Diabetes - DrugBank

Also known as: Diabetes / Diabetes mellitus / Diabetes mellitus (E08-E13) / Diabetes mellitus NOS

Drug	Drug Name	Drug Description
DB00641	Simvastatin	Simvastatin is a lipid-lowering agent that is derived synthetically from the fermentation of Aspergillus terreus. It is a potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (hydroxymethylglutaryl COA reductases), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL receptors, it increases breakdown of LDL cholesterol. [PubChem]

Drug	Drug Name	Target	Type
DB00641	Simvastatin	Cytochrome P450 3A4	enzyme
DB00641	Simvastatin	Cytochrome P450 3A5	enzyme
DB00641	Simvastatin	Cytochrome P450 3A7	enzyme
DB00641	Simvastatin	Cytochrome P450 2C8	enzyme
DB00641	Simvastatin	Cytochrome P450 2C9	enzyme
DB00641	Simvastatin	Cytochrome P450 2C19	enzyme
DB00641	Simvastatin	Cytochrome P450 2D6	enzyme
DB00641	Simvastatin	Cytochrome P450 2B6	enzyme
DB00641	Simvastatin	UDP-glucuronosyltransferase 1-1	enzyme
DB00641	Simvastatin	UDP-glucuronosyltransferase 1-3	enzyme
DB00641	Simvastatin	UDP-glucuronosyltransferase 2B7	enzyme
DB00641	Simvastatin	3-hydroxy-3-methylglutaryl-coenzyme A reductase	target
DB00641	Simvastatin	Integrin beta-2	target
DB00641	Simvastatin	Integrin alpha-L	target
DB00641	Simvastatin	Multidrug resistance protein 1	transporter
DB00641	Simvastatin	Solute carrier organic anion transporter family member 1A2	transporter
DB00641	Simvastatin	Solute carrier organic anion transporter family member 1B1	transporter
DB00641	Simvastatin	Canalicular multispecific organic anion transporter 1	transporter

Drug	Drug Name	Phase	Status	Count
DB00798	Gentamicin	0	Completed	1
DB00760	Meropenem	0	Completed	1
DB00512	Vancomycin	0	Completed	1
DB00316	Acetaminophen	1	Completed	1
DB00058	Alpha-1-proteinase inhibitor	1	Completed	1
DB01076	Atorvastatin	1	Completed	2
DB11773	BMS-903452	1	Completed	1
DB08907	Canagliflozin	1	Recruiting	1
DB00190	Carbidopa	1	Enrolling by Invitation	1
DB09050	Ceftolozane	1	Recruiting	1
DB06292	Dapagliflozin	1	Completed	1
DB00390	Digoxin	1	Completed	3
DB00402	Eszopiclone	1	Active Not Recruiting	1
DB00977	Ethinyl Estradiol	1	Completed	1
DB00695	Furosemide	1	Active Not Recruiting	1
DB00222	Glimepiride	1	Completed	1
DB00040	Glucagon recombinant	1	Completed	1
DB00400	Griseofulvin	1	Completed	1
DB01306	Insulin Aspart	1	Active Not Recruiting	1
DB01306	Insulin Aspart	1	Completed	33
DB01306	Insulin Aspart	1	Recruiting	1
DB09564	Insulin Degludec	1	Completed	35
DB09564	Insulin Degludec	1	Recruiting	1
DB09564	Insulin Degludec	1	Terminated	1
DB01307	Insulin Detemir	1	Completed	14
DB00047	Insulin Glargine	1	Completed	21
DB01309	Insulin Glulisine	1	Completed	2
DB00030	Insulin Human	1	Completed	6
DB00046	Insulin Lispro	1	Completed	1
DB00130	L-Glutamine	1	Completed	1
