Feeling Anxious

Also known as: Anxiety / Anxiousness / Anxiety reaction / Reaction anxiety / Anxiety neurosis

DrugDrug NameDrug Description
DB00945Acetylsalicylic acidAlso known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial infarction (MI) [FDA label]. Interestingly, the results of various studies have demonstrated that long-term use of acetylsalicylic acid may decrease the risk of various cancers, including colorectal, esophageal, breast, lung, prostate, liver and skin cancer [A177325]. Aspirin is classified as a _non-selective cyclooxygenase (COX) inhibitor_ [A32682, A177268] and is available in many doses and forms, including chewable tablets, suppositories, extended release formulations, and others [L5968]. Acetylsalicylic acid is a very common cause of accidental poisoning in young children. It should be kept out of reach from young children, toddlers, and infants [FDA label].
DB00404AlprazolamAlprazolam is a triazolobenzodiazepine indicated for the treatment of anxiety and panic disorders.[Label] It is mainly metabolized by CYP3As and so is contraindicated with CYP3A inhibitors like ketoconazole and itraconazole.[Label] Benzodiazepine treatment should be stopped gradually by tapering down a patient's dose to avoid withdrawal symptoms.[A18125] Alprazolam's adverse effects are generally related to the sedation it can cause.[A18125] Alprazolam has been mixed with alcohol as a drug of abuse to potentiate the sedative effects of the drug which may lead to coma and death.[A18125] Alprazolam was given FDA approval on October 16, 1981[L6148].
DB00543AmoxapineAmoxapine, the N-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, amoxapine does not affect mood or arousal, but may cause sedation. In depressed individuals, amoxapine exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. In addition, TCAs down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine H1 receptors, α1-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Amoxapine may be used to treat neurotic and reactive depressive disorders, endogenous and psychotic depression, and mixed symptoms of depression and anxiety or agitation.
DB00475ChlordiazepoxideAn anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal.
DB00829DiazepamA benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of gamma-aminobutyric acid activity. It is used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome. (From Martindale, The Extra Pharmacopoeia, 30th ed, p589) Given diazepam's storied history as a commonly used and effective medication for a variety of indications, contemporary advancements in the formulation and administration of the agent include the development and US FDA approval of an auto-injectable formulation for the rapid treatment of uncontrolled seizures in 2015-2016 [L5200]. Combining diazepam, a proven effective therapy for acute repetitive seizures, with an auto-injector designed for subcutaneous administration that is quickly and easily administered offers the potential for complete, consistent drug absorption and rapid onset of effect [L5200]. This current development is subsequently an important addition to the rescue therapy tool chest for patients with epilepsy [L5200].
DB01142DoxepinDoxepin is a psychotropic agent with tricyclic antidepressant and anxiolytic properties.[T559] It is a tertiary amine that can be presented as an (E) and (Z) stereoisomers from which the (Z) form corresponds to [cidoxepin]. The common products for doxepin included a racemic mixture 5:1 (E):(Z).[T83] In a strict sense, doxepin is not a tricyclic antidepressant but it is commonly associated with them as it shares a lot of properties with some of the members of this family such as [amitriptyline], [clomipramine], [desipramine], [imipramine], [nortriptyline], [protriptyline] and [trimipramine].[L5977] Doxepin was developed by Pfizer and FDA approved initially in 1969 as an antidepressive.[L5971] However, in 2010 it was approved for the treatment of insomnia. This later indication was presented by Pernix Therapeutics.[L5974]
DB00186LorazepamLorazepam is a short-acting and rapidly cleared benzodiazepine used commonly as a sedative and anxiolytic.[A957] It was developed by DJ Richards, presented and marketed initially by Wyeth Pharmaceuticals in the USA in 1977. The first historic FDA label approval is reported in 1985 by the company Mutual Pharm.[L5095]
DB00934MaprotilineMaprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does not appear to block serotonin reuptake. Maprotiline may be used to treat depressive affective disorders, including dysthymic disorder (depressive neurosis) and major depressive disorder. Maprotiline is effective at reducing symptoms of anxiety associated with depression.
