Knee Osteoarthritis (Knee OA)

Also known as: Osteoarthritis Of Knee / Osteoarthritis of the Knees / Osteoarthritis of the Knee / Osteoarthritis,Knee / Knee Osteoarthritis / Osteoarthritis, Knee / Osteoarthritis Knee / OA Knee / Osteo Arthritis Knee / Osteoarthritis (Knee) / Osteoarthritis; Knee / Osteo Arthritis of the Knee / Osteo Arthritis of the Knees / Osteoarthritis of knee, unspecified / Knee osteoarthritis NOS / Osteo arthritis knees / Osteoarthritis knees / O/A / OA / Osteoarthritis NOS / Degenerative joint disease / Osteoarthrosis, unspecified whether generalized or localized / Osteoarthrosis / Osteoarthritis

DrugDrug NameDrug Description
DB00586DiclofenacAn NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis.
DB00476DuloxetineA serotonin norepinephrine reuptake inhibitor used to treat generalized anxiety disorder, neuropathic pain, osteoarthritis, and stress incontinence.
DB09120ZucapsaicinA topical analgesic used as an adjunct to relieve severe pain of osteoarthritis of the knee in selected adult patients.
DrugDrug NameTargetType
DB00586DiclofenacProstaglandin G/H synthase 1target
DB00586DiclofenacProstaglandin G/H synthase 2target
DB00586DiclofenacTransthyretincarrier
DB00586DiclofenacCytochrome P450 2C9enzyme
DB00586DiclofenacCytochrome P450 2C19enzyme
DB00586DiclofenacCytochrome P450 1A2enzyme
DB00586DiclofenacCytochrome P450 2C8enzyme
DB00586DiclofenacSerum albumincarrier
DB00586DiclofenacMultidrug resistance-associated protein 4transporter
DB00586DiclofenacMultidrug resistance-associated protein 1transporter
DB00586DiclofenacSolute carrier family 22 member 6transporter
DB00586DiclofenacSolute carrier family 22 member 8transporter
DB00586DiclofenacSolute carrier organic anion transporter family member 1C1transporter
DB00586DiclofenacSolute carrier family 22 member 11transporter
DB00586DiclofenacUDP-glucuronosyltransferase 2B7enzyme
DB00586DiclofenacCytochrome P450 3A4enzyme
DB00586DiclofenacCytochrome P450 2B6enzyme
DB00586DiclofenacCytochrome P450 2C18enzyme
DB00586DiclofenacCytochrome P450 2E1enzyme
DB00586DiclofenacSolute carrier organic anion transporter family member 1B1transporter
DB00586DiclofenacBile salt export pumptransporter
DB00586DiclofenacUDP-glucuronosyltransferase 1-3enzyme
DB00586DiclofenacUDP-glucuronosyltransferase 1-9enzyme
DB00586DiclofenacUDP-glucuronosyltransferase 2B4enzyme
DB00586DiclofenacArachidonate 5-lipoxygenaseenzyme
DB00586DiclofenacSodium channel protein type 4 subunit alphatransporter
DB00586DiclofenacAcid-sensing ion channel 1transporter
DB00586DiclofenacPotassium voltage-gated channel subfamily KQT member 2transporter
DB00586DiclofenacPotassium voltage-gated channel subfamily KQT member 3transporter
DB00586DiclofenacPhospholipase A2, membrane associatedenzyme
DB00476DuloxetineSodium-dependent serotonin transportertarget
DB00476DuloxetineSodium-dependent dopamine transportertarget
DB00476DuloxetineSodium-dependent noradrenaline transportertarget
DB00476DuloxetineCytochrome P450 1A2enzyme
DB00476DuloxetineCytochrome P450 2D6enzyme
DB00476DuloxetineCytochrome P450 2C9enzyme