DB01235	Levodopa	1	Enrolling by Invitation	1
DB00367	Levonorgestrel	1	Completed	1
DB00451	Levothyroxine	1	Completed	1
DB06655	Liraglutide	1	Completed	31
DB00722	Lisinopril	1	Completed	2
DB00331	Metformin	1	Completed	9
DB00331	Metformin	1	Recruiting	1
DB00218	Moxifloxacin	1	Completed	2
DB00218	Moxifloxacin	1	Unknown Status	1
DB04899	Nesiritide	1	Active Not Recruiting	1
DB04224	Oleic Acid	1	Completed	1
DB00338	Omeprazole	1	Completed	1
DB01132	Pioglitazone	1	Completed	1
DB00912	Repaglinide	1	Completed	3
DB01098	Rosuvastatin	1	Active Not Recruiting	1
DB01098	Rosuvastatin	1	Completed	1
DB01098	Rosuvastatin	1	Recruiting	1
DB06335	Saxagliptin	1	Completed	1
DB09153	Sodium Chloride	1	Completed	1
DB01606	Tazobactam	1	Recruiting	1
DB09042	Tedizolid Phosphate	1	Recruiting	1
DB00682	Warfarin	1	Completed	2
DB12766	Cicletanine	1 / 2	Not Yet Recruiting	1
DB05408	Emricasan	1 / 2	Completed	1
DB01016	Glyburide	1 / 2	Completed	1
DB01378	Magnesium	1 / 2	Not Yet Recruiting	1
DB00834	Mifepristone	1 / 2	Recruiting	1
DB04876	Vildagliptin	1 / 2	Completed	1
DB00945	Acetylsalicylic acid	2	Completed	2
DB01217	Anastrozole	2	Completed	1
DB12000	Apabetalone	2	Completed	1
DB01076	Atorvastatin	2	Completed	1
DB00112	Bevacizumab	2	Recruiting	1
DB01136	Carvedilol	2	Recruiting	1
DB00169	Cholecalciferol	2	Recruiting	2
DB00766	Clavulanate	2	Completed	1
DB00575	Clonidine	2	Completed	1
DB00758	Clopidogrel	2	Completed	1
DB01234	Dexamethasone	2	Completed	1
DB01234	Dexamethasone	2	Recruiting	1
DB00222	Glimepiride	2	Completed	2
DB00999	Hydrochlorothiazide	2	Withdrawn	1
DB01306	Insulin Aspart	2	Completed	2
DB09564	Insulin Degludec	2	Completed	3
DB01307	Insulin Detemir	2	Completed	1
DB00047	Insulin Glargine	2	Completed	4
DB00030	Insulin Human	2	Completed	2
DB06655	Liraglutide	2	Completed	10
DB06655	Liraglutide	2	Recruiting	1
DB06655	Liraglutide	2	Terminated	1
DB12345	MBX-2982	2	Completed	1
DB00331	Metformin	2	Completed	6
DB01233	Metoclopramide	2	Completed	1
DB09046	Metreleptin	2	Unknown Status	2
DB01083	Orlistat	2	Recruiting	1
DB00082	Pegvisomant	2	Completed	1
DB00191	Phentermine	2	Completed	1
DB01132	Pioglitazone	2	Completed	1
DB06809	Plerixafor	2	Recruiting	1
DB00230	Pregabalin	2	Withdrawn	1
DB02709	Resveratrol	2	Completed	1
DB01261	Sitagliptin	2	Completed	1
DB09112	Sodium Nitrite	2	Active Not Recruiting	1
DB00421	Spironolactone	2	Recruiting	1
DB00624	Testosterone	2	Completed	1
DB00152	Thiamine	2	Completed	1
DB12003	Thymosin beta-4	2	Terminated	1
DB01607	Ticarcillin	2	Completed	1
DB00273	Topiramate	2	Completed	1
DB00437	Allopurinol	2 / 3	Completed	1
DB01238	Aripiprazole	2 / 3	Withdrawn	1
DB00796	Candesartan	2 / 3	Completed	1
DB06700	Desvenlafaxine	2 / 3	Terminated	1
DB00633	Dexmedetomidine	2 / 3	Completed	1
DB00331	Metformin	2 / 3	Completed	2