DB01403MethotrimeprazineA phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604)
DB00842OxazepamOxazepam is an intermediate-acting benzodiazepine used to treat alcohol withdrawal and anxiety disorders. Oxazepam is also the metabolite of other benzodiazpines.
DB01192OxymorphoneAn opioid analgesic with actions and uses similar to those of morphine, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092). On June 8, 2017, FDA requested Endo Pharmaceuticals to remove the medication from the market due to opioid misuse and abuse risks associated with the product's injectable reformulation.
DB00850PerphenazineAn antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine.
DB01174PhenobarbitalA barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
DB01323St. John's WortNot Available
DB00656TrazodoneA serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety. This drug does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. (From AMA Drug Evaluations Annual, 1994, p309)
DrugDrug NameTargetType
DB00945Acetylsalicylic acidProstaglandin G/H synthase 1target
DB00945Acetylsalicylic acidProstaglandin G/H synthase 2target
DB00945Acetylsalicylic acidAldo-keto reductase family 1 member C1target
DB00945Acetylsalicylic acidSolute carrier family 22 member 6transporter
DB00945Acetylsalicylic acidMultidrug resistance protein 1transporter
DB00945Acetylsalicylic acidCytochrome P450 2C19enzyme
DB00945Acetylsalicylic acidCytochrome P450 2C9enzyme
DB00945Acetylsalicylic acid5'-AMP-activated protein kinasetarget
DB00945Acetylsalicylic acidEndothelin-1 receptortarget
DB00945Acetylsalicylic acidNuclear factor kappa b beta subunittarget
DB00945Acetylsalicylic acidCellular tumor antigen p53target
DB00945Acetylsalicylic acid78 kDa glucose-regulated proteintarget
DB00945Acetylsalicylic acidRibosomal protein S6 kinase alpha-3target
DB00945Acetylsalicylic acidNF-kappa-B inhibitor alphatarget
DB00945Acetylsalicylic acidTumor necrosis factor-inducible gene 6 proteintarget
DB00945Acetylsalicylic acidCaspase-1target
DB00945Acetylsalicylic acidCaspase-3target
DB00945Acetylsalicylic acidInhibitor of nuclear factor kappa-B kinase subunit betatarget
DB00945Acetylsalicylic acidExtracellular signal-regulated kinase (ERK)target
DB00945Acetylsalicylic acidG1/S-specific cyclin-D1target
DB00945Acetylsalicylic acidMyc proto-oncogene proteintarget
DB00945Acetylsalicylic acidProliferating cell nuclear antigentarget
DB00945Acetylsalicylic acidCyclin Atarget
DB00945Acetylsalicylic acidUDP-glucuronosyltransferase 1-6enzyme
DB00945Acetylsalicylic acidArylamine N-acetyltransferase 2enzyme
DB00945Acetylsalicylic acidSolute carrier family 22 member 8transporter
DB00404AlprazolamGamma-aminobutyric acid receptor subunit alpha-1target
DB00404AlprazolamGamma-aminobutyric acid receptor subunit alpha-6target
DB00404AlprazolamTranslocator proteintarget
DB00404AlprazolamGamma-aminobutyric acid receptor subunit alpha-3target
DB00404AlprazolamGamma-aminobutyric acid receptor subunit alpha-4target
DB00404AlprazolamGamma-aminobutyric acid receptor subunit alpha-5target
