Fallopian Tube Cancer

Also known as: Fallopian tube cancer / Cancer, Fallopian Tube / Carcinoma of fallopian tube / Fallopian tube cancer NOS

DrugDrug NameDrug Description
DB11793NiraparibNiraparib is an orally active PARP inhibitor developed by Tesaro to treat ovarian cancer. FDA approval on March 2017.
DB09074OlaparibLynparza is an inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, including PARP1, PARP2, and PARP3. PARP enzymes are involved in normal cellular homeostasis, such as DNA transcription, cell cycle regulation, and DNA repair. Olaparib has been shown to inhibit growth of select tumor cell lines in vitro and decrease tumor growth in mouse xenograft models of human cancer both as monotherapy or following platinum-based chemotherapy. Increased cytotoxicity and anti-tumor activity following treatment with olaparib were noted in cell lines and mouse tumor models with deficiencies in BRCA. In vitro studies have shown that olaparib-induced cytotoxicity may involve inhibition of PARP enzymatic activity and increased formation of PARP-DNA complex, resulting in disruption of cellular homeostasis and cell death.
DB01229PaclitaxelPaclitaxel is a mitotic inhibitor used in cancer chemotherapy. It was discovered in a US National Cancer Institute program at the Research Triangle Institute in 1967 when Monroe E. Wall and Mansukh C. Wani isolated it from the bark of the Pacific yew tree, Taxus brevifolia and named it taxol. Later it was discovered that endophytic fungi in the bark synthesize paclitaxel. When it was developed commercially by Bristol-Myers Squibb (BMS), the generic name was changed to paclitaxel and the BMS compound is sold under the trademark Taxol. In this formulation, paclitaxel is dissolved in Kolliphor EL and ethanol, as a delivery agent. A newer formulation, in which paclitaxel is bound to albumin, is sold under the trademark Abraxane. [Wikipedia]
DrugDrug NameTargetType
DB11793NiraparibPoly [ADP-ribose] polymerase 1target
DB11793NiraparibPoly [ADP-ribose] polymerase 2target
DB11793NiraparibCarboxylesteraseenzyme
DB11793NiraparibBeta-glucuronidaseenzyme
DB09074OlaparibPoly [ADP-ribose] polymerase 1target
DB09074OlaparibCytochrome P450 3A4enzyme
DB09074OlaparibCytochrome P450 2B6enzyme
DB09074OlaparibPoly [ADP-ribose] polymerase 2target
DB09074OlaparibPoly [ADP-ribose] polymerase 3target
DB01229PaclitaxelApoptosis regulator Bcl-2target
DB01229PaclitaxelTubulin beta-1 chaintarget
DB01229PaclitaxelCytochrome P450 2C8enzyme
DB01229PaclitaxelCytochrome P450 3A4enzyme
DB01229PaclitaxelCytochrome P450 3A5enzyme
DB01229PaclitaxelCytochrome P450 3A7enzyme
DB01229PaclitaxelCytochrome P450 2C9enzyme
DB01229PaclitaxelBile salt export pumptransporter
DB01229PaclitaxelMultidrug resistance protein 1transporter
DB01229PaclitaxelMultidrug resistance-associated protein 1transporter
DB01229PaclitaxelMultidrug resistance-associated protein 7transporter
DB01229PaclitaxelCytochrome P450 19A1enzyme
DB01229PaclitaxelCytochrome P450 1B1enzyme
DB01229PaclitaxelSolute carrier organic anion transporter family member 1B3transporter
DB01229PaclitaxelNuclear receptor subfamily 1 group I member 2target
DB01229PaclitaxelMicrotubule-associated protein 4target
DB01229PaclitaxelMicrotubule-associated protein 2target