DB00476DuloxetineSerum albumincarrier
DB00476Duloxetinealpha1-acid glycoproteincarrier
DB00476DuloxetineP-glycoprotein 1transporter
DB09120ZucapsaicinTransient receptor potential cation channel subfamily V member 1target
DB09120ZucapsaicinCytochrome P450 1A2enzyme
DB09120ZucapsaicinCytochrome P450 2C19enzyme
DB09120ZucapsaicinCytochrome P450 2C9enzyme
DB09120ZucapsaicinCytochrome P450 2E1enzyme
DrugDrug NamePhaseStatusCount
DB08818Hyaluronic acid0Recruiting2
DB00281Lidocaine0Withdrawn1
DB00052Somatotropin0Recruiting1
DB00316Acetaminophen1Completed1
DB00026Anakinra1Recruiting1
DB00083Botulinum toxin type A1Completed1
DB06774Capsaicin1Completed2
DB14681Cortisone1Completed1
DB01234Dexamethasone1Completed1
DB11631Eptotermin Alfa1Completed1
DB12157Fasinumab1Recruiting1
DB01296Glucosamine1Unknown Status1
DB01050Ibuprofen1Completed1
DB01050Ibuprofen1Unknown Status1
DB12354Imrecoxib1Active Not Recruiting1
DB12354Imrecoxib1Recruiting1
DB12875Mavatrep1Completed1
DB00959Methylprednisolone1Completed1
DB00788Naproxen1Completed1
DB06515Resiniferatoxin1Recruiting1
DB12616Sprifermin1Completed1
DB00682Warfarin1Active Not Recruiting1
DB09120Zucapsaicin1Completed1
DB14940Aspartyl-alanyl-diketopiperazine1 / 2Completed1
DB00476Duloxetine1 / 2Active Not Recruiting1
DB12157Fasinumab1 / 2Completed1
DB00096Human Serum Albumin1 / 2Completed1
DB08818Hyaluronic acid1 / 2Completed2
DB08818Hyaluronic acid1 / 2Recruiting1
DB00281Lidocaine1 / 2Completed1
DB12335Tanezumab1 / 2Completed1
DB09085Tetracaine1 / 2Completed1
DB00661Verapamil1 / 2Terminated1
DB05050ADL58592Completed1
DB00051Adalimumab2Recruiting1
DB00513Aminocaproic acid2Completed1
DB01076Atorvastatin2Completed1
DB12239Balicatib2Completed1
DB00297Bupivacaine2Completed1
DB00482Celecoxib2Completed1
DB00482Celecoxib2Enrolling by Invitation1
DB00482Celecoxib2Not Yet Recruiting1
DB00482Celecoxib2Terminated1
DB00482Celecoxib2Unknown Status1
DB01234Dexamethasone2Recruiting1
DB00586Diclofenac2Completed3
DB00586Diclofenac2Enrolling by Invitation1
DB00586Diclofenac2Recruiting1
DB11938Difelikefalin2Completed1
DB00975Dipyridamole2Terminated1
DB00476Duloxetine2Not Yet Recruiting1
DB00668Epinephrine2Completed1
DB11631Eptotermin Alfa2Completed1
DB01628Etoricoxib2Completed1
DB12157Fasinumab2Enrolling by Invitation1
DB12157Fasinumab2Recruiting1
DB12102Fulranumab2Terminated2
DB11769Funapide2Completed1
DB11903GW8421662Completed1
DB14042Galcanezumab2Terminated1
DB15097Gefapixant2Completed1
DB08818Hyaluronic acid2Active Not Recruiting2
DB08818Hyaluronic acid2Completed2
DB08818Hyaluronic acid2Recruiting2
DB01611Hydroxychloroquine2Completed1
DB01050Ibuprofen2Recruiting1
DB01009Ketoprofen2Completed5
DB00465Ketorolac2Completed1
DB00281Lidocaine2Completed2
DB14883Lorecivivint2Completed1
DB14883Lorecivivint2Recruiting2
DB14146Loxicodegol2Completed1
DB14009Medical Cannabis2Recruiting1
DB00814Meloxicam2Completed1
DB14158Microcrystalline cellulose2Unknown Status2
DB00295Morphine2Completed1
DB00788Naproxen2Completed6
DB00788Naproxen2Enrolling by Invitation1
DB00788Naproxen2Terminated1
DB11620Neridronic Acid2Unknown Status1
DB00497Oxycodone2Completed2