DB00404AlprazolamGamma-aminobutyric acid receptor subunit alpha-2target
DB00404AlprazolamCytochrome P450 3A4enzyme
DB00404AlprazolamCytochrome P450 2C9enzyme
DB00404AlprazolamCytochrome P450 3A5enzyme
DB00404AlprazolamCytochrome P450 3A7enzyme
DB00404AlprazolamGABA-A receptor (anion channel)target
DB00404AlprazolamSerum albumincarrier
DB00404Alprazolamalpha1-acid glycoproteincarrier
DB00543AmoxapineSodium-dependent serotonin transportertarget
DB00543AmoxapineSodium-dependent noradrenaline transportertarget
DB00543AmoxapineAlpha-2A adrenergic receptortarget
DB00543AmoxapineD(2) dopamine receptortarget
DB00543AmoxapineAlpha-1A adrenergic receptortarget
DB00543AmoxapineD(1A) dopamine receptortarget
DB00543AmoxapineMuscarinic acetylcholine receptor M1target
DB00543AmoxapineGamma-aminobutyric acid receptor subunit alpha-1target
DB00543AmoxapineAlpha-1-acid glycoprotein 1carrier
DB00543AmoxapineCytochrome P450 2D6enzyme
DB00543Amoxapine5-hydroxytryptamine receptor 2Atarget
DB00543Amoxapine5-hydroxytryptamine receptor 2Ctarget
DB00543Amoxapine5-hydroxytryptamine receptor 6target
DB00543Amoxapine5-hydroxytryptamine receptor 7target
DB00543AmoxapineD(3) dopamine receptortarget
DB00543AmoxapineD(4) dopamine receptortarget
DB00543AmoxapineHistamine H1 receptortarget
DB00543AmoxapineAlpha-1 adrenergic receptorstarget
DB00543AmoxapineMuscarinic acetylcholine receptortarget
DB00543Amoxapine5-hydroxytryptamine receptor 2Btarget
DB00543Amoxapine5-hydroxytryptamine receptor 3Atarget
DB00543Amoxapine5-hydroxytryptamine receptor 1Atarget
DB00543Amoxapine5-hydroxytryptamine receptor 1Btarget
DB00543AmoxapineAlpha-2 adrenergic receptorstarget
DB00543AmoxapineHistamine H4 receptortarget
DB00543AmoxapineGABA-A receptor (anion channel)target
DB00543AmoxapineSodium-dependent dopamine transportertarget
DB00475ChlordiazepoxideCytochrome P450 3A4enzyme
DB00475ChlordiazepoxideGABA-A receptor (anion channel)target
DB00829DiazepamTranslocator proteintarget
DB00829DiazepamGamma-aminobutyric acid receptor subunit alpha-1target
DB00829DiazepamGamma-aminobutyric acid receptor subunit alpha-2target
DB00829DiazepamGamma-aminobutyric acid receptor subunit alpha-3target
DB00829DiazepamCytochrome P450 3A4enzyme
DB00829DiazepamSerum albumincarrier
DB00829DiazepamCytochrome P450 2C9enzyme
DB00829DiazepamCytochrome P450 2C19enzyme
DB00829DiazepamCytochrome P450 3A5enzyme
DB00829DiazepamCytochrome P450 3A7enzyme
DB00829DiazepamGamma-aminobutyric acid receptor subunit alpha-5target
DB00829DiazepamGamma-aminobutyric acid receptor subunit beta-1target
DB00829DiazepamGamma-aminobutyric acid receptor subunit beta-2target
DB00829DiazepamGamma-aminobutyric acid receptor subunit beta-3target
DB00829DiazepamGamma-aminobutyric acid receptor subunit gamma-1target
DB00829DiazepamGamma-aminobutyric acid receptor subunit gamma-2target
DB00829DiazepamGamma-aminobutyric acid receptor subunit gamma-3target
DB00829DiazepamGamma-aminobutyric acid receptor subunit deltatarget
DB00829DiazepamGamma-aminobutyric acid receptor subunit epsilontarget