DB00331	Metformin	2 / 3	Unknown Status	1
DB00264	Metoprolol	2 / 3	Completed	1
DB00295	Morphine	2 / 3	Completed	1
DB04861	Nebivolol	2 / 3	Completed	1
DB00334	Olanzapine	2 / 3	Withdrawn	1
DB00178	Ramipril	2 / 3	Completed	1
DB00734	Risperidone	2 / 3	Withdrawn	1
DB01261	Sitagliptin	2 / 3	Completed	2
DB05399	Succinobucol	2 / 3	Unknown Status	1
DB00945	Acetylsalicylic acid	3	Not Yet Recruiting	1
DB09026	Aliskiren	3	Completed	1
DB06203	Alogliptin	3	Completed	1
DB05358	Azilsartan medoxomil	3	Terminated	1
DB08822	Azilsartan medoxomil	3	Terminated	1
DB00542	Benazepril	3	Completed	2
DB01164	Calcium Chloride	3	Completed	2
DB08907	Canagliflozin	3	Recruiting	1
DB00169	Cholecalciferol	3	Completed	1
DB06292	Dapagliflozin	3	Active Not Recruiting	2
DB06292	Dapagliflozin	3	Completed	1
DB00012	Darbepoetin alfa	3	Active Not Recruiting	1
DB09045	Dulaglutide	3	Active Not Recruiting	1
DB09045	Dulaglutide	3	Completed	1
DB00974	Edetic Acid	3	Recruiting	1
DB09038	Empagliflozin	3	Active Not Recruiting	1
DB00016	Erythropoietin	3	Unknown Status	1
DB01276	Exenatide	3	Completed	5
DB00222	Glimepiride	3	Active Not Recruiting	1
DB00222	Glimepiride	3	Completed	5
DB00222	Glimepiride	3	Terminated	4
DB01016	Glyburide	3	Active Not Recruiting	1
DB01016	Glyburide	3	Completed	2
DB01016	Glyburide	3	Terminated	1
DB00702	Icodextrin	3	Completed	2
DB01306	Insulin Aspart	3	Active Not Recruiting	3
DB01306	Insulin Aspart	3	Completed	40
DB01306	Insulin Aspart	3	Recruiting	2
DB01306	Insulin Aspart	3	Terminated	5
DB09564	Insulin Degludec	3	Active Not Recruiting	3
DB09564	Insulin Degludec	3	Completed	28
DB09564	Insulin Degludec	3	Recruiting	4
DB01307	Insulin Detemir	3	Completed	34
DB01307	Insulin Detemir	3	Recruiting	1
DB01307	Insulin Detemir	3	Terminated	2
DB00047	Insulin Glargine	3	Active Not Recruiting	2
DB00047	Insulin Glargine	3	Completed	31
DB00047	Insulin Glargine	3	Recruiting	2
DB00030	Insulin Human	3	Completed	4
DB00046	Insulin Lispro	3	Completed	2
DB04398	Lactic Acid	3	Completed	2
DB06655	Liraglutide	3	Active Not Recruiting	4
DB06655	Liraglutide	3	Completed	23
DB06655	Liraglutide	3	Recruiting	4
DB06655	Liraglutide	3	Terminated	1
DB09407	Magnesium chloride	3	Completed	2
DB01277	Mecasermin	3	Completed	1
DB01065	Melatonin	3	Completed	1
DB00331	Metformin	3	Active Not Recruiting	1
DB00331	Metformin	3	Completed	18
DB00331	Metformin	3	Recruiting	1
DB00331	Metformin	3	Terminated	3
DB09046	Metreleptin	3	Enrolling by Invitation	2
DB01252	Mitiglinide	3	Completed	1
DB11133	Omega-3 fatty acids	3	Terminated	1
DB09539	Omega-3-acid ethyl esters	3	Terminated	1
DB00082	Pegvisomant	3	Completed	1
DB00790	Perindopril	3	Completed	1
DB01132	Pioglitazone	3	Completed	4
DB01132	Pioglitazone	3	Terminated	1
DB01132	Pioglitazone	3	Unknown Status	1
DB00178	Ramipril	3	Completed	2
DB00912	Repaglinide	3	Completed	2
