Hepatitis B Chronic Infection

Also known as: Hepatitis B, Chronic / Chronic Hepatitis B Infection / Chronic Hepatitis B / HEPATITIS B CHRONIC / Hepatitis B,Chronic / Chronic (viral) hepatitis B / Chronic viral hepatitis B

DrugDrug NameDrug Description
DB00718Adefovir dipivoxilAdefovir dipivoxil, previously called bis-POM PMEA, with trade names Preveon and Hepsera, is an orally-administered acyclic nucleotide analog reverse transcriptase inhibitor (ntRTI) used for treatment of hepatitis B. It is ineffective against HIV-1. Adefovir dipivoxil is the diester prodrug of adefovir.
DB00442EntecavirEntecavir is an oral antiviral drug used in the treatment of hepatitis B infection. It is marketed under the trade name Baraclude (BMS). Entecavir is a guanine analogue that inhibits all three steps in the viral replication process, and the manufacturer claims that it is more efficacious than previous agents used to treat hepatitis B (lamivudine and adefovir). It was approved by the U.S. Food and Drug Administration (FDA) in March 2005.
DB00709LamivudineA reverse transcriptase inhibitor and zalcitabine analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to treat Human Immunodeficiency Virus Type 1 (HIV-1) and hepatitis B (HBV).
DB00008Peginterferon alfa-2aPeginterferon alfa-2a is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in the United States, and affecting 72% of all chronic HCV patients [L852]. Treatment options for chronic Hepatitis C have advanced significantly since 2011, with the development of Direct Acting Antivirals (DAAs) resulting in less use of Peginterferon alfa-2a. Peginterferon alfa-2a is derived from the alfa-2a moeity of recombinant human interferon and acts by binding to human type 1 interferon receptors. Activation and dimerization of this receptor induces the body's innate antiviral response by activating the janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway. Use of Peginterferon alfa-2a is associated with a wide range of severe adverse effects including the aggravation and development of endocrine and autoimmune disorders, retinopathies, cardiovascular and neuropsychiatric complications, and increased risk of hepatic decompensation in patients with cirrhosis. The use of Peginterferon alfa-2a has largely declined since newer interferon-free antiviral therapies have been developed. In a joint recommendation published in 2016, the American Association for the Study of Liver Diseases (AASLD) and the Infectious Diseases Society of America (IDSA) no longer recommend Peginterferon alfa-2a for the treatment of Hepatitis C [A19593]. Peginterferon alfa-2a was used alongside [DB00811] with the intent to cure, or achieve a sustained virologic response (SVR), after 48 weeks of therapy. SVR and eradication of HCV infection is associated with significant long-term health benefits including reduced liver-related damage, improved quality of life, reduced incidence of Hepatocellular Carcinoma, and reduced all-cause mortality [A19626]. Peginterferon alfa-2a is available as a fixed dose injector (tradename Pegasys) used for the treatment of chronic Hepatitis C. Approved in 2002 by the FDA, Pegasys is indicated for the treatment of HCV with [DB00811] or other antiviral drugs [FDA Label]. When combined together, Peginterferon alfa-2a and [DB00811] have been shown to achieve a SVR between 36% for genotype 1 and 59% for genotypes 2-6 after 48 weeks of treatment.
DB01265TelbivudineTelbivudine is a synthetic thymidine nucleoside analog with specific activity against the hepatitis B virus. Telbivudine is orally administered, with good tolerance, lack of toxicity and no dose-limiting side effects.