DB00829DiazepamGamma-aminobutyric acid receptor subunit pitarget
DB00829DiazepamGamma-aminobutyric acid receptor subunit rho-1target
DB00829DiazepamGamma-aminobutyric acid receptor subunit rho-2target
DB00829DiazepamGamma-aminobutyric acid receptor subunit rho-3target
DB00829DiazepamGamma-aminobutyric acid receptor subunit thetatarget
DB00829DiazepamMultidrug resistance protein 1transporter
DB00829DiazepamCytochrome P450 2B6enzyme
DB00829DiazepamProstaglandin G/H synthase 1enzyme
DB00829DiazepamCytochrome P450 2C18enzyme
DB00829DiazepamCytochrome P450 2C8enzyme
DB00829DiazepamCytochrome P450 2E1enzyme
DB00829DiazepamGABA-A receptor (anion channel)target
DB01142DoxepinSodium-dependent serotonin transportertarget
DB01142DoxepinSodium-dependent noradrenaline transportertarget
DB01142DoxepinHistamine H1 receptortarget
DB01142DoxepinHistamine H2 receptortarget
DB01142DoxepinCytochrome P450 2D6enzyme
DB01142DoxepinMuscarinic acetylcholine receptor M1target
DB01142DoxepinMuscarinic acetylcholine receptor M2target
DB01142DoxepinMuscarinic acetylcholine receptor M3target
DB01142DoxepinMuscarinic acetylcholine receptor M4target
DB01142DoxepinMuscarinic acetylcholine receptor M5target
DB01142DoxepinAlpha-1A adrenergic receptortarget
DB01142Doxepin5-hydroxytryptamine receptor 1Atarget
DB01142Doxepin5-hydroxytryptamine receptor 2Atarget
DB01142DoxepinCytochrome P450 2C19enzyme
DB01142DoxepinCytochrome P450 2C9enzyme
DB01142DoxepinCytochrome P450 1A2enzyme
DB01142DoxepinMultidrug resistance protein 1transporter
DB01142Doxepin5-hydroxytryptamine receptor 2Btarget
DB01142Doxepin5-hydroxytryptamine receptor 2Ctarget
DB01142DoxepinAlpha-1B adrenergic receptortarget
DB01142DoxepinAlpha-1D adrenergic receptortarget
DB01142DoxepinCytochrome P450 3A4enzyme
DB01142Doxepin5-hydroxytryptamine receptor 6target
DB01142DoxepinHistamine H4 receptortarget
DB01142DoxepinPotassium voltage-gated channel subfamily H member 2target
DB01142DoxepinSerum albumincarrier
DB01142DoxepinAlpha-1-acid glycoprotein 1carrier
DB00186LorazepamTranslocator proteintarget
DB00186LorazepamUDP-glucuronosyltransferase 2B15enzyme
DB00186LorazepamGABA-A receptor (anion channel)target
DB00186LorazepamCytochrome P450 3A4enzyme
DB00934MaprotilineHistamine H1 receptortarget
DB00934MaprotilineSodium-dependent noradrenaline transportertarget
DB00934MaprotilineAlpha-1 adrenergic receptorstarget
DB00934MaprotilineCytochrome P450 2D6enzyme
DB00934MaprotilineAlpha-1-acid glycoprotein 1carrier
DB00934MaprotilineMuscarinic acetylcholine receptor M1target
DB00934MaprotilineMuscarinic acetylcholine receptor M2target
DB00934MaprotilineMuscarinic acetylcholine receptor M3target
DB00934MaprotilineMuscarinic acetylcholine receptor M4target
DB00934MaprotilineMuscarinic acetylcholine receptor M5target
DB00934MaprotilineCytochrome P450 1A2enzyme
DB00934Maprotiline5-hydroxytryptamine receptor 2Atarget
DB00934Maprotiline5-hydroxytryptamine receptor 2Ctarget
DB00934Maprotiline5-hydroxytryptamine receptor 7target
DB00934MaprotilineD(2) dopamine receptortarget
