Refractory Acute Lymphoblastic Leukemia

Also known as: Acute Lymphoblastic Leukemia, Refractory / Acute, refractory Lymphoblastic Leukemia / Acute, refractory Lymphocytic leukaemia / Acute, refractory Lymphocytic Leukemia / Acute lymphocytic leukemia refractory / Acute, refractory Lymphoblastic Leukaemia / Acute lymphocytic leukaemia refractory / Refractory Acute lymphoblastic leukaemia

DrugDrug NameDrug Description
DB00631ClofarabineA purine nucleoside used to treat relapsed or refractory acute lymphoblastic leukemia in patients 1 to 21 years old.
DB00619ImatinibA tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors.
DB01280NelarabineA purine nucleoside analog and antineoplastic agent used for the treatment of with acute T-cell lymphoblastic leukemia and T-cell lymphoblastic lymphoma with inadequate clinical response to prior chemotherapeutic treatments.
DrugDrug NameTargetType
DB00631ClofarabineDNA polymerase alpha catalytic subunittarget
DB00631ClofarabineRibonucleoside-diphosphate reductase large subunittarget
DB00631ClofarabineDeoxycytidine kinaseenzyme
DB00631ClofarabineDNAtarget
DB00631ClofarabineATP-binding cassette sub-family G member 2transporter
DB00619ImatinibPlatelet-derived growth factor receptor betatarget
DB00619ImatinibTyrosine-protein kinase ABL1target
DB00619ImatinibMast/stem cell growth factor receptor Kittarget
DB00619ImatinibRET proto-oncogenetarget
DB00619ImatinibHigh affinity nerve growth factor receptortarget
DB00619ImatinibMacrophage colony-stimulating factor 1 receptortarget
DB00619ImatinibPlatelet-derived growth factor receptor alphatarget
DB00619ImatinibEpithelial discoidin domain-containing receptor 1target
DB00619ImatinibCytochrome P450 3A4enzyme
DB00619ImatinibBreakpoint cluster region proteintarget
DB00619ImatinibCytochrome P450 1A2enzyme
DB00619ImatinibCytochrome P450 2D6enzyme
DB00619ImatinibCytochrome P450 2C9enzyme
DB00619ImatinibCytochrome P450 2C19enzyme
DB00619ImatinibCytochrome P450 3A5enzyme
DB00619ImatinibCytochrome P450 3A7enzyme
DB00619ImatinibSolute carrier family 22 member 1transporter
DB00619ImatinibP-glycoprotein 1transporter
DB00619ImatinibSolute carrier family 22 member 2transporter
DB00619ImatinibATP-binding cassette sub-family G member 2transporter
DB00619ImatinibATP-binding cassette sub-family A member 3transporter
DB00619ImatinibProstaglandin G/H synthase 1enzyme
DB00619ImatinibSerum albumincarrier
DB00619ImatinibAlpha-1-acid glycoprotein 1carrier
DB00619ImatinibBile salt export pumptransporter
DB00619ImatinibCytochrome P450 2C8enzyme
DB01280NelarabineDNAtarget
DB01280NelarabineAdenosine deaminaseenzyme
DB01280NelarabineDeoxycytidine kinaseenzyme
DB01280NelarabineDeoxyguanosine kinase, mitochondrialenzyme
DB01280NelarabineDNA polymerase alpha catalytic subunittarget
DrugDrug NamePhaseStatusCount
DB00023Asparaginase Escherichia coli1Recruiting1
DB00531Cyclophosphamide1Recruiting2
DB00987Cytarabine1Recruiting2
DB01262Decitabine1Recruiting1
DB01234Dexamethasone1Recruiting2
DB00997Doxorubicin1Recruiting1
DB01073Fludarabine1Recruiting3
DB00741Hydrocortisone1Recruiting1
DB00480Lenalidomide1Recruiting1
DB00888Mechlorethamine1Recruiting1
DB00563Methotrexate1Recruiting1
DB00688Mycophenolate mofetil1Recruiting1
DB09073Palbociclib1Recruiting1
DB00059Pegaspargase1Recruiting1
DB11759Pevonedistat1Recruiting1
DB00073Rituximab1Recruiting1
DB14797SEphB4-HSA1Recruiting1
DB00398Sorafenib1Recruiting1
DB00864Tacrolimus1Recruiting1
DB00541Vincristine1Recruiting2
DB09052Blinatumomab1 / 2Recruiting1
DB09110Coenzyme M1 / 2Recruiting1
DB00531Cyclophosphamide1 / 2Recruiting2
DB00091Cyclosporine1 / 2Recruiting1
DB01234Dexamethasone1 / 2Recruiting1
DB00099Filgrastim1 / 2Recruiting1
DB01073Fludarabine1 / 2Recruiting3
DB00075Muromonab1 / 2Recruiting1
DB00688Mycophenolate mofetil1 / 2Recruiting2
DB09037Pembrolizumab1 / 2Recruiting1
DB08901Ponatinib1 / 2Recruiting1
DB00073Rituximab1 / 2Recruiting1
DB00877Sirolimus1 / 2Recruiting2
DB00864Tacrolimus1 / 2Recruiting1
DB11581Venetoclax1 / 2Recruiting2
DB00541Vincristine1 / 2Recruiting1
DB09312Antilymphocyte immunoglobulin (horse)2Active Not Recruiting1
DB00098Antithymocyte immunoglobulin (rabbit)2Active Not Recruiting1
DB02379Beta-D-Glucose2Recruiting2
DB09052Blinatumomab2Recruiting3
DB00188Bortezomib2Recruiting1
DB01008Busulfan2Active Not Recruiting1
DB01008Busulfan2Recruiting1
DB00631Clofarabine2Active Not Recruiting1
DB06189Clofarabine2Active Not Recruiting1
DB00631Clofarabine2Recruiting2
DB06189Clofarabine2Recruiting1
DB14681Cortisone2Recruiting2
DB00531Cyclophosphamide2Active Not Recruiting1
DB00531Cyclophosphamide2Recruiting5
DB00987Cytarabine2Recruiting3
DB01254Dasatinib2Recruiting1
DB00694Daunorubicin2Recruiting1
DB01234Dexamethasone2Recruiting1
DB00997Doxorubicin2Recruiting1
DB00773Etoposide2Recruiting2
DB00099Filgrastim2Active Not Recruiting1
DB00099Filgrastim2Recruiting2
DB15223Flotetuzumab2Not Yet Recruiting1
DB01073Fludarabine2Active Not Recruiting1
DB01073Fludarabine2Recruiting2
DB05889Inotuzumab ozogamicin2Active Not Recruiting1
DB00888Mechlorethamine2Active Not Recruiting1
DB00888Mechlorethamine2Recruiting1
DB01033Mercaptopurine2Recruiting1
DB00563Methotrexate2Recruiting4
DB00075Muromonab2Recruiting3
DB00688Mycophenolate mofetil2Active Not Recruiting1
DB00688Mycophenolate mofetil2Recruiting1
DB06650Ofatumumab2Recruiting2
DB00019Pegfilgrastim2Recruiting2
DB08901Ponatinib2Recruiting2
DB00635Prednisone2Recruiting2
DB00073Rituximab2Active Not Recruiting1
DB00073Rituximab2Recruiting4
DB14546Sulfate ion2Recruiting2
DB00864Tacrolimus2Active Not Recruiting1
DB00864Tacrolimus2Recruiting1
DB04572Thiotepa2Recruiting1
DB03754Tromethamine2Recruiting1
DB00541Vincristine2Recruiting4
DB00877SirolimusNot AvailableTerminated1