DB09299Tenofovir alafenamideTenofovir alafenamide is a novel [tenofovir] prodrug developed in order to improve renal safety when compared to the counterpart [tenofovir disoproxil].[A178060] Both of these prodrugs were first created to cover the polar phosphonic acid group on tenofovir by using a novel oxycarbonyloxymethyl linkers to improve the oral bioavailability and intestinal diffusion.[T239] Tenofovir alafenamide is an alanine ester form characterized for presenting low systemic levels but high intracellular concentration.[A178219] It has been reported to produce a large antiviral efficacy at doses ten times lower than tenofovir disoproxil.[A178327] The first approved product including tenofovir alafenamide was developed by Gilead Sciences Inc and FDA approved on 2015.[L6271]
DB00300Tenofovir disoproxilTenofovir disoproxil fumarate (a prodrug of tenofovir), marketed by Gilead Sciences under the trade name _Viread_, belongs to a class of antiretroviral drugs known as nucleotide analogue reverse transcriptase inhibitors (nRTIs). This drug is prescribed in combination with other drugs in the management of HIV infection as well as in Hepatitis B therapy. Tenofovir disoproxil was initially approved in 2001 [FDA label].
DrugDrug NameTargetType
DB00718Adefovir dipivoxilDNA polymerase/reverse transcriptasetarget
DB00718Adefovir dipivoxilSolute carrier family 22 member 6transporter
DB00718Adefovir dipivoxilMultidrug resistance-associated protein 4transporter
DB00718Adefovir dipivoxilMultidrug resistance-associated protein 5transporter
DB00718Adefovir dipivoxilSolute carrier family 22 member 3transporter
DB00718Adefovir dipivoxilAdenylate kinase 2, mitochondrialenzyme
DB00718Adefovir dipivoxilAdenylate kinase 4, mitochondrialenzyme
DB00718Adefovir dipivoxilNucleoside diphosphate kinase Aenzyme
DB00718Adefovir dipivoxilNucleoside diphosphate kinase Benzyme
DB00442EntecavirDNAtarget
DB00709LamivudineDNAtarget
DB00709LamivudineProtein Ptarget
DB00709LamivudineMultidrug resistance-associated protein 1transporter
DB00709LamivudineSolute carrier family 22 member 6transporter
DB00709LamivudineATP-binding cassette sub-family G member 2transporter
DB00709LamivudineReverse transcriptase/RNaseHtarget
DB00709LamivudineSolute carrier family 22 member 1transporter
DB00709LamivudineSolute carrier family 22 member 2transporter
DB00709LamivudineSolute carrier family 22 member 3transporter
DB00709LamivudineDeoxycytidine kinaseenzyme
DB00709LamivudineUMP-CMP kinaseenzyme
DB00709LamivudinePhosphoglycerate kinase 1enzyme
DB00709LamivudineNucleoside diphosphate kinase Aenzyme
DB00709LamivudineNucleoside diphosphate kinase Benzyme
DB00709LamivudineCholine-phosphate cytidylyltransferase Aenzyme
DB00709LamivudineEthanolamine-phosphate cytidylyltransferaseenzyme
DB00709LamivudineMultidrug resistance protein 1transporter
DB00709LamivudineMultidrug resistance-associated protein 4transporter
DB00709LamivudineCanalicular multispecific organic anion transporter 2transporter
DB00709LamivudineCanalicular multispecific organic anion transporter 1transporter
DB00709Lamivudine5'(3')-deoxyribonucleotidase, cytosolic typeenzyme
DB00709LamivudineSerum albumincarrier