DB00497Oxycodone2Terminated1
DB12012PF-044578452Completed1
DB11645PF-41918342Terminated1
DB05495PG-5307422Completed1
DB05511Piclidenoson2Withdrawn1
DB00554Piroxicam2Completed1
DB12399Polmacoxib2Unknown Status1
DB00860Prednisolone2Terminated1
DB09153Sodium chloride2Completed1
DB12616Sprifermin2Active Not Recruiting1
DB11644Tafamidis2Completed6
DB09511Talc2Unknown Status1
DB12335Tanezumab2Terminated1
DB06204Tapentadol2Completed1
DB06285Teriparatide2Active Not Recruiting1
DB06285Teriparatide2Completed1
DB00193Tramadol2Not Yet Recruiting1
DB00302Tranexamic acid2Completed3
DB00302Tranexamic acid2Recruiting1
DB00620Triamcinolone2Completed6
DB00580Valdecoxib2Completed1
DB00297Bupivacaine2 / 3Recruiting1
DB00297Bupivacaine2 / 3Withdrawn1
DB01394Colchicine2 / 3Completed1
DB09341Dextrose, unspecified form2 / 3Completed1
DB12157Fasinumab2 / 3Completed1
DB08818Hyaluronic acid2 / 3Completed2
DB08818Hyaluronic acid2 / 3Enrolling by Invitation1
DB08818Hyaluronic acid2 / 3Unknown Status1
DB00742Mannitol2 / 3Completed1
DB00961Mepivacaine2 / 3Recruiting1
DB00107Oxytocin2 / 3Recruiting1
DB01638Sorbitol2 / 3Completed1
DB00316Acetaminophen3Completed4
DB14940Aspartyl-alanyl-diketopiperazine3Completed5
DB00297Bupivacaine3Recruiting1
DB00921Buprenorphine3Completed1
DB09061Cannabidiol3Not Yet Recruiting1
DB06774Capsaicin3Active Not Recruiting3
DB00482Celecoxib3Active Not Recruiting1
DB00482Celecoxib3Completed7
DB09301Chondroitin sulfate3Completed5
DB09301Chondroitin sulfate3Not Yet Recruiting1
DB09301Chondroitin sulfate3Unknown Status2
DB00318Codeine3Completed1
DB11874Crocin3Active Not Recruiting1
DB01234Dexamethasone3Not Yet Recruiting1
DB11994Diacerein3Active Not Recruiting1
DB00586Diclofenac3Completed7
DB00586Diclofenac3Recruiting1
DB00476Duloxetine3Completed2
DB01628Etoricoxib3Completed1
DB12157Fasinumab3Active Not Recruiting2
DB12009GW-4063813Completed1
DB01296Glucosamine3Completed4
DB01296Glucosamine3Not Yet Recruiting1
DB01296Glucosamine3Unknown Status2
DB05381Histamine3Completed1
DB00062Human Serum Albumin3Completed1
DB08818Hyaluronic acid3Completed4
DB08818Hyaluronic acid3Terminated1
DB00327Hydromorphone3Completed3
DB01009Ketoprofen3Completed4
DB00825Levomenthol3Withdrawn1
DB14883Lorecivivint3Recruiting1
DB01283Lumiracoxib3Completed2
DB00814Meloxicam3Not Yet Recruiting1
DB00788Naproxen3Active Not Recruiting1
DB00788Naproxen3Completed2
DB00497Oxycodone3Completed4
DB06515Resiniferatoxin3Not Yet Recruiting1
DB02709Resveratrol3Recruiting1
DB06228Rivaroxaban3Completed1
DB00533Rofecoxib3Completed1
DB14546Sulfate ion3Completed1
DB11644Tafamidis3Active Not Recruiting1
DB11644Tafamidis3Completed2
DB12335Tanezumab3Completed3
DB06204Tapentadol3Completed3
DB00193Tramadol3Completed4
DB00620Triamcinolone3Active Not Recruiting1
DB00620Triamcinolone3Completed4
DB11094Vitamin D3Completed1
DB09120Zucapsaicin3Completed2
DB06736Aceclofenac4Completed1
DB00316Acetaminophen4Completed1
DB00316Acetaminophen4Recruiting1
DB00443Betamethasone4Recruiting1
DB00083Botulinum toxin type A4Recruiting1
DB00297Bupivacaine4Active Not Recruiting1
DB00297Bupivacaine4Completed2