DB00934MaprotilineAlpha-2 adrenergic receptorstarget
DB01403MethotrimeprazineD(3) dopamine receptortarget
DB01403MethotrimeprazineHistamine H1 receptortarget
DB01403MethotrimeprazineMuscarinic acetylcholine receptor M1target
DB01403MethotrimeprazineMuscarinic acetylcholine receptor M2target
DB01403MethotrimeprazineMuscarinic acetylcholine receptor M3target
DB01403MethotrimeprazineMuscarinic acetylcholine receptor M4target
DB01403MethotrimeprazineMuscarinic acetylcholine receptor M5target
DB01403MethotrimeprazineAlpha-1A adrenergic receptortarget
DB01403MethotrimeprazineAlpha-1B adrenergic receptortarget
DB01403MethotrimeprazineAlpha-1D adrenergic receptortarget
DB01403MethotrimeprazineCytochrome P450 2D6enzyme
DB01403MethotrimeprazineD(2) dopamine receptortarget
DB01403MethotrimeprazineD(1A) dopamine receptortarget
DB01403MethotrimeprazineD(1B) dopamine receptortarget
DB01403MethotrimeprazineD(4) dopamine receptortarget
DB01403MethotrimeprazineAlpha-2A adrenergic receptortarget
DB01403MethotrimeprazineAlpha-2B adrenergic receptortarget
DB01403MethotrimeprazineAlpha-2C adrenergic receptortarget
DB01403Methotrimeprazine5-hydroxytryptamine receptor 2Atarget
DB01403Methotrimeprazine5-hydroxytryptamine receptor 2Ctarget
DB01403MethotrimeprazineCytochrome P450 2E1enzyme
DB00842OxazepamGamma-aminobutyric acid receptor subunit alpha-1target
DB00842OxazepamGamma-aminobutyric acid receptor subunit alpha-2target
DB00842OxazepamGamma-aminobutyric acid receptor subunit alpha-3target
DB00842OxazepamGamma-aminobutyric acid receptor subunit alpha-4target
DB00842OxazepamGamma-aminobutyric acid receptor subunit alpha-5target
DB00842OxazepamGamma-aminobutyric acid receptor subunit alpha-6target
DB00842OxazepamGamma-aminobutyric acid receptor subunit beta-1target
DB00842OxazepamGamma-aminobutyric acid receptor subunit beta-2target
DB00842OxazepamGamma-aminobutyric acid receptor subunit beta-3target
DB00842OxazepamGamma-aminobutyric acid receptor subunit gamma-1target
DB00842OxazepamGamma-aminobutyric acid receptor subunit gamma-2target
DB00842OxazepamGamma-aminobutyric acid receptor subunit gamma-3target
DB00842OxazepamGamma-aminobutyric acid receptor subunit deltatarget
DB00842OxazepamGamma-aminobutyric acid receptor subunit epsilontarget
DB00842OxazepamGamma-aminobutyric acid receptor subunit pitarget
DB00842OxazepamGamma-aminobutyric acid receptor subunit rho-1target
DB00842OxazepamGamma-aminobutyric acid receptor subunit rho-2target
DB00842OxazepamGamma-aminobutyric acid receptor subunit thetatarget
DB00842OxazepamGamma-aminobutyric acid receptor subunit rho-3target
DB00842OxazepamCytochrome P450 3A4enzyme
DB00842OxazepamCytochrome P450 3A43enzyme
DB00842OxazepamUDP-glucuronosyltransferase 2B15enzyme
DB00842OxazepamUDP-glucuronosyltransferase 2B7enzyme
DB00842OxazepamUDP-glucuronosyltransferase 1-9enzyme
DB00842OxazepamGABA-A receptor (anion channel)target
DB01192OxymorphoneMu-type opioid receptortarget
DB01192OxymorphoneCytochrome P450 2D6enzyme
DB01192OxymorphoneDelta-type opioid receptortarget