DB00008Peginterferon alfa-2aInterferon alpha/beta receptor 2target
DB00008Peginterferon alfa-2aInterferon alpha/beta receptor 1target
DB00008Peginterferon alfa-2aCytochrome P450 1A2enzyme
DB01265TelbivudineProtein Ptarget
DB01265TelbivudineDNAtarget
DB09299Tenofovir alafenamideReverse transcriptase/RNaseHtarget
DB09299Tenofovir alafenamideMultidrug resistance protein 1transporter
DB09299Tenofovir alafenamideMultidrug resistance-associated protein 4transporter
DB09299Tenofovir alafenamideSolute carrier family 22 member 6transporter
DB09299Tenofovir alafenamideSolute carrier family 22 member 8transporter
DB09299Tenofovir alafenamideLysosomal protective proteinenzyme
DB09299Tenofovir alafenamideLiver carboxylesterase 1enzyme
DB09299Tenofovir alafenamideATP-binding cassette sub-family G member 2transporter
DB09299Tenofovir alafenamideSolute carrier organic anion transporter family member 1B1transporter
DB09299Tenofovir alafenamideSolute carrier organic anion transporter family member 1B3transporter
DB09299Tenofovir alafenamideReverse transcriptasetarget
DB09299Tenofovir alafenamideDNA polymerasetarget
DB09299Tenofovir alafenamideSerum albumincarrier
DB09299Tenofovir alafenamideCytochrome P450 3A4enzyme
DB09299Tenofovir alafenamideAdenylate kinase isoenzyme 1enzyme
DB09299Tenofovir alafenamideAdenylate kinase 2, mitochondrialenzyme
DB09299Tenofovir alafenamideNucleoside diphosphate kinase Aenzyme
DB09299Tenofovir alafenamideNucleoside diphosphate kinase Benzyme
DB00300Tenofovir disoproxilReverse transcriptase/RNaseHtarget
DB00300Tenofovir disoproxilSolute carrier family 22 member 6transporter
DB00300Tenofovir disoproxilSolute carrier family 22 member 8transporter
DB00300Tenofovir disoproxilMultidrug resistance-associated protein 7transporter
DB00300Tenofovir disoproxilMultidrug resistance-associated protein 4transporter
DB00300Tenofovir disoproxilCanalicular multispecific organic anion transporter 1transporter
DB00300Tenofovir disoproxilAdenylate kinase 2, mitochondrialenzyme
DB00300Tenofovir disoproxilAdenylate kinase 4, mitochondrialenzyme
DB00300Tenofovir disoproxilMultidrug resistance protein 1transporter
DB00300Tenofovir disoproxilNucleoside diphosphokinaseenzyme
DB00300Tenofovir disoproxilCreatine Kinasesenzyme
DB00300Tenofovir disoproxilDNA polymerase/reverse transcriptasetarget
DrugDrug NamePhaseStatusCount
DB00718Adefovir dipivoxil1Completed2
DB00442Entecavir1Completed4
DB00442Entecavir1Recruiting1
DB00442Entecavir1Terminated1
DB11627Hepatitis B Vaccine (Recombinant)1Unknown Status1
DB00709Lamivudine1Completed1
DB00683Midazolam1Recruiting1
DB00008Peginterferon alfa-2a1Completed6
DB00503Ritonavir1Recruiting1
DB01265Telbivudine1Completed1
DB09299Tenofovir alafenamide1Completed1
DB00300Tenofovir disoproxil1Completed4
DB00300Tenofovir disoproxil1Terminated1
DB05020ANA3801 / 2Completed1
DB05396Albinterferon Alfa-2B1 / 2Terminated1
DB11121Chloroxylenol1 / 2Completed1
DB11121Chloroxylenol1 / 2Unknown Status1
DB09110Coenzyme M1 / 2Completed1
DB00442Entecavir1 / 2Completed3
DB00442Entecavir1 / 2Not Yet Recruiting1
DB00442Entecavir1 / 2Unknown Status1
DB12232KRN-70001 / 2Completed1
DB14853Myrcludex B1 / 2Completed1
DB00008Peginterferon alfa-2a1 / 2Completed3