DB00412	Rosiglitazone	3	Completed	6
DB00412	Rosiglitazone	3	Terminated	3
DB06335	Saxagliptin	3	Active Not Recruiting	1
DB06335	Saxagliptin	3	Completed	4
DB00203	Sildenafil	3	Completed	1
DB01261	Sitagliptin	3	Active Not Recruiting	2
DB01261	Sitagliptin	3	Completed	5
DB01261	Sitagliptin	3	Not Yet Recruiting	1
DB09153	Sodium Chloride	3	Completed	2
DB00052	Somatotropin	3	Completed	1
DB00177	Valsartan	3	Completed	2
DB04876	Vildagliptin	3	Not Yet Recruiting	1
DB00284	Acarbose	4	Completed	1
DB00284	Acarbose	4	Unknown Status	1
DB09026	Aliskiren	4	Terminated	2
DB00381	Amlodipine	4	Completed	3
DB00381	Amlodipine	4	Terminated	1
DB00098	Antithymocyte immunoglobulin (rabbit)	4	Unknown Status	1
DB06605	Apixaban	4	Recruiting	1
DB01238	Aripiprazole	4	Completed	2
DB01076	Atorvastatin	4	Completed	1
DB00542	Benazepril	4	Completed	1
DB13100	Biguanide	4	Recruiting	1
DB01164	Calcium Chloride	4	Completed	1
DB01136	Carvedilol	4	Completed	1
DB00878	Chlorhexidine	4	Completed	1
DB00310	Chlorthalidone	4	Terminated	1
DB04540	Cholesterol	4	Completed	1
DB01432	Cholestyramine	4	Recruiting	1
DB00758	Clopidogrel	4	Not Yet Recruiting	1
DB00091	Cyclosporine	4	Unknown Status	1
DB06292	Dapagliflozin	4	Active Not Recruiting	2
DB06292	Dapagliflozin	4	Recruiting	1
DB00633	Dexmedetomidine	4	Not Yet Recruiting	1
DB00975	Dipyridamole	4	Completed	1
DB09075	Edoxaban	4	Recruiting	1
DB09038	Empagliflozin	4	Not Yet Recruiting	1
DB09038	Empagliflozin	4	Recruiting	1
DB00153	Ergocalciferol	4	Unknown Status	1
DB01175	Escitalopram	4	Completed	1
DB01276	Exenatide	4	Recruiting	1
DB01276	Exenatide	4	Unknown Status	1
DB00973	Ezetimibe	4	Completed	2
DB01039	Fenofibrate	4	Unknown Status	1
DB01120	Gliclazide	4	Completed	2
DB01120	Gliclazide	4	Recruiting	1
DB00222	Glimepiride	4	Completed	4
DB01251	Gliquidone	4	Completed	1
DB00040	Glucagon recombinant	4	Completed	1
DB01016	Glyburide	4	Completed	3
DB00702	Icodextrin	4	Completed	1
DB01306	Insulin Aspart	4	Completed	25
DB01306	Insulin Aspart	4	Recruiting	2
DB01306	Insulin Aspart	4	Terminated	2
DB01306	Insulin Aspart	4	Withdrawn	1
DB01307	Insulin Detemir	4	Completed	17
DB01307	Insulin Detemir	4	Recruiting	1
DB01307	Insulin Detemir	4	Terminated	3
DB00047	Insulin Glargine	4	Completed	13
DB00047	Insulin Glargine	4	Recruiting	1
DB00047	Insulin Glargine	4	Unknown Status	1
DB01309	Insulin Glulisine	4	Completed	1
DB00030	Insulin Human	4	Completed	8
DB00030	Insulin Human	4	Unknown Status	1
DB01029	Irbesartan	4	Active Not Recruiting	1
DB00134	L-Methionine	4	Not Yet Recruiting	1
DB04398	Lactic Acid	4	Completed	1
DB00451	Levothyroxine	4	Unknown Status	1
DB00281	Lidocaine	4	Completed	1
DB08882	Linagliptin	4	Not Yet Recruiting	1
DB08882	Linagliptin	4	Recruiting	1
DB06655	Liraglutide	4	Completed	5
DB06655	Liraglutide	4	Recruiting	2