DB01192OxymorphoneCytochrome P450 3A4enzyme
DB00850PerphenazineD(1A) dopamine receptortarget
DB00850PerphenazineD(2) dopamine receptortarget
DB00850PerphenazineCalmodulintarget
DB00850PerphenazineCytochrome P450 2D6enzyme
DB00850PerphenazineCytochrome P450 1A2enzyme
DB00850PerphenazineCytochrome P450 2B6enzyme
DB00850PerphenazineCytochrome P450 2C18enzyme
DB00850PerphenazineCytochrome P450 2C19enzyme
DB00850PerphenazineCytochrome P450 2C8enzyme
DB00850PerphenazineCytochrome P450 2C9enzyme
DB00850PerphenazineCytochrome P450 3A4enzyme
DB01174PhenobarbitalGamma-aminobutyric acid receptor subunit alpha-1target
DB01174PhenobarbitalCytochrome P450 2C19enzyme
DB01174PhenobarbitalCytochrome P450 2C9enzyme
DB01174PhenobarbitalCytochrome P450 2B6enzyme
DB01174PhenobarbitalCytochrome P450 2C8enzyme
DB01174PhenobarbitalCytochrome P450 1A2enzyme
DB01174PhenobarbitalCytochrome P450 3A4enzyme
DB01174PhenobarbitalCanalicular multispecific organic anion transporter 2transporter
DB01174PhenobarbitalBile salt export pumptransporter
DB01174PhenobarbitalMultidrug resistance protein 1transporter
DB01174PhenobarbitalMultidrug resistance-associated protein 1transporter
DB01174PhenobarbitalSolute carrier organic anion transporter family member 2A1transporter
DB01174PhenobarbitalCanalicular multispecific organic anion transporter 1transporter
DB01174PhenobarbitalNeuronal acetylcholine receptor subunit alpha-4target
DB01174PhenobarbitalNeuronal acetylcholine receptor subunit alpha-7target
DB01174PhenobarbitalGlutamate receptor 2target
DB01174PhenobarbitalGlutamate receptor ionotropic, kainate 2target
DB01174PhenobarbitalCytochrome P450 2A6enzyme
DB01174PhenobarbitalCytochrome P450 2E1enzyme
DB01174PhenobarbitalCytochrome P450 3A5enzyme
DB01174PhenobarbitalCytochrome P450 4A11enzyme
DB01174PhenobarbitalCytochrome P450 1A1enzyme
DB01174PhenobarbitalCytochrome P450 1B1enzyme
DB01174PhenobarbitalCytochrome P450 2C18enzyme
DB01174PhenobarbitalCytochrome P450 3A7enzyme
DB01174PhenobarbitalCytochrome P450 4B1enzyme
DB01174PhenobarbitalNMDA receptortarget
DB01174PhenobarbitalNuclear receptor subfamily 1 group I member 2target
DB01174PhenobarbitalUDP-glucuronosyltransferase 1-1enzyme
DB01174PhenobarbitalUDP-glucuronosyltransferase 2B7enzyme
DB01323St. John's WortMultidrug resistance protein 1transporter
DB01323St. John's WortCytochrome P450 3A4enzyme
DB01323St. John's WortCytochrome P450 2D6enzyme
DB01323St. John's WortCytochrome P450 2C19enzyme
DB00656Trazodone5-hydroxytryptamine receptor 2Atarget
DB00656TrazodoneSodium-dependent serotonin transportertarget
DB00656TrazodoneAlpha-1A adrenergic receptortarget
DB00656TrazodoneAlpha-2A adrenergic receptortarget
DB00656TrazodoneHistamine H1 receptortarget
DB00656Trazodone5-hydroxytryptamine receptor 1Atarget
DB00656TrazodoneCytochrome P450 2D6enzyme
DB00656TrazodoneCytochrome P450 3A4enzyme
DB00656Trazodone5-hydroxytryptamine receptor 2Ctarget
DB00656TrazodoneAlpha-1-acid glycoprotein 1carrier
DB00656TrazodoneCytochrome P450 3A5enzyme
DB00656TrazodoneCytochrome P450 3A7enzyme