DB00008Peginterferon alfa-2a1 / 2Not Yet Recruiting1
DB00008Peginterferon alfa-2a1 / 2Terminated1
DB00008Peginterferon alfa-2a1 / 2Unknown Status1
DB01265Telbivudine1 / 2Completed1
DB01265Telbivudine1 / 2Not Yet Recruiting1
DB14126Tenofovir1 / 2Completed1
DB00300Tenofovir disoproxil1 / 2Completed1
DB04900Thymalfasin1 / 2Completed1
DB05020ANA3802Completed1
DB05020ANA3802Unknown Status1
DB00718Adefovir dipivoxil2Completed1
DB01114Chlorphenamine2Terminated1
DB01075Diphenhydramine2Terminated1
DB06236Elvucitabine2Terminated1
DB00879Emtricitabine2Completed4
DB00442Entecavir2Active Not Recruiting2
DB00442Entecavir2Completed9
DB00442Entecavir2Enrolling by Invitation1
DB00442Entecavir2Recruiting1
DB00442Entecavir2Terminated2
DB00442Entecavir2Unknown Status1
DB05276Hepatitis B Immune Globulin2Completed1
DB05276Hepatitis B Immune Globulin2Recruiting1
DB06299Hydronidone2Recruiting1
DB15062Inarigivir2Recruiting1
DB15063Inarigivir soproxil2Recruiting2
DB00709Lamivudine2Completed3
DB00422Methylphenidate2Recruiting1
DB00507Nitazoxanide2Not Yet Recruiting1
DB00008Peginterferon alfa-2a2Active Not Recruiting1
DB00008Peginterferon alfa-2a2Completed5
DB00008Peginterferon alfa-2a2Withdrawn1
DB00022Peginterferon alfa-2b2Completed1
DB05478Pradefovir Mesylate2Completed1
DB05478Pradefovir Mesylate2Terminated1
DB00503Ritonavir2Recruiting1
DB00020Sargramostim2Completed1
DB01265Telbivudine2Completed1
DB14126Tenofovir2Enrolling by Invitation1
DB09299Tenofovir alafenamide2Active Not Recruiting3
DB09299Tenofovir alafenamide2Recruiting3
DB00300Tenofovir disoproxil2Active Not Recruiting1
DB00300Tenofovir disoproxil2Completed10
DB00300Tenofovir disoproxil2Terminated1
DB12687Vesatolimod2Completed2
DB00718Adefovir dipivoxil3Approved for Marketing1
DB00718Adefovir dipivoxil3Completed10
DB00718Adefovir dipivoxil3Unknown Status1
DB06683Clevudine3Completed1
DB00879Emtricitabine3Completed2
DB00442Entecavir3Active Not Recruiting1
DB00442Entecavir3Completed9
DB00442Entecavir3Recruiting1
DB00442Entecavir3Terminated2
DB00442Entecavir3Unknown Status1
DB05276Hepatitis B Immune Globulin3Withdrawn1
DB09053Ibrutinib3Recruiting1
DB00709Lamivudine3Active Not Recruiting1
DB00709Lamivudine3Completed8
DB00008Peginterferon alfa-2a3Active Not Recruiting2
DB00008Peginterferon alfa-2a3Completed5
DB00008Peginterferon alfa-2a3Terminated2
DB00008Peginterferon alfa-2a3Unknown Status2
DB00022Peginterferon alfa-2b3Completed1
DB00022Peginterferon alfa-2b3Recruiting1
DB00022Peginterferon alfa-2b3Terminated1
DB00022Peginterferon alfa-2b3Unknown Status1
DB00811Ribavirin3Not Yet Recruiting1
DB01265Telbivudine3Completed8
DB01265Telbivudine3Unknown Status1
DB14126Tenofovir3Not Yet Recruiting1
DB09299Tenofovir alafenamide3Active Not Recruiting1
DB00300Tenofovir disoproxil3Active Not Recruiting3
DB00300Tenofovir disoproxil3Completed6
DB00300Tenofovir disoproxil3Enrolling by Invitation1
DB00300Tenofovir disoproxil3Recruiting2
DB00300Tenofovir disoproxil3Terminated2
DB00718Adefovir dipivoxil4Active Not Recruiting3
DB00718Adefovir dipivoxil4Completed14
DB00718Adefovir dipivoxil4Recruiting2
DB00718Adefovir dipivoxil4Terminated2
DB00718Adefovir dipivoxil4Unknown Status5
DB00718Adefovir dipivoxil4Withdrawn3