DB09265	Lixisenatide	4	Completed	1
DB01046	Lubiprostone	4	Completed	1
DB09407	Magnesium chloride	4	Completed	1
DB12148	Menatetrenone	4	Completed	1
DB00331	Metformin	4	Active Not Recruiting	1
DB00331	Metformin	4	Completed	22
DB00331	Metformin	4	Recruiting	2
DB00331	Metformin	4	Terminated	1
DB00264	Metoprolol	4	Completed	1
DB00688	Mycophenolate mofetil	4	Unknown Status	1
DB01024	Mycophenolic acid	4	Unknown Status	1
DB00627	Niacin	4	Completed	1
DB00334	Olanzapine	4	Completed	4
DB06819	Phenylbutyric acid	4	Completed	1
DB01132	Pioglitazone	4	Completed	4
DB01132	Pioglitazone	4	Unknown Status	1
DB06809	Plerixafor	4	Completed	1
DB01278	Pramlintide	4	Completed	1
DB06209	Prasugrel	4	Not Yet Recruiting	1
DB00175	Pravastatin	4	Recruiting	1
DB00635	Prednisone	4	Unknown Status	1
DB00178	Ramipril	4	Active Not Recruiting	1
DB00178	Ramipril	4	Completed	1
DB00912	Repaglinide	4	Completed	10
DB00912	Repaglinide	4	Terminated	1
DB01045	Rifampicin	4	Not Yet Recruiting	1
DB00734	Risperidone	4	Completed	1
DB06228	Rivaroxaban	4	Recruiting	1
DB01098	Rosuvastatin	4	Completed	3
DB01098	Rosuvastatin	4	Recruiting	1
DB01098	Rosuvastatin	4	Withdrawn	1
DB01399	Salsalate	4	Completed	1
DB01104	Sertraline	4	Completed	1
DB01104	Sertraline	4	Unknown Status	1
DB00203	Sildenafil	4	Completed	1
DB00641	Simvastatin	4	Completed	1
DB01261	Sitagliptin	4	Completed	8
DB01261	Sitagliptin	4	Terminated	1
DB01261	Sitagliptin	4	Unknown Status	1
DB09153	Sodium Chloride	4	Completed	1
DB09484	Sodium monofluorophosphate	4	Completed	1
DB01079	Tegaserod	4	Terminated	1
DB00966	Telmisartan	4	Completed	1
DB00624	Testosterone	4	Completed	2
DB00624	Testosterone	4	Withdrawn	1
DB08816	Ticagrelor	4	Not Yet Recruiting	1
DB00519	Trandolapril	4	Completed	2
DB00177	Valsartan	4	Completed	2
DB00661	Verapamil	4	Completed	2
DB04876	Vildagliptin	4	Completed	3
DB00682	Warfarin	4	Recruiting	1
DB00246	Ziprasidone	4	Completed	1
DB06151	Acetylcysteine	Not Available	Completed	1
DB09026	Aliskiren	Not Available	Completed	1
DB00770	Alprostadil	Not Available	Recruiting	1
DB06288	Amisulpride	Not Available	Completed	1
DB01076	Atorvastatin	Not Available	Unknown Status	1
DB09061	Cannabidiol	Not Available	Unknown Status	1
DB01136	Carvedilol	Not Available	Completed	1
DB00930	Colesevelam	Not Available	Completed	1
DB00633	Dexmedetomidine	Not Available	Unknown Status	1
DB03756	Doconexent	Not Available	Completed	1
DB00470	Dronabinol	Not Available	Unknown Status	1
DB00476	Duloxetine	Not Available	Unknown Status	1
DB00153	Ergocalciferol	Not Available	Completed	1
DB01276	Exenatide	Not Available	Unknown Status	1
DB04854	Febuxostat	Not Available	Completed	1
DB01039	Fenofibrate	Not Available	Unknown Status	1
DB12412	Gemigliptin	Not Available	Recruiting	1
DB00222	Glimepiride	Not Available	Recruiting	1