DB00297Bupivacaine4Recruiting2
DB00297Bupivacaine4Suspended1
DB00297Bupivacaine4Withdrawn2
DB06774Capsaicin4Completed2
DB01112Cefuroxime4Completed1
DB00482Celecoxib4Completed8
DB00482Celecoxib4Recruiting1
DB00482Celecoxib4Terminated1
DB00482Celecoxib4Unknown Status1
DB00608Chloroquine4Completed1
DB00356Chlorzoxazone4Completed1
DB09301Chondroitin sulfate4Completed2
DB09301Chondroitin sulfate4Unknown Status1
DB00575Clonidine4Enrolling by Invitation1
DB00575Clonidine4Withdrawn1
DB01394Colchicine4Not Yet Recruiting1
DB01234Dexamethasone4Completed2
DB01234Dexamethasone4Recruiting3
DB11994Diacerein4Completed2
DB11994Diacerein4Recruiting1
DB00586Diclofenac4Completed2
DB00476Duloxetine4Not Yet Recruiting2
DB01225Enoxaparin4Not Yet Recruiting1
DB00668Epinephrine4Completed3
DB00668Epinephrine4Enrolling by Invitation1
DB00668Epinephrine4Withdrawn2
DB00813Fentanyl4Completed3
DB08917Ferric carboxymaltose4Completed1
DB08917Ferric carboxymaltose4Not Yet Recruiting2
DB14501Ferrous glycine sulfate4Completed1
DB00996Gabapentin4Completed1
DB11242Gelatin4Not Yet Recruiting2
DB01296Glucosamine4Completed4
DB01109Heparin4Not Yet Recruiting1
DB08818Hyaluronic acid4Active Not Recruiting1
DB08818Hyaluronic acid4Completed4
DB08818Hyaluronic acid4Not Yet Recruiting1
DB08818Hyaluronic acid4Recruiting4
DB08818Hyaluronic acid4Unknown Status2
DB00741Hydrocortisone4Recruiting1
DB01050Ibuprofen4Completed4
DB12354Imrecoxib4Unknown Status1
DB00065Infliximab4Completed1
DB01592Iron4Completed1
DB00465Ketorolac4Completed2
DB00465Ketorolac4Enrolling by Invitation1
DB00465Ketorolac4Recruiting1
DB00465Ketorolac4Withdrawn1
DB00825Levomenthol4Terminated1
DB00281Lidocaine4Completed1
DB00281Lidocaine4Terminated1
DB06655Liraglutide4Completed1
DB00959Methylprednisolone4Completed2
DB14644Methylprednisolone hemisuccinate4Completed1
DB04896Milnacipran4Completed1
DB00295Morphine4Completed2
DB00295Morphine4Withdrawn1
DB00461Nabumetone4Unknown Status1
DB00788Naproxen4Completed1
DB04743Nimesulide4Completed1
DB12150Pelubiprofen4Completed1
DB00860Prednisolone4Completed1
DB00230Pregabalin4Recruiting1
DB09290Ramosetron4Completed1
DB06228Rivaroxaban4Completed1
DB06228Rivaroxaban4Not Yet Recruiting2
DB00296Ropivacaine4Active Not Recruiting2
DB00296Ropivacaine4Completed2
DB00296Ropivacaine4Enrolling by Invitation1
DB00296Ropivacaine4Not Yet Recruiting1
DB00296Ropivacaine4Withdrawn1
DB09153Sodium chloride4Completed1
DB09153Sodium chloride4Enrolling by Invitation1
DB09153Sodium chloride4Not Yet Recruiting1
DB00421Spironolactone4Completed1
DB11644Tafamidis4Recruiting1
DB06204Tapentadol4Recruiting1
DB11300Thrombin4Not Yet Recruiting2
DB00302Tranexamic acid4Active Not Recruiting1
DB00302Tranexamic acid4Completed1
DB00302Tranexamic acid4Not Yet Recruiting3
DB00302Tranexamic acid4Recruiting1
DB00302Tranexamic acid4Unknown Status1
DB00752Tranylcypromine4Completed1
DB00752Tranylcypromine4Not Yet Recruiting3
DB00620Triamcinolone4Completed2
DB00620Triamcinolone4Not Yet Recruiting1
DB00620Triamcinolone4Recruiting3
DB01593Zinc4Completed1
DB00316AcetaminophenNot AvailableCompleted8
DB00945Acetylsalicylic acidNot AvailableCompleted1