DB00656TrazodoneMultidrug resistance protein 1transporter
DrugDrug NamePhaseStatusCount
DB01050Ibuprofen0Recruiting1
DB03323Maltose0Completed1
DB12210AZD-62801Completed1
DB13994AZD-73251Completed1
DB00404Alprazolam1Completed2
DB14335Bergamot oil1Completed1
DB00898Ethanol1Completed1
DB12951Pivagabine1Completed1
DB00457Prazosin1Recruiting1
DB11664Psilocybine1Completed1
DB00633Dexmedetomidine1 / 2Completed1
DB00633Dexmedetomidine1 / 2Recruiting1
DB00996Gabapentin1 / 2Completed1
DB11196Inositol1 / 2Not Yet Recruiting1
DB01065Melatonin1 / 2Completed1
DB00490Buspirone2Completed1
DB00490Buspirone2Recruiting1
DB09061Cannabidiol2Not Yet Recruiting1
DB09061Cannabidiol2Recruiting1
DB01136Carvedilol2Withdrawn1
DB00575Clonidine2Unknown Status1
DB00260Cycloserine2Completed1
DB00590Doxazosin2Completed1
DB00470Dronabinol2Not Yet Recruiting1
DB13961Fish oil2Completed1
DB00557Hydroxyzine2Completed1
DB01221Ketamine2Terminated1
DB04465Lactose2Completed1
DB00281Lidocaine2Completed1
DB00186Lorazepam2Completed1
DB04829Lysergic acid diethylamide2Completed1
DB12583Maltodextrin2Withdrawn1
DB14009Medical Cannabis2Not Yet Recruiting1
DB00683Midazolam2Terminated1
DB01454Midomafetamine2Completed1
DB00107Oxytocin2Recruiting1
DB00230Pregabalin2Completed1
DB00571Propranolol2Unknown Status1
DB11664Psilocybine2Completed1
DB11664Psilocybine2Withdrawn1
DB01104Sertraline2Recruiting1
DB11599Starch, corn2Completed1
DB09034Suvorexant2Completed1
DB00624Testosterone2Completed1
DB00316Acetaminophen2 / 3Recruiting1
DB09061Cannabidiol2 / 3Recruiting1
DB00215Citalopram2 / 3Unknown Status1
DB00633Dexmedetomidine2 / 3Recruiting1
DB00470Dronabinol2 / 3Recruiting1
DB00683Midazolam2 / 3Recruiting1
DB01104Sertraline2 / 3Completed1
DB09128Brexpiprazole3Completed1
DB00476Duloxetine3Completed1
DB01175Escitalopram3Completed1
DB01175Escitalopram3Withdrawn1
DB01065Melatonin3Active Not Recruiting1
DB00683Midazolam3Completed1
DB00230Pregabalin3Completed1
DB01224Quetiapine3Completed2
DB01224Quetiapine3Unknown Status1
DB06660Saredutant3Completed1
DB01104Sertraline3Completed1
DB00285Venlafaxine3Completed1
DB00404Alprazolam4Completed2
DB00381Amlodipine4Not Yet Recruiting1
DB11376Azaperone4Completed1
DB00083Botulinum toxin type A4Terminated1
DB00201Caffeine4Completed1
DB00215Citalopram4Withdrawn1
DB00349Clobazam4Recruiting1
DB00575Clonidine4Active Not Recruiting1
DB00633Dexmedetomidine4Active Not Recruiting1
DB00633Dexmedetomidine4Recruiting1
DB00829Diazepam4Completed1
DB00668Epinephrine4Completed1
DB01175Escitalopram4Enrolling by Invitation1
DB01175Escitalopram4Withdrawn1
DB00402Eszopiclone4Completed1
DB00502Haloperidol4Completed1
DB00999Hydrochlorothiazide4Active Not Recruiting1
DB00741Hydrocortisone4Completed1
DB00557Hydroxyzine4Not Yet Recruiting1
DB01050Ibuprofen4Completed1
DB01221Ketamine4Recruiting1
DB01221Ketamine4Withdrawn1
DB00281Lidocaine4Completed1
DB00281Lidocaine4Withdrawn1
DB00186Lorazepam4Completed1
DB01065Melatonin4Completed1
DB00454Meperidine4Completed1
DB00683Midazolam4Active Not Recruiting1
DB00683Midazolam4Completed7