DB00040	Glucagon recombinant	Not Available	Recruiting	2
DB01016	Glyburide	Not Available	Recruiting	1
DB00502	Haloperidol	Not Available	Completed	1
DB01306	Insulin Aspart	Not Available	Completed	23
DB01306	Insulin Aspart	Not Available	Withdrawn	1
DB09564	Insulin Degludec	Not Available	Active Not Recruiting	3
DB09564	Insulin Degludec	Not Available	Enrolling by Invitation	1
DB01307	Insulin Detemir	Not Available	Active Not Recruiting	2
DB01307	Insulin Detemir	Not Available	Completed	45
DB01307	Insulin Detemir	Not Available	Enrolling by Invitation	1
DB00047	Insulin Glargine	Not Available	Active Not Recruiting	1
DB00047	Insulin Glargine	Not Available	Completed	5
DB00030	Insulin Human	Not Available	Active Not Recruiting	1
DB00030	Insulin Human	Not Available	Completed	6
DB00030	Insulin Human	Not Available	Terminated	1
DB00046	Insulin Lispro	Not Available	Completed	1
DB08820	Ivacaftor	Not Available	Not Yet Recruiting	2
DB00160	L-Alanine	Not Available	Completed	1
DB00134	L-Methionine	Not Available	Completed	1
DB00281	Lidocaine	Not Available	Recruiting	1
DB00166	Lipoic Acid	Not Available	Completed	1
DB06655	Liraglutide	Not Available	Completed	10
DB06655	Liraglutide	Not Available	Enrolling by Invitation	1
DB06655	Liraglutide	Not Available	Unknown Status	1
DB09280	Lumacaftor	Not Available	Not Yet Recruiting	2
DB00331	Metformin	Not Available	Active Not Recruiting	1
DB00331	Metformin	Not Available	Completed	5
DB00331	Metformin	Not Available	Recruiting	2
DB00331	Metformin	Not Available	Terminated	1
DB00422	Methylphenidate	Not Available	Completed	1
DB00688	Mycophenolate mofetil	Not Available	Recruiting	1
DB00994	Neomycin	Not Available	Completed	1
DB00334	Olanzapine	Not Available	Completed	2
DB11133	Omega-3 fatty acids	Not Available	Active Not Recruiting	1
DB06819	Phenylbutyric acid	Not Available	Completed	1
DB01132	Pioglitazone	Not Available	Completed	3
DB01132	Pioglitazone	Not Available	Terminated	1
DB00881	Quinapril	Not Available	Completed	1
DB00912	Repaglinide	Not Available	Active Not Recruiting	1
DB00912	Repaglinide	Not Available	Completed	6
DB00912	Repaglinide	Not Available	Withdrawn	1
DB01220	Rifaximin	Not Available	Completed	1
DB00734	Risperidone	Not Available	Completed	1
DB01098	Rosuvastatin	Not Available	Completed	1
DB01399	Salsalate	Not Available	Completed	1
DB00641	Simvastatin	Not Available	Completed	1
DB01261	Sitagliptin	Not Available	Active Not Recruiting	1
DB01261	Sitagliptin	Not Available	Completed	1
DB09153	Sodium Chloride	Not Available	Completed	1
DB09099	Somatostatin	Not Available	Completed	1
DB09422	Soybean oil	Not Available	Completed	2
DB02772	Sucrose	Not Available	Unknown Status	1
DB00864	Tacrolimus	Not Available	Recruiting	1
DB08834	Tauroursodeoxycholic acid	Not Available	Completed	1
DB01273	Varenicline	Not Available	Completed	1