed	1
DB01073	Fludarabine	1	Recruiting	1
DB01073	Fludarabine	1	Terminated	1
DB01073	Fludarabine	1	Withdrawn	1
DB00888	Mechlorethamine	1	Completed	1
DB00888	Mechlorethamine	1	Recruiting	1
DB00888	Mechlorethamine	1	Withdrawn	1
DB00688	Mycophenolate mofetil	1	Recruiting	1
DB00688	Mycophenolate mofetil	1	Terminated	1
DB08877	Ruxolitinib	1	Completed	1
DB08877	Ruxolitinib	1	Withdrawn	1
DB00877	Sirolimus	1	Completed	1
DB00877	Sirolimus	1	Withdrawn	1
DB00864	Tacrolimus	1	Completed	1
DB00864	Tacrolimus	1	Recruiting	1
DB00864	Tacrolimus	1	Withdrawn	1
DB08910	Pomalidomide	1 / 2	Active Not Recruiting	1
DB08910	Pomalidomide	1 / 2	Completed	1
DB08877	Ruxolitinib	1 / 2	Active Not Recruiting	1
DB09312	Antilymphocyte immunoglobulin (horse)	2	Completed	1
DB00098	Antithymocyte immunoglobulin (rabbit)	2	Completed	1
DB00928	Azacitidine	2	Terminated	1
DB11105	Benzalkonium	2	Active Not Recruiting	1
DB01008	Busulfan	2	Active Not Recruiting	1
DB01008	Busulfan	2	Completed	2
DB01008	Busulfan	2	Recruiting	1
DB01008	Busulfan	2	Terminated	1
DB00531	Cyclophosphamide	2	Active Not Recruiting	1
DB00531	Cyclophosphamide	2	Completed	4
DB00531	Cyclophosphamide	2	Recruiting	3
DB00531	Cyclophosphamide	2	Terminated	1
DB00091	Cyclosporine	2	Completed	1
DB01406	Danazol	2	Completed	1
DB01262	Decitabine	2	Active Not Recruiting	1
DB01262	Decitabine	2	Recruiting	1
DB01262	Decitabine	2	Terminated	1
DB01609	Deferasirox	2	Completed	1
DB00773	Etoposide	2	Completed	1
DB12500	Fedratinib	2	Recruiting	3
DB00099	Filgrastim	2	Recruiting	1
DB01073	Fludarabine	2	Active Not Recruiting	2
DB01073	Fludarabine	2	Completed	2
DB01073	Fludarabine	2	Recruiting	2
DB01073	Fludarabine	2	Terminated	1
DB05036	Grn163l	2	Completed	1
DB14909	Imetelstat	2	Completed	1
DB05258	Interferon alfa	2	Active Not Recruiting	1
DB12154	Itacitinib	2	Active Not Recruiting	1
DB12154	Itacitinib	2	Recruiting	1
DB12085	LCL-161	2	Completed	1
DB00888	Mechlorethamine	2	Active Not Recruiting	2
DB00888	Mechlorethamine	2	Recruiting	2
DB01042	Melphalan	2	Completed	2
DB16620	Methopterin	2	Active Not Recruiting	1
DB16620	Methopterin	2	Recruiting	1
DB00563	Methotrexate	2	Active Not Recruiting	1
DB00563	Methotrexate	2	Completed	2
DB00563	Methotrexate	2	Recruiting	1
DB00959	Methylprednisolone	2	Completed	1
DB00688	Mycophenolate mofetil	2	Active Not Recruiting	1
DB00688	Mycophenolate mofetil	2	Completed	3
DB00688	Mycophenolate mofetil	2	Recruiting	2
DB09035	Nivolumab	2	Recruiting	1
DB11697	Pacritinib	2	Recruiting	1
DB00635	Prednisone	2	Completed	1
DB00172	Proline	2	Active Not Recruiting	1
DB15119	Ropeginterferon alfa-2b	2	Active Not Recruiting	1
DB08877	Ruxolitinib	2	Active Not Recruiting	1
DB06164	Ruxolitinib	2	Completed	1
DB08877	Ruxolitinib	2	Completed	1
DB08877	Ruxolitinib	2	Recruiting	3
DB00877	Sirolimus	2	Active Not Recruiting	1
DB00877	Sirolimus	2	Completed	1
DB00864	Tacrolimus	2	Active Not Recruiting	2
DB00864	Tacrolimus	2	Completed	3
DB00864	Tacrolimus	2	Recruiting	3
DB01041	Thalidomide	2	Completed	1
DB00099	Filgrastim	3	Completed	1
DB01008	Busulfan	Not Available	Completed	1
DB01008	Busulfan	Not Available	No Longer Available	1
DB00531	Cyclophosphamide	Not Available	Completed	1
DB00987	Cytarabine	Not Available	No Longer Available	1
DB01073	Fludarabine	Not Available	No Longer Available	1
DB00529	Foscarnet	Not Available	Completed	1
DB01004	Ganciclovir	Not Available	Completed	1
DB00563	Methotrexate	Not Available	Completed	1
DB00688	Mycophenolate mofetil	Not Available	No Longer Available	1
DB00864	Tacrolimus	Not Available	Completed	1
DB00864	Tacrolimus	Not Available	No Longer Available	1
DB01610	Valganciclovir	Not Available	Completed	1