DB00297BupivacaineNot AvailableActive Not Recruiting1
DB00297BupivacaineNot AvailableCompleted3
DB00921BuprenorphineNot AvailableNot Yet Recruiting1
DB06774CapsaicinNot AvailableCompleted1
DB00482CelecoxibNot AvailableCompleted1
DB00482CelecoxibNot AvailableRecruiting1
DB00482CelecoxibNot AvailableTerminated1
DB00575ClonidineNot AvailableCompleted2
DB14681CortisoneNot AvailableCompleted1
DB09213DexibuprofenNot AvailableCompleted1
DB09214DexketoprofenNot AvailableCompleted1
DB09341Dextrose, unspecified formNot AvailableCompleted1
DB00586DiclofenacNot AvailableCompleted2
DB00586DiclofenacNot AvailableRecruiting1
DB00476DuloxetineNot AvailableNot Yet Recruiting1
DB00668EpinephrineNot AvailableCompleted2
DB00736EsomeprazoleNot AvailableCompleted1
DB00005EtanerceptNot AvailableRecruiting2
DB00749EtodolacNot AvailableCompleted1
DB01628EtoricoxibNot AvailableCompleted1
DB00813FentanylNot AvailableCompleted1
DB09222Fibrinogen HumanNot AvailableCompleted1
DB00996GabapentinNot AvailableCompleted1
DB01296GlucosamineNot AvailableCompleted1
DB01296GlucosamineNot AvailableNot Yet Recruiting1
DB11571Human ThrombinNot AvailableCompleted1
DB08818Hyaluronic acidNot AvailableActive Not Recruiting1
DB08818Hyaluronic acidNot AvailableCompleted2
DB08818Hyaluronic acidNot AvailableNot Yet Recruiting1
DB08818Hyaluronic acidNot AvailableRecruiting5
DB08818Hyaluronic acidNot AvailableWithdrawn1
DB01050IbuprofenNot AvailableCompleted5
DB00328IndomethacinNot AvailableCompleted1
DB00753IsofluraneNot AvailableCompleted1
DB01221KetamineNot AvailableActive Not Recruiting1
DB01221KetamineNot AvailableUnknown Status1
DB00465KetorolacNot AvailableCompleted3
DB01002LevobupivacaineNot AvailableCompleted1
DB00281LidocaineNot AvailableActive Not Recruiting1
DB00281LidocaineNot AvailableCompleted2
DB06725LornoxicamNot AvailableCompleted1
DB00814MeloxicamNot AvailableCompleted3
DB00660MetaxaloneNot AvailableCompleted1
DB00563MethotrexateNot AvailableNot Yet Recruiting1
DB00959MethylprednisoloneNot AvailableUnknown Status1
DB00295MorphineNot AvailableCompleted1
DB00461NabumetoneNot AvailableCompleted1
DB00788NaproxenNot AvailableCompleted1
DB00788NaproxenNot AvailableUnknown Status1
DB00497OxycodoneNot AvailableActive Not Recruiting1
DB00497OxycodoneNot AvailableCompleted1
DB00213PantoprazoleNot AvailableCompleted2
DB03255PhenolNot AvailableRecruiting1
DB00818PropofolNot AvailableCompleted1
DB00296RopivacaineNot AvailableActive Not Recruiting1
DB00296RopivacaineNot AvailableCompleted3
DB00296RopivacaineNot AvailableNot Yet Recruiting1
DB00296RopivacaineNot AvailableRecruiting1
DB00296RopivacaineNot AvailableUnknown Status2
DB09153Sodium chlorideNot AvailableCompleted1
DB09153Sodium chlorideNot AvailableRecruiting1
DB09267Strontium ranelateNot AvailableRecruiting1
DB00469TenoxicamNot AvailableCompleted1
DB01600Tiaprofenic acidNot AvailableCompleted1
DB00193TramadolNot AvailableCompleted1
DB00302Tranexamic acidNot AvailableCompleted3
DB00302Tranexamic acidNot AvailableNot Yet Recruiting1
DB00620TriamcinoloneNot AvailableCompleted1
DB00620TriamcinoloneNot AvailableRecruiting1