DB01229PaclitaxelMicrotubule-associated protein tautarget
DB01229PaclitaxelATP-binding cassette sub-family G member 2transporter
DB01229PaclitaxelCanalicular multispecific organic anion transporter 1transporter
DrugDrug NamePhaseStatusCount
DB00465Ketorolac0Active Not Recruiting1
DB09037Pembrolizumab0Recruiting1
DB11760Talazoparib0Active Not Recruiting1
DB019337-Hydroxystaurosporine1Completed1
DB00087Alemtuzumab1Terminated1
DB00112Bevacizumab1Active Not Recruiting4
DB00112Bevacizumab1Completed3
DB00112Bevacizumab1Recruiting1
DB00188Bortezomib1Completed2
DB00958Carboplatin1Active Not Recruiting1
DB00958Carboplatin1Completed13
DB00958Carboplatin1Not Yet Recruiting1
DB00958Carboplatin1Recruiting2
DB12033Cediranib1Active Not Recruiting1
DB00515Cisplatin1Active Not Recruiting1
DB00515Cisplatin1Completed3
DB00531Cyclophosphamide1Active Not Recruiting2
DB00531Cyclophosphamide1Completed3
DB00531Cyclophosphamide1Recruiting1
DB01254Dasatinib1Completed1
DB00004Denileukin diftitox1Active Not Recruiting1
DB01248Docetaxel1Completed4
DB00997Doxorubicin1Recruiting2
DB11714Durvalumab1Not Yet Recruiting1
DB00773Etoposide1Completed1
DB00773Etoposide1Terminated1
DB01590Everolimus1Recruiting1
DB00099Filgrastim1Active Not Recruiting1
DB00099Filgrastim1Completed2
DB00099Filgrastim1Terminated1
DB00441Gemcitabine1Completed2
DB00441Gemcitabine1Terminated1
DB00125L-Arginine1Terminated1
DB01042Melphalan1Completed1
DB12489Mirvetuximab Soravtansine1Recruiting1
DB12634Navicixizumab1Recruiting1
DB09074Olaparib1Active Not Recruiting1
DB09074Olaparib1Completed1
DB00526Oxaliplatin1Completed1
DB01229Paclitaxel1Active Not Recruiting3
DB01229Paclitaxel1Completed8
DB01229Paclitaxel1Not Yet Recruiting1
DB01229Paclitaxel1Recruiting1
DB09037Pembrolizumab1Recruiting1
DB00642Pemetrexed1Completed1
DB00571Propranolol1Completed1
DB11730Ribociclib1Not Yet Recruiting1
DB12376Ricolinostat1Active Not Recruiting1
DB00020Sargramostim1Completed1
DB12473Taurolidine1Completed1
DB00853Temozolomide1Completed1
DB06287Temsirolimus1Active Not Recruiting1
DB01030Topotecan1Completed7
DB01030Topotecan1Terminated2
DB00072Trastuzumab1Completed1
DB12056Trebananib1Completed1
DB04879Vatalanib1Completed1
DB07232Veliparib1Completed1
DB08885Aflibercept1 / 2Completed1
DB11945Avelumab1 / 2Recruiting1
DB05015Belinostat1 / 2Completed1
DB00958Carboplatin1 / 2Active Not Recruiting2
DB00958Carboplatin1 / 2Completed3
DB00958Carboplatin1 / 2Recruiting3
DB00958Carboplatin1 / 2Terminated1
DB00958Carboplatin1 / 2Unknown Status1
DB00515Cisplatin1 / 2Completed1
DB00515Cisplatin1 / 2Terminated1
DB01248Docetaxel1 / 2Completed2
DB01248Docetaxel1 / 2Unknown Status1
DB00997Doxorubicin1 / 2Completed1
DB00997Doxorubicin1 / 2Terminated2
DB11714Durvalumab1 / 2Recruiting1
DB00530Erlotinib1 / 2Completed1
DB00773Etoposide1 / 2Unknown Status1
DB00099Filgrastim1 / 2Unknown Status1
DB12047Ganetespib1 / 2Suspended1
DB00317Gefitinib1 / 2Active Not Recruiting1
DB00441Gemcitabine1 / 2Active Not Recruiting1
DB00441Gemcitabine1 / 2Terminated1
DB04915Idronoxil1 / 2Completed1
DB04915Idronoxil1 / 2Unknown Status1
DB04845Ixabepilone1 / 2Completed1
DB00480Lenalidomide1 / 2Terminated1
DB11793Niraparib1 / 2Recruiting1
DB09074Olaparib1 / 2Recruiting1
DB01229Paclitaxel1 / 2Completed2
DB01229Paclitaxel1 / 2Recruiting3
DB01229Paclitaxel1 / 2Suspended1
