Refractory Acute Lymphoblastic Leukemia

Also known as: Acute Lymphoblastic Leukemia, Refractory / Acute, refractory Lymphoblastic Leukemia / Acute, refractory Lymphocytic leukaemia / Acute, refractory Lymphocytic Leukemia / Acute lymphocytic leukemia refractory / Acute, refractory Lymphoblastic Leukaemia / Acute lymphocytic leukaemia refractory / Refractory Acute lymphoblastic leukaemia

DrugDrug NameDrug Description
DB00631ClofarabineClofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaemia (ALL), only after at least two other types of treatment have failed. It is not known if the drug extends life expectancy. Its potential use in acute myeloid leukaemia (AML) and juvenile myelomonocytic leukaemia (JMML) has been investigated.
DB00619ImatinibImatinib is a small molecule kinase inhibitor used to treat certain types of cancer. It is currently marketed by Novartis as Gleevec (USA) or Glivec (Europe/Australia) as its mesylate salt, imatinib mesilate (INN). It is occasionally referred to as CGP57148B or STI571 (especially in older publications). It is used in treating chronic myelogenous leukemia (CML), gastrointestinal stromal tumors (GISTs) and a number of other malignancies. It is the first member of a new class of agents that act by inhibiting particular tyrosine kinase enzymes, instead of non-specifically inhibiting rapidly dividing cells.
DB01280NelarabineNelarabine is an antineoplastic agent that is typically employed to treat acute T-cell lymphoblastic leukemia. Nelarabine is a purine nucleoside analog converted to its corresponding arabinosylguanine nucleotide triphosphate (araGTP), resulting in inhibition of DNA synthesis and cytotoxicity.
DrugDrug NameTargetType
DB00631ClofarabineDNA polymerase alpha catalytic subunittarget
DB00631ClofarabineRibonucleoside-diphosphate reductase large subunittarget
DB00631ClofarabineDeoxycytidine kinaseenzyme
DB00631ClofarabineDNAtarget
DB00631ClofarabineATP-binding cassette sub-family G member 2transporter
DB00619ImatinibPlatelet-derived growth factor receptor betatarget
DB00619ImatinibTyrosine-protein kinase ABL1target
DB00619ImatinibMast/stem cell growth factor receptor Kittarget
DB00619ImatinibRET proto-oncogenetarget
DB00619ImatinibHigh affinity nerve growth factor receptortarget
DB00619ImatinibMacrophage colony-stimulating factor 1 receptortarget
DB00619ImatinibPlatelet-derived growth factor receptor alphatarget
DB00619ImatinibEpithelial discoidin domain-containing receptor 1target
DB00619ImatinibCytochrome P450 3A4enzyme
DB00619ImatinibBCR/ABL fusion protein isoform X9target
DB00619ImatinibCytochrome P450 1A2enzyme
DB00619ImatinibCytochrome P450 2D6enzyme
DB00619ImatinibCytochrome P450 2C9enzyme
DB00619ImatinibCytochrome P450 2C19enzyme
DB00619ImatinibCytochrome P450 3A5enzyme
DB00619ImatinibCytochrome P450 3A7enzyme
DB00619ImatinibSolute carrier family 22 member 1transporter
DB00619ImatinibP-glycoprotein 1transporter
DB00619ImatinibSolute carrier family 22 member 2transporter
DB00619ImatinibATP-binding cassette sub-family G member 2transporter
DB00619ImatinibATP-binding cassette sub-family A member 3transporter
DB00619ImatinibProstaglandin G/H synthase 1enzyme
DB00619ImatinibSerum albumincarrier