DB11121Chloroxylenol4Recruiting1
DB06683Clevudine4Completed3
DB06683Clevudine4Terminated4
DB00879Emtricitabine4Not Yet Recruiting2
DB00879Emtricitabine4Unknown Status2
DB00442Entecavir4Active Not Recruiting3
DB00442Entecavir4Completed15
DB00442Entecavir4Enrolling by Invitation1
DB00442Entecavir4Not Yet Recruiting2
DB00442Entecavir4Recruiting10
DB00442Entecavir4Terminated3
DB00442Entecavir4Unknown Status10
DB00442Entecavir4Withdrawn2
DB11627Hepatitis B Vaccine (Recombinant)4Completed1
DB10993Hepatitis B Vaccine (Recombinant)4Enrolling by Invitation1
DB11627Hepatitis B Vaccine (Recombinant)4Enrolling by Invitation1
DB14865Human interleukin-24Completed1
DB00105Interferon alfa-2b4Completed1
DB00709Lamivudine4Active Not Recruiting1
DB00709Lamivudine4Completed11
DB00709Lamivudine4Recruiting2
DB00709Lamivudine4Terminated2
DB00709Lamivudine4Unknown Status6
DB00709Lamivudine4Withdrawn2
DB00008Peginterferon alfa-2a4Active Not Recruiting3
DB00008Peginterferon alfa-2a4Completed17
DB00008Peginterferon alfa-2a4Recruiting9
DB00008Peginterferon alfa-2a4Unknown Status2
DB00008Peginterferon alfa-2a4Withdrawn1
DB00022Peginterferon alfa-2b4Completed1
DB00022Peginterferon alfa-2b4Recruiting1
DB00860Prednisolone4Unknown Status1
DB01265Telbivudine4Active Not Recruiting2
DB01265Telbivudine4Completed12
DB01265Telbivudine4Unknown Status6
DB01265Telbivudine4Withdrawn3
DB09299Tenofovir alafenamide4Active Not Recruiting1
DB09299Tenofovir alafenamide4Recruiting3
DB00300Tenofovir disoproxil4Active Not Recruiting6
DB13426Tenofovir disoproxil4Active Not Recruiting1
DB00300Tenofovir disoproxil4Completed9
DB00300Tenofovir disoproxil4Enrolling by Invitation2
DB00300Tenofovir disoproxil4Recruiting5
DB00300Tenofovir disoproxil4Unknown Status3
DB00300Tenofovir disoproxil4Withdrawn1
DB06361rsPSMA Vaccine4Active Not Recruiting1
DB01281AbataceptNot AvailableRecruiting1
DB00718Adefovir dipivoxilNot AvailableActive Not Recruiting1
DB00718Adefovir dipivoxilNot AvailableCompleted1
DB00442EntecavirNot AvailableCompleted3
DB00442EntecavirNot AvailableNot Yet Recruiting1
DB00442EntecavirNot AvailableRecruiting1
DB00442EntecavirNot AvailableUnknown Status2
DB05276Hepatitis B Immune GlobulinNot AvailableCompleted1
DB05276Hepatitis B Immune GlobulinNot AvailableRecruiting1
DB00709LamivudineNot AvailableCompleted2
DB00008Peginterferon alfa-2aNot AvailableCompleted7
DB00008Peginterferon alfa-2aNot AvailableNot Yet Recruiting2
DB00008Peginterferon alfa-2aNot AvailableRecruiting2
DB00022Peginterferon alfa-2bNot AvailableRecruiting1
DB00022Peginterferon alfa-2bNot AvailableUnknown Status1
DB00020SargramostimNot AvailableRecruiting1
DB01265TelbivudineNot AvailableCompleted1
DB01265TelbivudineNot AvailableWithdrawn2
DB09299Tenofovir alafenamideNot AvailableNot Yet Recruiting1
DB09299Tenofovir alafenamideNot AvailableRecruiting1
DB00300Tenofovir disoproxilNot AvailableActive Not Recruiting1
DB00300Tenofovir disoproxilNot AvailableCompleted3
DB00300Tenofovir disoproxilNot AvailableRecruiting3
DB00300Tenofovir disoproxilNot AvailableTerminated1
DB00300Tenofovir disoproxilNot AvailableWithdrawn1
DB12687VesatolimodNot AvailableTerminated1
DB06361rsPSMA VaccineNot AvailableCompleted1