DB01229Paclitaxel1 / 2Terminated1
DB01229Paclitaxel1 / 2Unknown Status1
DB06589Pazopanib1 / 2Recruiting1
DB06589Pazopanib1 / 2Terminated1
DB00019Pegfilgrastim1 / 2Completed1
DB00022Peginterferon alfa-2b1 / 2Terminated1
DB09037Pembrolizumab1 / 2Recruiting2
DB06813Pralatrexate1 / 2Active Not Recruiting1
DB11787Ralimetinib1 / 2Active Not Recruiting1
DB12332Rucaparib1 / 2Active Not Recruiting1
DB10286Streptococcus pneumoniae type 4 capsular polysaccharide diphtheria crm197 protein conjugate antigen1 / 2Active Not Recruiting1
DB04572Thiotepa1 / 2Unknown Status1
DB01030Topotecan1 / 2Active Not Recruiting1
DB01030Topotecan1 / 2Unknown Status1
DB11771Tremelimumab1 / 2Recruiting1
DB02546Vorinostat1 / 2Terminated1
DB019337-Hydroxystaurosporine2Completed1
DB08885Aflibercept2Completed1
DB00041Aldesleukin2Terminated1
DB05220Alisertib2Active Not Recruiting1
DB00437Allopurinol2Terminated1
DB01143Amifostine2Terminated1
DB05015Belinostat2Completed2
DB00112Bevacizumab2Active Not Recruiting1
DB00112Bevacizumab2Completed9
DB00112Bevacizumab2Not Yet Recruiting1
DB00112Bevacizumab2Recruiting3
DB00112Bevacizumab2Terminated4
DB00112Bevacizumab2Unknown Status1
DB01128Bicalutamide2Completed1
DB11752Bryostatin 12Completed1
DB12962CP-5476322Completed1
DB04972Canfosfamide2Completed1
DB01101Capecitabine2Completed1
DB01101Capecitabine2Terminated1
DB00958Carboplatin2Active Not Recruiting2
DB00958Carboplatin2Completed13
DB00958Carboplatin2Not Yet Recruiting1
DB00958Carboplatin2Recruiting1
DB00958Carboplatin2Suspended1
DB00958Carboplatin2Terminated6
DB00958Carboplatin2Unknown Status3
DB00958Carboplatin2Withdrawn1
DB11960Carboxyamidotriazole2Completed1
DB04849Cediranib2Completed1
DB00493Cefotaxime2Active Not Recruiting1
DB00482Celecoxib2Active Not Recruiting1
DB00515Cisplatin2Completed4
DB00515Cisplatin2Not Yet Recruiting1
DB00515Cisplatin2Recruiting1
DB00515Cisplatin2Terminated2
DB00531Cyclophosphamide2Active Not Recruiting1
DB00531Cyclophosphamide2Completed3
DB00531Cyclophosphamide2Not Yet Recruiting1
DB00531Cyclophosphamide2Terminated2
DB00091Cyclosporine2Completed1
DB01262Decitabine2Terminated1
DB01248Docetaxel2Completed4
DB01248Docetaxel2Terminated1
DB01248Docetaxel2Unknown Status1
DB00997Doxorubicin2Active Not Recruiting1
DB00997Doxorubicin2Completed1
DB00997Doxorubicin2Terminated2
DB11714Durvalumab2Recruiting1
DB04940Eribulin2Completed1
DB08871Eribulin2Completed1
DB00530Erlotinib2Completed4
DB01590Everolimus2Completed1
DB01590Everolimus2Unknown Status1
DB12185Exatecan2Completed1
DB05595Farletuzumab2Completed1
DB00099Filgrastim2Completed2
DB01073Fludarabine2Completed1
DB01073Fludarabine2Terminated1
DB00569Fondaparinux sodium2Completed1
DB01004Ganciclovir2Unknown Status1
DB00317Gefitinib2Completed1
DB00441Gemcitabine2Active Not Recruiting1
DB00441Gemcitabine2Completed6
DB00441Gemcitabine2Terminated2
DB00441Gemcitabine2Unknown Status3
DB00441Gemcitabine2Withdrawn1
DB00014Goserelin2Completed1
DB00619Imatinib2Completed1
DB00724Imiquimod2Active Not Recruiting1
DB00762Irinotecan2Completed2
DB00762Irinotecan2Terminated1
DB11733Irofulven2Completed1
DB04845Ixabepilone2Recruiting1
DB00125L-Arginine2Completed1
DB12574LY-2955012Unknown Status1
DB01006Letrozole2Terminated1
DB01006Letrozole2Withdrawn1
DB00959Methylprednisolone2Completed1
DB00834Mifepristone2Completed1