DB00683Midazolam4Recruiting1
DB00683Midazolam4Terminated1
DB00370Mirtazapine4Completed1
DB00295Morphine4Completed1
DB06690Nitrous oxide4Completed1
DB00497Oxycodone4Completed1
DB09140Oxygen4Not Yet Recruiting1
DB00230Pregabalin4Terminated1
DB00230Pregabalin4Unknown Status1
DB01224Quetiapine4Completed1
DB01104Sertraline4Terminated1
DB09153Sodium chloride4Completed3
DB12833Tandospirone4Not Yet Recruiting1
DB09085Tetracaine4Withdrawn1
DB06684Vilazodone4Withdrawn1
DB01198Zopiclone4Completed1
DB00659AcamprosateNot AvailableCompleted1
DB00802AlfentanilNot AvailableRecruiting1
DB00479AmikacinNot AvailableRecruiting1
DB00513Aminocaproic AcidNot AvailableRecruiting1
DB00559BosentanNot AvailableRecruiting1
DB00297BupivacaineNot AvailableCompleted1
DB00490BuspironeNot AvailableNot Yet Recruiting1
DB00490BuspironeNot AvailableRecruiting1
DB01413CefepimeNot AvailableRecruiting1
DB11121ChloroxylenolNot AvailableCompleted1
DB00369CidofovirNot AvailableRecruiting1
DB00537CiprofloxacinNot AvailableRecruiting1
DB00215CitalopramNot AvailableCompleted1
DB00575ClonidineNot AvailableCompleted1
DB00575ClonidineNot AvailableTerminated1
DB00363ClozapineNot AvailableRecruiting1
DB00633DexmedetomidineNot AvailableCompleted1
DB00476DuloxetineNot AvailableTerminated1
DB01175EscitalopramNot AvailableRecruiting3
DB01175EscitalopramNot AvailableUnknown Status1
DB00813FentanylNot AvailableNot Yet Recruiting1
DB00828FosfomycinNot AvailableRecruiting1
DB00502HaloperidolNot AvailableRecruiting1
DB00598LabetalolNot AvailableRecruiting1
DB00451LevothyroxineNot AvailableCompleted1
DB08815LurasidoneNot AvailableRecruiting1
DB14009Medical CannabisNot AvailableRecruiting2
DB00959MethylprednisoloneNot AvailableRecruiting1
DB00683MidazolamNot AvailableCompleted6
DB00683MidazolamNot AvailableNot Yet Recruiting1
DB00683MidazolamNot AvailableRecruiting1
DB00370MirtazapineNot AvailableCompleted1
DB01618MolindoneNot AvailableRecruiting1
DB00295MorphineNot AvailableWithdrawn1
DB00607NafcillinNot AvailableRecruiting1
DB01115NifedipineNot AvailableRecruiting1
DB06690Nitrous oxideNot AvailableNot Yet Recruiting1
DB00497OxycodoneNot AvailableRecruiting1
DB00312PentobarbitalNot AvailableRecruiting1
DB00413PramipexoleNot AvailableRecruiting1
DB00728RocuroniumNot AvailableRecruiting1
DB01104SertralineNot AvailableActive Not Recruiting1
DB01104SertralineNot AvailableRecruiting1
DB00658SevelamerNot AvailableRecruiting1
DB09153Sodium chlorideNot AvailableCompleted1
DB00421SpironolactoneNot AvailableRecruiting1
DB00624TestosteroneNot AvailableCompleted1
DB01420Testosterone propionateNot AvailableCompleted1
DB00684TobramycinNot AvailableRecruiting1
DB00302Tranexamic acidNot AvailableRecruiting1
DB00897TriazolamNot AvailableNot Yet Recruiting1
DB00512VancomycinNot AvailableRecruiting1
DB01273VareniclineNot AvailableActive Not Recruiting1
DB01339VecuroniumNot AvailableRecruiting1
DB00285VenlafaxineNot AvailableActive Not Recruiting1
DB00682WarfarinNot AvailableRecruiting1
DB00246ZiprasidoneNot AvailableRecruiting1
DB00425ZolpidemNot AvailableRecruiting1