DB00619ImatinibAlpha-1-acid glycoprotein 1carrier
DB00619ImatinibBile salt export pumptransporter
DB00619ImatinibCytochrome P450 2C8enzyme
DB01280NelarabineDNAtarget
DB01280NelarabineAdenosine deaminaseenzyme
DB01280NelarabineDeoxycytidine kinaseenzyme
DB01280NelarabineDeoxyguanosine kinase, mitochondrialenzyme
DB01280NelarabineDNA polymerase alpha catalytic subunittarget
DrugDrug NamePhaseStatusCount
DB00023Asparaginase Escherichia coli1Recruiting1
DB00531Cyclophosphamide1Recruiting2
DB00987Cytarabine1Recruiting2
DB01262Decitabine1Recruiting1
DB01234Dexamethasone1Recruiting2
DB00997Doxorubicin1Recruiting1
DB01073Fludarabine1Recruiting3
DB00741Hydrocortisone1Recruiting1
DB00160L-Alanine1Recruiting1
DB00480Lenalidomide1Recruiting1
DB00888Mechlorethamine1Recruiting1
DB01042Melphalan1Recruiting1
DB00563Methotrexate1Recruiting1
DB00688Mycophenolate mofetil1Recruiting1
DB09073Palbociclib1Recruiting1
DB00059Pegaspargase1Recruiting1
DB11759Pevonedistat1Recruiting1
DB00073Rituximab1Recruiting1
DB14797SEphB4-HSA1Recruiting1
DB00398Sorafenib1Recruiting1
DB00864Tacrolimus1Recruiting1
DB00541Vincristine1Recruiting2
DB09052Blinatumomab1 / 2Recruiting1
DB09110Coenzyme M1 / 2Recruiting1
DB00531Cyclophosphamide1 / 2Recruiting1
DB00091Cyclosporine1 / 2Recruiting1
DB01234Dexamethasone1 / 2Recruiting1
DB01073Fludarabine1 / 2Recruiting2
DB00075Muromonab1 / 2Recruiting1
DB00688Mycophenolate mofetil1 / 2Recruiting1
DB09037Pembrolizumab1 / 2Recruiting1
DB08901Ponatinib1 / 2Recruiting1
DB00073Rituximab1 / 2Recruiting1
DB00877Sirolimus1 / 2Recruiting1
DB11581Venetoclax1 / 2Recruiting2
DB00541Vincristine1 / 2Recruiting1
DB09312Antilymphocyte immunoglobulin (horse)2Active Not Recruiting1
DB00098Antithymocyte immunoglobulin (rabbit)2Active Not Recruiting1
DB02379Beta-D-Glucose2Recruiting1
DB09052Blinatumomab2Recruiting1
DB00188Bortezomib2Recruiting1
DB01008Busulfan2Active Not Recruiting1
DB01008Busulfan2Recruiting1
DB00631Clofarabine2Active Not Recruiting1
DB06189Clofarabine2Active Not Recruiting1
DB00631Clofarabine2Recruiting2
DB06189Clofarabine2Recruiting1
DB00531Cyclophosphamide2Active Not Recruiting1
DB00531Cyclophosphamide2Recruiting4
DB00987Cytarabine2Recruiting3
DB00694Daunorubicin2Recruiting1
DB01234Dexamethasone2Recruiting1
DB00773Etoposide2Recruiting1
DB00099Filgrastim2Active Not Recruiting1
DB00099Filgrastim2Recruiting2
DB15223Flotetuzumab2Not Yet Recruiting1
DB01073Fludarabine2Active Not Recruiting1
DB01073Fludarabine2Recruiting2
DB05889Inotuzumab ozogamicin2Active Not Recruiting1
DB00160L-Alanine2Active Not Recruiting1
DB00160L-Alanine2Recruiting1
DB00888Mechlorethamine2Active Not Recruiting1
DB00888Mechlorethamine2Recruiting1
DB01042Melphalan2Active Not Recruiting1
DB01042Melphalan2Recruiting1
DB00563Methotrexate2Recruiting3
DB00075Muromonab2Recruiting1
DB00688Mycophenolate mofetil2Active Not Recruiting1
DB00688Mycophenolate mofetil2Recruiting1
DB06650Ofatumumab2Recruiting1
DB00019Pegfilgrastim2Recruiting2
DB08901Ponatinib2Recruiting2
DB00073Rituximab2Active Not Recruiting1
DB00073Rituximab2Recruiting3
DB00864Tacrolimus2Active Not Recruiting1
DB00864Tacrolimus2Recruiting1
DB04572Thiotepa2Recruiting1
DB03754Tromethamine2Recruiting1
DB00541Vincristine2Recruiting2
DB00877SirolimusNot AvailableTerminated1