DB00745Modafinil2Recruiting1
DB12303Motolimod2Active Not Recruiting1
DB09079Nintedanib2Active Not Recruiting2
DB11793Niraparib2Not Yet Recruiting1
DB09035Nivolumab2Recruiting1
DB09074Olaparib2Recruiting1
DB09074Olaparib2Withdrawn1
DB04964Oregovomab2Unknown Status2
DB00526Oxaliplatin2Terminated1
DB01229Paclitaxel2Active Not Recruiting3
DB01229Paclitaxel2Completed13
DB01229Paclitaxel2Not Yet Recruiting2
DB01229Paclitaxel2Recruiting1
DB01229Paclitaxel2Terminated6
DB01229Paclitaxel2Unknown Status3
DB01269Panitumumab2Terminated1
DB06589Pazopanib2Active Not Recruiting1
DB06589Pazopanib2Completed1
DB00019Pegfilgrastim2Completed1
DB09037Pembrolizumab2Not Yet Recruiting1
DB09037Pembrolizumab2Recruiting1
DB00642Pemetrexed2Completed1
DB06366Pertuzumab2Completed1
DB12257Platinum2Completed1
DB05578Ramucirumab2Completed1
DB08896Regorafenib2Terminated1
DB12332Rucaparib2Active Not Recruiting1
DB00020Sargramostim2Active Not Recruiting1
DB00020Sargramostim2Completed3
DB11857Seribantumab2Completed1
DB00398Sorafenib2Completed1
DB00398Sorafenib2Terminated1
DB01268Sunitinib2Completed1
DB00675Tamoxifen2Completed1
DB00675Tamoxifen2Unknown Status1
DB11941Tasisulam2Completed1
DB06287Temsirolimus2Completed1
DB11800Tivozanib2Terminated1
DB01030Topotecan2Completed8
DB05109Trabectedin2Completed1
DB12056Trebananib2Active Not Recruiting1
DB05294Vandetanib2Completed1
DB07232Veliparib2Terminated1
DB00361Vinorelbine2Completed1
DB00361Vinorelbine2Not Yet Recruiting1
DB00958Carboplatin2 / 3Completed1
DB00958Carboplatin2 / 3Unknown Status1
DB01181Ifosfamide2 / 3Unknown Status1
DB01229Paclitaxel2 / 3Completed2
DB11805Saracatinib2 / 3Completed1
DB06274Alvimopan3Completed1
DB11595Atezolizumab3Recruiting1
DB00112Bevacizumab3Completed1
DB00112Bevacizumab3Recruiting1
DB00958Carboplatin3Completed9
DB00958Carboplatin3Recruiting2
DB00958Carboplatin3Terminated1
DB00958Carboplatin3Unknown Status1
DB00515Cisplatin3Completed2
DB00515Cisplatin3Recruiting1
DB01248Docetaxel3Completed1
DB00997Doxorubicin3Completed2
DB00997Doxorubicin3Recruiting1
DB00445Epirubicin3Completed1
DB00530Erlotinib3Completed1
DB00927Famotidine3Not Yet Recruiting1
DB00441Gemcitabine3Completed1
DB00441Gemcitabine3Recruiting1
DB04915Idronoxil3Completed1
DB12489Mirvetuximab Soravtansine3Recruiting1
DB00104Octreotide3Completed1
DB01229Paclitaxel3Completed9
DB01229Paclitaxel3Recruiting3
DB01229Paclitaxel3Terminated1
DB01229Paclitaxel3Unknown Status1
DB03010Patupilone3Completed1
DB12332Rucaparib3Active Not Recruiting1
DB12332Rucaparib3Recruiting1
DB00675Tamoxifen3Completed1
DB01041Thalidomide3Completed1
DB01030Topotecan3Completed2
DB01030Topotecan3Recruiting1
DB12056Trebananib3Completed1
DB12056Trebananib3Terminated1
DB01157Trimetrexate3Completed1
DB00112BevacizumabNot AvailableActive Not Recruiting1
DB00958CarboplatinNot AvailableActive Not Recruiting1
DB00958CarboplatinNot AvailableCompleted1
DB00813FentanylNot AvailableCompleted1
DB00327HydromorphoneNot AvailableCompleted1
DB00465KetorolacNot AvailableRecruiting1
DB05296Motexafin lutetiumNot AvailableTerminated1
DB01229PaclitaxelNot AvailableActive Not Recruiting1
DB01229PaclitaxelNot AvailableCompleted1
DB12257PlatinumNot AvailableCompleted1
DB00571PropranololNot AvailableActive Not Recruiting1
DB00296RopivacaineNot AvailableCompleted1